A rare leucine codon in adpA is implicated in the morphological defect of bldA mutants of Streptomyces coelicolor

Molecular Microbiology

Volumn 50, Issue 2, 2003, Pages 475-486

  Takano, E ^a,e   Tao, M ^a,b,e   Long, F ^b   Bibb, Maureen J ^a   Wang, L ^b   Li, W ^b   Buttner, M J ^a   Bibb, Mervyn J ^a,c   Deng, Z X ^b,d   Chater, K F ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^c DIVERSA CORPORATION   (United States)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; GAMMA BUTYROLACTONE; LEUCINE; MESSENGER RNA; PYRIMIDINE NUCLEOTIDE; SIGMA FACTOR;

ADPA C GENE; ADPA G GENE; ADSA GENE; ARTICLE; BACTERIAL GENE; BACTERIUM COLONY; BACTERIUM CULTURE; BALDA GENE; BALDH109 GENE; BALDN GENE; CODON; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENE ACTIVITY; GENE CONSTRUCT; GENE MUTATION; GENE SEQUENCE; GENETIC ENGINEERING; HOST; KARYOTYPE; LIQUID; MORPHOLOGY; MYCELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; ORNA GENE; PHENOTYPE; PRIORITY JOURNAL; RNA ANALYSIS; RNA TRANSLATION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEUS;

BACTERIAL PROTEINS; CODON; GENE EXPRESSION REGULATION; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; LEUCINE; PHENOTYPE; RNA, BACTERIAL; RNA, TRANSFER, LEU; STREPTOMYCES;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEUS; STREPTOMYCINEAE; UNCULTURED ACTINOMYCETE;

EID: 0142125295     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2003.03728.x     Document Type: Article

References (40)

