Antioxidant inhibitors for cancer therapy

Medical Hypotheses

Volumn 51, Issue 5, 1998, Pages 405-409

  Kong, Q ^a   Lillehei, K O ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ARTICLE; CANCER; DNA DAMAGE; HUMAN; LIPID PEROXIDATION; PRIORITY JOURNAL;

EID: 0031795520     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(98)90036-6     Document Type: Article

References (51)

1. Gierz H, Flohe L. Mediatoren der Entzundung und Allergie. In: Forth W, Henschler D, Rummel W, Starke K, eds. Pharmakologie und Toxicologie. Mannheim: B.I. Wissen-Schaftsverlag, 1992, Vol. 7: 329-332.
2. Feig D I, Reid T M, Loeb L A. Reactive oxygen species in tumorigenesis. Cancer Res 1994; 54 (Suppl.): 1890-1894.
3. Breimer L H. Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage [review]. Mol Carcinogen 1990; 3: 188-197.
4. Slaga T J. Inhibition of the induction of cancer by antioxidants [review]. Adv Exp Med Biol 1995; 369: 167-174.
5. Sanchiz F, Milla A, Artola N et al. Prevention of radioinduced cystitis by orgotein: a randomized study. Anticancer Res 1996; 16: 2025-2028.
6. St Clair D K, Jordan J A, Wan X S, Gairola C G. Protective role of manganese superoxide dismutase against cigarette smoke-induced cytotoxicity. J Toxicol Environ Health 1994; 43: 239-249.
7. Lefaix J L, Delanian S, Leplat J J et al. Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study. Int J Radiation Oncol Biol Phys 1996; 35: 305-312.
8. Elford H L, van't Riet B, Mikhail E A, Zweier J L. Free radical scavengers, Trimidox and Didox, protect against cardiac toxicity and improve antitumor activity of anthracyclines [Meeting abstract]. Proc Annu Meet Am Assoc Cancer Res 1995; 36: A1760
9. Custodio J B, Dinis T C, Almeida L M, Madeira V M. Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation: evidence for peroxyl radical scavenging activity. Biochem Pharmacol 1994; 47: 1989-1998.
10. Ingle J N, Kuross S A, Mailliard J A et al. Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy. Cancer 1994; 74: 1733-1738.
11. Seifert C F, Nesser M E, Thompson D F. Dexrazoxane in the prevention of doxorubicin-induced cardiotoxicity [review]. Ann Pharmacother 1994; 28: 1063-1072.
12. Wong G H. Protective roles of cytokines against radiation: induction of mitochondrial MnSOD [review]. Biochim Biophys Acta 1995; 1271: 205-209.
13. Hirose K. Longo D L, Oppenheim J J, Matsushima K. Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation. FASEB J 1993; 7: 361-368.
14. Urano M, Kuroda M, Reynolds R, Oberley T D, St Clair D K. Expression of manganese Superoxide dismutase reduces tumor control radiation dose: gene-radiotherapy. Cancer Res 1995; 55: 2490-2493.
15. Nakano T, Oka K, Taniguchi N. Manganese superoxide dismutase expression correlates with p53 status and local recurrence of cervical carcinoma treated with radiation therapy. Cancer Res 1996; 56: 2771-2775.
16. Yamaguchi S, Sakurada S, Nagumo M. Role of intracellular SOD in protecting human leukemic and cancer cells against superoxide and radiation. Free Radical Biol Med 1994; 17: 389-395.
17. Look M P, Musch E. Lipid peroxides in the polychemotherapy of cancer patients. Chemotherapy 1994; 40: 8-15.
18. 2 for platelet-derived growth factor signal transduction. Science 1995; 270: 296-299.
19. Irani K, Xia Y, Zweier J L et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibrolasts. Science 1997; 275: 1649-1652.
20. Burdon R H, Gill V, Alliangana D. Hydrogen peroxide in relation to proliferation and apoptosis in BHK-21 hamster fibroblasts. Free Radical Res 1996; 24: 81-93.
21. Cruz T F, Morgan A, Min W. Antineoplastic effect of vanadium compounds [meeting abstract]. Proc Annu Meet Am Assoc Cancer Res 1995; 36: 2357.
22. Kumar G S, Das U N. Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. Cancer Lett 1995; 92: 27-38.
23. Yoshikawa T, Kokura S, Tainaka K et al. The role of active oxygen species and lipid peroxidation in the antitumor effect of hyperthermia. Cancer Res 1993; 53 (Suppl. 10): 2326-2329.
24. Yoshikawa T, Kokura S, Oyamada H. Antitumor effect of ischemia-reperfusion injury induced by transient embolization. Cancer Res 1994; 54: 5033-5035.
25. Yoshikawa T, Kokura S, Tainaka K, Naito Y, Kondo M. A novel cancer therapy based on oxygen radicals. Cancer Res 1995; 55: 1617-1620.
26. Mizutani Y, Bonavida B, Koishihara Y, Akamatsu K, Ohsugi Y, Yoshida O. Sensitization of human renal cell carcinoma cells to cis-diamminedichloroplatinum (II) by anti-interleukin 6 monoclonal antibody or anti-interleukin 6 receptor monoclonal antibody. Cancer Res 1995; 55: 590-596.
