메뉴 건너뛰기




Volumn 27, Issue 6, 2013, Pages 261-267

Dickkopf-1 is a key regulator of myeloma bone disease: Opportunities and challenges for therapeutic intervention

Author keywords

Antibody; DKK1; Myeloma bone disease; Proteasome inhibitor; Vaccine

Indexed keywords

BETA CATENIN; BHQ 880; BORTEZOMIB; DICKKOPF 1 DNA VACCINE; DICKKOPF 1 NEUTRALIZING ANTIBODY; DICKKOPF 1 PROTEIN; DNA VACCINE; ENDOTHELIN 1; NEUTRALIZING ANTIBODY; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; UNCLASSIFIED DRUG;

EID: 84887606571     PISSN: 0268960X     EISSN: 15321681     Source Type: Journal    
DOI: 10.1016/j.blre.2013.08.002     Document Type: Article
Times cited : (53)

References (60)
  • 2
    • 3042805477 scopus 로고    scopus 로고
    • Bone lesions in molecular subtypes of multiple myeloma
    • Robbiani D.F., Chesi M., Bergsagel P.L. Bone lesions in molecular subtypes of multiple myeloma. N Engl J Med 2004, 351:197-198.
    • (2004) N Engl J Med , vol.351 , pp. 197-198
    • Robbiani, D.F.1    Chesi, M.2    Bergsagel, P.L.3
  • 3
    • 33845359084 scopus 로고    scopus 로고
    • Function and biological roles of the Dickkopf family of Wnt modulators
    • Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006, 25:7469-7481.
    • (2006) Oncogene , vol.25 , pp. 7469-7481
    • Niehrs, C.1
  • 4
    • 57649158485 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment
    • Heider U., Kaiser M., Mieth M., Lamottke B., Rademacher J., Jakob C., et al. Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. Eur J Haematol 2009, 82:31-38.
    • (2009) Eur J Haematol , vol.82 , pp. 31-38
    • Heider, U.1    Kaiser, M.2    Mieth, M.3    Lamottke, B.4    Rademacher, J.5    Jakob, C.6
  • 5
    • 84862908226 scopus 로고    scopus 로고
    • Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma
    • Qian J., Zheng Y., Zheng C., Wang L., Qin H., Hong S., et al. Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma. Blood 2012, 119:161-169.
    • (2012) Blood , vol.119 , pp. 161-169
    • Qian, J.1    Zheng, Y.2    Zheng, C.3    Wang, L.4    Qin, H.5    Hong, S.6
  • 6
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus A., Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008, 8:387-398.
    • (2008) Nat Rev Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 7
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E., Zhan F., Walker R., Rasmussen E., Ma Y., Barlogie B., et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003, 349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6
  • 8
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    • Oshima T., Abe M., Asano J., Hara T., Kitazoe K., Sekimoto E., et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood 2005, 106:3160-3165.
    • (2005) Blood , vol.106 , pp. 3160-3165
    • Oshima, T.1    Abe, M.2    Asano, J.3    Hara, T.4    Kitazoe, K.5    Sekimoto, E.6
  • 9
    • 41949093576 scopus 로고    scopus 로고
    • Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    • Edwards C.M., Edwards J.R., Lwin S.T., Esparza J., Oyajobi B.O., McCluskey B., et al. Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo. Blood 2008, 111:2833-2842.
    • (2008) Blood , vol.111 , pp. 2833-2842
    • Edwards, C.M.1    Edwards, J.R.2    Lwin, S.T.3    Esparza, J.4    Oyajobi, B.O.5    McCluskey, B.6
  • 10
    • 34247471689 scopus 로고    scopus 로고
    • VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells
    • Cianferotti L., Demay M.B. VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells. J Cell Biochem 2007, 101:80-88.
    • (2007) J Cell Biochem , vol.101 , pp. 80-88
    • Cianferotti, L.1    Demay, M.B.2
  • 11
    • 0033516577 scopus 로고    scopus 로고
    • Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling
    • Fedi P., Bafico A., Nieto Soria A., Burgess W.H., Miki T., Bottaro D.P., et al. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem 1999, 274:19465-19472.
    • (1999) J Biol Chem , vol.274 , pp. 19465-19472
    • Fedi, P.1    Bafico, A.2    Nieto Soria, A.3    Burgess, W.H.4    Miki, T.5    Bottaro, D.P.6
  • 12
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • Glinka A., Wu W., Delius H., Monaghan A.P., Blumenstock C., Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998, 391:357-362.
