Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells

Food and Chemical Toxicology

Volumn 46, Issue 7, 2008, Pages 2358-2364

  Hwang, Eun Sun ^a,b   Lee, Hyong Joo ^c  

^a Seoul National University   (South Korea)

^b Ministry of Agriculture and Forestry Korea   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Benzyl isothiocyanate; Matrix metalloproteinase; Metastasis; Mitogen activated protein kinase; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; BENZYL ISOTHIOCYANATE; GELATIN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CARCINOMA; METASTASIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOTHIOCYANATES; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METALLOPROTEASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 44749089457     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.03.016     Document Type: Article

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