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Volumn 28, Issue 4, 2014, Pages 928-934

VTD consolidation, without bisphosphonates, reduces bone resorption and is associated with a very low incidence of skeletal-related events in myeloma patients post ASCT

Author keywords

bone markers; consolidation; multiple myeloma; skeletal related events; VTD

Indexed keywords

ACETYLSALICYLIC ACID; ALKALINE PHOSPHATASE BONE ISOENZYME; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CARBOXY TERMINAL TELOPEPTIDE; COTRIMOXAZOLE; DEXAMETHASONE; LOW MOLECULAR WEIGHT HEPARIN; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; THALIDOMIDE; VALACICLOVIR; WARFARIN;

EID: 84898439909     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.267     Document Type: Article
Times cited : (32)

References (22)
  • 1
    • 77956538095 scopus 로고    scopus 로고
    • Total therapy 3 for multiple myeloma: Prognostic implications of cumulative dosing and premature discontinuation of VTD maintenance components, bortezomib, thalidomide and dexamethasone, relevant to all phases of therapy
    • van Rhee F, Szymonifka J, Anaissie E, Nair B, Waheed S, Alsayed Y et al. Total therapy 3 for multiple myeloma: prognostic implications of cumulative dosing and premature discontinuation of VTD maintenance components, bortezomib, thalidomide and dexamethasone, relevant to all phases of therapy. Blood 2010; 116: 1220-1227.
    • (2010) Blood , vol.116 , pp. 1220-1227
    • Van Rhee, F.1    Szymonifka, J.2    Anaissie, E.3    Nair, B.4    Waheed, S.5    Alsayed, Y.6
  • 2
    • 84887321995 scopus 로고    scopus 로고
    • Consolidation with VTd significantly improves the complete remission rate and time to progression following VTdinduction and single autologous stem cell transplantation in multiple myeloma
    • Leleu X, Fouquet G, Hebraud B, Roussel M, Caillot D, Chré tien ML et al. Consolidation with VTd significantly improves the complete remission rate and time to progression following VTdinduction and single autologous stem cell transplantation in multiple myeloma. Leukemia 2013; 27: 2242-2244.
    • (2013) Leukemia , vol.27 , pp. 2242-2244
    • Leleu, X.1    Fouquet, G.2    Hebraud, B.3    Roussel, M.4    Caillot, D.5    Chrétien, M.L.6
  • 3
    • 84857363858 scopus 로고    scopus 로고
    • Sequential vincristine, adriamycin, dexamethasone (VAD) followed by bortezomib, thalidomide, dexamethasone (VTD) as induction, followed by high-dose therapy with autologous stem cell transplant and consolidation therapy with bortezomib for newly diagnosed multiple myeloma: Results of a phase II trial
    • Kim HJ, Yoon SS, Lee DS, Sohn SK, Eom HS, Lee JL et al. Sequential vincristine, adriamycin, dexamethasone (VAD) followed by bortezomib, thalidomide, dexamethasone (VTD) as induction, followed by high-dose therapy with autologous stem cell transplant and consolidation therapy with bortezomib for newly diagnosed multiple myeloma: results of a phase II trial. Ann Hematol 2012; 91: 249-256.
    • (2012) Ann Hematol , vol.91 , pp. 249-256
    • Kim, H.J.1    Yoon, S.S.2    Lee, D.S.3    Sohn, S.K.4    Eom, H.S.5    Lee, J.L.6
  • 4
    • 84863576232 scopus 로고    scopus 로고
    • Bortezomib-thalidomide-dexamethasone is superior to thalidomide- dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
    • Cavo M, Pantani L, Petrucci MT, Patriarca F, Zamagni E, Donnarumma D et al. Bortezomib-thalidomide-dexamethasone is superior to thalidomide- dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma. Blood 2012; 120: 1597-1600.
    • (2012) Blood , vol.120 , pp. 1597-1600
    • Cavo, M.1    Pantani, L.2    Petrucci, M.T.3    Patriarca, F.4    Zamagni, E.5    Donnarumma, D.6
  • 5
    • 77951625298 scopus 로고    scopus 로고
    • Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma
    • Ladetto M, Pagliano G, Ferrero S, Cavallo F, Drandi D, Santo L et al. Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma. J Clin Oncol 2010; 28: 2077-2084.
    • (2010) J Clin Oncol , vol.28 , pp. 2077-2084
    • Ladetto, M.1    Pagliano, G.2    Ferrero, S.3    Cavallo, F.4    Drandi, D.5    Santo, L.6
  • 7
    • 77954253348 scopus 로고    scopus 로고
    • Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the combination of bortezomib, dexamethasone and zoledronic acid
    • Terpos E, Christoulas D, Kokkoris P, Anargyrou K, Gavriatopoulou M, Migkou M et al. Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the combination of bortezomib, dexamethasone and zoledronic acid. Ann Oncol 2010; 21: 1561-1562.
    • (2010) Ann Oncol , vol.21 , pp. 1561-1562
    • Terpos, E.1    Christoulas, D.2    Kokkoris, P.3    Anargyrou, K.4    Gavriatopoulou, M.5    Migkou, M.6
  • 8
    • 79551627290 scopus 로고    scopus 로고
    • A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated withbortezomib response in multiple myeloma patients
    • Zangari M, Yaccoby S, Pappas L, Cavallo F, Kumar NS, Ranganathan S et al. A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated withbortezomib response in multiple myeloma patients. Haematologica 2011; 96: 333-336.