    • (1998) Nature , vol.391 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3    Monaghan, A.P.4    Blumenstock, C.5    Niehrs, C.6
  • 13
    • 18044399916 scopus 로고    scopus 로고
    • Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse
    • Mukhopadhyay M., Shtrom S., Rodriguez-Esteban C., Chen L., Tsukui T., Gomer L., et al. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell 2001, 1:423-434.
    • (2001) Dev Cell , vol.1 , pp. 423-434
    • Mukhopadhyay, M.1    Shtrom, S.2    Rodriguez-Esteban, C.3    Chen, L.4    Tsukui, T.5    Gomer, L.6
  • 14
    • 13244291649 scopus 로고    scopus 로고
    • Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
    • Foley A.C., Mercola M. Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Genes Dev 2005, 19:387-396.
    • (2005) Genes Dev , vol.19 , pp. 387-396
    • Foley, A.C.1    Mercola, M.2
  • 16
    • 84860331458 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    • Estrada K., Styrkarsdottir U., Evangelou E., Hsu Y.H., Duncan E.L., Ntzani E.E., et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet 2012, 44:491-501.
    • (2012) Nat Genet , vol.44 , pp. 491-501
    • Estrada, K.1    Styrkarsdottir, U.2    Evangelou, E.3    Hsu, Y.H.4    Duncan, E.L.5    Ntzani, E.E.6
  • 17
    • 84870672155 scopus 로고    scopus 로고
    • Rheumatoid arthritis: genetic variants in DKK1 linked to severity of joint damage in RA
    • Buckland J. Rheumatoid arthritis: genetic variants in DKK1 linked to severity of joint damage in RA. Nat Rev Rheumatol 2012, 8:694.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 694
    • Buckland, J.1
  • 18
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., et al. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 2001, 411:321-325.
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6
  • 19
    • 80555131057 scopus 로고    scopus 로고
    • Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
    • Cheng Z., Biechele T., Wei Z., Morrone S., Moon R.T., Wang L., et al. Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol 2011, 18:1204-1210.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 1204-1210
    • Cheng, Z.1    Biechele, T.2    Wei, Z.3    Morrone, S.4    Moon, R.T.5    Wang, L.6
  • 20
    • 0037030681 scopus 로고    scopus 로고
    • Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    • Mao B., Wu W., Davidson G., Marhold J., Li M., Mechler B.M., et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002, 417:664-667.
    • (2002) Nature , vol.417 , pp. 664-667
    • Mao, B.1    Wu, W.2    Davidson, G.3    Marhold, J.4    Li, M.5    Mechler, B.M.6
  • 21
    • 48849093745 scopus 로고    scopus 로고
    • Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen
    • Cselenyi C.S., Lee E. Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen. Sci Signal 2008, 1:pe10.
    • (2008) Sci Signal , vol.1
    • Cselenyi, C.S.1    Lee, E.2
  • 22
    • 43549108372 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
    • Kaiser M., Mieth M., Liebisch P., Oberlander R., Rademacher J., Jakob C., et al. Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur J Haematol 2008, 80:490-494.
    • (2008) Eur J Haematol , vol.80 , pp. 490-494
    • Kaiser, M.1    Mieth, M.2    Liebisch, P.3    Oberlander, R.4    Rademacher, J.5    Jakob, C.6
  • 23
    • 60249086335 scopus 로고    scopus 로고
    • The role of Dickkopf-1 in bone development, homeostasis, and disease
    • Pinzone J.J., Hall B.M., Thudi N.K., Vonau M., Qiang Y.W., Rosol T.J., et al. The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood 2009, 113:517-525.
    • (2009) Blood , vol.113 , pp. 517-525
    • Pinzone, J.J.1    Hall, B.M.2    Thudi, N.K.3    Vonau, M.4    Qiang, Y.W.5    Rosol, T.J.6
  • 24
    • 33845193025 scopus 로고    scopus 로고
    • Myeloma bone disease: pathogenetic mechanisms and clinical assessment
    • Silvestris F., Lombardi L., De Matteo M., Bruno A., Dammacco F. Myeloma bone disease: pathogenetic mechanisms and clinical assessment. Leuk Res 2007, 31:129-138.
