메뉴 건너뛰기




Volumn 45, Issue 2, 2014, Pages 107-121

Biology and management of myeloma-related bone disease

Author keywords

Bisphosphonates; Denosumab; Multiple myeloma; RANKL; Zoledronic acid

Indexed keywords

ACTIVIN A; ANTINEOPLASTIC AGENT; BHQ 880; BHQ880; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CLODRONIC ACID; DENOSUMAB; ETIDRONIC ACID; IMMUNOMODULATING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 3; INTERLEUKIN 6; LENALIDOMIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; OSTEOPROTEGERIN; PAMIDRONIC ACID; PARATHYROID HORMONE RELATED PROTEIN; POMALIDOMIDE; ROMOSOZUMAB; SCATTER FACTOR; SCLEROSTIN; SOTATERCEPT; STROMAL CELL DERIVED FACTOR 1ALPHA; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; ZOLEDRONIC ACID;

EID: 84901634720     PISSN: 00015814     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.achaem.2014.04.010     Document Type: Review
Times cited : (1)

References (168)
  • 1
    • 0037216353 scopus 로고    scopus 로고
    • Review of 1027 patients with newly diagnosed multiple myeloma
    • Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003;78:21-33
    • (2003) Mayo Clin Proc , vol.78 , pp. 21-33
    • Kyle, R.A.1    Gertz, M.A.2    Witzig, T.E.3
  • 5
    • 34447266200 scopus 로고    scopus 로고
    • An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ-MY20) in assessing the quality of life of patients with multiple myeloma
    • Cocks K, Cohen D, Wisløff F, et al. An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ-MY20) in assessing the quality of life of patients with multiple myeloma. Eur J Cancer 2007;43:1670-1678
    • (2007) Eur J Cancer , vol.43 , pp. 1670-1678
    • Cocks, K.1    Cohen, D.2    Wisløff, F.3
  • 6
    • 0032956189 scopus 로고    scopus 로고
    • Economic impact of using clodronate in the management of patients with multiple myeloma
    • Bruce NJ, McCloskey EV, Kanis JA, Guest JF. Economic impact of using clodronate in the management of patients with multiple myeloma. Br J Haematol 1999;104:358-364
    • (1999) Br J Haematol , vol.104 , pp. 358-364
    • Bruce, N.J.1    McCloskey, E.V.2    Kanis, J.A.3    Guest, J.F.4
  • 7
    • 35048875471 scopus 로고    scopus 로고
    • Pathologic fractures correlate with reduced survival in patients with malignant bone disease
    • Saad F, Lipton A, Cook R, Chen YM, Smith M, Coleman R. Pathologic fractures correlate with reduced survival in patients with malignant bone disease. Cancer 2007;110:1860-1867
    • (2007) Cancer , vol.110 , pp. 1860-1867
    • Saad, F.1    Lipton, A.2    Cook, R.3    Chen, Y.M.4    Smith, M.5    Coleman, R.6
  • 8
    • 0025783336 scopus 로고
    • Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma
    • Bataille R, Chappard D, Marcelli C, et al. Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J Clin Invest 1991;88:62-66
    • (1991) J Clin Invest , vol.88 , pp. 62-66
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3
  • 9
    • 23844551832 scopus 로고    scopus 로고
    • Myeloma bone disease: Pathophysiology and management
    • Terpos E, Dimopoulos MA. Myeloma bone disease: pathophysiology and management. Ann Oncol 2005;16:1223-1231
    • (2005) Ann Oncol , vol.16 , pp. 1223-1231
    • Terpos, E.1    Dimopoulos, M.A.2
  • 10
    • 4944230728 scopus 로고    scopus 로고
    • Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: A vicious cycle between bone destruction and myeloma expansion
    • Abe M, Hiura K, Wilde J, et al. Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. Blood 2004;104:2484-2491
    • (2004) Blood , vol.104 , pp. 2484-2491
    • Abe, M.1    Hiura, K.2    Wilde, J.3
  • 11
    • 33847368961 scopus 로고    scopus 로고
    • Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: A role for vascular endothelial cell growth factor and osteopontin
    • Tanaka Y, Abe M, Hiasa M, et al. Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin. Clin Cancer Res 2007;13:816-823
    • (2007) Clin Cancer Res , vol.13 , pp. 816-823
    • Tanaka, Y.1    Abe, M.2    Hiasa, M.3
  • 12
    • 84890285795 scopus 로고    scopus 로고
    • Contribution of regulatory T cells to immunosuppression and disease progression in multiple myeloma patients
    • Raja KR, Hajek R. Contribution of regulatory T cells to immunosuppression and disease progression in multiple myeloma patients. Oncoimmunology 2013;2:e25619
    • (2013) Oncoimmunology , vol.2
    • Raja, K.R.1    Hajek, R.2
  • 13
    • 0037114636 scopus 로고    scopus 로고
    • Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: A potential role in multiple myeloma bone disease
    • Giuliani N, Colla S, Sala R, et al. Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Blood 2002;100:4615-4621
    • (2002) Blood , vol.100 , pp. 4615-4621
    • Giuliani, N.1    Colla, S.2    Sala, R.3
  • 14
    • 78149322663 scopus 로고    scopus 로고
    • A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    • Noonan K, Marchionni L, Anderson J, Pardoll D, Roodman GD, Borrello I. A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood 2010;4116:3554-3563
    • (2010) Blood , vol.4116 , pp. 3554-3563
    • Noonan, K.1    Marchionni, L.2    Anderson, J.3    Pardoll, D.4    Roodman, G.D.5    Borrello, I.6
  • 15
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S, Wezeman MJ, Zangari M, et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006;91:192-199
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3
  • 16
    • 0032589103 scopus 로고    scopus 로고
    • Expression of interleukin-1beta and tumour necrosis factor-alpha in plasma cells from patients with multiple myeloma
    • Sati HI, Greaves M, Apperley JF, Russell RG, Croucher PI. Expression of interleukin-1beta and tumour necrosis factor-alpha in plasma cells from patients with multiple myeloma. Br J Haematol 1999;104:350-357
    • (1999) Br J Haematol , vol.104 , pp. 350-357
    • Sati, H.I.1    Greaves, M.2    Apperley, J.F.3    Russell, R.G.4    Croucher, P.I.5
  • 17
    • 0038579121 scopus 로고    scopus 로고
    • Dual effects of macrophage inflammatory protein-1 alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    • Oyajobi BO, Franchin G, Williams PJ, et al. Dual effects of macrophage inflammatory protein-1 alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. Blood 2003;102:311-319
    • (2003) Blood , vol.102 , pp. 311-319
    • Oyajobi, B.O.1    Franchin, G.2    Williams, P.J.3
  • 18
    • 33746326785 scopus 로고    scopus 로고
    • The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: Interplay of growth factors, their receptors and stromal interactions
    • Mitsiades CS, Mitsiades NS, Munshi NC, Richardson PG, Anderson KC. The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions. Eur J Cancer 2006;42:1564-1573
    • (2006) Eur J Cancer , vol.42 , pp. 1564-1573
    • Mitsiades, C.S.1    Mitsiades, N.S.2    Munshi, N.C.3    Richardson, P.G.4    Anderson, K.C.5
  • 19
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu H, Lacey DL, Dunstan CR, et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 1999;96:3540-3545
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3540-3545
    • Hsu, H.1    Lacey, D.L.2    Dunstan, C.R.3
  • 20
    • 0032545355 scopus 로고    scopus 로고
    • RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
    • Nakagawa N, Kinosaki M, Yamaguchi K, et al. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun 1998;253:395-400
