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Volumn 29, Issue 3, 2014, Pages 281-290

Modifiers of TGF-β1 effector function as novel therapeutic targets of pulmonary fibrosis

Author keywords

Amphiregulin; Chitotriosidase; Pulmonary fibrosis; Response modifiers; Transforming growth factor beta1

Indexed keywords

AMPHIREGULIN; CHITOTRIOSIDASE; EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; BETA N ACETYLHEXOSAMINIDASE; EGFR PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 84901350491     PISSN: 12263303     EISSN: 20056648     Source Type: Journal    
DOI: 10.3904/kjim.2014.29.3.281     Document Type: Review
Times cited : (70)

References (76)
  • 1
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007;117:524-529.
    • (2007) J Clin Invest , vol.117 , pp. 524-529
    • Wynn, T.A.1
  • 2
    • 0005588573 scopus 로고    scopus 로고
    • Interstitial lung diseases: A clinical overview and general approach
    • In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack AI, eds., New York: Mc-Graw Hill
    • Raghu G. Interstitial lung diseases: a clinical overview and general approach. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack AI, eds. Fishman's Pulmonary Diseases and Disorders. New York: Mc-Graw Hill, 1998:1037-1053.
    • (1998) Fishman's Pulmonary Diseases and Disorders , pp. 1037-1053
    • Raghu, G.1
  • 3
    • 0036936550 scopus 로고    scopus 로고
    • Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease
    • Krein PM, Winston BW. Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease. Chest 2002;122(6 Suppl):289S-293S.
    • (2002) Chest , vol.122 , Issue.6 SUPPL.
    • Krein, P.M.1    Winston, B.W.2
  • 4
    • 0035895243 scopus 로고    scopus 로고
    • American Thoracic Society; European Respiratory Society; American College of Chest Physicians. Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    • Selman M, King TE, Pardo A; American Thoracic Society; European Respiratory Society; American College of Chest Physicians. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001;134:136-151.
    • (2001) Ann Intern Med , vol.134 , pp. 136-151
    • Selman, M.1    King, T.E.2    Pardo, A.3
  • 5
    • 65649092106 scopus 로고    scopus 로고
    • Recent advances in molecular targets and treatment of idiopathic pulmonary f ibrosis: Focus on TGFbeta signaling and the myof ibroblast
    • Gharaee-Kermani M, Hu B, Phan SH, Gyetko MR. Recent advances in molecular targets and treatment of idiopathic pulmonary f ibrosis: focus on TGFbeta signaling and the myof ibroblast. Curr Med Chem 2009;16:1400-1417.
    • (2009) Curr Med Chem , vol.16 , pp. 1400-1417
    • Gharaee-Kermani, M.1    Hu, B.2    Phan, S.H.3    Gyetko, M.R.4
  • 6
    • 67649947512 scopus 로고    scopus 로고
    • Emerging concepts in the pathogenesis of lung fibrosis
    • Hardie WD, Glasser SW, Hagood JS. Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol 2009;175:3-16.
    • (2009) Am J Pathol , vol.175 , pp. 3-16
    • Hardie, W.D.1    Glasser, S.W.2    Hagood, J.S.3
  • 7
    • 73449133450 scopus 로고    scopus 로고
    • The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis
    • Strieter RM, Keeley EC, Burdick MD, Mehrad B. The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis. Trans Am Clin Climatol Assoc 2009;120:49-59.
    • (2009) Trans Am Clin Climatol Assoc , vol.120 , pp. 49-59
    • Strieter, R.M.1    Keeley, E.C.2    Burdick, M.D.3    Mehrad, B.4
  • 9
    • 84865113809 scopus 로고    scopus 로고
    • New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis
    • Fernandez IE, Eickelberg O. New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. Lancet 2012;380:680-688.
    • (2012) Lancet , vol.380 , pp. 680-688
    • Fernandez, I.E.1    Eickelberg, O.2
  • 10
    • 84865808428 scopus 로고    scopus 로고
    • The impact of TGF-βon lung fibrosis: From targeting to biomarkers
    • Fernandez IE, Eickelberg O. The impact of TGF-βon lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc 2012;9:111-116.
