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Volumn 89, Issue 1, 2014, Pages 34-40

The combination of lenalidomide and dexamethasone reduces bone resorption in responding patients with relapsed/refractory multiple myeloma but has no effect on bone formation: Final results on 205 patients of the Greek myeloma study group

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CARBOXY TERMINAL TELOPEPTIDE; DEXAMETHASONE; DICKKOPF 1 PROTEIN; LENALIDOMIDE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

EID: 84892897649     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23577     Document Type: Article
Times cited : (28)

References (34)
  • 1
    • 42449114035 scopus 로고    scopus 로고
    • Multiple myeloma
    • Kyle RA, Rajkumar SV. Multiple myeloma. Blood 2008;111:2962-2972.
    • (2008) Blood , vol.111 , pp. 2962-2972
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 2
    • 67349240834 scopus 로고    scopus 로고
    • Improved survival of patients with multiple myeloma after the introduction of novel agents and the applicability of the International Staging System (ISS): An analysis of the Greek Myeloma Study Group (GMSG)
    • Kastritis E, Zervas K, Symeonidis A, et al. Improved survival of patients with multiple myeloma after the introduction of novel agents and the applicability of the International Staging System (ISS): An analysis of the Greek Myeloma Study Group (GMSG). Leukemia 2009;23:1152-1157.
    • (2009) Leukemia , vol.23 , pp. 1152-1157
    • Kastritis, E.1    Zervas, K.2    Symeonidis, A.3
  • 3
    • 36349023319 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
    • Dimopoulos M, Spencer A, Attal M, et al. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med 2007;357:2123-2132.
    • (2007) N Engl J Med , vol.357 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 4
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber DM, Chen C, Niesvizky R, et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 2007;357:2133-2142.
    • (2007) N Engl J Med , vol.357 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 5
    • 0037216353 scopus 로고    scopus 로고
    • Review of 1027 patients with newly diagnosed multiple myeloma
    • Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003;78:21-33.
    • (2003) Mayo Clin Proc , vol.78 , pp. 21-33
    • Kyle, R.A.1    Gertz, M.A.2    Witzig, T.E.3
  • 6
    • 0346219279 scopus 로고    scopus 로고
    • New insights into the pathophysiology and management of bone disease in multiple myeloma
    • Terpos E, Politou M, Rahemtulla A. New insights into the pathophysiology and management of bone disease in multiple myeloma. Br J Haematol 2003;123:758-769.
    • (2003) Br J Haematol , vol.123 , pp. 758-769
    • Terpos, E.1    Politou, M.2    Rahemtulla, A.3
  • 7
    • 62549117773 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman GD. Pathogenesis of myeloma bone disease. Leukemia 2009;23:435-441.
    • (2009) Leukemia , vol.23 , pp. 435-441
    • Roodman, G.D.1
  • 8
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • Sezer O, Heider U, Zavrski I, et al. RANK ligand and osteoprotegerin in myeloma bone disease. Blood 2003;101:2094-2098.
    • (2003) Blood , vol.101 , pp. 2094-2098
    • Sezer, O.1    Heider, U.2    Zavrski, I.3
  • 9
    • 0037439916 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    • Vanderkerken K, De Leenheer E, Shipman C, et al. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res 2003;63:287-289.
    • (2003) Cancer Res , vol.63 , pp. 287-289
    • Vanderkerken, K.1    De Leenheer, E.2    Shipman, C.3
  • 10
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappa-B ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E, Szydlo R, Apperley JF, et al. Soluble receptor activator of nuclear factor kappa-B ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index. Blood 2003;102:1064-1069.
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3
  • 11
    • 0142182080 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis
    • Grimaud E, Soubigou L, Couillaud S, et al. Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. Am J Pathol 2003;163:2021-2031.
    • (2003) Am J Pathol , vol.163 , pp. 2021-2031
    • Grimaud, E.1    Soubigou, L.2    Couillaud, S.3
  • 12
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 13
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou MC, Heath DJ, Rahemtulla A, et al. Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer 2006;119:1728-1731.