    • (2007) Leuk Res , vol.31 , pp. 129-138
    • Silvestris, F.1    Lombardi, L.2    De Matteo, M.3    Bruno, A.4    Dammacco, F.5
  • 25
    • 0042346318 scopus 로고    scopus 로고
    • The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow
    • Gregory C.A., Singh H., Perry A.S., Prockop D.J. The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. J Biol Chem 2003, 278:28067-28078.
    • (2003) J Biol Chem , vol.278 , pp. 28067-28078
    • Gregory, C.A.1    Singh, H.2    Perry, A.S.3    Prockop, D.J.4
  • 26
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • Gunn W.G., Conley A., Deininger L., Olson S.D., Prockop D.J., Gregory C.A. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells 2006, 24:986-991.
    • (2006) Stem Cells , vol.24 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3    Olson, S.D.4    Prockop, D.J.5    Gregory, C.A.6
  • 28
    • 35148897797 scopus 로고    scopus 로고
    • Mesenchymal stem cell abnormalities in patients with multiple myeloma
    • Garderet L., Mazurier C., Chapel A., Ernou I., Boutin L., Holy X., et al. Mesenchymal stem cell abnormalities in patients with multiple myeloma. Leuk Lymphoma 2007, 48:2032-2041.
    • (2007) Leuk Lymphoma , vol.48 , pp. 2032-2041
    • Garderet, L.1    Mazurier, C.2    Chapel, A.3    Ernou, I.4    Boutin, L.5    Holy, X.6
  • 29
    • 33748156090 scopus 로고    scopus 로고
    • Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
    • Li J., Sarosi I., Cattley R.C., Pretorius J., Asuncion F., Grisanti M., et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 2006, 39:754-766.
    • (2006) Bone , vol.39 , pp. 754-766
    • Li, J.1    Sarosi, I.2    Cattley, R.C.3    Pretorius, J.4    Asuncion, F.5    Grisanti, M.6
  • 30
    • 47249140444 scopus 로고    scopus 로고
    • Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma
    • Qiang Y.W., Chen Y., Stephens O., Brown N., Chen B., Epstein J., et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 2008, 112:196-207.
    • (2008) Blood , vol.112 , pp. 196-207
    • Qiang, Y.W.1    Chen, Y.2    Stephens, O.3    Brown, N.4    Chen, B.5    Epstein, J.6
  • 31
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N., Bataille R., Mancini C., Lazzaretti M., Barille S. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 2001, 98:3527-3533.
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3    Lazzaretti, M.4    Barille, S.5
  • 32
    • 79551617573 scopus 로고    scopus 로고
    • Pharmaceutical inhibition of glycogen synthetase kinase-3beta reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model
    • Gunn W.G., Krause U., Lee N., Gregory C.A. Pharmaceutical inhibition of glycogen synthetase kinase-3beta reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model. Blood 2011, 117:1641-1651.
    • (2011) Blood , vol.117 , pp. 1641-1651
    • Gunn, W.G.1    Krause, U.2    Lee, N.3    Gregory, C.A.4
  • 33
    • 22044436959 scopus 로고    scopus 로고
    • How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow
    • Gregory C.A., Gunn W.G., Reyes E., Smolarz A.J., Munoz J., Spees J.L., et al. How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Ann N Y Acad Sci 2005, 1049:97-106.
    • (2005) Ann N Y Acad Sci , vol.1049 , pp. 97-106
    • Gregory, C.A.1    Gunn, W.G.2    Reyes, E.3    Smolarz, A.J.4    Munoz, J.5    Spees, J.L.6
  • 35
    • 25444433584 scopus 로고    scopus 로고
    • Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells
    • van der Horst G., van der Werf S.M., Farih-Sips H., van Bezooijen R.L., Lowik C.W., Karperien M. Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J Bone Miner Res 2005, 20:1867-1877.
    • (2005) J Bone Miner Res , vol.20 , pp. 1867-1877
    • van der Horst, G.1    van der Werf, S.M.2    Farih-Sips, H.3    van Bezooijen, R.L.4    Lowik, C.W.5    Karperien, M.6
  • 36
    • 37749040562 scopus 로고    scopus 로고
    • Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF
    • Fujita K., Janz S. Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. Mol Cancer 2007, 6:71.