    • (2012) Proc Am Thorac Soc , vol.9 , pp. 111-116
    • Fernandez, I.E.1    Eickelberg, O.2
  • 11
    • 84871099822 scopus 로고    scopus 로고
    • MicroRNAs, transforming growth factor beta-1, and tissue f ibrosis
    • Bowen T, Jenkins RH, Fraser DJ. MicroRNAs, transforming growth factor beta-1, and tissue f ibrosis. J Pathol 2013;229:274-285.
    • (2013) J Pathol , vol.229 , pp. 274-285
    • Bowen, T.1    Jenkins, R.H.2    Fraser, D.J.3
  • 12
    • 84868305344 scopus 로고    scopus 로고
    • TGF-βsignaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities
    • Samarakoon R, Overstreet JM, Higgins PJ. TGF-βsignaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities. Cell Signal 2013;25:264-268.
    • (2013) Cell Signal , vol.25 , pp. 264-268
    • Samarakoon, R.1    Overstreet, J.M.2    Higgins, P.J.3
  • 13
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFβsignalling pathway in disease
    • Akhurst RJ, Hata A. Targeting the TGFβsignalling pathway in disease. Nat Rev Drug Discov 2012;11:790-811.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 14
    • 0029952544 scopus 로고    scopus 로고
    • Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene
    • Zhou L, Dey CR, Wert SE, Whitsett JA. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene. Dev Biol 1996;175:227-238.
    • (1996) Dev Biol , vol.175 , pp. 227-238
    • Zhou, L.1    Dey, C.R.2    Wert, S.E.3    Whitsett, J.A.4
  • 15
    • 3543109115 scopus 로고    scopus 로고
    • Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis
    • Lee CG, Cho SJ, Kang MJ, et al. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004;200:377-389.
    • (2004) J Exp Med , vol.200 , pp. 377-389
    • Lee, C.G.1    Cho, S.J.2    Kang, M.J.3
  • 16
    • 51249120776 scopus 로고    scopus 로고
    • Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis
    • Pulichino AM, Wang IM, Caron A, et al. Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis. Am J Respir Cell Mol Biol 2008;39:324-336.
    • (2008) Am J Respir Cell Mol Biol , vol.39 , pp. 324-336
    • Pulichino, A.M.1    Wang, I.M.2    Caron, A.3
  • 17
    • 84871333772 scopus 로고    scopus 로고
    • Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary f ibrosis
    • Zhou Y, Lee JY, Lee CM, et al. Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary f ibrosis. J Biol Chem 2012;287:41991-42000.
    • (2012) J Biol Chem , vol.287 , pp. 41991-42000
    • Zhou, Y.1    Lee, J.Y.2    Lee, C.M.3
  • 18
    • 84865411180 scopus 로고    scopus 로고
    • Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling
    • Lee CG, Herzog EL, Ahangari F, et al. Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling. J Immunol 2012;189:2635-2644.
    • (2012) J Immunol , vol.189 , pp. 2635-2644
    • Lee, C.G.1    Herzog, E.L.2    Ahangari, F.3
  • 19
    • 0030076509 scopus 로고    scopus 로고
    • TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: An immunohistochemical study
    • Khalil N, O'Connor RN, Flanders KC, Unruh H. TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol 1996;14:131-138.
    • (1996) Am J Respir Cell Mol Biol , vol.14 , pp. 131-138
    • Khalil, N.1    O'Connor, R.N.2    Flanders, K.C.3    Unruh, H.4
  • 20
    • 0035181092 scopus 로고    scopus 로고
    • Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis
    • Khalil N, Parekh TV, O'Connor R, et al. Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis. Thorax 2001;56:907-915.
    • (2001) Thorax , vol.56 , pp. 907-915
    • Khalil, N.1    Parekh, T.V.2    O'Connor, R.3
  • 23
    • 0032719815 scopus 로고    scopus 로고
    • Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
    • Nakao A, Fujii M, Matsumura R, et al. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999;104:5-11.
    • (1999) J Clin Invest , vol.104 , pp. 5-11
    • Nakao, A.1    Fujii, M.2    Matsumura, R.3
  • 24
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung
    • Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997;100:768-776.
    • (1997) J Clin Invest , vol.100 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 25
    • 0037241857 scopus 로고    scopus 로고
    • Re-evaluation of fibrogenic cytokines in lung fibrosis
    • Kelly M, Kolb M, Bonniaud P, Gauldie J. Re-evaluation of fibrogenic cytokines in lung fibrosis. Curr Pharm Des 2003;9:39-49.