    • (2006) Int J Cancer , vol.119 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3
  • 14
    • 43549108372 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
    • Kaiser M, Mieth M, Liebisch P, et al. Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur J Haematol 2008;80:490-494.
    • (2008) Eur J Haematol , vol.80 , pp. 490-494
    • Kaiser, M.1    Mieth, M.2    Liebisch, P.3
  • 15
    • 34548128339 scopus 로고    scopus 로고
    • The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma
    • Terpos E, Dimopoulos MA, Sezer O. The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma. Leukemia 2007;21:1875-1884.
    • (2007) Leukemia , vol.21 , pp. 1875-1884
    • Terpos, E.1    Dimopoulos, M.A.2    Sezer, O.3
  • 16
    • 33750566914 scopus 로고    scopus 로고
    • Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
    • Terpos E, Heath DJ, Rahemtulla A, et al. Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Br J Haematol 2006;135:688-692.
    • (2006) Br J Haematol , vol.135 , pp. 688-692
    • Terpos, E.1    Heath, D.J.2    Rahemtulla, A.3
  • 17
    • 79551627290 scopus 로고    scopus 로고
    • A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated with bortezomib response in multiple myeloma patients
    • Zangari M, Yaccoby S, Pappas L, et al. A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated with bortezomib response in multiple myeloma patients. Haematologica 2011;96:333-336.
    • (2011) Haematologica , vol.96 , pp. 333-336
    • Zangari, M.1    Yaccoby, S.2    Pappas, L.3
  • 18
    • 79954426340 scopus 로고    scopus 로고
    • Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalan-prednisone in the phase III VISTA trial in multiple myeloma
    • Delforge M, Terpos E, Richardson PG, et al. Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalan-prednisone in the phase III VISTA trial in multiple myeloma. Eur J Haematol 2011;86:372-384.
    • (2011) Eur J Haematol , vol.86 , pp. 372-384
    • Delforge, M.1    Terpos, E.2    Richardson, P.G.3
  • 19
    • 33645736007 scopus 로고    scopus 로고
    • Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1
    • Anderson G, Gries M, Kurihara N, et al. Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1. Blood 2006;107:3098-3105.
    • (2006) Blood , vol.107 , pp. 3098-3105
    • Anderson, G.1    Gries, M.2    Kurihara, N.3
  • 20
    • 27644523704 scopus 로고    scopus 로고
    • The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio
    • Terpos E, Mihou D, Szydlo R, et al. The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio. Leukemia 2005;19:1969-1976.
    • (2005) Leukemia , vol.19 , pp. 1969-1976
    • Terpos, E.1    Mihou, D.2    Szydlo, R.3
  • 21
    • 33645725851 scopus 로고    scopus 로고
    • First-line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma
    • Tosi P, Zamagni E, Cellini C, et al. First-line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma. Eur J Haematol 2006;76:399-404.
    • (2006) Eur J Haematol , vol.76 , pp. 399-404
    • Tosi, P.1    Zamagni, E.2    Cellini, C.3
  • 22
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S, et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2008;22:1925-1932.
    • (2008) Leukemia , vol.22 , pp. 1925-1932
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 23
    • 84865017968 scopus 로고    scopus 로고
    • Therapy with lenalidomide plus dexamethasone-induced bone formation in a patient with refractory multiple myeloma
    • Tsuda H, Yamasaki H, Tsuji T, Yokoo E. Therapy with lenalidomide plus dexamethasone-induced bone formation in a patient with refractory multiple myeloma. Int J Hematol 2012;95:706-710.
    • (2012) Int J Hematol , vol.95 , pp. 706-710
    • Tsuda, H.1    Yamasaki, H.2    Tsuji, T.3    Yokoo, E.4
  • 24
    • 77957996812 scopus 로고    scopus 로고
    • Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: Prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    • Dimopoulos MA, Kastritis E, Christoulas D, et al. Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: Prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies. Leukemia 2010;24:1769-1778.
