Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells

British Journal of Pharmacology

Volumn 171, Issue 12, 2014, Pages 3037-3050

  Hsieh, Ming Ju ^a,b   Lin, Chiao Wen ^b,c   Yang, Shun Fa ^b,c   Chen, Mu Kuan ^a,b   Chiou, Hui Ling ^b,c  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

glabridin; hepatoma; invasion; matrix metalloproteinase 9; migration

Indexed keywords

GELATINASE B; GLABRIDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR AP 1; ANTINEOPLASTIC AGENT; ISOFLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MMP9 PROTEIN, HUMAN; PHENOL DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TIMP1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR INVASION; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING; WOUND HEALING; ZYMOGRAPHY; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; CELL MOTION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; LIVER NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; TIME; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; ISOFLAVONES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MALE; MATRIX METALLOPROTEINASE 9; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NF-KAPPA B; PHENOLS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901421076     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12626     Document Type: Article

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