    • (2003) Curr Pharm Des , vol.9 , pp. 39-49
    • Kelly, M.1    Kolb, M.2    Bonniaud, P.3    Gauldie, J.4
  • 26
    • 0036335052 scopus 로고    scopus 로고
    • Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases
    • Kuwano K, Maeyama T, Inoshima I, et al. Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases. Respirology 2002;7:15-21.
    • (2002) Respirology , vol.7 , pp. 15-21
    • Kuwano, K.1    Maeyama, T.2    Inoshima, I.3
  • 27
    • 0032622244 scopus 로고    scopus 로고
    • The involvement of Fas-Fas ligand pathway in fibrosing lung diseases
    • Kuwano K, Miyazaki H, Hagimoto N, et al. The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. Am J Respir Cell Mol Biol 1999;20:53-60.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 53-60
    • Kuwano, K.1    Miyazaki, H.2    Hagimoto, N.3
  • 28
    • 0030215822 scopus 로고    scopus 로고
    • P21Waf1/ Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis
    • Kuwano K, Kunitake R, Kawasaki M, et al. P21Waf1/ Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1996;154:477-483.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 477-483
    • Kuwano, K.1    Kunitake, R.2    Kawasaki, M.3
  • 29
    • 0032717522 scopus 로고    scopus 로고
    • Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
    • Kuwano K, Hagimoto N, Kawasaki M, et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest 1999;104:13-19.
    • (1999) J Clin Invest , vol.104 , pp. 13-19
    • Kuwano, K.1    Hagimoto, N.2    Kawasaki, M.3
  • 30
    • 0036231985 scopus 로고    scopus 로고
    • Transforming growth factor-beta1: Its anti-inflammatory and pro-fibrotic effects
    • Ling E, Robinson DS. Transforming growth factor-beta1: its anti-inflammatory and pro-fibrotic effects. Clin Exp Allergy 2002;32:175-178.
    • (2002) Clin Exp Allergy , vol.32 , pp. 175-178
    • Ling, E.1    Robinson, D.S.2
  • 31
    • 0036124599 scopus 로고    scopus 로고
    • Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
    • Flanders KC, Sullivan CD, Fujii M, et al. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol 2002;160:1057-1068.
    • (2002) Am J Pathol , vol.160 , pp. 1057-1068
    • Flanders, K.C.1    Sullivan, C.D.2    Fujii, M.3
  • 32
    • 0035501062 scopus 로고    scopus 로고
    • TGF-beta signaling in cancer: A double-edged sword
    • Akhurst RJ, Derynck R. TGF-beta signaling in cancer: a double-edged sword. Trends Cell Biol 2001;11:S44-S51.
    • (2001) Trends Cell Biol , vol.11
    • Akhurst, R.J.1    Derynck, R.2
  • 34
    • 0026751479 scopus 로고
    • Differential effect of transforming growth factor beta on the synthesis of Th1-and Th2-like lymphokines by human T lymphocytes
    • Fargeas C, Wu CY, Nakajima T, Cox D, Nutman T, Delespesse G. Differential effect of transforming growth factor beta on the synthesis of Th1-and Th2-like lymphokines by human T lymphocytes. Eur J Immunol 1992;22:2173-2176.
    • (1992) Eur J Immunol , vol.22 , pp. 2173-2176
    • Fargeas, C.1    Wu, C.Y.2    Nakajima, T.3    Cox, D.4    Nutman, T.5    Delespesse, G.6
  • 35
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998;16:137-161.
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 36
    • 0029149596 scopus 로고
    • Control of CD4 effector fate: Transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion
    • Zhang X, Giangreco L, Broome HE, Dargan CM, Swain SL. Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J Exp Med 1995;182:699-709.
    • (1995) J Exp Med , vol.182 , pp. 699-709
    • Zhang, X.1    Giangreco, L.2    Broome, H.E.3    Dargan, C.M.4    Swain, S.L.5
  • 37
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    • Lee CG, Homer RJ, Zhu Z, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001;194:809-821.
    • (2001) J Exp Med , vol.194 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3
  • 38
    • 0034178260 scopus 로고    scopus 로고
    • TGF-beta1 and radiation fibrosis: A master switch and a specific therapeutic target?
    • Martin M, Lefaix J, Delanian S. TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 2000;47:277-290.
