메뉴 건너뛰기




Volumn 73, Issue 6, 2014, Pages 519-535

Mechanisms involved in spinal cord central synapse loss in a mouse model of spinal muscular atrophy

Author keywords

Glia; Motoneuron; Nitric oxide; RhoA ROCK pathway; SMN 7 mouse; Spinal muscular atrophy; Synaptic afferents

Indexed keywords

CD68 ANTIGEN; MYOSIN LIGHT CHAIN; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN; PROTEIN IBA 1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; NERVE PROTEIN; SMN2 PROTEIN, HUMAN; SURVIVAL MOTOR NEURON PROTEIN 2; VESICULAR INHIBITORY AMINO ACID TRANSPORTER; VIAAT PROTEIN, MOUSE;

EID: 84901344068     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0000000000000074     Document Type: Article
Times cited : (52)

References (98)
  • 1
    • 0030130574 scopus 로고    scopus 로고
    • The neurobiology of childhood spinal muscular atrophy
    • Crawford TO, Pardo CA. The neurobiology of childhood spinal muscular atrophy. Neurobiol Dis 1996;3:97-110
    • (1996) Neurobiol Dis , vol.3 , pp. 97-110
    • Crawford, T.O.1    Pardo, C.A.2
  • 2
    • 0025998134 scopus 로고
    • Population frequencies of inherited neuromuscular diseases Va world survey
    • Emery AE. Population frequencies of inherited neuromuscular diseases Va world survey. Neuromuscul Disord 1991;1:19-29
    • (1991) Neuromuscul Disord , vol.1 , pp. 19-29
    • Emery, A.E.1
  • 3
    • 0028797783 scopus 로고
    • Identification and characterization of a spinal muscular atrophyYdetermining gene
    • Lefebvre S, Bürglen L, Reboullet S, et al. Identification and characterization of a spinal muscular atrophyYdetermining gene. Cell 1995;80: 155-65
    • (1995) Cell , vol.80 , pp. 155-165
    • Lefebvre, S.1    Burglen, L.2    Reboullet, S.3
  • 4
    • 0032567036 scopus 로고    scopus 로고
    • A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
    • Pellizzoni L, Kataoka N, Charroux B, et al. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell 1998;95:615-24
    • (1998) Cell , vol.95 , pp. 615-624
    • Pellizzoni, L.1    Kataoka, N.2    Charroux, B.3
  • 5
    • 0029147787 scopus 로고
    • Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients
    • Gennarelli M, Lucarelli M, Capon F, et al. Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients. Biochem Biophys Res Commun 1995;213:342-48
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 342-348
    • Gennarelli, M.1    Lucarelli, M.2    Capon, F.3
  • 6
    • 20144385587 scopus 로고    scopus 로고
    • SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN
    • Le TT, Pham LT, Butchbach MER, et al. SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. Hum Mol Genet 2005;14:845-57
    • (2005) Hum Mol Genet , vol.14 , pp. 845-857
    • Le Pham, T.T.L.T.1    Butchbach, M.E.R.2
  • 7
    • 0030931720 scopus 로고    scopus 로고
    • Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos
    • Schrank B, Gotz R, Gunnersen JM, et al. Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. Proc Natl Acad Sci USA 1997;94:9920-25
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9920-9925
    • Schrank, B.1    Gotz, R.2    Gunnersen, J.M.3
  • 8
    • 33847358736 scopus 로고    scopus 로고
    • Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy
    • Avila AM, Burnett BG, Taye AA, et al. Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. J Clin Invest 2007;117:659-71
    • (2007) J Clin Invest , vol.117 , pp. 659-671
    • Avila, A.M.1    Burnett, B.G.2    Taye, A.A.3
  • 9
    • 41149113045 scopus 로고    scopus 로고
    • Selective vulnerability of motor neurons and dissociation of pre-and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy