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 395-400
    • Nakagawa, N.1    Kinosaki, M.2    Yamaguchi, K.3
  • 21
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423:337-342
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 22
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda H, Shima N, Nakagawa N, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 1998;95:3597-3602
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3597-3602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3
  • 23
    • 0031869001 scopus 로고    scopus 로고
    • Osteoprotegerin and its cognate ligand: A new paradigm of osteoclastogenesis
    • Hofbauer LC, Heufelder AE. Osteoprotegerin and its cognate ligand: a new paradigm of osteoclastogenesis. Eur J Endocrinol 1998;139:152-154
    • (1998) Eur J Endocrinol , vol.139 , pp. 152-154
    • Hofbauer, L.C.1    Heufelder, A.E.2
  • 24
    • 0033568341 scopus 로고    scopus 로고
    • RANK is essential for osteoclast and lymph node development
    • Dougall WC, Glaccum M, Charrier K, et al. RANK is essential for osteoclast and lymph node development. Genes Dev 1999;13:2412-2424
    • (1999) Genes Dev , vol.13 , pp. 2412-2424
    • Dougall, W.C.1    Glaccum, M.2    Charrier, K.3
  • 25
    • 0032546449 scopus 로고    scopus 로고
    • Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha, 25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone
    • Tsukii K, Shima N, Mochizuki S, et al. Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha, 25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone. Biochem Biophys Res Commun 1998;246:337-341
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 337-341
    • Tsukii, K.1    Shima, N.2    Mochizuki, S.3
  • 26
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999;397:315-323
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3
  • 28
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165-176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 29
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin- deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay N, Sarosi I, Dunstan CR, et al. Osteoprotegerin- deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998;12:1260-1268
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.R.3
  • 30
    • 0032577903 scopus 로고    scopus 로고
    • Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/ osteoprotegerin
    • Mizuno A, Amizuka N, Irie K, et al. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/ osteoprotegerin. Biochem Biophys Res Commun 1998;247:610-615
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 610-615
    • Mizuno, A.1    Amizuka, N.2    Irie, K.3
  • 31
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997;89:309-319
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 32
    • 0033984313 scopus 로고    scopus 로고
    • The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
    • Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 2000;15:2-12
    • (2000) J Bone Miner Res , vol.15 , pp. 2-12
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3    Lacey, D.L.4    Boyle, W.J.5    Riggs, B.L.6
  • 33
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse RN, Sordillo EM, Yaccoby S, et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 2001;98:11581-11586
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3
  • 34
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/ osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N, Bataille R, Mancini C, Lazzaretti M, Barillé S. Myeloma cells induce imbalance in the osteoprotegerin/ osteoprotegerin ligand system in the human bone marrow environment. Blood 2001;98:3527-3533
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3    Lazzaretti, M.4    Barillé, S.5
  • 35
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
    • Croucher PI, Shipman CM, Lippitt J, et al. Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood 2001;98:3534-3540
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1    Shipman, C.M.2    Lippitt, J.3
  • 36
    • 0037389602 scopus 로고    scopus 로고
    • Expression of receptor activator of nuclear factor kappa B ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma
    • Heider U, Langelotz C, Jakob C, et al. Expression of receptor activator of nuclear factor kappa B ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma. Clin Cancer Res 2003;9:1436-1440
    • (2003) Clin Cancer Res , vol.9 , pp. 1436-1440
    • Heider, U.1    Langelotz, C.2    Jakob, C.3
  • 37
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappa B ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia AN, Atkins GJ, To LB, et al. Receptor activator of nuclear factor-kappa B ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 2003;63:5438-5445
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3
  • 38
    • 47249140444 scopus 로고    scopus 로고
    • Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma
    • Qiang YW, Chen Y, Stephens O, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 2008;112:196-207
    • (2008) Blood , vol.112 , pp. 196-207
    • Qiang, Y.W.1    Chen, Y.2    Stephens, O.3
  • 39
    • 0037108435 scopus 로고    scopus 로고
    • Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells
    • Standal T, Seidel C, Hjertner O, et al. Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells. Blood 2002;100:3002-3007
    • (2002) Blood , vol.100 , pp. 3002-3007
    • Standal, T.1    Seidel, C.2    Hjertner, O.3
  • 40
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB ligand osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E, Szydlo R, Apperley JF, et al. Soluble receptor activator of nuclear factor kappaB ligand osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 2003;102:1064-1069
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3
  • 41
    • 4544360663 scopus 로고    scopus 로고
    • Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS)
    • Politou M, Terpos E, Anagnostopoulos A, et al. Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS). Br J Haematol 2004;126:686-689
    • (2004) Br J Haematol , vol.126 , pp. 686-689
    • Politou, M.1    Terpos, E.2    Anagnostopoulos, A.3
  • 42
    • 0342322717 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma
    • Choi SJ, Cruz JC, Craig F, et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood 2000;96:671-675
    • (2000) Blood , vol.96 , pp. 671-675
    • Choi, S.J.1    Cruz, J.C.2    Craig, F.3
  • 43
    • 0037105599 scopus 로고    scopus 로고
    • Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma
    • Abe M, Hiura K, Wilde J, et al. Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma. Blood 2002;100:2195-2202
    • (2002) Blood , vol.100 , pp. 2195-2202
    • Abe, M.1    Hiura, K.2    Wilde, J.3
  • 44
    • 0035664488 scopus 로고    scopus 로고
    • Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease
    • Choi SJ, Oba Y, Gazitt Y, et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 2001;108:1833-1841
    • (2001) J Clin Invest , vol.108 , pp. 1833-1841
    • Choi, S.J.1    Oba, Y.2    Gazitt, Y.3
  • 45
    • 0035383761 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand
    • Han JH, Choi SJ, Kurihara N, Koide M, Oba Y, Roodman GD. Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood 2001;97:3349-3353
    • (2001) Blood , vol.97 , pp. 3349-3353
    • Han, J.H.1    Choi, S.J.2    Kurihara, N.3    Koide, M.4    Oba, Y.5    Roodman, G.D.6
