메뉴 건너뛰기




Volumn 19, Issue 3, 2000, Pages 203-209

In vivo functions of integrins: Lessons from null mutations in mice

Author keywords

Extracellular matrix; Integrin; Knockout mice

Indexed keywords

INTEGRIN; PROTEIN SUBUNIT;

EID: 0034233562     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(00)00065-2     Document Type: Short Survey
Times cited : (124)

References (47)
  • 1
    • 0033073443 scopus 로고    scopus 로고
    • Distinct functions of α3 and αv integrin receptors in neuronal migration and laminar organization of the cerebral cortex
    • Anton E.S., Kreidberg J.A., Rakic P. Distinct functions of α3 and αv integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron. 22:1999;277-289.
    • (1999) Neuron , vol.22 , pp. 277-289
    • Anton, E.S.1    Kreidberg, J.A.2    Rakic, P.3
  • 2
    • 0030604540 scopus 로고    scopus 로고
    • Differential requirements for α4 integrins during fetal and adult hematopoiesis
    • Arroyo A.G., Yang J.T., Rayburn H., Hynes R.O. Differential requirements for α4 integrins during fetal and adult hematopoiesis. Cell. 85:1996;997-1008.
    • (1996) Cell , vol.85 , pp. 997-1008
    • Arroyo, A.G.1    Yang, J.T.2    Rayburn, H.3    Hynes, R.O.4
  • 3
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins
    • Bader B.L., Rayburn H., Crowley D., Hynes R.O. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins. Cell. 95:1998;507-519.
    • (1998) Cell , vol.95 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 4
    • 0032521681 scopus 로고    scopus 로고
    • Knockout and knockin of the β1 exon D define distinct roles for integrin splice variants in heart function and embryonic development
    • Baudoin C., Goumans M.J., Mummery C., Sonnenberg A. Knockout and knockin of the β1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev. 12:1998;1202-1216.
    • (1998) Genes Dev. , vol.12 , pp. 1202-1216
    • Baudoin, C.1    Goumans, M.J.2    Mummery, C.3    Sonnenberg, A.4
  • 5
    • 0025799922 scopus 로고
    • Characterization of the integrin alpha 8 subunit: A new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos
    • Bossy B., Bossy W.E., Reichardt L.F. Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos. EMBO J. 10:1991;2375-2385.
    • (1991) EMBO J. , vol.10 , pp. 2375-2385
    • Bossy, B.1    Bossy, W.E.2    Reichardt, L.F.3
  • 6
    • 0030483324 scopus 로고    scopus 로고
    • A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation
    • Coxon A., Rieu P., Barkalow F.J. et al. A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 5:1996;653-666.
    • (1996) Immunity , vol.5 , pp. 653-666
    • Coxon, A.1    Rieu, P.2    Barkalow, F.J.3
  • 9
    • 0029666420 scopus 로고    scopus 로고
    • β4 Integrin is required for hemidesmmosome formation, cell adhesion and cell survival
    • Dowling J., Yu Q.-C., Fuchs E. β4 Integrin is required for hemidesmmosome formation, cell adhesion and cell survival. J. Cell Biol. 134:1996;559-572.
    • (1996) J. Cell Biol. , vol.134 , pp. 559-572
    • Dowling, J.1    Yu, Q.-C.2    Fuchs, E.3
  • 10
    • 0028979154 scopus 로고
    • Consequences of lack of β1 integrin gene expression in mice
    • Fässler R., Meyer M. Consequences of lack of β1 integrin gene expression in mice. Genes Dev. 9:1995;1896-1908.
    • (1995) Genes Dev. , vol.9 , pp. 1896-1908
    • Fässler, R.1    Meyer, M.2
  • 11
    • 0033035808 scopus 로고    scopus 로고
    • Absence of integrin α1β1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis
    • Gardner H., Broberg A., Pozzi A., Laato M., Heino J. Absence of integrin α1β1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis. J. Cell Sci. 112:1999;263-267.