    • (2000) Int J Radiat Oncol Biol Phys , vol.47 , pp. 277-290
    • Martin, M.1    Lefaix, J.2    Delanian, S.3
  • 40
    • 0034977190 scopus 로고    scopus 로고
    • TGF-beta is a critical mediator of acute lung injury
    • Pittet JF, Griffiths MJ, Geiser T, et al. TGF-beta is a critical mediator of acute lung injury. J Clin Invest 2001;107:1537-1544.
    • (2001) J Clin Invest , vol.107 , pp. 1537-1544
    • Pittet, J.F.1    Griffiths, M.J.2    Geiser, T.3
  • 41
    • 0035701641 scopus 로고    scopus 로고
    • Negative effect of transforming growth factor-beta-1 on intestinal anastomotic tissue regeneration
    • Fukuda H, Motohiro T, Nakai K, et al. Negative effect of transforming growth factor-beta-1 on intestinal anastomotic tissue regeneration. Eur Surg Res 2001;33:388-394.
    • (2001) Eur Surg Res , vol.33 , pp. 388-394
    • Fukuda, H.1    Motohiro, T.2    Nakai, K.3
  • 42
    • 0036317623 scopus 로고    scopus 로고
    • Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor-beta1 transgenic mouse
    • Chan T, Ghahary A, Demare J, et al. Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor-beta1 transgenic mouse. Wound Repair Regen 2002;10:177-187.
    • (2002) Wound Repair Regen , vol.10 , pp. 177-187
    • Chan, T.1    Ghahary, A.2    Demare, J.3
  • 43
    • 0037092499 scopus 로고    scopus 로고
    • Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds
    • Amendt C, Mann A, Schirmacher P, Blessing M. Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds. J Cell Sci 2002;115:2189-2198.
    • (2002) J Cell Sci , vol.115 , pp. 2189-2198
    • Amendt, C.1    Mann, A.2    Schirmacher, P.3    Blessing, M.4
  • 45
    • 0035984567 scopus 로고    scopus 로고
    • Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains
    • Kolb M, Bonniaud P, Galt T, et al. Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains. Am J Respir Cell Mol Biol 2002;27:141-150.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 141-150
    • Kolb, M.1    Bonniaud, P.2    Galt, T.3
  • 46
    • 0024342135 scopus 로고
    • Radiation-induced pulmonary endothelial dysfunction and hydroxyproline accumulation in four strains of mice
    • Ward WF, Sharplin J, Franko AJ, Hinz JM. Radiation-induced pulmonary endothelial dysfunction and hydroxyproline accumulation in four strains of mice. Radiat Res 1989;120:113-120.
    • (1989) Radiat Res , vol.120 , pp. 113-120
    • Ward, W.F.1    Sharplin, J.2    Franko, A.J.3    Hinz, J.M.4
  • 47
    • 0032997844 scopus 로고    scopus 로고
    • Reduced tumor necrosis factor-alpha and transforming growth factor-beta1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure
    • Brass DM, Hoyle GW, Poovey HG, Liu JY, Brody AR. Reduced tumor necrosis factor-alpha and transforming growth factor-beta1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure. Am J Pathol 1999;154:853-862.
    • (1999) Am J Pathol , vol.154 , pp. 853-862
    • Brass, D.M.1    Hoyle, G.W.2    Poovey, H.G.3    Liu, J.Y.4    Brody, A.R.5
  • 48
    • 58149239731 scopus 로고    scopus 로고
    • Ski and SnoN, potent negative regulators of TGF-beta signaling
    • Deheuninck J, Luo K. Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res 2009;19:47-57.
    • (2009) Cell Res , vol.19 , pp. 47-57
    • Deheuninck, J.1    Luo, K.2
  • 49
    • 0035694910 scopus 로고    scopus 로고
    • Smad regulation in TGF-beta signal transduction
    • Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci 2001;114:4359-4369.
    • (2001) J Cell Sci , vol.114 , pp. 4359-4369
    • Moustakas, A.1    Souchelnytskyi, S.2    Heldin, C.H.3
  • 50
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 51
    • 33748304169 scopus 로고    scopus 로고
    • Gefitinib prevents bleomycin-induced lung fibrosis in mice
    • Ishii Y, Fujimoto S, Fukuda T. Gefitinib prevents bleomycin-induced lung fibrosis in mice. Am J Respir Crit Care Med 2006;174:550-556.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 550-556
    • Ishii, Y.1    Fujimoto, S.2    Fukuda, T.3
  • 52
    • 0023656288 scopus 로고
    • Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes
    • Laato M, Kahari VM, Niinikoski J, Vuorio E. Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes. Biochem J 1987;247:385-388.