  • 46
    • 0030791806 scopus 로고    scopus 로고
    • Mechanisms of bone lesions in multiple myeloma and lymphoma
    • Roodman GD. Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer 1997;80:1557-1563
    • (1997) Cancer , vol.80 , pp. 1557-1563
    • Roodman, G.D.1
  • 47
    • 0141707692 scopus 로고    scopus 로고
    • Serum levels of macrophage inflammatory protein-1 alpha (MIP-1a) correlate with the extent of bone disease and survival in patients with Multiple Myeloma
    • Terpos E, Politou M, Szydlo R, Goldman JM, Apperley JF, Rahemtulla A. Serum levels of macrophage inflammatory protein-1 alpha (MIP-1a) correlate with the extent of bone disease and survival in patients with Multiple Myeloma. Br J Haematol 2003;123:106-109
    • (2003) Br J Haematol , vol.123 , pp. 106-109
    • Terpos, E.1    Politou, M.2    Szydlo, R.3    Goldman, J.M.4    Apperley, J.F.5    Rahemtulla, A.6
  • 48
    • 10744221725 scopus 로고    scopus 로고
    • Gene expression profiling of multiple myeloma reveals molecular portraits in relation to the pathogenesis of the disease
    • Magrangeas F, Nasser V, Avet-Loiseau H, et al. Gene expression profiling of multiple myeloma reveals molecular portraits in relation to the pathogenesis of the disease. Blood 2003;101:4998-5006
    • (2003) Blood , vol.101 , pp. 4998-5006
    • Magrangeas, F.1    Nasser, V.2    Avet-Loiseau, H.3
  • 49
    • 0038386032 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells
    • Lentzsch S, Gries M, Janz M, Bargou R, Dörken B, Mapara MY. Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells. Blood 2003;101:3568-3573
    • (2003) Blood , vol.101 , pp. 3568-3573
    • Lentzsch, S.1    Gries, M.2    Janz, M.3    Bargou, R.4    Dörken, B.5    Mapara, M.Y.6
  • 50
    • 1542313900 scopus 로고    scopus 로고
    • IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells
    • Lee JW, Chung HY, Ehrlich LA, et al. IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells. Blood 2004;103:2308- 2315
    • (2004) Blood , vol.103 , pp. 2308-2315
    • Lee, J.W.1    Chung, H.Y.2    Ehrlich, L.A.3
  • 51
    • 23744507989 scopus 로고    scopus 로고
    • IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma
    • Ehrlich LA, Chung HY, Ghobrial I, et al. IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma. Blood 2005;106:1407-1414
    • (2005) Blood , vol.106 , pp. 1407-1414
    • Ehrlich, L.A.1    Chung, H.Y.2    Ghobrial, I.3
  • 52
    • 0030052779 scopus 로고    scopus 로고
    • Serum interleukin-6 (IL-6) and interleukin-4 (IL-4) in patients with multiple myeloma (MM)
    • Kyrstsonis MC, Dedoussis G, Baxevanis C, Stamatelou M, Maniatis A. Serum interleukin-6 (IL-6) and interleukin-4 (IL-4) in patients with multiple myeloma (MM). Br J Haematol 1996;92:420-422
    • (1996) Br J Haematol , vol.92 , pp. 420-422
    • Kyrstsonis, M.C.1    Dedoussis, G.2    Baxevanis, C.3    Stamatelou, M.4    Maniatis, A.5
  • 53
    • 0031810469 scopus 로고    scopus 로고
    • Interleukin-6 is expressed by plasma cells from patients with multiple myeloma and monoclonal gammopathy of undetermined significance
    • Sati HI, Apperley JF, Greaves M, et al. Interleukin-6 is expressed by plasma cells from patients with multiple myeloma and monoclonal gammopathy of undetermined significance. Br J Haematol 1998;101:287-295
    • (1998) Br J Haematol , vol.101 , pp. 287-295
    • Sati, H.I.1    Apperley, J.F.2    Greaves, M.3
  • 54
    • 85047686517 scopus 로고    scopus 로고
    • IL-1beta expression in IgM monoclonal gammopathy and its relationship to multiple myeloma
    • Donovan KA, Lacy MQ, Gertz MA, Lust JA. IL-1beta expression in IgM monoclonal gammopathy and its relationship to multiple myeloma. Leukemia 2002;16: 382-385
    • (2002) Leukemia , vol.16 , pp. 382-385
    • Donovan, K.A.1    Lacy, M.Q.2    Gertz, M.A.3    Lust, J.A.4
  • 55
    • 4143119930 scopus 로고    scopus 로고
    • Impaired osteoblastogenesis in myeloma bone disease: Role of upregulated apoptosis by cytokines and malignant plasma cells
    • Silvestris F, Cafforio P, Calvani N, Dammacco F. Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells. Br J Haematol 2004;126:475-486
    • (2004) Br J Haematol , vol.126 , pp. 475-486
    • Silvestris, F.1    Cafforio, P.2    Calvani, N.3    Dammacco, F.4
  • 56
    • 0034523328 scopus 로고    scopus 로고
    • TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
    • Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000;106:1481-1488
    • (2000) J Clin Invest , vol.106 , pp. 1481-1488
    • Lam, J.1    Takeshita, S.2    Barker, J.E.3    Kanagawa, O.4    Ross, F.P.5    Teitelbaum, S.L.6
  • 57
    • 4644258648 scopus 로고    scopus 로고
    • Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
    • Tjin EP, Derksen PW, Kataoka H, Spaargaren M, Pals ST. Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator. Blood 2004;104:2172-2175
    • (2004) Blood , vol.104 , pp. 2172-2175
    • Tjin, E.P.1    Derksen, P.W.2    Kataoka, H.3    Spaargaren, M.4    Pals, S.T.5
  • 58
    • 0034655957 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
    • Dankbar B, Padro T, Leo R, et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood 2000;95:2630-2636
    • (2000) Blood , vol.95 , pp. 2630-2636
    • Dankbar, B.1    Padro, T.2    Leo, R.3
  • 59
    • 2942606661 scopus 로고    scopus 로고
    • Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma
    • Standal T, Hjorth-Hansen H, Rasmussen T, et al. Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma. Haematologica 2004;89:174-182
    • (2004) Haematologica , vol.89 , pp. 174-182
    • Standal, T.1    Hjorth-Hansen, H.2    Rasmussen, T.3
  • 60
    • 33846169078 scopus 로고    scopus 로고
    • Skeletal metastasis: Established and emerging roles of parathyroid hormone related protein (PTHrP)
    • Liao J, McCauley LK. Skeletal metastasis: Established and emerging roles of parathyroid hormone related protein (PTHrP). Cancer Metast Rev 2006;25:559-571
    • (2006) Cancer Metast Rev , vol.25 , pp. 559-571
    • Liao, J.1    McCauley, L.K.2
  • 61
    • 0030861712 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein and bone metastases
    • Guise TA. Parathyroid hormone-related protein and bone metastases. Cancer 1997;80:1572-1580
    • (1997) Cancer , vol.80 , pp. 1572-1580
    • Guise, T.A.1
  • 62
    • 0033305046 scopus 로고    scopus 로고
    • Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: Correlation with osteoclast-like cell formation
    • Lee SK, Lorenzo JA. Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology 1999;140:3552-3561
    • (1999) Endocrinology , vol.140 , pp. 3552-3561
    • Lee, S.K.1    Lorenzo, J.A.2
  • 63
    • 0034980787 scopus 로고    scopus 로고
    • Expression and in vitro modification of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP-receptor in human myeloma cells
    • Otsuki T, Yamada O, Kurebayashi J, et al. Expression and in vitro modification of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP-receptor in human myeloma cells. Leuk Lymph 2001;41:397-409
    • (2001) Leuk Lymph , vol.41 , pp. 397-409
    • Otsuki, T.1    Yamada, O.2    Kurebayashi, J.3
  • 64
    • 84890894704 scopus 로고    scopus 로고
    • PTHrP produced by myeloma plasma cells regulates their survival and pro-osteoclast activity for bone disease progression