    • (1999) J. Cell Sci. , vol.112 , pp. 263-267
    • Gardner, H.1    Broberg, A.2    Pozzi, A.3    Laato, M.4    Heino, J.5
  • 12
    • 0029894277 scopus 로고    scopus 로고
    • Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific defect in cell adhesion
    • Gardner H., Kriedberg J., Koteliansky V., Jaenisch R. Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific defect in cell adhesion. Dev. Biol. 175:1996;301-313.
    • (1996) Dev. Biol. , vol.175 , pp. 301-313
    • Gardner, H.1    Kriedberg, J.2    Koteliansky, V.3    Jaenisch, R.4
  • 14
    • 0032487578 scopus 로고    scopus 로고
    • Cre-loxP-mediated inactivation of the α6A integrin splice variant in vivo: Evidence for a specific functional role of α6A in lymphocyte migration but not in heart development
    • Gimond C., Baudoin C., van der Neut R., Kramer D., Calafat J., Sonnenberg A. Cre-loxP-mediated inactivation of the α6A integrin splice variant in vivo: evidence for a specific functional role of α6A in lymphocyte migration but not in heart development. J. Cell Biol. 143:1998;253-266.
    • (1998) J. Cell Biol. , vol.143 , pp. 253-266
    • Gimond, C.1    Baudoin, C.2    Van Der Neut, R.3    Kramer, D.4    Calafat, J.5    Sonnenberg, A.6
  • 15
    • 0028855419 scopus 로고
    • Targeted disruption of the murine VCAM-1 gene in chorioallantoic fusion and placentation
    • Gurtner G.C., Davis V., Li H., McCoy M.J., Sharp A., Cybulsky M.I. Targeted disruption of the murine VCAM-1 gene in chorioallantoic fusion and placentation. Genes Dev. 9:1995;1-14.
    • (1995) Genes Dev. , vol.9 , pp. 1-14
    • Gurtner, G.C.1    Davis, V.2    Li, H.3    McCoy, M.J.4    Sharp, A.5    Cybulsky, M.I.6
  • 16
    • 0032493934 scopus 로고    scopus 로고
    • Novel roles for the α3β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes
    • Hodivala-Dilke K.M., DiPersio C.M., Kreidberg J.A., Hynes R.O. Novel roles for the α3β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes. J. Cell Biol. 142:1998;1357-1369.
    • (1998) J. Cell Biol. , vol.142 , pp. 1357-1369
    • Hodivala-Dilke, K.M.1    Dipersio, C.M.2    Kreidberg, J.A.3    Hynes, R.O.4
  • 17
    • 0032590042 scopus 로고    scopus 로고
    • β3-Integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    • Hodivala-Dilke K.M., McHugh K.P., Tsakiris D.A. et al. β3-Integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Invest. 103:1999;229-238.
    • (1999) J. Clin. Invest. , vol.103 , pp. 229-238
    • Hodivala-Dilke, K.M.1    McHugh, K.P.2    Tsakiris, D.A.3
  • 18
    • 15844376477 scopus 로고    scopus 로고
    • Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
    • Huang X., Wu J., Cass D. et al. Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J. Cell Biol. 133:1996;921-928.
    • (1996) J. Cell Biol. , vol.133 , pp. 921-928
    • Huang, X.1    Wu, J.2    Cass, D.3
  • 19
    • 0033982574 scopus 로고    scopus 로고
    • Impaired cell migration and adhesion but normal development in β5 deficient mice
    • Huang X.Z., Griffiths M., Wu J.F., Farese R.F. Jr., Sheppard D. Impaired cell migration and adhesion but normal development in β5 deficient mice. Mol. Cell Biol. 20:2000;755-759.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 755-759
    • Huang, X.Z.1    Griffiths, M.2    Wu, J.F.3    Farese R.F., Jr.4    Sheppard, D.5
  • 21
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes R.O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69:1992;11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 22
  • 23
    • 0028952534 scopus 로고
    • Defective development of the embryonic and extra-embryonic circulatory system in vascular cell adhesion molecule (VCAM-1) deficient mice
    • Kwee L., Baldwin S., Stewart C.S., Buck C., Labow M.A. Defective development of the embryonic and extra-embryonic circulatory system in vascular cell adhesion molecule (VCAM-1) deficient mice. Development. 121:1995;489-503.