    • (1987) Biochem J , vol.247 , pp. 385-388
    • Laato, M.1    Kahari, V.M.2    Niinikoski, J.3    Vuorio, E.4
  • 53
    • 84882727355 scopus 로고    scopus 로고
    • Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
    • Samarakoon R, Dobberfuhl AD, Cooley C, et al. Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Cell Signal 2013;25:2198-2209.
    • (2013) Cell Signal , vol.25 , pp. 2198-2209
    • Samarakoon, R.1    Dobberfuhl, A.D.2    Cooley, C.3
  • 54
    • 35548984723 scopus 로고    scopus 로고
    • Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases
    • Bussink AP, Speijer D, Aerts JM, Boot RG. Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases. Genetics 2007;177:959-970.
    • (2007) Genetics , vol.177 , pp. 959-970
    • Bussink, A.P.1    Speijer, D.2    Aerts, J.M.3    Boot, R.G.4
  • 55
    • 34547842599 scopus 로고    scopus 로고
    • Chitinase family GH18: Evolutionary insights from the genomic history of a diverse protein family
    • Funkhouser JD, Aronson NN Jr. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. BMC Evol Biol 2007;7:96.
    • (2007) BMC Evol Biol , vol.7 , pp. 96
    • Funkhouser, J.D.1    Aronson Jr., N.N.2
  • 56
    • 0035907263 scopus 로고    scopus 로고
    • A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin
    • Chang NC, Hung SI, Hwa KY, et al. A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin. J Biol Chem 2001;276:17497-17506.
    • (2001) J Biol Chem , vol.276 , pp. 17497-17506
    • Chang, N.C.1    Hung, S.I.2    Hwa, K.Y.3
  • 58
    • 23044498185 scopus 로고    scopus 로고
    • Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages
    • Di Rosa M, Musumeci M, Scuto A, Musumeci S, Malaguarnera L. Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages. Clin Chem Lab Med 2005;43:499-502.
    • (2005) Clin Chem Lab Med , vol.43 , pp. 499-502
    • Rosa, M.D.1    Musumeci, M.2    Scuto, A.3    Musumeci, S.4    Malaguarnera, L.5
  • 59
    • 19744379293 scopus 로고    scopus 로고
    • Interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide promote chitotriosidase gene expression in human macrophages
    • Malaguarnera L, Musumeci M, Di Rosa M, Scuto A, Musumeci S. Interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide promote chitotriosidase gene expression in human macrophages. J Clin Lab Anal 2005;19:128-132.
    • (2005) J Clin Lab Anal , vol.19 , pp. 128-132
    • Malaguarnera, L.1    Musumeci, M.2    Rosa, M.D.3    Scuto, A.4    Musumeci, S.5
  • 60
    • 27744465969 scopus 로고    scopus 로고
    • Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity
    • van Eijk M, van Roomen CP, Renkema GH, et al. Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity. Int Immunol 2005;17:1505-1512.
    • (2005) Int Immunol , vol.17 , pp. 1505-1512
    • van Eijk, M.1    van Roomen, C.P.2    Renkema, G.H.3
  • 61
    • 62349111259 scopus 로고    scopus 로고
    • Chitotriosidase and gene therapy for fungal infections
    • Gordon-Thomson C, Kumari A, Tomkins L, et al. Chitotriosidase and gene therapy for fungal infections. Cell Mol Life Sci 2009;66:1116-1125.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1116-1125
    • Gordon-Thomson, C.1    Kumari, A.2    Tomkins, L.3
  • 64
    • 70449535514 scopus 로고    scopus 로고
    • Plasma chitotriosidase and CCL18 as surro gate markers for granulomatous macrophages in sarcoidosis
    • Boot RG, Hollak CE, Verhoek M, Alberts C, Jonkers RE, Aerts JM. Plasma chitotriosidase and CCL18 as surro gate markers for granulomatous macrophages in sarcoidosis. Clin Chim Acta 2010;411:31-36.