    • Cafforio P, Savonarola A, Stucci S, et al. PTHrP produced by myeloma plasma cells regulates their survival and pro-osteoclast activity for bone disease progression. J Bone Miner Res 2014;29:55-66
    • (2014) J Bone Miner Res , vol.29 , pp. 55-66
    • Cafforio, P.1    Savonarola, A.2    Stucci, S.3
  • 65
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf JJ, Kahler RA, Schroeder TM. Wnt signaling in osteoblasts and bone diseases. Gene 2004;341:19-39
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 66
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003;116:2627-2634
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 67
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-2494
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 68
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou MC, Heath DJ, Rahemtulla A, et al. Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer 2006;119:1728-1731
    • (2006) Int J Cancer , vol.119 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3
  • 69
    • 43549108372 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
    • Kaiser M, Mieth M, Liebisch P, et al. Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur J Haematol 2008;80:490-494
    • (2008) Eur J Haematol , vol.80 , pp. 490-494
    • Kaiser, M.1    Mieth, M.2    Liebisch, P.3
  • 70
    • 57649158485 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment
    • Heider U, Kaiser M, Mieth M, et al. Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. Eur J Haematol 2009;82:31-38
    • (2009) Eur J Haematol , vol.82 , pp. 31-38
    • Heider, U.1    Kaiser, M.2    Mieth, M.3
  • 71
    • 20244373613 scopus 로고    scopus 로고
    • Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass II DA, Bialek P, Ahn JD, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005;8:751-764
    • (2005) Dev Cell , vol.8 , pp. 751-764
    • Glass, I.I.D.A.1    Bialek, P.2    Ahn, J.D.3
  • 72
    • 33646808104 scopus 로고    scopus 로고
    • Wnt signalling in osteoblasts regulates expression of the receptor activator of NF kappaB ligand and inhibits osteoclastogenesis in vitro
    • Spencer GJ, Utting JC, Etheridge SL, Arnett TR, Genever PG. Wnt signalling in osteoblasts regulates expression of the receptor activator of NF kappaB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci 2006;119:1283-1296
    • (2006) J Cell Sci , vol.119 , pp. 1283-1296
    • Spencer, G.J.1    Utting, J.C.2    Etheridge, S.L.3    Arnett, T.R.4    Genever, P.G.5
  • 73
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP- 2
    • Oshima T, Abe M, Asano J, et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP- 2. Blood 2005;106:3160-3165
    • (2005) Blood , vol.106 , pp. 3160-3165
    • Oshima, T.1    Abe, M.2    Asano, J.3
  • 75
    • 84890912443 scopus 로고    scopus 로고
    • Clinical utility of serum sclerostin measurements
    • Clarke BL, Drake MT. Clinical utility of serum sclerostin measurements. Bonekey Rep 2013;2:361
    • (2013) Bonekey Rep , vol.2 , pp. 361
    • Clarke, B.L.1    Drake, M.T.2
  • 76
    • 81255210568 scopus 로고    scopus 로고
    • Sclerostin is overexpressed by plasma cells of multiple myeloma patients
    • Brunetti G, Oranger A, Mori G, et al. Sclerostin is overexpressed by plasma cells of multiple myeloma patients. Ann N Y Acad Sci 2011;1237:19-23
    • (2011) Ann N y Acad Sci , vol.1237 , pp. 19-23
    • Brunetti, G.1    Oranger, A.2    Mori, G.3
  • 77
    • 84864144433 scopus 로고    scopus 로고
    • Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: Reduction post-bortezomib monotherapy
    • Terpos E, Christoulas D, Katodritou E, et al. Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: reduction post-bortezomib monotherapy. Int J Cancer 2012;131:1466-1471
    • (2012) Int J Cancer , vol.131 , pp. 1466-1471
    • Terpos, E.1    Christoulas, D.2    Katodritou, E.3
  • 78
    • 77950438331 scopus 로고    scopus 로고
    • Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease
    • Vallet S, Mukherjee S, Vaghela N, et al. Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A 2010;107:5124-5129
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5124-5129
    • Vallet, S.1    Mukherjee, S.2    Vaghela, N.3
  • 79
    • 84867135322 scopus 로고    scopus 로고
    • Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; No alterations post-lenalidomide and dexamethasone therapy
    • Terpos E, Kastritis E, Christoulas D, et al. Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; no alterations post-lenalidomide and dexamethasone therapy. Ann Oncol 2012;23:2681-2686
    • (2012) Ann Oncol , vol.23 , pp. 2681-2686
    • Terpos, E.1    Kastritis, E.2    Christoulas, D.3
  • 80
    • 77957727888 scopus 로고    scopus 로고
    • Inhibiting activin- A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo
    • Chantry AD, Heath D, Mulivor AW, et al. Inhibiting activin- A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo. J Bone Miner Res 2010;25:2633-2646
    • (2010) J Bone Miner Res , vol.25 , pp. 2633-2646
    • Chantry, A.D.1    Heath, D.2    Mulivor, A.W.3
  • 82
    • 0033664271 scopus 로고    scopus 로고
    • Imaging of myeloma bone disease-implications for staging, prognosis and follow-up
    • Dimopoulos MA, Moulopoulos LA, Datseris I, et al. Imaging of myeloma bone disease-implications for staging, prognosis and follow-up. Acta Oncol 2000;39:823-827
    • (2000) Acta Oncol , vol.39 , pp. 823-827
    • Dimopoulos, M.A.1    Moulopoulos, L.A.2    Datseris, I.3
  • 83
    • 70349303765 scopus 로고    scopus 로고
    • International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma
    • Dimopoulos M, Terpos E, Comenzo RL, et al. International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma. Leukemia 2009;23:1545-1556.
    • (2009) Leukemia , vol.23 , pp. 1545-1556
    • Dimopoulos, M.1    Terpos, E.2    Comenzo, R.L.3
  • 84
    • 33646239372 scopus 로고    scopus 로고
    • Biochemical markers of bone metabolism in multiple myeloma
    • Terpos E. Biochemical markers of bone metabolism in multiple myeloma. Cancer Treat Rev 2006;32:15-19
    • (2006) Cancer Treat Rev , vol.32 , pp. 15-19
    • Terpos, E.1
  • 85
    • 24644479228 scopus 로고    scopus 로고
    • Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
    • Coleman RE, Major P, Lipton A, et al. Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. J Clin Oncol 2005;23:4925-4935
    • (2005) J Clin Oncol , vol.23 , pp. 4925-4935
    • Coleman, R.E.1    Major, P.2    Lipton, A.3
  • 86
    • 0037278205 scopus 로고    scopus 로고
    • Comparison of five biochemical markers of bone resorption in multiple myeloma: Elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy
    • Abildgaard N, Brixen K, Kristensen JE, Eriksen EF, Nielsen JL, Heickendorff L. Comparison of five biochemical markers of bone resorption in multiple myeloma: elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy. Br J Haematol 2003;120:235-242
    • (2003) Br J Haematol , vol.120 , pp. 235-242
    • Abildgaard, N.1    Brixen, K.2    Kristensen, J.E.3    Eriksen, E.F.4    Nielsen, J.L.5    Heickendorff, L.6
  • 87
    • 0034665761 scopus 로고    scopus 로고
    • Solitary plasmacytoma of bone and asymptomatic multiple myeloma
    • Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R. Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood 2000;96:2037-2044
    • (2000) Blood , vol.96 , pp. 2037-2044
    • Dimopoulos, M.A.1    Moulopoulos, L.A.2    Maniatis, A.3    Alexanian, R.4