    • (2011) Haematologica , vol.96 , pp. 333-336
    • Zangari, M.1    Yaccoby, S.2    Pappas, L.3    Cavallo, F.4    Kumar, N.S.5    Ranganathan, S.6
  • 9
    • 84883021288 scopus 로고    scopus 로고
    • International Myeloma Working Group recommendations for the treatment of multiple myeloma related bone disease
    • Terpos E, Morgan G, Dimopoulos M, Drake M, Lentzsch S, Raje N et al. International Myeloma Working Group recommendations for the treatment of multiple myeloma related bone disease. J Clin Oncol 2013; 31: 2347-2357.
    • (2013) J Clin Oncol , vol.31 , pp. 2347-2357
    • Terpos, E.1    Morgan, G.2    Dimopoulos, M.3    Drake, M.4    Lentzsch, S.5    Raje, N.6
  • 10
    • 57849161431 scopus 로고    scopus 로고
    • The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis
    • Terpos E, Kastritis E, Roussou M, Heath D, Christoulas D, Anagnostopoulos N et al. The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis. Leukemia 2008; 22: 2247-2256.
    • (2008) Leukemia , vol.22 , pp. 2247-2256
    • Terpos, E.1    Kastritis, E.2    Roussou, M.3    Heath, D.4    Christoulas, D.5    Anagnostopoulos, N.6
  • 12
    • 0034667613 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover following high-dose chemotherapy and autografting in multiple myeloma
    • Clark RE, Flory AJ, Ion EM, Woodcock BE, Durham BH, Fraser WD. Biochemical markers of bone turnover following high-dose chemotherapy and autografting in multiple myeloma. Blood 2000; 96: 2697-2702.
    • (2000) Blood , vol.96 , pp. 2697-2702
    • Clark, R.E.1    Flory, A.J.2    Ion, E.M.3    Woodcock, B.E.4    Durham, B.H.5    Fraser, W.D.6
  • 13
    • 4344588926 scopus 로고    scopus 로고
    • Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma
    • DOI 10.1038/sj.leu.2403423
    • Terpos E, Politou M, Szydlo R, Nadal E, Avery S, Olavarria E et al. Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma. Leukemia 2004; 18: 1420-1426. (Pubitemid 39136753)
    • (2004) Leukemia , vol.18 , Issue.8 , pp. 1420-1426
    • Terpos, E.1    Politou, M.2    Szydlo, R.3    Nadal, E.4    Avery, S.5    Olavaria, E.6    Kanfer, E.7    Goldman, J.M.8    Apperley, J.F.9    Rahemtulla, A.10
  • 15
    • 27644523704 scopus 로고    scopus 로고
    • The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio
    • DOI 10.1038/sj.leu.2403890, PII 2403890
    • Terpos E, Mihou D, Szydlo R, Tsimirika K, Karkantaris C, Politou M et al. The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio. Leukemia 2005; 19: 1969-1976. (Pubitemid 41554006)
    • (2005) Leukemia , vol.19 , Issue.11 , pp. 1969-1976
    • Terpos, E.1    Mihou, D.2    Szydlo, R.3    Tsimirika, K.4    Karkantaris, C.5    Politou, M.6    Voskaridou, E.7    Rahemtulla, A.8    Dimopoulos, M.A.9    Zervas, K.10
  • 16
    • 33645725851 scopus 로고    scopus 로고
    • First-line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma
    • Tosi P, Zamagni E, Cellini C, Parente R, Cangini D, Tacchetti P et al. First-line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma. Eur J Haematol 2006; 76: 399-404.
    • (2006) Eur J Haematol , vol.76 , pp. 399-404
    • Tosi, P.1    Zamagni, E.2    Cellini, C.3    Parente, R.4    Cangini, D.5    Tacchetti, P.6
  • 18
    • 79954426340 scopus 로고    scopus 로고
    • Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. Melphalanprednisone in the phase III VISTA trial in multiple myeloma
    • Delforge M, Terpos E, Richardson PG, Shpilberg O, Khuageva NK, Schlag R et al. Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalanprednisone in the phase III VISTA trial in multiple myeloma. Eur J Haematol 2011; 86: 372-384.
    • (2011) Eur J Haematol , vol.86 , pp. 372-384
    • Delforge, M.1    Terpos, E.2    Richardson, P.G.3    Shpilberg, O.4    Khuageva, N.K.5    Schlag, R.6
  • 19
    • 77956259865 scopus 로고    scopus 로고
    • Importance of achieving a complete response in multiple myeloma, and the impact of novel agents
    • Chanan-Khan AA, Giralt S. Importance of achieving a complete response in multiple myeloma, and the impact of novel agents. J Clin Oncol 2010; 28: 2612-2624.
    • (2010) J Clin Oncol , vol.28 , pp. 2612-2624
    • Chanan-Khan, A.A.1    Giralt, S.2
  • 20
    • 70350433797 scopus 로고    scopus 로고
    • The role of complete response in multiple myeloma
    • Harousseau JL, Attal M, Avet-Loiseau H. The role of complete response in multiple myeloma. Blood 2009; 114: 3139-3146.
    • (2009) Blood , vol.114 , pp. 3139-3146
    • Harousseau, J.L.1    Attal, M.2    Avet-Loiseau, H.3
  • 22
    • 84860709392 scopus 로고    scopus 로고
    • Lenalidomide maintenance after stem cell transplantation for multiple myeloma
    • Attal M, Lauwers-Cances V, Marit G, Caillot D, Moreau P, Facon T et al. Lenalidomide maintenance after stem cell transplantation for multiple myeloma. N Engl J Med 2012; 366: 1782-1791.
    • (2012) N Engl J Med , vol.366 , pp. 1782-1791
    • Attal, M.1    Lauwers-Cances, V.2    Marit, G.3    Caillot, D.4    Moreau, P.5    Facon, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.