    • (2007) Mol Cancer , vol.6 , pp. 71
    • Fujita, K.1    Janz, S.2
  • 37
    • 84860537254 scopus 로고    scopus 로고
    • Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1
    • Fowler J.A., Mundy G.R., Lwin S.T., Edwards C.M. Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1. Cancer Res 2012, 72:2183-2189.
    • (2012) Cancer Res , vol.72 , pp. 2183-2189
    • Fowler, J.A.1    Mundy, G.R.2    Lwin, S.T.3    Edwards, C.M.4
  • 38
    • 33750696322 scopus 로고    scopus 로고
    • New potential targets for treating myeloma bone disease
    • Roodman G.D. New potential targets for treating myeloma bone disease. Clin Cancer Res 2006, 12:6270s-6273s.
    • (2006) Clin Cancer Res , vol.12
    • Roodman, G.D.1
  • 39
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • Qiang Y.W., Barlogie B., Rudikoff S., Shaughnessy J.D. Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 2008, 42:669-680.
    • (2008) Bone , vol.42 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3    Shaughnessy, J.D.4
  • 41
    • 33750566914 scopus 로고    scopus 로고
    • Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
    • Terpos E., Heath D.J., Rahemtulla A., Zervas K., Chantry A., Anagnostopoulos A., et al. Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Br J Haematol 2006, 135:688-692.
    • (2006) Br J Haematol , vol.135 , pp. 688-692
    • Terpos, E.1    Heath, D.J.2    Rahemtulla, A.3    Zervas, K.4    Chantry, A.5    Anagnostopoulos, A.6
  • 42
    • 34548008809 scopus 로고    scopus 로고
    • Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment
    • Giuliani N., Morandi F., Tagliaferri S., Lazzaretti M., Donofrio G., Bonomini S., et al. Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res 2007, 67:7665-7674.
    • (2007) Cancer Res , vol.67 , pp. 7665-7674
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3    Lazzaretti, M.4    Donofrio, G.5    Bonomini, S.6
  • 43
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou M.C., Heath D.J., Rahemtulla A., Szydlo R., Anagnostopoulos A., Dimopoulos M.A., et al. Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer 2006, 119:1728-1731.
    • (2006) Int J Cancer , vol.119 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3    Szydlo, R.4    Anagnostopoulos, A.5    Dimopoulos, M.A.6
  • 44
    • 36849026690 scopus 로고    scopus 로고
    • Myeloma cell expression of 10 candidate genes for osteolytic bone disease. Only overexpression of DKK1 correlates with clinical bone involvement at diagnosis
    • Haaber J., Abildgaard N., Knudsen L.M., Dahl I.M., Lodahl M., Thomassen M., et al. Myeloma cell expression of 10 candidate genes for osteolytic bone disease. Only overexpression of DKK1 correlates with clinical bone involvement at diagnosis. Br J Haematol 2008, 140:25-35.
    • (2008) Br J Haematol , vol.140 , pp. 25-35
    • Haaber, J.1    Abildgaard, N.2    Knudsen, L.M.3    Dahl, I.M.4    Lodahl, M.5    Thomassen, M.6
  • 45
    • 70350092339 scopus 로고    scopus 로고
    • Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma
    • Durie B.G., Van Ness B., Ramos C., Stephens O., Haznadar M., Hoering A., et al. Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma. Leukemia 2009, 23:1913-1919.
    • (2009) Leukemia , vol.23 , pp. 1913-1919
    • Durie, B.G.1    Van Ness, B.2    Ramos, C.3    Stephens, O.4    Haznadar, M.5    Hoering, A.6
  • 46
    • 80053537013 scopus 로고    scopus 로고
    • A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment
    • Wu P., Walker B.A., Brewer D., Gregory W.M., Ashcroft J., Ross F.M., et al. A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment. Clin Cancer Res 2011, 17:6347-6355.
    • (2011) Clin Cancer Res , vol.17 , pp. 6347-6355
    • Wu, P.1    Walker, B.A.2    Brewer, D.3    Gregory, W.M.4    Ashcroft, J.5    Ross, F.M.6
  • 47
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S., Ling W., Zhan F., Walker R., Barlogie B., Shaughnessy J.D. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007, 109:2106-2111.
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy, J.D.6
  • 48
  • 49
    • 61849137831 scopus 로고    scopus 로고
    • Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma
    • Heath D.J., Chantry A.D., Buckle C.H., Coulton L., Shaughnessy J.D., Evans H.R., et al. Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. J Bone Miner Res 2009, 24:425-436.
