Ent-kaurane diterpenoids from rabdosia rubescens and their cytotoxic effects on human cancer cell lines

Planta Medica

Volumn 76, Issue 2, 2010, Pages 140-145

  Bai, Naisheng ^a   He, Kan ^b   Zhou, Zhu ^c   Tsai, Mei Ling ^d   Zhang, Li ^a   Quan, Zheng ^b   Shao, Xi ^a   Pan, Min Hsiung ^d   Ho, Chi Tang ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Naturex Inc   (United States)

^c FUDAN UNIVERSITY   (China)

^d NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

Author keywords

Antitumor; Cytotoxicity; Ent kaurane; Labiatae; Rabdosia rubescens

Indexed keywords

1,14 O,O DIACETYL ORIDONIN; 11,15 O,O DIACETYL RABDOTERNIN DERIVATIVE; 14 O ACETYL ORIDONIN; 16,17 EXOEPOXIDE ORIDONIN; ANTINEOPLASTIC AGENT; DITERPENOID; EFFUSANIN E; KAURENE DERIVATIVE; ORIDONIN; PLANT EXTRACT; PONICIDIN; RABDOSIA RUBESCENS EXTRACT; ROSTHORIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; RABDOSIA; RABDOSIA RUBESCENS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DITERPENES, KAURANE; HUMANS; NEOPLASMS; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; RABDOSIA;

LAMIACEAE; RABDOSIA RUBESCENS;

EID: 74349115990     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1186002     Document Type: Article

References (24)

1. The Health Department and National Chinese Medicine Management Office. Zhong Hua Ben Cao, Vol. 7. Shanghai Shanghai Science and Technology Press 1999 150-154
2. Takeda Y, Otsuka H. Recent advances in the chemistry of diterpenoids from Rabdosia species. Stud Nat Prod Chem 1995 15 111-185
3. Liu C, Zhao Z. Advances in research of Rabdosia rubescens (Hemsl.) Hara. Zhongguo Yaoxue Zazhi (Beijing) 1998 33 577-581
4. Sun H D., Lin Z W., Qin C Q., Chao J H., Zhao Q Z. Studies on the chemical constituents of antitumor plant Rabdosia rubescens (Hemsl.) Hara. Yun-nan Chih Wu Yen Chiu 1981 3 95-100
5. Sun H D., Chao J H., Lin Z W., Marunaka T, Minami Y, Fujita T. The structure of rubescensin C: a new minor diterpenoid isolated from Rabdosia rubescens. Chem Pharm Bull 1982 30 341-343
6. Taiho Pharmaceutical Co., Ltd., Japan. Rubescensin C. JP 57179185 A2 19821104 1982
7. Liu Z, Yue Z. Study on chemical constituent of Rabdosia racemosa. Zhongcaoyao 1997 28 334-337
8. Taiho Pharmaceutical Co., Ltd., Japan. Rubescensin D. JP 58152838 A2 19830910 1983
9. Li J, Liu C, Sun H, Lin Z. Structures of lushanrubescensin B and C: new diterpenoids from Rabdosia rubescens f. lushanensis. Yunnan Zhiwu Yanjiu 1986 8 93-97
10. Li J, Sun H, Lin Z. The structure of lushanrubescensin E. Yunnan Zhiwu Yanjiu 1987 9 485-488
11. Mosmann J. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983 65 55-63
12. Fujita E, Fujita T, Katayama H, Shibuya M, Shingu T. Terpenoids. XV. Structure and absolute configuration oridonin isolated from Isodon japonicus and Isodon trichocarpus. JCS 1970 12 1674-1681
13. Mori S, Shudo K, Ageta T, Koizumi T, Okamoto T. Constituents of Isodon trichocarpus. I. Isolation of the constituents and the structures of isodonol, enmedol, and enmenol. Chem Pharm Bull 1970 18 871-883
14. Li G, Wang Y. Studies on the diterpenoids of Rabdosia rosthornii (Diels) Hara. Yaoxue Xuebao 1984 19 590-592
15. Hou A J., Zhao Q S., Li M L., Jiang B, Lin Z W., Sun H D., Zhou Y P., Lu Y, Zheng Q T. Cytotoxic 7,20-epoxy ent-kauranoids from Isodon xerophilus. Phytochemistry 2001 58 179-183
16. Xu M, Tang M, Cheng P. Studies on the antitumor constituents of Rabdosia nervosa. Zhongcaoyao 1985 16 51-52
17. Fujita T, Takeda Y, Shingu T, Ueno A. Structures of effusanins, antibacterial diterpenoids from Rabdosia effusa. Chem Lett 1980 12 1635-1638
18. Wang X R., Wang H P., Hu H P., Sun H D., Wang S Q., Ueda S, Kuroda Y, Fujita T. Structures of macrocalyxin B, F, G and H, and maoyerabdosin from Isodon macrocalyx. Phytochemistry 1995 38 921-926
19. Liu H M., Yan X B., Kiuchi F, Liu Z Z. A new diterpene glycoside from Rabdosia rubescens. Chem Pharm Bull 2000 48 148-149
20. Takeda Y, Takeda K, Fujita T, Sun H D., Minami Y. Rabdoternins DG, ent-7,20-epoxykaurenes from Rabdosia ternifolia. Phytochemistry 1994 35 1513-1516
21. Takeda Y, Takeda K, Fujita T, Sun H D., Minami Y. Studies on the diterpenoid constituents of Rabdosia ternifolia: structural elucidation of new diterpenoids, rabdoternins A, B and C. Chem Pharm Bull 1990 38 439-442
22. Han Q B., Li R T., Li M L., Mou Y K., Tian Q E., Li S W., Sun H D. Ent-kauranoids from Isodon rubescens var. taihangensis. J Asian Nat Prod Res 2005 7 31-36
23. Ho C T., Bai N S., Dong Z G., Bode A M., Dushenkov S. Bioactive compounds and methods of uses thereof. US Patent 7353739 2008
24. Nagashima F, Kondoh M, Uematsu T, Nishiyama A, Saito S, Sato M, Asakawa Y. Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata NEES. Chem Pharm Bull 2002 50 808-813