27. Isoda H, Akagi K, Hasegawa T et al. Detection of an increase in ascorbate radical in an irradiated experimental tumour system using ESR. Int J Radiation Biol 1993; 68: 467-473.
28. Emerit I, Arutyunyan R, Oganesian N et al. Radiation-induced clastogenic factors: anticlastogenic effect of Ginkgo biloba extract. Free Radical Biol Med 1995; 18: 985-991.
29. Milovanovic S R, Monje E, Szepeshazi K, Radulovic S, Schally A. Effect of treatment with LHRH analogs containing cytotoxic radicals on the binding characteristics of receptors for luteinizing-hormone-releasing hormone in MXT mouse mammary carcinoma. J Cancer Res Clin Oncol 1993; 119: 273-278.
30. Das U N, Prasad V V, Reddy D R. Local application of gamma-linolenic acid in the treatment of human gliomas. Cancer Lett 1995; 94: 147-155.
31. Hudson S E. Oxidation and photoinduced damage of nucleic acids by synthetic analogues of metallobleomycins. Diss Abstr Int [B] 1993; 53: 4654.
32. Baas P, van Geel I P, Veenhuizen R B et al. Photodynamic therapy. Annu Rep Neth Cancer Inst 1993: 82-83.
33. Bai Y H, Wang D W, Wang L P, Chen J Z, Yang Y. The role of free radicals in the development of radiation interstitial pneumonias. J Environ Pathol Toxicol Oncol 1993; 12: 199-204.
34. Boitier E, Merad-Boudia M, Guguen-Guillouzo C et al. Impairment of the mitochondrial respiratory chain activity in diethylnitrosamine-induced rat hepatomas: possible involvement of oxygen free radicals. Cancer Res 1995; 55: 3028-3035.
35. Powis G. Toxicity of free radical forming anticancer agents. In: Powis G, Hacker M P, eds. The Toxicity of Anticancer Drugs. New York: Pergamon, 1991: 106-151.
36. Yen H C, Oberley T D, Vichitbandha S, Ho Y S, St Clair D K. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest 1996; 98: 1253-1260.
37. Miller A C, Samid D. Tumor resistance to oxidative stress: association with ras oncogene expression and reversal by lovastatin, an inhibitor of p21ras isoprenylation. Int J Cancer 1995; 60: 249-254.
38. Cobbs C S, Levi D S, Aldape K, Israel M A. Manganese Superoxide dismutase expression in human central nervous system tumors. Cancer Res 1996; 56: 3192-3195.
39. Ishikawa M, Yaginuma Y, Hayashi H, Shimizu T, Endo Y, Taniguchi N. Reactivity of a monoclonal antibody to manganese superoxide dismutase with human ovarian carcinoma. Cancer Res 1990; 50: 2538-2542.
40. Nishiura T, Suzuki K, Kawaguchi T et al. Elevated serum manganese superoxide dismutase in acute leukemias. Cancer Lett 1992; 62: 211-215.
41. Maeda M, Watanabe N, Okamoto T, Tsuji N, Niitsu Y. Endogenous tumor necrosis factor functions as a resistant factor against adriamycin. Int J Cancer 1994; 58: 376-379.
42. Lin P S, Ho K C, Sung S J, Tsai S. Cytotoxicity and manganese superoxide dismutase induction by tumor necrosis factor-alpha and ionizing radiation in MCF-7 human breast carcinoma cells. Lymphokine Cytokine Res 1993; 12: 303-308.
43. Harris C A, Derbin K S, Hunte-McDonough B et al. Manganese superoxide dismutase is induced by IFN-gamma in multiple cell types: synergistic induction by IFN-gamma and tumur necrosis factor or IL-1. J Immunol 1991; 147: 149-154.
44. Wong G H, Kaspar R L, Vehar G. Tumor necrosis factor and lymphotoxin: protection against oxidative stress through induction of MnSOD [review]. EXS 1996; 77: 321-333.
45. Kong Q, Lillehei K O. Synergism of antioxidant inhibitors and free radical generators in their cytotoxicity on brain tumor cell lines [abstract]. Proc Am Assoc Cancer Res 1997; 38: 608.
46. Lillehei K O, Kong Q. The in vitro cytotoxicity of antioxidant inhibitors on brain tumor cell lines [abstract]. Proc Am Assoc Cancer Res 1997; 38: 607.
47. Nicotera T M, Privalle C, Wang T C, Oshimura M, Barrett J C. Differential proliferative responses of Syrian hamster embryo fibroblasts to paraquat-generated superoxide radicals depending on tumor suppressor gene function. Cancer Res 1994; 54: 3884-3888.
48. Perera C S, St. Clair D K, McClain C J. Differential regulation of manganese superoxide dismutase activity by alcohol and TNF in human hepatoma cells. Arch Biochem Biophys 1995; 323: 471-476.
49. Salovsky P, Shopova V. Synergic lung changes in rats receiving combined exposure to paraquat and ionizing radiation. Environ Res 1993; 60: 44-54.
50. Lillehei K O, Kong Q, Withdrow S J, DeMasters B K. Efficacy of interstitial cisplatin impregnated biodegradable polymer for the treatment of 9L gliosarcoma in the rat. Neurosurgery 1996; 39: 1191-1199.
51. Kong Q, DeMasters B K, Lillehei K O. Intraletionally implanted cisplatin cures primary brain tumor in rats. J Surg Oncol 1997 (in press).