    • (1995) Development , vol.121 , pp. 489-503
    • Kwee, L.1    Baldwin, S.2    Stewart, C.S.3    Buck, C.4    Labow, M.A.5
  • 24
    • 0031000635 scopus 로고    scopus 로고
    • LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
    • Lu H., Smith C.W., Perrard J. et al. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J. Clin. Invest. 99:1997;1340-1350.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1340-1350
    • Lu, H.1    Smith, C.W.2    Perrard, J.3
  • 25
    • 0030724952 scopus 로고    scopus 로고
    • Absence of integrin α7 causes a novel form of muscular dystrophy
    • Mayer U., Saher G., Fassler R. et al. Absence of integrin α7 causes a novel form of muscular dystrophy. Nat. Genet. 17:1997;318-323.
    • (1997) Nat. Genet. , vol.17 , pp. 318-323
    • Mayer, U.1    Saher, G.2    Fassler, R.3
  • 26
    • 0033621890 scopus 로고    scopus 로고
    • Mice lacking β3 integrins are osteosclerotic due to dysfunctional osteoclasts
    • McHugh K.P., Hodivala-Dilke K., Zheng M.-H. et al. Mice lacking β3 integrins are osteosclerotic due to dysfunctional osteoclasts. J. Clin. Invest. 105:2000;433-440.
    • (2000) J. Clin. Invest. , vol.105 , pp. 433-440
    • McHugh, K.P.1    Hodivala-Dilke, K.2    Zheng, M.-H.3
  • 27
    • 0030614865 scopus 로고    scopus 로고
    • Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis
    • Meuller U., Wang D., Denda S., Meneses J.J., Pedersen R.A., Reichardt L.F. Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 88:1997;603-613.
    • (1997) Cell , vol.88 , pp. 603-613
    • Meuller, U.1    Wang, D.2    Denda, S.3    Meneses, J.J.4    Pedersen, R.A.5    Reichardt, L.F.6
  • 28
    • 0033524949 scopus 로고    scopus 로고
    • The integrin αvβ6 binds and activates latent TGFβ1: A mechanism for regulating pulmonary inflammation and fibrosis
    • Munger J.S., Huang X.Z., Kawakatsu H. et al. The integrin αvβ6 binds and activates latent TGFβ1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 96:1999;319-328.
    • (1999) Cell , vol.96 , pp. 319-328
    • Munger, J.S.1    Huang, X.Z.2    Kawakatsu, H.3
  • 29
    • 0032528060 scopus 로고    scopus 로고
    • Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin β4 cytoplasmic domain
    • Murgia C., Blaikie P., Kin N., Dans M., Petrie H.T., Giancotti F.G. Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin β4 cytoplasmic domain. EMBO J. 17:1998;394-3951.
    • (1998) EMBO J. , vol.17 , pp. 394-3951
    • Murgia, C.1    Blaikie, P.2    Kin, N.3    Dans, M.4    Petrie, H.T.5    Giancotti, F.G.6
  • 30
    • 0029990621 scopus 로고    scopus 로고
    • Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: Consequences for hemidesmosome formation and adhesion properties
    • Niessen C.M., van der Raaij-Helmer M.H., Hulsman E.H., van der Neut R., Jonkman M.F., Sonnenberg A. Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J. Cell Sci. 109:1996;1695-1706.