    • Murray LM, Comley LH, Thomson D, et al. Selective vulnerability of motor neurons and dissociation of pre-and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet 2008;17:949-62
    • (2008) Hum Mol Genet , vol.17 , pp. 949-962
    • Murray, L.M.1    Comley, L.H.2    Thomson, D.3
  • 10
    • 84867555865 scopus 로고    scopus 로고
    • An SMN-dependent U12 splicing event essential for motor circuit function
    • Lotti F, Imlach WL, Saieva L, et al. An SMN-dependent U12 splicing event essential for motor circuit function. Cell 2012;151:440-54
    • (2012) Cell , vol.151 , pp. 440-454
    • Lotti, F.1    Imlach, W.L.2    Saieva, L.3
  • 11
    • 0000220374 scopus 로고
    • Infantile muscular atrophy
    • Byers RK, Banker BQ. Infantile muscular atrophy. Arch Neurol 1961;5: 140-64
    • (1961) Arch Neurol , vol.5 , pp. 140-164
    • Byers, R.K.1    Banker, B.Q.2
  • 12
    • 79957445159 scopus 로고    scopus 로고
    • Defective neuromuscular junction organization and postnatal myogenesis in mice with severe spinal muscular atrophy
    • Dachs E, Hereu M, Piedrafita L, et al. Defective neuromuscular junction organization and postnatal myogenesis in mice with severe spinal muscular atrophy. J Neuropathol Exp Neurol 2011;70:444-61
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 444-461
    • Dachs, E.1    Hereu, M.2    Piedrafita, L.3
  • 13
    • 84882653841 scopus 로고    scopus 로고
    • Chronic treatment with lithium does not improve neuromuscular phenotype in a mouse model of severe spinal muscular atrophy
    • Dachs E, Piedrafita L, Hereu M, et al. Chronic treatment with lithium does not improve neuromuscular phenotype in a mouse model of severe spinal muscular atrophy. Neuroscience 2013;250:417-33
    • (2013) Neuroscience , vol.250 , pp. 417-433
    • Dachs, E.1    Piedrafita, L.2    Hereu, M.3
  • 14
    • 79952312218 scopus 로고    scopus 로고
    • New insights into the pathogenesis of spinal muscular atrophy
    • Ito Y, Shibata N, Saito K, et al. New insights into the pathogenesis of spinal muscular atrophy. Brain Dev 2011;33:321-31
    • (2011) Brain Dev , vol.33 , pp. 321-331
    • Ito, Y.1    Shibata, N.2    Saito, K.3
  • 15
    • 48249145306 scopus 로고    scopus 로고
    • Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy
    • Kariya S, Park G-H, Maeno-Hikichi Y, et al. Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 2008;17:2552-69
    • (2008) Hum Mol Genet , vol.17 , pp. 2552-2569
    • Kariya, S.1    Park, G.-H.2    Maeno-Hikichi, Y.3
  • 16
    • 0034639645 scopus 로고    scopus 로고
    • The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(j/j) mice and results in a mouse with spinal muscular atrophy
    • Monani UR, Sendtner M, Coovert DD, et al. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(j/j) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet 2000;9:333-39
    • (2000) Hum Mol Genet , vol.9 , pp. 333-339
    • Monani, U.R.1    Sendtner, M.2    Coovert, D.D.3
  • 17
    • 58849103600 scopus 로고    scopus 로고
    • Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice
    • Kong L, Wang X, Choe DW, et al. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci 2009;29:842-51
    • (2009) J Neurosci , vol.29 , pp. 842-851
    • Kong, L.1    Wang, X.2    Choe, D.W.3
  • 18
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005;50:427-34
    • (2005) Glia , vol.50 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 19
    • 0036850023 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer?s disease and prion disease
    • Eikelenboom P, Bate C, Van Gool WA, et al. Neuroinflammation in Alzheimer?s disease and prion disease. Glia 2002;40:232-39
