Lasiodin inhibits proliferation of human nasopharyngeal carcinoma cells by simultaneous modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB signaling pathways

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Lin, Lianzhu ^a   Deng, Wuguo ^b   Tian, Yun ^b   Chen, Wangbing ^b   Wang, Jingshu ^b   Fu, Lingyi ^b   Shi, Dingbo ^b   Zhao, Mouming ^a   Luo, Wei ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LASIODIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; KAURANE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BINDING;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PURIFICATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MIGRATION INHIBITION; MITOSIS INHIBITION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; CELL MOTION; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; NASOPHARYNX TUMOR; TUMOR CELL LINE; VASCULAR PLANT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYCLOOXYGENASE 2; CYTOCHROMES C; DITERPENES, KAURANE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NASOPHARYNGEAL NEOPLASMS; NF-KAPPA B; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRACHEOBIONTA;

EID: 84901353252     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097799     Document Type: Article

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