Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

Chemical Communications

Volumn 48, Issue 40, 2012, Pages 4839-4841

  Kurzwernhart, Andrea ^a   Kandioller, Wolfgang ^a   Bartel, Caroline ^a   Bächler, Simone ^a   Trondl, Robert ^a   Mühlgassner, Gerhard ^a   Jakupec, Michael A ^a   Arion, Vladimir B ^a   Marko, Doris ^a   Keppler, Bernhard K ^a   Hartinger, Christian G ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; FLAVONOID; GYRASE INHIBITOR; RUTHENIUM COMPLEX; RUTHENIUM FLAVONOID COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DRUG DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

EID: 84860320655     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c2cc31040f     Document Type: Article

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