  • 88
  • 89
    • 84859631459 scopus 로고    scopus 로고
    • 18F-fluoro-deoxyglucose positron emission tomography in assessment of myeloma- related bone disease: A systematicreview
    • Van Lammeren-Venema D, Regelink JC, Riphagen II, et al. 18F-fluoro-deoxyglucose positron emission tomography in assessment of myeloma- related bone disease: A systematicreview. Cancer 2012;118:1971-1981
    • (2012) Cancer , vol.118 , pp. 1971-1981
    • Van Lammeren-Venema, D.1    Regelink, J.C.2    Riphagen, I.I.3
  • 91
    • 79954427850 scopus 로고    scopus 로고
    • Impact of radiotherapy on pain relief and recalcification in plasma cell neoplasms: Long-term experience
    • Balducci M, Chiesa S, Manfrida S, et al. Impact of radiotherapy on pain relief and recalcification in plasma cell neoplasms: Long-term experience. Strahlenther Onkol 2011;187:114-119
    • (2011) Strahlenther Onkol , vol.187 , pp. 114-119
    • Balducci, M.1    Chiesa, S.2    Manfrida, S.3
  • 92
    • 84883021288 scopus 로고    scopus 로고
    • International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease
    • Terpos E, Morgan G, Dimopoulos MA, et al. International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease. J Clin Oncol 2013;31:2347-2357
    • (2013) J Clin Oncol , vol.31 , pp. 2347-2357
    • Terpos, E.1    Morgan, G.2    Dimopoulos, M.A.3
  • 93
    • 0037280373 scopus 로고    scopus 로고
    • Percutaneous vertebroplasty: Indications, contraindications, and technique
    • Peh WC, Gilula LA. Percutaneous vertebroplasty: indications, contraindications, and technique. Br J Radiol 2003;76:69-75
    • (2003) Br J Radiol , vol.76 , pp. 69-75
    • Peh, W.C.1    Gilula, L.A.2
  • 94
    • 0036570231 scopus 로고    scopus 로고
    • Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma
    • Dudeney S, Lieberman IH, Reinhardt MK, Hussein M. Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol 2002;20:2382-2387
    • (2002) J Clin Oncol , vol.20 , pp. 2382-2387
    • Dudeney, S.1    Lieberman, I.H.2    Reinhardt, M.K.3    Hussein, M.4
  • 95
    • 14944341603 scopus 로고    scopus 로고
    • Incidence of subsequent vertebral fracture after kyphoplasty
    • Fribourg D, Tang C, Sra P, Delamarter R, Bae H. Incidence of subsequent vertebral fracture after kyphoplasty. Spine 2004;29:2270-2276
    • (2004) Spine , vol.29 , pp. 2270-2276
    • Fribourg, D.1    Tang, C.2    Sra, P.3    Delamarter, R.4    Bae, H.5
  • 96
    • 63949086827 scopus 로고    scopus 로고
    • Vertebroplasty and kyphoplasty are associated with an increased risk of secondary vertebral compression fractures: A population- based cohort study
    • Mudano AS, Bian J, Cope JU, et al. Vertebroplasty and kyphoplasty are associated with an increased risk of secondary vertebral compression fractures: a population- based cohort study. Osteoporos Int 2008;5:819-826
    • (2008) Osteoporos Int , vol.5 , pp. 819-826
    • Mudano, A.S.1    Bian, J.2    Cope, J.U.3
  • 97
    • 0034659773 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of action of bisphosphonates
    • Rogers MJ, Gordon S, Benford HL, et al. Cellular and molecular mechanisms of action of bisphosphonates. Cancer 2000;88:2961
    • (2000) Cancer , vol.88 , pp. 2961
    • Rogers, M.J.1    Gordon, S.2    Benford, H.L.3
  • 98
    • 69449108135 scopus 로고    scopus 로고
    • The use of bisphosphonates in multiple myeloma recommendations of an expert panel on behalf of the European Myeloma Network
    • Terpos E, Sezer O, Croucher PI, et al. The use of bisphosphonates in multiple myeloma recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009;20:1303
    • (2009) Ann Oncol , vol.20 , pp. 1303
    • Terpos, E.1    Sezer, O.2    Croucher, P.I.3
  • 99
    • 0022553220 scopus 로고
    • Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix
    • Boonekamp PM, van der Wee-Pals LJ, van Wijk-van Lennep MM, et al. Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner 1986;1:27
    • (1986) Bone Miner , vol.1 , pp. 27
    • Boonekamp, P.M.1    Van Der Wee-Pals, L.J.2    Van Wijk-Van Lennep, M.M.3
  • 100
    • 0032771029 scopus 로고    scopus 로고
    • Relationship between bisphosphonate concentration and osteoclast activity and viability
    • Rowe DJ, Etre LA, Lovdahl MJ, Pietrzyk DJ. Relationship between bisphosphonate concentration and osteoclast activity and viability. In Vitro Cell Dev Biol Anim 1999;35:383
    • (1999) Vitro Cell Dev Biol Anim , vol.35 , pp. 383
    • Rowe, D.J.1    Etre, L.A.2    Lovdahl, M.J.3    Pietrzyk, D.J.4
  • 102
    • 0032491041 scopus 로고    scopus 로고
    • Bisphosphonates as anticancer drugs
    • Mundy GR, Yoneda T. Bisphosphonates as anticancer drugs. N Engl J Med 1998;339-398
    • (1998) N Engl J Med , pp. 339-398
    • Mundy, G.R.1    Yoneda, T.2
  • 103
    • 0032918414 scopus 로고    scopus 로고
    • TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
    • Yin JJ, Selander K, Chirgwin JM, et al. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest 1999;103:197
    • (1999) J Clin Invest , vol.103 , pp. 197
    • Yin, J.J.1    Selander, K.2    Chirgwin, J.M.3
  • 104
    • 0032491037 scopus 로고    scopus 로고
    • Reduction in new metastases in breast cancer with adjuvant clodronate treatment
    • Diel IJ, Solomayer EF, Costa SD, et al. Reduction in new metastases in breast cancer with adjuvant clodronate treatment. N Engl J Med 1998;339:357
    • (1998) N Engl J Med , vol.339 , pp. 357
    • Diel, I.J.1    Solomayer, E.F.2    Costa, S.D.3
  • 105
    • 0031932783 scopus 로고    scopus 로고
    • In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates
    • Aparicio A, Gardner A, Tu Y, et al. In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates. Leukemia 1998;12:220
    • (1998) Leukemia , vol.12 , pp. 220
    • Aparicio, A.1    Gardner, A.2    Tu, Y.3
  • 106
    • 0030931858 scopus 로고    scopus 로고
    • Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity
    • Shipman CM, Rogers MJ, Apperley JF, et al. Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity. Br J Haematol 1997;98:665
    • (1997) Br J Haematol , vol.98 , pp. 665
    • Shipman, C.M.1    Rogers, M.J.2    Apperley, J.F.3
  • 107
    • 0031782314 scopus 로고    scopus 로고
    • Anti-myeloma activity of pamidronate in vivo
    • Dhodapkar MV, Singh J, Mehta J, et al. Anti-myeloma activity of pamidronate in vivo. Br J Haematol 1998;103:530
    • (1998) Br J Haematol , vol.103 , pp. 530
    • Dhodapkar, M.V.1    Singh, J.2    Mehta, J.3
  • 108
    • 0025916366 scopus 로고
    • Effect of daily etidronate on the osteolysis of multiple myeloma
    • Belch AR, Bergsagel DE, Wilson K, et al. Effect of daily etidronate on the osteolysis of multiple myeloma. J Clin Oncol 1991;9:1397-1402
    • (1991) J Clin Oncol , vol.9 , pp. 1397-1402
    • Belch, A.R.1    Bergsagel, D.E.2    Wilson, K.3
  • 109
    • 0027331171 scopus 로고
    • Treatment of multiple myeloma with etidronate: Results of a multicentre double-blind study
    • Daragon A, Humez C, Michot C, et al. Treatment of multiple myeloma with etidronate: results of a multicentre double-blind study. Eur J Med 1993;2:449-452
    • (1993) Eur J Med , vol.2 , pp. 449-452
    • Daragon, A.1    Humez, C.2    Michot, C.3
  • 110
    • 0026646339 scopus 로고
    • Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma
    • Lahtinen R, Laakso M, Palva I, Virkkunen P, Elomaa I. Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma. Lancet 1992;340:1049-1052
    • (1992) Lancet , vol.340 , pp. 1049-1052
    • Lahtinen, R.1    Laakso, M.2    Palva, I.3    Virkkunen, P.4    Elomaa, I.5
  • 111
    • 0028106385 scopus 로고
    • Subgroup and cost-benefit analysis of the Finnish multicentre trial of clodronate in multiple myeloma
    • Laakso M, Lahtinen R, Virkkunen P, Elomaa I. Subgroup and cost-benefit analysis of the Finnish multicentre trial of clodronate in multiple myeloma. Br J Haematol 1994;87:725-729
    • (1994) Br J Haematol , vol.87 , pp. 725-729
    • Laakso, M.1    Lahtinen, R.2    Virkkunen, P.3    Elomaa, I.4
  • 112
    • 0031911183 scopus 로고    scopus 로고
    • A randomized trial of the effect of clodronate on skeletal morbidity in multiple myeloma. MRC Working Party on Leukaemia in Adults
    • McCloskey EV, MacLennan IC, Drayson MT, et al. A randomized trial of the effect of clodronate on skeletal morbidity in multiple myeloma. MRC Working Party on Leukaemia in Adults. Br J Haematol 1998;100:317-325
    • (1998) Br J Haematol , vol.100 , pp. 317-325
    • McCloskey, E.V.1    Maclennan, I.C.2    Drayson, M.T.3
  • 113
    • 0034937438 scopus 로고    scopus 로고
    • Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma
    • McCloskey EV, Dunn JA, Kanis JA, MacLennan IC, Drayson MT. Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma. Br J Haematol 2001;113:1035-1043
    • (2001) Br J Haematol , vol.113 , pp. 1035-1043
    • McCloskey, E.V.1    Dunn, J.A.2    Kanis, J.A.3    Maclennan, I.C.4    Drayson, M.T.5
  • 114
    • 9044219839 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group
    • Berenson JR, Lichtenstein A, Porter L, et al. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 1996;334:488-493
    • (1996) N Engl J Med , vol.334 , pp. 488-493
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 115
    • 6844252283 scopus 로고    scopus 로고
    • Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group
    • Berenson JR, Lichtenstein A, Porter L, et al. Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group. J Clin Oncol 1998;16:593-602
    • (1998) J Clin Oncol , vol.16 , pp. 593-602
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 116
    • 0031810467 scopus 로고    scopus 로고
    • Failure of oral pamidronate to reduce skeletal morbidity in multiple myeloma: A double-blind placebo-controlled trial. Danish- Swedish co-operative study group
    • Brincker H, Westin J, Abildgaard N, et al. Failure of oral pamidronate to reduce skeletal morbidity in multiple myeloma: a double-blind placebo-controlled trial. Danish- Swedish co-operative study group. Br J Haematol 1998;101:280-286
    • (1998) Br J Haematol , vol.101 , pp. 280-286
    • Brincker, H.1    Westin, J.2    Abildgaard, N.3
  • 117
    • 0035312469 scopus 로고    scopus 로고
    • Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases
    • Berenson JR, Rosen LS, Howell A, et al. Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases. Cancer 2001;91:1191-1200
    • (2001) Cancer , vol.91 , pp. 1191-1200
    • Berenson, J.R.1    Rosen, L.S.2    Howell, A.3
  • 118
    • 0035463593 scopus 로고    scopus 로고
    • Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial
    • Rosen LS, Gordon D, Kaminski M, et al. Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial. Cancer J 2001;7:377-387
    • (2001) Cancer J , vol.7 , pp. 377-387
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3
  • 119
    • 10744233021 scopus 로고    scopus 로고
    • Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: A randomized, double-blind, multicenter, comparative trial
    • Rosen LS, Gordon D, Kaminski M, et al. Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial. Cancer 2003;98:1735-1744
    • (2003) Cancer , vol.98 , pp. 1735-1744
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3
  • 120
    • 54049124120 scopus 로고    scopus 로고
    • A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma
    • Musto P, Petrucci MT, Bringhen S, et al. A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma. Cancer 2008;113:1588-1595
    • (2008) Cancer , vol.113 , pp. 1588-1595
    • Musto, P.1    Petrucci, M.T.2    Bringhen, S.3
  • 121
    • 78650174738 scopus 로고    scopus 로고
    • First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): A randomised controlled trial
    • * *An important study which showed superiority of zoledronic acid over clodronate in reducing of SREs but also in offering survival advantage in treated patients 1999
    • Morgan GJ, Davies FE, Gregory WM, et al. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet 2010;376(9757):1989- 1999. * *An important study which showed superiority of zoledronic acid over clodronate in reducing of SREs but also in offering survival advantage in treated patients
    • (2010) Lancet , vol.376 , Issue.9757
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3
  • 122
    • 84862524640 scopus 로고    scopus 로고
    • Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: MRC myeloma IX trial
    • Morgan GJ, Davies FE, Gregory WM, et al. Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: MRC myeloma IX trial. Blood 2012;119:5374-5383
    • (2012) Blood , vol.119 , pp. 5374-5383
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3
  • 123
    • 0242308942 scopus 로고    scopus 로고
    • Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: Evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival
    • Croucher PI, De Hendrik R, Perry MJ, et al. Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival. J Bone Miner Res 2003;18:482-492
    • (2003) J Bone Miner Res , vol.18 , pp. 482-492
    • Croucher, P.I.1    De Hendrik, R.2    Perry, M.J.3
  • 124
    • 12244266675 scopus 로고    scopus 로고
    • Evaluation of bone mineral density and fat-lean distribution in patients with multiple myeloma in sustained remission
    • Roux S, Bergot C, Fermand JP, Frija J, Brouet JC, Mariette X. Evaluation of bone mineral density and fat-lean distribution in patients with multiple myeloma in sustained remission. J Bone Miner Res 2003;18:231-236
    • (2003) J Bone Miner Res , vol.18 , pp. 231-236
    • Roux, S.1    Bergot, C.2    Fermand, J.P.3    Frija, J.4    Brouet, J.C.5    Mariette, X.6
  • 125
    • 46949100434 scopus 로고    scopus 로고
    • Prevalence and significance of vitamin D deficiency in multiple myeloma patients
    • Badros A, Goloubeva O, Terpos E, et al. Prevalence and significance of vitamin D deficiency in multiple myeloma patients. Br J Haematol 2008;142:492-494
    • (2008) Br J Haematol , vol.142 , pp. 492-494
    • Badros, A.1    Goloubeva, O.2    Terpos, E.3
  • 126
    • 77953823347 scopus 로고    scopus 로고
    • Vitamin D deficiency does not alter biochemical markers of bone metabolism before or after autograft in patients with multiple myeloma
    • Laroche M, Lemaire O, Attal M. Vitamin D deficiency does not alter biochemical markers of bone metabolism before or after autograft in patients with multiple myeloma. Eur J Haematol 2010;85:65-67
    • (2010) Eur J Haematol , vol.85 , pp. 65-67
    • Laroche, M.1    Lemaire, O.2    Attal, M.3
  • 127
    • 78650886291 scopus 로고    scopus 로고
    • The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know
    • Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011;96:53-58
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 53-58