    • (1996) J. Cell Sci. , vol.109 , pp. 1695-1706
    • Niessen, C.M.1    Van Der Raaij-Helmer, M.H.2    Hulsman, E.H.3    Van Der Neut, R.4    Jonkman, M.F.5    Sonnenberg, A.6
  • 31
    • 0027520443 scopus 로고
    • Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle
    • Palmer E.L., Ruegg C., Ferrando R., Pytela R., Sheppard D. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. J. Cell Biol. 123:1993;1289-1297.
    • (1993) J. Cell Biol. , vol.123 , pp. 1289-1297
    • Palmer, E.L.1    Ruegg, C.2    Ferrando, R.3    Pytela, R.4    Sheppard, D.5
  • 32
    • 0032572410 scopus 로고    scopus 로고
    • Integrin α1β1 mediates a unique collagen-dependent proliferation pathway in vivo
    • Pozzi A., Wary K.K., Giancotti F.G., Gardner H.A. Integrin α1β1 mediates a unique collagen-dependent proliferation pathway in vivo. J. Cell Biol. 142:1998;587-594.
    • (1998) J. Cell Biol. , vol.142 , pp. 587-594
    • Pozzi, A.1    Wary, K.K.2    Giancotti, F.G.3    Gardner, H.A.4
  • 33
    • 0026708853 scopus 로고
    • Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis
    • Rosen G.D., Sanes J.R., LaChance R., Cunningham J.M., Roman J., Dean D.C. Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis. Cell. 69:1992;1107-1119.
    • (1992) Cell , vol.69 , pp. 1107-1119
    • Rosen, G.D.1    Sanes, J.R.2    Lachance, R.3    Cunningham, J.M.4    Roman, J.5    Dean, D.C.6
  • 34
    • 0032534315 scopus 로고    scopus 로고
    • Impaired mast cell development and innate immunity in mac-1 (CD11b/CD18, CR3)-deficient mice
    • Rosenkranz A.R., Coxon A., Maurer M. et al. Impaired mast cell development and innate immunity in mac-1 (CD11b/CD18, CR3)-deficient mice. J. Immunol. 161:1998;6463-6467.
    • (1998) J. Immunol. , vol.161 , pp. 6463-6467
    • Rosenkranz, A.R.1    Coxon, A.2    Maurer, M.3
  • 35
    • 18244415152 scopus 로고    scopus 로고
    • Spontaneous skin ulceration and defective T cell function in CD18 null mice
    • Scharffetter-Kochanek K., Lu H., Norman K. et al. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J. Exp. Med. 188:1998;119-131.
    • (1998) J. Exp. Med. , vol.188 , pp. 119-131
    • Scharffetter-Kochanek, K.1    Lu, H.2    Norman, K.3
  • 36
    • 0033151953 scopus 로고    scopus 로고
    • Mucosal T lymphocyte numbers are selectively reduced in integrin αe (CD103)-deficient mice
    • Scheon M.P., Arya A., Murphy E.A. et al. Mucosal T lymphocyte numbers are selectively reduced in integrin αE (CD103)-deficient mice. J. Immunol. 162:1999;6641-6649.
    • (1999) J. Immunol. , vol.162 , pp. 6641-6649
    • Scheon, M.P.1    Arya, A.2    Murphy, E.A.3
  • 37
    • 15844379199 scopus 로고    scopus 로고
    • LFA-1 deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor
    • Schmits R., Kundig T.M., Baker D.M. et al. LFA-1 deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183:1996;1415-1426.