    • (2002) Glia , vol.40 , pp. 232-239
    • Eikelenboom, P.1    Bate, C.2    Van Gool, W.A.3
  • 20
    • 84873278957 scopus 로고    scopus 로고
    • Inflammation and neurovascular changes in amyotrophic lateral sclerosis
    • Evans MC, Couch Y, Sibson N, et al. Inflammation and neurovascular changes in amyotrophic lateral sclerosis. Mol Cell Neurosci 2013;53: 34-41
    • (2013) Mol Cell Neurosci , vol.53 , pp. 34-41
    • Evans, M.C.1    Couch, Y.2    Sibson, N.3
  • 21
    • 72449204160 scopus 로고    scopus 로고
    • Does neuroinflammation fan the flame in neurodegenerative diseases
    • Frank-Cannon TC, Alto LT, McAlpine FE, et al. Does neuroinflammation fan the flame in neurodegenerative diseases Mol Neurodegener 2009;4:47
    • (2009) Mol Neurodegener , vol.4 , pp. 47
    • Frank-Cannon, T.C.1    Alto, L.T.2    Mc Alpine, F.E.3
  • 22
    • 0036787810 scopus 로고    scopus 로고
    • Inflammatory processes in amyotrophic lateral sclerosis
    • McGeer PL, McGeer EG. Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve 2002;26:459-70
    • (2002) Muscle Nerve , vol.26 , pp. 459-470
    • Mc Geer, P.L.1    Mc Geer, E.G.2
  • 23
    • 33750998792 scopus 로고    scopus 로고
    • Innate immunity in amyotrophic lateral sclerosis
    • Moisse K, Strong MJ. Innate immunity in amyotrophic lateral sclerosis. Biochim Biophys Acta 2006;1762:1083-93
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 1083-1093
    • Moisse, K.1    Strong, M.J.2
  • 24
    • 25444522220 scopus 로고    scopus 로고
    • Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis
    • Sargsyan SA, Monk PN, Shaw PJ. Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis. Glia 2005;51: 241-53
    • (2005) Glia , vol.51 , pp. 241-253
    • Sargsyan, S.A.1    Monk, P.N.2    Shaw, P.J.3
  • 25
    • 78649723966 scopus 로고    scopus 로고
    • Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy
    • Ling KKY, Lin M-Y, Zingg B, et al. Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy. PLoS One 2010;5:e15457
    • (2010) PLoS One , vol.5
    • Ling, K.K.Y.1    Lin, M.-Y.2    Zingg, B.3
  • 26
    • 84880836806 scopus 로고    scopus 로고
    • Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production
    • McGivern JV, Patitucci TN, Nord JA, et al. Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production. Glia 2013;61:1418-28
    • (2013) Glia , vol.61 , pp. 1418-1428
    • Mc Givern, J.V.1    Patitucci, T.N.2    Nord, J.A.3
  • 27
    • 75949107667 scopus 로고    scopus 로고
    • Inflammation in ALS and SMA: Sorting out the good from the evil
    • Papadimitriou D, Le Verche V, Jacquier A, et al. Inflammation in ALS and SMA: Sorting out the good from the evil. Neurobiol Dis 2010;37: 493-502
    • (2010) Neurobiol Dis , vol.37 , pp. 493-502
    • Papadimitriou, D.1    Le Verche, V.2    Jacquier, A.3
  • 28
    • 78149449524 scopus 로고    scopus 로고
    • Regulation of synaptic connectivity by glia
    • Eroglu C, Barres BA. Regulation of synaptic connectivity by glia. Nature 2010;468:223-31
    • (2010) Nature , vol.468 , pp. 223-231
    • Eroglu, C.1    Barres, B.A.2
  • 29
    • 71749091926 scopus 로고    scopus 로고
    • Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model
    • Cifuentes-Diaz C, Nicole S, Velasco ME, et al. Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model. Hum Mol Genet 2002;11:1439-47
    • (2002) Hum Mol Genet , vol.11 , pp. 1439-1447
    • Cifuentes-Diaz, C.1    Nicole, S.2    Velasco, M.E.3
  • 30
    • 83455213467 scopus 로고    scopus 로고
    • Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy
