Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations

PLoS Genetics

Volumn 10, Issue 2, 2014, Pages

  Chou, Hsin Hung ^a,b,e   Delaney, Nigel F ^a,f   Draghi, Jeremy A ^c,d   Marx, Christopher J ^a,g  

^a HARVARD UNIVERSITY   (United States)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g UNIVERSITY OF IDAHO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL MUTATION; BACTERIAL STRAIN; CATALYSIS; CONTROLLED STUDY; EPISTASIS; GENE INTERACTION; GENE MAPPING; GENE MUTATION; GENETIC LINE; GENETIC VARIABILITY; METHYLOBACTERIUM EXTORQUENS; MOLECULAR EVOLUTION; NONHUMAN; PROTEIN EXPRESSION; ADAPTATION; GENE EXPRESSION REGULATION; GENETIC SELECTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MUTATION; PHENOTYPE; REPRODUCTIVE FITNESS;

ADAPTATION, PHYSIOLOGICAL; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC FITNESS; METHYLOBACTERIUM EXTORQUENS; MUTATION; PHENOTYPE; SELECTION, GENETIC;

EID: 84901742626     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004149     Document Type: Article

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