1. Aigle, B., Wietzorrek, A., Takano, E., and Bibb, M.J. (2000) A single amino acid substitution in region 1.2 of the principal σ factor of Streptomyces coelicolor A3(2) results in the pleiotropic loss of antibiotic production. Mol Microbiol 37: 995-1004.
2. Bentley, S.D., Chater, K.F., Cerdeno-Tarraga, A.M., Challis, G.L., Thomson, N.R., James, K.D., et al. (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417: 141-147.
3. Bibb, M.J., and Buttner, M.J. (2003) Evidence that the Streptomyces coelicolor developmental transcription factor BldN is synthesized as a pro-protein. J Bacteriol 185: 2338-2345.
4. BldN, an extracytoplasmic function RNA polymerase sigma factor required for aerial mycelium formation in Streptomyces coelicolor A3(2). J Bacteriol 182: 4606-4616.
5. Bierman, M., Logan, R., O'Brien, K., Seno, E.T., Rao, R.N., and Schoner, B.E. (1992) Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116: 43-49.
6. Bignell, D.R., Warawa, J.L., Strap, J.L., Chater, K.F., and Leskiw, B.K. (2000) Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation. Microbiology 46: 2161-2173.
7. Chakraburtty, R., and Bibb, M.J. (1997) The ppGpp synthetase gene (re/A) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation. J Bacteriol 179: 5854-5861.
8. Champness, W.C. (1988) New loci required for Streptomyces coelicolor morphological and physiological differentiation. J Bacteriol 170: 1168-1174.
9. Chater, K.F. (2001) Regulation of sporulation in Streptomyces coelicolor A3(2): a checkpoint multiplex? Curr Opin Microbiol 4: 667-673.
10. Chater, K.F., and Horinouchi, S. (2003) Signalling early developmental events in two highly diverged Streptomyces species. Mol Microbiol 48: 9-15.
11. Datsenko, K.A., and Wanner, B.L. (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA 97: 6640-6645.
12. Elliot, M., Damji, F., Passantino, R., Chater, K., and Leskiw, B. (1998) The bldD gene of Streptomyces coelicolor A3(2): a regulatory gene involved in morphogenesis and antibiotic production. J Bacteriol 180: 1549-1555.
13. Elliot, M.A., Bibb, M.J., Buttner, M.J., and Leskiw, B.K. (2001) BIdD is a direct regulator of key developmental genes in Streptomyces coelicolor A3(2). Mol Microbiol 40: 257-269.
14. Fernandez-Moreno, M.A., Caballero, J.L., Hopwood, D.A., and Malpartida, F. (1991) The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Cell 66: 769-780.
15. Flett, F., Mersinias, V., and Smith, C.P. (1997) High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli methyl DNA-restricting streptomycetes. FEMS Microbiol Lett 155: 223-229.
16. Gust, B., Challis, G.L., Fowler, K., Kieser, T., and Chater, K.F. (2003) PCR-targeted Streptomyces gene disruption identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc Natl Acad Sci USA 100: 1541-1546.
17. Guthrie, E.P., Flaxman, C.S., White, J., Hodgson, D.A., Bibb, M.J., and Chater, K.F. (1998) A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket. Microbiology 144: 727-738.
18. Horinouchi, S. (2002) A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Front Biosci 7: 2045-2057.
19. Horinouchi, S., Suzuki, H., Nishiyama, M., and Beppu, T. (1989) Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis. J Bacteriol 171: 1206-1210.
20. Kieser, T., and Melton, R.E. (1988) Plasmid plJ699, a multicopy positive-selection vector for Streptomyces. Gene 65: 83-91.
21. Kieser, T., Bibb, M.J., Buttner, M.J., Chater, K.F., and Hopwood, D.A. (2000) Practical Streptomyces Genetics. Norwich: John Innes Foundation.
22. Kuhstoss, S., and Rao, R.N. (1991) Analysis of the integration function of the streptomycete bacteriophage φC31. J Mol Biol 222: 897-908.
23. Lawlor, E.J., Baylis, H.A., and Chater, K.F. (1987) Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2). Genes Dev 1: 1305-1310.
24. Leskiw, B.K., Lawlor, E.J., Fernandez-Abalos, J.M., and Chater, K.F. (1991) TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc Natl Acad Sci USA 88: 2461-2465.
25. MacNeil, D.J., Occi, J.L., Gewain, K.M., MacNeil, T., Gibbons, P.H., Ruby, C.L., and Danid, S.J. (1992) Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthetase. Gene 155:119-125.
26. Merrick, M.J. (1976) A morphological and genetic mapping study of bald colony mutants of Streptomyces coelicolor. J Gen Microbiol 96: 299-315.
27. Murray, M.G. (1986) Use of sodium trichloroacetate and mung bean nuclease to increase sensitivity and precision during transcription mapping. Anal Biochem 158: 165-170.
28. Nodwell, J.R., and Losick, R. (1998) Purification of an extracellular signaling molecule involved in aerial mycelium formation by Streptomyces coelicolor. J Bacteriol 180: 1334-1337.
29. Nodwell, J.R., McGovern, K., and Losick, R. (1996) An oligopeptide permease responsible for the import of an extracellular signal governing aerial mycelium formation in Streptomyces coelicolor. Mol Microbiol 22: 881-893.
30. Ohnishi, Y., Kameyama, S., Onaka, H., and Horinouchi, S. (1999) The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 34: 102-111.
31. Ohnishi, Y., Nishiyama, Y., Sato, R., Kameyama, S., and Horinouchi, S. (2000) An oligoribonuclease gene in Streptomyces griseus. J Bacteriol 182: 4647-4653.
32. Passantino, R., Puglia, A.M., and Chater, K. (1991) Additional copies of the actll regulatory gene induce actinorhodin production in pleiotropic bid mutants of Streptomyces coelicolor A3(2). J Gen Microbiol 137: 2059-2064.
33. Redenbach, M., Kieser, H.M., Denapaite, D., Eichner, A., Cullum, J., Kinashi, H., and Hopwood, D.A. (1996) A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome. Mol Microbiol 21: 77-96.
34. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
35. Strauch, E., Takano, E., Baylis, H.A., and Bibb, M.J. (1991) The stringent response in Streptomyces coelicolor A3(2). Mol Microbiol 5: 289-298.
36. Takano, E., Chakraburtty, R., Nihira, T., Yamada, Y., and Bibb, M.J. (2001) A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2). Mol Microbiol 41: 1015-1028.
37. Trepanier, N.K., Jensen, S.E., Alexander, D.C., and Leskiw, B.K. (2002) The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant. Microbiology 148: 643-656.
38. White, J., and Bibb, M. (1997) bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade. J Bacteriol 179: 627-633.
39. Willey, J., Schwedock, J., and Losick, R. (1993) Multiple extracellular signals govern the production of a morphogenetic protein involved in aerial mycelium formation by Streptomyces coelicolor. Genes Dev 7: 895-903.
40. AdsA) that is essential for morphological development in Streptomyces griseus. J Bacteriol 182: 4596-4605.