Inhibition of TGF-β signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction

Cardiovascular Research

Volumn 64, Issue 3, 2004, Pages 526-535

  Ikeuchi, Masaki ^a   Tsutsui, Hiroyuki ^a   Shiomi, Tetsuya ^a   Matsusaka, Hidenori ^a   Matsushima, Shouji ^a   Wen, Jing ^a   Kubota, Toru ^a   Takeshita, Akira ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Cytokine; Extracellular matrix; Gene therapy; Infarction; Remodeling

Indexed keywords

INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROSING ALVEOLITIS; GENE EXPRESSION; HEART DISEASE; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART VENTRICLE REMODELING; LEFT CORONARY ARTERY; LIGATION; MALE; MORTALITY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE;

ANIMALS; CHEMOKINE CCL2; ECHOCARDIOGRAPHY; GENE EXPRESSION; INTERLEUKIN-1; MALE; MICE; MICE, INBRED STRAINS; MYOCARDIAL INFARCTION; MYOCARDIUM; NEUTROPHIL INFILTRATION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; VENTRICULAR REMODELING;

EID: 8644268825     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.07.017     Document Type: Article

References (24)

1. M.A. Pfeffer, and E. Braunwald Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications Circulation 81 1990 1161 1172
2. W.A. Border, and N.A. Noble Transforming growth factor beta in tissue fibrosis N. Engl. J. Med. 331 1994 1286 1292
3. F. Kuwahara, H. Kai, K. Tokuda, M. Kai, A. Takeshita, and K. Egashira Transforming growth factor-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats Circulation 106 2002 130 135
4. A. Deten, A. Holzl, M. Leicht, W. Barth, and H.G. Zimmer Changes in extracellular matrix and in transforming growth factor β isoforms after coronary artery ligation in rats J. Mol. Cell. Cardiol. 33 2001 1191 1207
5. J.L. Mehta, H.J. Chen, and D.Y. Li Protection of myocytes from hypoxia-reoxygenation injury by nitric oxide is mediated by modulation of transforming growth factor-β1 Circulation 105 2002 2206 2211
6. A.M. Lefer, P. Tsao, N. Aoki, and M.A. Palladino Jr. Mediation of cardioprotection by transforming growth factor-β Science 249 1990 61 64
7. M. Nakano, A.A. Knowlton, Z. Dibbs, and D.L. Mann Tumor necrosis factor-α confers resistance to hypoxic injury in the adult mammalian cardiac myocyte Circulation 97 1998 1392 1400
8. K.M. Kurrelmeyer, L.H. Michael, G. Baumgarten, G.E. Taffet, J.J. Peschon, and N. Sivasubramanian Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction Proc. Natl. Acad. Sci. U. S. A. 97 2000 5456 5461
9. 2+ transients and contraction of adult rat cardiomyocytes Am. J. Physiol. Cell Physiol. 282 2002 C1339 C1347
10. T. Kubota, C.F. McTiernan, C.S. Frye, S.E. Slawson, B.H. Lemster, and A.P. Koretsky Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-α Circ. Res. 81 1997 627 635
11. T. Ide, H. Tsutsui, S. Kinugawa, N. Suematsu, S. Hayashidani, and K. Ichikawa Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium Circ. Res. 86 2000 152 157
12. H. Ueno, T. Sakamoto, T. Nakamura, Z. Qi, N. Astuchi, and A. Takeshita A soluble transforming growth factor β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats Hum. Gene. Ther. 11 2000 33 42
13. T. Shiomi, H. Tsutsui, S. Hayashidani, N. Suematsu, M. Ikeuchi, and J. Wen Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction Circulation 106 2002 3126 3132
14. L.H. Michael, M.L. Entman, C.J. Hartley, K.A. Youker, J. Zhu, and S.R. Hall Myocardial ischemia and reperfusion: a murine model Am. J. Physiol. 269 1995 H2147 H2154
15. W. Lukita-Atmadja, Y. Ito, G.L. Baker, and R.S. McCuskey Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin Shock 17 2002 399 403
16. J. Schultz Jel, S.A. Witt, B.J. Glascock, M.L. Nieman, P.J. Reiser, and S.L. Nix TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II J. Clin. Invest. 109 2002 787 796
17. A. Desmouliere, A. Geinoz, F. Gabbiani, and G. Gabbiani Transforming growth factor-β 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts J. Cell Biol. 122 1993 103 111
18. V.V. Petrov, R.H. Fagard, and P.J. Lijnen Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts Hypertension 39 2002 258 263
19. P. Lijnen, V. Petrov, K. Rumilla, and R. Fagard Transforming growth factor-beta 1 promotes contraction of collagen gel by cardiac fibroblasts through their differentiation into myofibroblasts Methods Find Exp. Clin. Pharmacol. 25 2003 79 86
20. C.S. Long Autocrine and paracrine regulation of myocardial cell growth in vitro. The TGF-beta paradigm Trends. Cardiovasc. Med. 6 1996 217 226
21. D.J. Pinsky, B. Cai, X. Yang, C. Rodriguez, R.R. Sciacca, and P.J. Cannon The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor β J. Clin. Invest. 95 1995 677 685
22. H. Chen, D. Li, T. Saldeen, and J.L. Mehta TGF-beta(1) modulates NOS expression and phosphorylation of Akt/PKB in rat myocytes exposed to hypoxia-reoxygenation Am. J. Physiol., Heart Circ. Physiol. 281 2001 H1035 H1039
23. A.M. Janczewski, T. Kadokami, B. Lemster, C.S. Frye, C.F. McTiernan, and A.F. Feldman Morphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-α Am. J. Physiol., Heart Circ. Physiol. 284 2003 H960 H969
24. T. Shiomi, H. Tsutsui, H. Matsusaka, K. Murakami, S. Hayashidani, and M. Ikeuchi Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice Circulation 109 2004 544 549