Ferrocenyl and dicobalt hexacarbonyl chromones - New organometallics inducing oxidative stress and arresting human cancer cells in G2/M phase

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 289-300

  Kowalski, Konrad ^a   Hikisz, Paweł ^a   Szczupak, Łukasz ^a   Therrien, Bruno ^b   Koceva Chyła, Aneta ^a  

^a UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITY OF NEUCHÂTEL   (Switzerland)

Author keywords

Anticancer activity; Apoptosis; Cell cycle; Chromone; Ferrocene; ROS

Indexed keywords

ALKYNE DERIVATIVE; ANTINEOPLASTIC AGENT; CHROMONE DERIVATIVE; DIALKYNE; DICOBALT HEXACARBONYL; DICOBALT HEXACARBONYL CHROMONE; FERROCENYL; ORGANOMETALLIC COMPOUND; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; COBALT; DNA; FERROUS ION;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG STRUCTURE; G2 PHASE CELL CYCLE CHECKPOINT; HEPG2 CELL LINE; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MCF 7 CELL LINE; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY DIFFRACTION; CELL CYCLE CHECKPOINT; CELL CYCLE G2 PHASE; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; COBALT; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FERROUS COMPOUNDS; G2 PHASE; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84901354377     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.023     Document Type: Article

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