    • (2009) J Bone Miner Res , vol.24 , pp. 425-436
    • Heath, D.J.1    Chantry, A.D.2    Buckle, C.H.3    Coulton, L.4    Shaughnessy, J.D.5    Evans, H.R.6
  • 50
    • 84873487461 scopus 로고    scopus 로고
    • In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma
    • Pozzi S., Fulciniti M., Yan H., Vallet S., Eda H., Patel K., et al. In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma. Bone 2013, 53:487-496.
    • (2013) Bone , vol.53 , pp. 487-496
    • Pozzi, S.1    Fulciniti, M.2    Yan, H.3    Vallet, S.4    Eda, H.5    Patel, K.6
  • 51
    • 60349105063 scopus 로고    scopus 로고
    • Tipping the balance: modulating the Wnt pathway for tissue repair
    • Zhao J., Kim K.A., Abo A. Tipping the balance: modulating the Wnt pathway for tissue repair. Trends Biotechnol 2009, 27:131-136.
    • (2009) Trends Biotechnol , vol.27 , pp. 131-136
    • Zhao, J.1    Kim, K.A.2    Abo, A.3
  • 53
    • 66149127277 scopus 로고    scopus 로고
    • Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling
    • Qiang Y.W., Hu B., Chen Y., Zhong Y., Shi B., Barlogie B., et al. Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling. Blood 2009, 113:4319-4330.
    • (2009) Blood , vol.113 , pp. 4319-4330
    • Qiang, Y.W.1    Hu, B.2    Chen, Y.3    Zhong, Y.4    Shi, B.5    Barlogie, B.6
  • 54
    • 34848853850 scopus 로고    scopus 로고
    • Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease
    • Oyajobi B.O., Garrett I.R., Gupta A., Flores A., Esparza J., Munoz S., et al. Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease. Br J Haematol 2007, 139:434-438.
    • (2007) Br J Haematol , vol.139 , pp. 434-438
    • Oyajobi, B.O.1    Garrett, I.R.2    Gupta, A.3    Flores, A.4    Esparza, J.5    Munoz, S.6
  • 55
    • 14344262210 scopus 로고    scopus 로고
    • Efficacy of bortezomib therapy for extramedullary relapse of myeloma after autologous and non-myeloablative allogeneic transplantation
    • Patriarca F., Prosdocimo S., Tomadini V., Vasciaveo A., Bruno B., Fanin R. Efficacy of bortezomib therapy for extramedullary relapse of myeloma after autologous and non-myeloablative allogeneic transplantation. Haematologica 2005, 90:278-279.
    • (2005) Haematologica , vol.90 , pp. 278-279
    • Patriarca, F.1    Prosdocimo, S.2    Tomadini, V.3    Vasciaveo, A.4    Bruno, B.5    Fanin, R.6
  • 56
    • 77955513184 scopus 로고    scopus 로고
    • Peptide-based immunotherapy for multiple myeloma: current approaches
    • Zhou F.L., Meng S., Zhang W.G., Wei Y.C., Cao X.M., Bai G.G., et al. Peptide-based immunotherapy for multiple myeloma: current approaches. Vaccine 2010, 28:5939-5946.
    • (2010) Vaccine , vol.28 , pp. 5939-5946
    • Zhou, F.L.1    Meng, S.2    Zhang, W.G.3    Wei, Y.C.4    Cao, X.M.5    Bai, G.G.6
  • 57
    • 34548828781 scopus 로고    scopus 로고
    • Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma
    • Qian J., Xie J., Hong S., Yang J., Zhang L., Han X., et al. Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma. Blood 2007, 110:1587-1594.
    • (2007) Blood , vol.110 , pp. 1587-1594
    • Qian, J.1    Xie, J.2    Hong, S.3    Yang, J.4    Zhang, L.5    Han, X.6
  • 58
    • 0029116310 scopus 로고
    • Endothelins
    • Levin E.R. Endothelins. N Engl J Med 1995, 333:356-363.
    • (1995) N Engl J Med , vol.333 , pp. 356-363
    • Levin, E.R.1
  • 59
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    • Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988, 332:411-415.
    • (1988) Nature , vol.332 , pp. 411-415
    • Yanagisawa, M.1    Kurihara, H.2    Kimura, S.3    Tomobe, Y.4    Kobayashi, M.5    Mitsui, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.