    • (1996) J. Exp. Med. , vol.183 , pp. 1415-1426
    • Schmits, R.1    Kundig, T.M.2    Baker, D.M.3
  • 38
    • 0028981367 scopus 로고
    • The human integrin α8β1 functions as a receptor for tenascin, fibronectin, and vitronectin
    • Schnapp L.M., Hatch N., Ramos D., Kliminskaya I.V., Sheppard D., Pytela R. The human integrin α8β1 functions as a receptor for tenascin, fibronectin, and vitronectin. J. Biol. Chem. 270:1995;23196-23202.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23196-23202
    • Schnapp, L.M.1    Hatch, N.2    Ramos, D.3    Kliminskaya, I.V.4    Sheppard, D.5    Pytela, R.6
  • 39
    • 0028979153 scopus 로고
    • Deletion of β1 integrins in mice results in inner cell mass failure and peri-implantation lethality
    • Stephens L.S., Klimanskaya I.V., Andrieux A., Meneses J., Pedersen R.A., Damsky C.H. Deletion of β1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 9:1995;1883-1895.
    • (1995) Genes Dev. , vol.9 , pp. 1883-1895
    • Stephens, L.S.1    Klimanskaya, I.V.2    Andrieux, A.3    Meneses, J.4    Pedersen, R.A.5    Damsky, C.H.6
  • 40
    • 0030784483 scopus 로고    scopus 로고
    • A role for Mac-1 (CD11b/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcγ receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis
    • Tang T., Rosenkranz A., Assmann K.J.M. et al. A role for Mac-1 (CD11b/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcγ receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J. Exp. Med. 186:1997;1853-1863.
    • (1997) J. Exp. Med. , vol.186 , pp. 1853-1863
    • Tang, T.1    Rosenkranz, A.2    Assmann, K.J.M.3
  • 41
    • 0032476651 scopus 로고    scopus 로고
    • Dystrophic muscle in mice chimeric for expression of α5 integrin
    • Taverna D., Disatnik M.-H., Rayburn H. et al. Dystrophic muscle in mice chimeric for expression of α5 integrin. J. Cell Biol. 143:1998;849-859.
    • (1998) J. Cell Biol. , vol.143 , pp. 849-859
    • Taverna, D.1    Disatnik, M.-H.2    Rayburn, H.3
  • 43
    • 0029665856 scopus 로고    scopus 로고
    • Critical role for β7 integrins in formation of the gut-associated lymphoid tissue
    • Wagner N., Lohler J., Kumkel E.J. et al. Critical role for β7 integrins in formation of the gut-associated lymphoid tissue. Nature. 382:1996;366-370.
    • (1996) Nature , vol.382 , pp. 366-370
    • Wagner, N.1    Lohler, J.2    Kumkel, E.J.3
  • 44
    • 0027257221 scopus 로고
    • Gene targeting yields a CD18-mutant mouse for study of inflammation
    • Wilson R.W., Ballantyne C.M., Smith C.W. et al. Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151:1993;1571-1578.
    • (1993) J. Immunol. , vol.151 , pp. 1571-1578
    • Wilson, R.W.1    Ballantyne, C.M.2    Smith, C.W.3
  • 45
    • 0027371908 scopus 로고
    • Embryonic mesodermal defects in α5 integrin-deficient mice
    • Yang J.T., Rayburn H., Hynes R.O. Embryonic mesodermal defects in α5 integrin-deficient mice. Development. 119:1993;1093-1105.
    • (1993) Development , vol.119 , pp. 1093-1105
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 46
    • 0028955748 scopus 로고
    • Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development
    • Yang J.T., Rayburn H., Hynes R.O. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development. 121:1995;549-560.
    • (1995) Development , vol.121 , pp. 549-560
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 47
    • 0029826158 scopus 로고    scopus 로고
    • Genetic analysis of α4 integrin functions in the development of mouse skeletal muscle
    • Yang J.T., Rando T.A., Mohler W.A., Rayburn H., Blau H.M., Hynes R.O. Genetic analysis of α4 integrin functions in the development of mouse skeletal muscle. J. Cell Biol. 135:1996;829-835.
    • (1996) J. Cell Biol. , vol.135 , pp. 829-835
    • Yang, J.T.1    Rando, T.A.2    Mohler, W.A.3    Rayburn, H.4    Blau, H.M.5    Hynes, R.O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.