No evident dose-response relationship between cellular ROS level and its cytotoxicity - A paradoxical issue in ROS-based cancer therapy

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Zhu, Chunpeng ^a   Hu, Wei ^b   Wu, Hao ^a   Hu, Xun ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; GLUTATHIONE; ISOTHIOCYANIC ACID DERIVATIVE; PHENETHYL ISOTHIOCYANATE; PIPERLONGUMININE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; LACTIC ACIDOSIS; METABOLISM; NEOPLASMS; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TUMOR CELL CULTURE;

ACIDOSIS, LACTIC; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL PROLIFERATION; DIOXOLANES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HUMANS; ISOTHIOCYANATES; NEOPLASMS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 84901372958     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05029     Document Type: Article

References (53)

1. Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROSmediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8, 579-591 (2009).
2. Cabello, C. M., Bair, W. B. 3rd &Wondrak, G. T. Experimental therapeutics: targeting the redox Achilles heel of cancer. CurrOpin Investig Drugs 8, 1022-1037 (2007). (Pubitemid 350224328)
3. Engel, R. H. & Evens, A. M. Oxidative stress and apoptosis: a new treatment paradigm in cancer. Front Biosci 11, 300-312 (2006). (Pubitemid 43253493)
4. Patel, B. P. et al. Lipid peroxidation, total antioxidant status, and total thiol levels predict overall survival in patients with oral squamous cell carcinoma. Integr Cancer Ther 6, 365-372 (2007). (Pubitemid 350136020)
5. Kumar, B., Koul, S., Khandrika, L., Meacham, R. B. & Koul, H. K. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 68, 1777-1785 (2008). (Pubitemid 351416563)
6. Pervaiz, S. & Clement, M. V. Tumor intracellular redox status and drug resistance-serendipity or a causal relationship? Curr Pharm Des 10, 1969-1977 (2004). (Pubitemid 38647581)
7. Tiligada, E. Chemotherapy: induction of stress responses. Endocr Relat Cancer 13 Suppl 1, S115-124 (2006).
8. Sullivan, R. & Graham, C. H. Chemosensitization of cancer by nitric oxide. Curr Pharm Des 14, 1113-1123 (2008). (Pubitemid 351982558)
9. Kong, Q. & Lillehei, K. O. Antioxidant inhibitors for cancer therapy. Med Hypotheses 51, 405-409 (1998). (Pubitemid 28508678)
10. Kong, Q., Beel, J. A. & Lillehei, K. O. A threshold concept for cancer therapy. in Med Hypotheses. 55, 29-35 (2000). (Pubitemid 30612080)
11. Raj, L. et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475, 231-234 (2011).
12. Adams, D. J. et al. Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. Proc Natl Acad Sci U S A 109, 15115-15120 (2012).
13. Adams, D. J. et al. Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. ACS Chem Biol 8, 923-929 (2013).
14. Trachootham,D. et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10, 241-252 (2006). (Pubitemid 44311067)
15. Schumacker, P. T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10, 175-176 (2006). (Pubitemid 44311072)
16. Trachootham, D. et al. Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism. Blood 112, 1912-1922 (2008).
17. Zhang, H. et al. Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism. Leukemia 22, 1191-1199 (2008). (Pubitemid 351833787)
18. Hu, Y. et al. Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound beta-phenylethyl isothiocyanate. Blood 116, 2732-2741 (2010).
19. Martin-Cordero, C., Leon-Gonzalez, A. J., Calderon-Montano, J. M., Burgos- Moron, E. & Lopez-Lazaro, M. Pro-oxidant natural products as anticancer agents. Curr Drug Targets 13, 1006-1028 (2012).
20. Gewirtz, D. A. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 57, 727-741 (1999). (Pubitemid 29094544)
21. Pelicano, H. et al. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem 278, 37832-37839 (2003). (Pubitemid 37175311)
22. Gatenby, R. A. & Gillies, R. J. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4, 891-899 (2004). (Pubitemid 39472955)
23. Vegran, F., Boidot, R., Michiels, C., Sonveaux, P. & Feron, O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NFkappaB/ IL-8 pathway that drives tumor angiogenesis. Cancer Res 71, 2550-2560 (2011).
