Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 866-869

  Ott, Ingo ^a   Kowalski, Konrad ^b   Gust, Ronald ^c   Maurer, Jörg ^d   Mücke, Philipp ^d   Winter, Rainer F ^d  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF LODZ   (Poland)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Antitumor agents; Bioorganometallic chemistry; Ferrocene; Ruthenium

Indexed keywords

ANTIESTROGEN; ANTINEOPLASTIC AGENT; ETHYLENE; FERROCENE DERIVATIVE; FERROCENE RUTHENIUM ORGANOMETALLIC COMPUND; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG; ETHYLENE DERIVATIVE; FERROCENE; FERROUS ION; ORGANOMETALLIC COMPOUND; RUTHENIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG UPTAKE; ELECTRON; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; IC 50; OXIDATION REDUCTION POTENTIAL; TUMOR CELL LINE; CHEMISTRY; COMPARATIVE STUDY; HT 29 CELL LINE; PROCEDURES;

CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; ETHYLENES; FERROUS COMPOUNDS; HT29 CELLS; HUMANS; ORGANOMETALLIC COMPOUNDS; RUTHENIUM;

EID: 74049118509     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.080     Document Type: Article

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17. 50 values were calculated as that concentration reducing the cell growth to 50%. Further details on this assay are given in Refs. 18,19. For cellular uptake measurements at least 70% confluent cell layers were exposed to 10 μM of the agents for 6 h. Afterwards cells were isolated, lysed and the obtained lysates were investigated for their ruthenium content by atomic absorption spectroscopy and for their protein content by the Bradford method. Accordingly, the amount of complex taken up into the cells was expressed as ng ruthenium per mg cellular protein. Further details on this assay can be found in Refs. 19,20. Hormonal activity measurements were essentially performed as described in Ref. 24.
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