    • (2010) Clin Chim Acta , vol.411 , pp. 31-36
    • Boot, R.G.1    Hollak, C.E.2    Verhoek, M.3    Alberts, C.4    Jonkers, R.E.5    Aerts, J.M.6
  • 65
    • 34548250955 scopus 로고    scopus 로고
    • Chitotriosidase activity in patients with interstitial lung diseases
    • Bargagli E, Margollicci M, Luddi A, et al. Chitotriosidase activity in patients with interstitial lung diseases. Respir Med 2007;101:2176-2181.
    • (2007) Respir Med , vol.101 , pp. 2176-2181
    • Bargagli, E.1    Margollicci, M.2    Luddi, A.3
  • 66
    • 34547615729 scopus 로고    scopus 로고
    • Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis
    • Bargagli E, Margollicci M, Nikiforakis N, et al. Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis. Respiration 2007;74:548-552.
    • (2007) Respiration , vol.74 , pp. 548-552
    • Bargagli, E.1    Margollicci, M.2    Nikiforakis, N.3
  • 67
    • 0035089825 scopus 로고    scopus 로고
    • Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor beta receptors
    • Ihn H, Yamane K, Kubo M, Tamaki K. Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors. Arthritis Rheum 2001;44:474-480.
    • (2001) Arthritis Rheum , vol.44 , pp. 474-480
    • Ihn, H.1    Yamane, K.2    Kubo, M.3    Tamaki, K.4
  • 68
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts. Arthritis Rheum 2005;52:2897-2905.
    • (2005) Arthritis Rheum , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 69
    • 80052518623 scopus 로고    scopus 로고
    • Prostaglandin E2 and the pathogenesis of pulmonary fibrosis
    • Bozyk PD, Moore BB. Prostaglandin E2 and the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol 2011;45:445-452.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 445-452
    • Bozyk, P.D.1    Moore, B.B.2
  • 70
    • 84873338159 scopus 로고    scopus 로고
    • Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity
    • Miyoshi K, Yanagi S, Kawahara K, et al. Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity. Am J Respir Crit Care Med 2013;187:262-275.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 262-275
    • Miyoshi, K.1    Yanagi, S.2    Kawahara, K.3
  • 71
    • 34147099468 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inf lammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12
    • Kang HR, Cho SJ, Lee CG, Homer RJ, Elias JA. Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inf lammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem 2007;282:7723-7732.
    • (2007) J Biol Chem , vol.282 , pp. 7723-7732
    • Kang, H.R.1    Cho, S.J.2    Lee, C.G.3    Homer, R.J.4    Elias, J.A.5
  • 72
    • 34249057411 scopus 로고    scopus 로고
    • Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis
    • Kang HR, Lee CG, Homer RJ, Elias JA. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. J Exp Med 2007;204:1083-1093.
    • (2007) J Exp Med , vol.204 , pp. 1083-1093
    • Kang, H.R.1    Lee, C.G.2    Homer, R.J.3    Elias, J.A.4
  • 73
    • 84889886646 scopus 로고    scopus 로고
    • Targeting of αv integrin identifies a core molecular pathway that regulates f ibrosis in several organs
    • Henderson NC, Arnold TD, Katamura Y, et al. Targeting of αv integrin identifies a core molecular pathway that regulates f ibrosis in several organs. Nat Med 2013;19:1617-1624.
    • (2013) Nat Med , vol.19 , pp. 1617-1624
    • Henderson, N.C.1    Arnold, T.D.2    Katamura, Y.3
  • 74
    • 77956425361 scopus 로고    scopus 로고
    • Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
    • Barry-Hamilton V, Spangler R, Marshall D, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med 2010;16:1009-1017.
    • (2010) Nat Med , vol.16 , pp. 1009-1017
    • Barry-Hamilton, V.1    Spangler, R.2    Marshall, D.3
  • 75
    • 0033862955 scopus 로고    scopus 로고
    • Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor
    • Wang R, Ibarra-Sunga O, Verlinski L, Pick R, Uhal BD. Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 2000;279:L143-L151.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Wang, R.1    Ibarra-Sunga, O.2    Verlinski, L.3    Pick, R.4    Uhal, B.D.5
  • 76
    • 84880746051 scopus 로고    scopus 로고
    • Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing
    • Toonkel RL, Hare JM, Matthay MA, Glassberg MK. Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Am J Respir Crit Care Med 2013;188:133-140.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 133-140
    • Toonkel, R.L.1    Hare, J.M.2    Matthay, M.A.3    Glassberg, M.K.4


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