    • Ross, A.C.1    Manson, J.E.2    Abrams, S.A.3
  • 128
    • 33644841755 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors
    • Bamias A, Kastritis E, Bamia C, et al. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. Clin Oncol 2005;23:8580-8590
    • (2005) Clin Oncol , vol.23 , pp. 8580-8590
    • Bamias, A.1    Kastritis, E.2    Bamia, C.3
  • 129
    • 33745792743 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: Evidence of increased risk after treatment with zoledronic acid
    • Dimopoulos MA, Kastritis E, Anagnostopoulos A, et al. Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acid. Haematologica 2006;91:968-971
    • (2006) Haematologica , vol.91 , pp. 968-971
    • Dimopoulos, M.A.1    Kastritis, E.2    Anagnostopoulos, A.3
  • 130
    • 33747426633 scopus 로고    scopus 로고
    • Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: A single-centre experience in 303 patients
    • Zervas K, Verrou E, Teleioudis Z, et al. Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: a single-centre experience in 303 patients. Br J Haematol 2006;134: 620-623
    • (2006) Br J Haematol , vol.134 , pp. 620-623
    • Zervas, K.1    Verrou, E.2    Teleioudis, Z.3
  • 131
    • 58049204529 scopus 로고    scopus 로고
    • Natural history of osteonecrosis of the jaw in patients with multiple myeloma
    • Badros A, Terpos E, Katodritou E, et al. Natural history of osteonecrosis of the jaw in patients with multiple myeloma. J Clin Oncol 2008;26:5904-5909
    • (2008) J Clin Oncol , vol.26 , pp. 5904-5909
    • Badros, A.1    Terpos, E.2    Katodritou, E.3
  • 132
    • 58949104001 scopus 로고    scopus 로고
    • Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid
    • Dimopoulos MA, Kastritis E, Bamia C, et al. Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Ann Oncol 2009;20:117-120
    • (2009) Ann Oncol , vol.20 , pp. 117-120
    • Dimopoulos, M.A.1    Kastritis, E.2    Bamia, C.3
  • 133
    • 57049173860 scopus 로고    scopus 로고
    • Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates
    • Montefusco V, Gay F, Spina F, et al. Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates. Leuk Lymphoma 2008;49:2156-2162
    • (2008) Leuk Lymphoma , vol.49 , pp. 2156-2162
    • Montefusco, V.1    Gay, F.2    Spina, F.3
  • 134
    • 29144436466 scopus 로고    scopus 로고
    • Managing the care of patients with bisphosphonate-associated osteonecrosis: An American Academy of Oral Medicine position paper
    • Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo SB. Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper. J Am Dent Assoc 2005;136:1658-1668
    • (2005) J Am Dent Assoc , vol.136 , pp. 1658-1668
    • Migliorati, C.A.1    Casiglia, J.2    Epstein, J.3    Jacobsen, P.L.4    Siegel, M.A.5    Woo, S.B.6
  • 135
    • 79952281080 scopus 로고    scopus 로고
    • Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study
    • Ripamonti CI, Cislaghi E, Mariani L, Maniezzo M. Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study. Oral Oncol 2011;47:185-190
    • (2011) Oral Oncol , vol.47 , pp. 185-190
    • Ripamonti, C.I.1    Cislaghi, E.2    Mariani, L.3    Maniezzo, M.4
  • 136
    • 84870901837 scopus 로고    scopus 로고
    • Bisphosphonate- related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy
    • Agrillo A, Filiaci F, Ramieri V, et al. Bisphosphonate- related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy. Eur Rev Med Pharmacol Sci 2012;16:1741-1747
    • (2012) Eur Rev Med Pharmacol Sci , vol.16 , pp. 1741-1747
    • Agrillo, A.1    Filiaci, F.2    Ramieri, V.3
  • 137
    • 0036181668 scopus 로고    scopus 로고
    • Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
    • Yaccoby S, Pearse RN, Johnson CL, Barlogie B, Choi Y, Epstein J. Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol 2002;116:278-290
    • (2002) Br J Haematol , vol.116 , pp. 278-290
    • Yaccoby, S.1    Pearse, R.N.2    Johnson, C.L.3    Barlogie, B.4    Choi, Y.5    Epstein, J.6
  • 138
    • 0037439916 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    • Vanderkerken K, De Leenheer E, Shipman C, et al. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res 2003;63:287-289
    • (2003) Cancer Res , vol.63 , pp. 287-289
    • Vanderkerken, K.1    De Leenheer, E.2    Shipman, C.3
  • 139
    • 58649113384 scopus 로고    scopus 로고
    • Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases bone density in knock-in mice that express chimeric (murine/human) RANKL
    • Kostenuik P, Nguyen H, McCabe J, et al. Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases bone density in knock-in mice that express chimeric (murine/human) RANKL. J Bone Miner Res 2009;24:182-195
    • (2009) J Bone Miner Res , vol.24 , pp. 182-195
    • Kostenuik, P.1    Nguyen, H.2    McCabe, J.3
  • 140
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body JJ, Facon T, Coleman RE, et al. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 2006;12:1221-1228
    • (2006) Clin Cancer Res , vol.12 , pp. 1221-1228
    • Body, J.J.1    Facon, T.2    Coleman, R.E.3
  • 141
    • 43549116878 scopus 로고    scopus 로고
    • Phase 1 trial of denosumab safety, pharmacokinetics, and pharmacodynamics in Japanese women with breast cancer-related bone metastases
    • Yonemori K, Fujiwara Y, Minami H, et al. Phase 1 trial of denosumab safety, pharmacokinetics, and pharmacodynamics in Japanese women with breast cancer-related bone metastases. Cancer Sci 2008;99: 1237-1242
    • (2008) Cancer Sci , vol.99 , pp. 1237-1242
    • Yonemori, K.1    Fujiwara, Y.2    Minami, H.3
  • 142
    • 77953452823 scopus 로고    scopus 로고
    • An Open-label phase 2 trial of denosumab in the treatment of relapsed (R) or plateau-phase (PP) multiple myeloma (mm)
    • Vij R, Horvath N, Spencer A, et al. An open-label, phase 2 trial of denosumab in the treatment of relapsed (R) or plateau-phase (PP) multiple myeloma (MM). In: Presented at: 49th ASH Annual Meeting and Exposition; 2007
    • (2007) Presented At: 49th ASH Annual Meeting and Exposition
    • Vij, R.1    Horvath, N.2    Spencer, A.3
  • 143
    • 63749094012 scopus 로고    scopus 로고
    • Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates
    • Fizazi K, Lipton A, Mariette X, et al. Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol 2009;27: 1564-1571
    • (2009) J Clin Oncol , vol.27 , pp. 1564-1571
    • Fizazi, K.1    Lipton, A.2    Mariette, X.3
  • 144
    • 84867582660 scopus 로고    scopus 로고
    • Superiority of denosumab to zoledronic acid for prevention of skeletal- related events: A combined analysis of 3 pivotal, randomised, phase 3 trials
    • Lipton A, Fizazi K, Stopeck AT, et al. Superiority of denosumab to zoledronic acid for prevention of skeletal- related events: a combined analysis of 3 pivotal, randomised, phase 3 trials. Eur J Cancer 2012;48:3082-3092
    • (2012) Eur J Cancer , vol.48 , pp. 3082-3092
    • Lipton, A.1    Fizazi, K.2    Stopeck, A.T.3
  • 145
    • 79952761418 scopus 로고    scopus 로고
    • Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
    • The first randomized study which compared denosumab with zoledronic acid and included myeloma patients
    • Henry DH, Costa L, Goldwasser F, et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol 2011;29:1125-1132. The first randomized study which compared denosumab with zoledronic acid and included myeloma patients.
