Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis

Journal of Biological Chemistry

Volumn 287, Issue 50, 2012, Pages 41991-42000

  Zhou, Yang ^a   Lee, Jae Young ^b   Lee, Chang Min ^a   Cho, Won Kyung ^a   Kang, Min Jong ^a   Koff, Jonathan L ^a   Yoon, Pyeong Oh ^c   Chae, Jeiwook ^c   Park, Han Oh ^c   Elias, Jack A ^a   Lee, Chun Geun ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Hallym University   (South Korea)

^c Bioneer Corporation   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; ANIMAL MODEL; CHEMICAL INHIBITION; COLLAGEN ACCUMULATION; CYTOKINES; DOSE-DEPENDENT MANNER; EGFR SIGNALING; EPIDERMAL GROWTH FACTOR RECEPTORS; EXTRACELLULAR; FIBROBLAST CELLS; FIBROBLAST PROLIFERATION; GEFITINIB; IDIOPATHIC PULMONARY FIBROSIS; IN-VITRO; IN-VIVO; PULMONARY FIBROSIS; SIRNA SILENCING; SMAD SIGNALING; SMOOTH MUSCLE ACTINS; THERAPEUTIC TARGETS; TRANSFORMING GROWTH FACTORS; TRANSGENIC MICE;

BIOLOGICAL ORGANS; CELL CULTURE; CELL PROLIFERATION; COLLAGEN; ENZYME INHIBITION; FIBROBLASTS; GROWTH KINETICS;

GENE EXPRESSION;

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALPHA SMOOTH MUSCLE ACTIN; AMPHIREGULIN; COLLAGEN; GEFITINIB; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SCLEROPROTEIN; SMAD PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; ENZYME ACTIVATION; EXTRACELLULAR MATRIX ASSOCIATED GENE; FIBROBLAST; GENE SILENCING; IN VITRO STUDY; LUNG FIBROSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LUNG; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; NIH 3T3 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY FIBROSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 84871333772     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.356824     Document Type: Article

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