    • (2010) Leukemia , vol.24 , pp. 1769-1778
    • Dimopoulos, M.A.1    Kastritis, E.2    Christoulas, D.3
  • 25
    • 84988241358 scopus 로고    scopus 로고
    • International uniform response criteria for multiple myeloma
    • Durie BG, Harousseau JL, Miguel JS, et al. International uniform response criteria for multiple myeloma. Leukemia 2006;20:1467-1473.
    • (2006) Leukemia , vol.20 , pp. 1467-1473
    • Durie, B.G.1    Harousseau, J.L.2    Miguel, J.S.3
  • 26
    • 70450230539 scopus 로고    scopus 로고
    • Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    • Dimopoulos MA, Chen C, Spencer A, et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia 2009;23:2147-2152.
    • (2009) Leukemia , vol.23 , pp. 2147-2152
    • Dimopoulos, M.A.1    Chen, C.2    Spencer, A.3
  • 27
    • 84860744403 scopus 로고    scopus 로고
    • Continuous lenalidomide treatment for newly diagnosed multiple myeloma
    • Palumbo A, Hajek R, Delforge M, et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N Engl J Med 2012;366:1759-1769.
    • (2012) N Engl J Med , vol.366 , pp. 1759-1769
    • Palumbo, A.1    Hajek, R.2    Delforge, M.3
  • 28
    • 64549125118 scopus 로고    scopus 로고
    • Bone marrow adipocytes support dexamethasone-induced osteoclast differentiation
    • Hozumi A, Osaki M, Goto H, et al. Bone marrow adipocytes support dexamethasone-induced osteoclast differentiation. Biochem Biophys Res Commun 2009;382:780-784.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 780-784
    • Hozumi, A.1    Osaki, M.2    Goto, H.3
  • 29
    • 0036295812 scopus 로고    scopus 로고
    • Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts
    • Viereck V, Emons G, Lauck V, et al. Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun 2002;291:680-686.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 680-686
    • Viereck, V.1    Emons, G.2    Lauck, V.3
  • 30
    • 84855928396 scopus 로고    scopus 로고
    • Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro
    • Koch FP, Merkel C, Ziebart T, et al. Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro. Clin Oral Investig 2012;16:79-86.
    • (2012) Clin Oral Investig , vol.16 , pp. 79-86
    • Koch, F.P.1    Merkel, C.2    Ziebart, T.3
  • 31
    • 51049090172 scopus 로고    scopus 로고
    • Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma
    • Burington B, Barlogie B, Zhan F, et al. Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma. Clin Cancer Res 2008;14:4821-4829.
    • (2008) Clin Cancer Res , vol.14 , pp. 4821-4829
    • Burington, B.1    Barlogie, B.2    Zhan, F.3
  • 32
    • 84892875126 scopus 로고    scopus 로고
    • DKK1 is an immediate early gene in multiple myeloma cells modulated by cell density and IL-6
    • ASH abstracts volume
    • Tian E, Qiang Y, Barlogie B, Shaughnessy JD Jr. DKK1 is an immediate early gene in multiple myeloma cells modulated by cell density and IL-6. Blood 2010;116 (ASH abstracts volume):802-803.
    • (2010) Blood , vol.116 , pp. 802-803
    • Tian, E.1    Qiang, Y.2    Barlogie, B.3    Shaughnessy Jr, J.D.4
  • 33
    • 1942424854 scopus 로고    scopus 로고
    • Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: Novel mechanism of glucocorticoid-induced osteoporosis
    • Ohnaka K, Taniguchi H, Kawate H, et al. Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: Novel mechanism of glucocorticoid-induced osteoporosis. Biochem Biophys Res Commun 2004;318:259-264.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 259-264
    • Ohnaka, K.1    Taniguchi, H.2    Kawate, H.3
  • 34
    • 77954253348 scopus 로고    scopus 로고
    • Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the combination of bortezomib, dexamethasone and zoledronic acid
    • Terpos E, Christoulas D, Kokkoris P, et al. Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the combination of bortezomib, dexamethasone and zoledronic acid. Ann Oncol 2010;21:1561-1562.
    • (2010) Ann Oncol , vol.21 , pp. 1561-1562
    • Terpos, E.1    Christoulas, D.2    Kokkoris, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.