    • (2011) J Clin Oncol , vol.29 , pp. 1125-1132
    • Henry, D.H.1    Costa, L.2    Goldwasser, F.3
  • 146
    • 77957727888 scopus 로고    scopus 로고
    • Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo
    • Chantry AD, Heath D, Mulivor AW, Pearsall S, Baud'huin M, Coulton L. Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo. J Bone Miner Res 2010;25:2633-2646
    • (2010) J Bone Miner Res , vol.25 , pp. 2633-2646
    • Chantry, A.D.1    Heath, D.2    Mulivor, A.W.3    Pearsall, S.4    Baud'Huin, M.5    Coulton, L.6
  • 147
    • 65549147617 scopus 로고    scopus 로고
    • Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women
    • Ruckle J, Jacobs M, Kramer W, et al. Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women. J Bone Miner Res 2009;24:744-752
    • (2009) J Bone Miner Res , vol.24 , pp. 744-752
    • Ruckle, J.1    Jacobs, M.2    Kramer, W.3
  • 148
    • 84901692001 scopus 로고    scopus 로고
    • Sotatercept in patients with osteolytic lesions of multiple myeloma
    • in press]
    • Abdulkadyrov KM, Salogub GN, Khuazheva NK, et al. Sotatercept in patients with osteolytic lesions of multiple myeloma. Br J Haematol 2014. http://dx.doi.org/10.1111/bjh.12835 [in press]
    • (2014) Br J Haematol
    • Abdulkadyrov, K.M.1    Salogub, G.N.2    Khuazheva, N.K.3
  • 149
    • 84881475207 scopus 로고    scopus 로고
    • Lenalidomide in combination with an activin A-neutralizing antibody: Preclinical rationale for a novel anti-myeloma strategy
    • Scullen T, Santo L, Vallet S, et al. Lenalidomide in combination with an activin A-neutralizing antibody: preclinical rationale for a novel anti-myeloma strategy. Leukemia 2013;27:1715-1721
    • (2013) Leukemia , vol.27 , pp. 1715-1721
    • Scullen, T.1    Santo, L.2    Vallet, S.3
  • 150
    • 84887606571 scopus 로고    scopus 로고
    • Dickkopf-1 is a key regulator of myeloma bone disease: Opportunities and challenges for therapeutic intervention
    • Zhou F, Meng S, Song H, Claret FX. Dickkopf-1 is a key regulator of myeloma bone disease: Opportunities and challenges for therapeutic intervention. Blood Rev 2013;27:261-267
    • (2013) Blood Rev , vol.27 , pp. 261-267
    • Zhou, F.1    Meng, S.2    Song, H.3    Claret, F.X.4
  • 151
    • 85030413623 scopus 로고    scopus 로고
    • Dickkopf- 1 is elevated in newly-diagnosed, symptomatic patients and in relapsed patients with multiple myeloma correlations with advanced disease features: A single-center experience in 284 patients
    • Terpos E, Christoulas D, Papatheodorou A, et al. Dickkopf- 1 is elevated in newly-diagnosed, symptomatic patients and in relapsed patients with multiple myeloma;correlations with advanced disease features: a single-center experience in 284 patients. In: Presented at: 15th Congress of the European Hematology Association; 2010
    • (2010) Presented At: 15th Congress of the European Hematology Association
    • Terpos, E.1    Christoulas, D.2    Papatheodorou, A.3
  • 152
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T, et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 2009;114:371-379
    • (2009) Blood , vol.114 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 153
    • 61849137831 scopus 로고    scopus 로고
    • Inhibiting dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma
    • Heath DJ, Chantry AD, Buckle CH, et al. Inhibiting dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. J Bone Miner Res 2009;24:425-436
    • (2009) J Bone Miner Res , vol.24 , pp. 425-436
    • Heath, D.J.1    Chantry, A.D.2    Buckle, C.H.3
  • 154
    • 84856744449 scopus 로고    scopus 로고
    • A phase I/II study of BHQ880, a novel osteoblat activating, anti-DKK1 human monoclonal antibody, in relapsed and refractory multiple myeloma (MM) patients treated with zoledronic acid (Zol) and anti-myeloma therapy (MM Tx
    • Presented at: 51st ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 December 2009
    • Padmanabhan S, Beck JT, Kelly KR, et al. A phase I/II study of BHQ880, a novel osteoblat activating, anti-DKK1 human monoclonal antibody, in relapsed and refractory multiple myeloma (MM) patients treated with zoledronic acid (Zol) and anti-myeloma therapy (MM Tx). Blood (ASH Annual Meeting Abstracts) 2009;114:750. Presented at: 51st ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 December 2009
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 750
    • Padmanabhan, S.1    Beck, J.T.2    Kelly, K.R.3
  • 155
    • 84893044528 scopus 로고    scopus 로고
    • Romosozumab in postmenopausal women with low bone mineral density
    • McClung MR, Grauer A, Boonen S, et al. Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med 2014;370:412-420
    • (2014) N Engl J Med , vol.370 , pp. 412-420
    • McClung, M.R.1    Grauer, A.2    Boonen, S.3
  • 156
    • 20444441871 scopus 로고    scopus 로고
    • Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function
    • Zavrski I, Krebbel H, Wildemann B, et al. Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function. Biochem Biophys Res Commun 2005;333:200-205
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 200-205
    • Zavrski, I.1    Krebbel, H.2    Wildemann, B.3
  • 157
    • 34548133601 scopus 로고    scopus 로고
    • Bortezomib inhibits human osteoclastogenesis
    • Von Metzler I, Krebbel H, Hecht M, et al. Bortezomib inhibits human osteoclastogenesis. Leukemia 2007;21:2025-2034
    • (2007) Leukemia , vol.21 , pp. 2025-2034
    • Von Metzler, I.1    Krebbel, H.2    Hecht, M.3
  • 158
    • 48949107708 scopus 로고    scopus 로고
    • Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions
    • Boissy P, Andersen TL, Lund T, et al. Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions. Leuk Res 2008;32:1661-1668
    • (2008) Leuk Res , vol.32 , pp. 1661-1668
    • Boissy, P.1    Andersen, T.L.2    Lund, T.3
  • 159
    • 38849130851 scopus 로고    scopus 로고
    • Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
    • Mukherjee S, Raje N, Schoonmaker JA, et al. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest 2008;118:491-504
    • (2008) J Clin Invest , vol.118 , pp. 491-504
    • Mukherjee, S.1    Raje, N.2    Schoonmaker, J.A.3
  • 160
    • 34347400592 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients
    • Giuliani N, Morandi F, Tagliaferri S, et al. The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients. Blood 2007;110:334-338
    • (2007) Blood , vol.110 , pp. 334-338
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3
  • 161
    • 33750566914 scopus 로고    scopus 로고
    • Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
    • Terpos E, Heath DJ, Rahemtulla A, et al. Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Br J Haematol 2006;135: 688-692
    • (2006) Br J Haematol , vol.135 , pp. 688-692
    • Terpos, E.1    Heath, D.J.2    Rahemtulla, A.3
  • 162
    • 77954253348 scopus 로고    scopus 로고
    • Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the combination of bortezomib, dexamethasone and zoledronic acid
    • Terpos E, Christoulas D, Kokkoris P, et al. Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the
    • (2010) Ann Oncol , vol.21 , pp. 1561-1562
    • Terpos, E.1    Christoulas, D.2    Kokkoris, P.3
  • 163
    • 84896711506 scopus 로고    scopus 로고
    • The effects of bortezomib on bone disease in patients with multiple myeloma
    • Mohty M, Malard F, Mohty B, Savani B, Moreau P, Terpos E. The effects of bortezomib on bone disease in patients with multiple myeloma. Cancer 2014;120:618-623
    • (2014) Cancer , vol.120 , pp. 618-623
    • Mohty, M.1    Malard, F.2    Mohty, B.3    Savani, B.4    Moreau, P.5    Terpos, E.6
  • 164
    • 84898439909 scopus 로고    scopus 로고
    • VTD consolidation, without bisphosphonates, reduces bone resorption and is associated with a very low incidence of skeletal-related events in myeloma patients post ASCT
    • Terpos E, Christoulas D, Kastritis E, et al. VTD consolidation, without bisphosphonates, reduces bone resorption and is associated with a very low incidence of skeletal-related events in myeloma patients post ASCT. Leukemia 2014;(28):928-934
    • (2014) Leukemia , vol.28 , pp. 928-934
    • Terpos, E.1    Christoulas, D.2    Kastritis, E.3
  • 165
    • 27644523704 scopus 로고    scopus 로고
    • The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio
    • Terpos E, Mihou D, Szydlo R, et al. The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio. Leukemia 2005;19:1969-1976
    • (2005) Leukemia , vol.19 , pp. 1969-1976
    • Terpos, E.1    Mihou, D.2    Szydlo, R.3
  • 166
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S, et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2008;22:1925-1932
    • (2008) Leukemia , vol.22 , pp. 1925-1932
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 167
    • 84892897649 scopus 로고    scopus 로고
    • The combination of lenalidomide and dexamethasone reduces bone resorption in responding patients with relapsed/refractory multiple myeloma but has no effect on bone formation: Final results on 205 patients of the Greek myeloma study group
    • Terpos E, Christoulas D, Kastritis E, et al. The combination of lenalidomide and dexamethasone reduces bone resorption in responding patients with relapsed/refractory multiple myeloma but has no effect on bone formation: final results on 205 patients of the Greek myeloma study group. Am J Hematol 2014;89: 34-40
    • (2014) Am J Hematol , vol.89 , pp. 34-40
    • Terpos, E.1    Christoulas, D.2    Kastritis, E.3
  • 168
    • 33645736007 scopus 로고    scopus 로고
    • Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1
    • Anderson G, Gries M, Kurihara N, et al. Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1. Blood 2006;107:3098-3105.
    • (2006) Blood , vol.107 , pp. 3098-3105
    • Anderson, G.1    Gries, M.2    Kurihara, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.