The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: Tacrolimus (FK506) and butyrolactone synthetases production control

Applied Microbiology and Biotechnology

Volumn 98, Issue 11, 2014, Pages 4919-4936

  Salehi Najafabadi, Zahra ^a,b,c   Barreiro, Carlos ^b   Rodríguez García, Antonio ^a,b   Cruz, Anthony ^c   López, Gustavo E ^c   Martín, Juan F ^a,b  

^a UNIVERSITY OF LEÓN   (Spain)

^b Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

^c CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Butyrolactone; FK506; Immunosuppressant; Secondary metabolite; Streptomyces; Tacrolimus

Indexed keywords

BIOCHEMISTRY; DIMERS; ELECTROPHORETIC MOBILITY; GENES; MOLECULAR BIOLOGY; PRODUCTION CONTROL; STRUCTURAL OPTIMIZATION; SYNTHESIS (CHEMICAL);

BUTYROLACTONES; FK506; IMMUNOSUPPRESSANT; SECONDARY METABOLITES; STREPTOMYCES; TACROLIMUS;

BACTERIA;

BACTERIAL PROTEIN; BUTYROLACTONE; DIMER; DOCKING PROTEIN; GAMMA BUTYROLACTONE; GAMMA BUTYROLACTONE RECEPTOR 1; GAMMA BUTYROLACTONE RECEPTOR 2; GAMMA BUTYROLACTONE SYNTHETASE 1; GAMMA BUTYROLACTONE SYNTHETASE 2; MONOMER; RECEPTOR; RECOMBINANT PROTEIN; SYNTHETASE; TACROLIMUS; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; 4-BUTYROLACTONE RECEPTOR; BACTERIAL DNA; LIGASE;

BACTERIUM; CHEMICAL BINDING; ELECTROKINESIS; ENZYME ACTIVITY; IMMUNOASSAY; MOLECULAR ANALYSIS; MUTATION; PROTEIN; SECONDARY METABOLITE;

AMINO ACID SEQUENCE; ARTICLE; AUTOREGULATION; BACTERIAL GENE; BINDING SITE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME SYNTHESIS; GEL MOBILITY SHIFT ASSAY; GENE CLUSTER; GENE DELETION; GENE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOOTPRINTING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RECEPTOR BINDING; REGULATOR GENE; REGULATORY SEQUENCE; STREPTOMYCES TSUKUBAENSIS; CHEMISTRY; DNA FOOTPRINTING; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES TSUKUBAENSIS;

4-BUTYROLACTONE; BINDING SITES; DNA FOOTPRINTING; DNA, BACTERIAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; LIGASES; MOLECULAR SEQUENCE DATA; RECEPTORS, GABA-A; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; TACROLIMUS;

EID: 84901652912     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-5595-9     Document Type: Article

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