24. Wu, H. et al. Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. J Pathol 227, 189-199 (2012).
25. Griffith, O. W. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem 257, 13704-13712 (1982). (Pubitemid 13187133)
26. Broquist, H. P. Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants. Nutr Rev 50, 110-111 (1992).
27. Fath, M. A., Ahmad, I. M., Smith, C. J., Spence, J. & Spitz, D. R. Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism. Clin Cancer Res 17, 6206-6217 (2011).
28. Miller, A. C., Gafner, J., Clark, E. P. & Samid, D. Posttranscriptional downregulation of ras oncogene expression by inhibitors of cellular glutathione. Mol Cell Biol 13, 4416-4422 (1993). (Pubitemid 23187671)
29. Wardman, P. Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. Free Radic Biol Med 43, 995-1022 (2007). (Pubitemid 47302656)
30. Wardman, P. Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. Free Radic Biol Med 43, 995-1022 (2007). (Pubitemid 47302656)
31. Mi, L., Di Pasqua, A. J. & Chung, F. L. Proteins as binding targets of isothiocyanates in cancer prevention. Carcinogenesis 32, 1405-1413 (2011).
32. Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROSmediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8, 579-591 (2009).
33. Chen, J. L. et al. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 4, e1000293 (2008).
34. Sonveaux, P. et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118, 3930-3942 (2008).
35. Chen, J. L. et al. Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet 6 (2010).
36. Dai, C., Sun, F., Zhu, C. & Hu, X. Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability-an implication in aneuploid human tumors. PLoS ONE 8, e63054 (2013).
37. Silva, A. S., Yunes, J. A., Gillies, R. J. &Gatenby, R. A. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res 69, 2677-2684 (2009).
38. Robey, I. F. et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res 69, 2260-2268 (2009).
39. Brizel, D. M. et al. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys 51, 349-353 (2001). (Pubitemid 32884281)
40. Schwickert, G., Walenta, S., Sundfor, K., Rofstad, E. K. & Mueller-Klieser, W. Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 55, 4757-4759 (1995).
41. Walenta, S. et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60, 916-921 (2000). (Pubitemid 30129526)
42. Walenta, S. et al. Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol 150, 409-415 (1997). (Pubitemid 27073770)
43. Yokota, H. et al. Lactate, choline, and creatine levels measured by vitro 1H-MRS as prognostic parameters in patients with non-small-cell lung cancer. J Magn Reson Imaging 25, 992-999 (2007). (Pubitemid 46697569)
44. Paschen,W., Djuricic, B., Mies, G., Schmidt-Kastner, R. & Linn, F. Lactate and pH in the brain: association and dissociation in different pathophysiological states. J Neurochem 48, 154-159 (1987). (Pubitemid 17031379)
45. Glaysher, S. & Cree, I. A. Isolation and culture of colon cancer cells and cell lines. Methods Mol Biol 731, 135-140 (2011).
46. Park, J. G., Ku, J. L. & Park, S. Y. Isolation and culture of colon cancer cell lines. Methods Mol Biol 88, 79-92 (2004).
47. McBain, J. A., Weese, J. L., Meisner, L. F., Wolberg, W. H. & Willson, J. K. Establishment and characterization of human colorectal cancer cell lines. Cancer Res 44, 5813-5821 (1984). (Pubitemid 15183597)
48. Buege, J. A. & Aust, S. D. Microsomal lipid peroxidation. Method Enzymol 52, 302-310 (1978).
49. Sun, Y., Oberley, L. W. & Li, Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 34, 497-500 (1988).
50. Goth, L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 196, 143-151 (1991).
51. Flohe, L. & Gunzler, W. A. Assays of glutathione peroxidase. Method Enzymol 105, 114-121 (1984). (Pubitemid 14165378)
52. Carlberg, I. & Mannervik, B. Glutathione reductase. Method Enzymol 113, 484-490 (1985). (Pubitemid 16195819)
53. Rahman, I., Kode, A. & Biswas, S. K. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 1, 3159-3165 (2006).