    • Ling KK, Gibbs RM, Feng Z, et al. Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy. Hum Mol Genet 2012;21:185-95
    • (2012) Hum Mol Genet , vol.21 , pp. 185-195
    • Ling, K.K.1    Gibbs, R.M.2    Feng, Z.3
  • 31
    • 77949909934 scopus 로고    scopus 로고
    • Review: Neuromuscular synaptic vulnerability in motor neurone disease: Amyotrophic lateral sclerosis and spinal muscular atrophy
    • Murray LM, Talbot K, Gillingwater TH. Review: Neuromuscular synaptic vulnerability in motor neurone disease: Amyotrophic lateral sclerosis and spinal muscular atrophy. Neuropathol Appl Neurobiol 2010;36: 133-56
    • (2010) Neuropathol Appl Neurobiol , vol.36 , pp. 133-156
    • Murray, L.M.1    Talbot, K.2    Gillingwater, T.H.3
  • 32
    • 80053958802 scopus 로고    scopus 로고
    • SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals
    • Torres-Benito L, Neher MF, Cano R, et al. SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals. PLoS One 2011;6:e26164
    • (2011) PLoS One , vol.6
    • Torres-Benito, L.1    Neher, M.F.2    Cano, R.3
  • 33
    • 79551663958 scopus 로고    scopus 로고
    • Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy
    • Mentis GZ, Blivis D, Liu W, et al. Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy. Neuron 2011;69:453-67
    • (2011) Neuron , vol.69 , pp. 453-467
    • Mentis, G.Z.1    Blivis, D.2    Liu, W.3
  • 34
    • 77956603926 scopus 로고    scopus 로고
    • Reduced survival of motor neuron (SMN) protein in motor neuronal progenitors functions cell autonomously to cause spinal muscular atrophy in model mice expressing the human centromeric (SMN2) gene
    • Park G-H, Maeno-Hikichi Y, Awano T, et al. Reduced survival of motor neuron (SMN) protein in motor neuronal progenitors functions cell autonomously to cause spinal muscular atrophy in model mice expressing the human centromeric (SMN2) gene. J Neurosci 2010;30:12005-19
    • (2010) J Neurosci , vol.30 , pp. 12005-12019
    • Park, G.-H.1    Maeno-Hikichi, Y.2    Awano, T.3
  • 35
    • 13844254736 scopus 로고    scopus 로고
    • Nitric-oxideYdirected synaptic remodeling in the adult mammal CNS
    • Sunico CR, Portillo F, Gonzalez-Forero D, et al. Nitric-oxideYdirected synaptic remodeling in the adult mammal CNS. J Neurosci 2005;25:1448-58
    • (2005) J Neurosci , vol.25 , pp. 1448-1458
    • Sunico, C.R.1    Portillo, F.2    Gonzalez-Forero, D.3
  • 36
    • 75749150160 scopus 로고    scopus 로고
    • Nitric oxide induces pathological synapse loss by a protein kinase GY, Rho kinaseYdependent mechanism preceded by myosin light chain phosphorylation
    • Sunico CR, Gonzalez-Forero D, Dominguez G, et al. Nitric oxide induces pathological synapse loss by a protein kinase GY, Rho kinaseYdependent mechanism preceded by myosin light chain phosphorylation. J Neurosci 2010;30:973-84
    • (2010) J Neurosci , vol.30 , pp. 973-984
    • Sunico, C.R.1    Gonzalez-Forero, D.2    Dominguez, G.3
  • 37
    • 0030885062 scopus 로고    scopus 로고
    • Effects of excitatory amino acids on neuromuscular development in the chick embryo
    • Calderó J, Ciutat D, Lladó J, et al. Effects of excitatory amino acids on neuromuscular development in the chick embryo. J Comp Neurol 1997; 387:73-95
    • (1997) J Comp Neurol , vol.387 , pp. 73-95
    • Caldero, J.1    Ciutat, D.2    Llado, J.3
  • 38
    • 0029185514 scopus 로고
    • Neuron death in vertebrate development in vitro methods
    • Clarke PG, Oppenheim RW. Neuron death in vertebrate development: In vitro methods. Methods Cell Biol 1995;46:277-321
    • (1995) Methods Cell Biol , vol.46 , pp. 277-321
    • Clarke, P.G.1    Oppenheim, R.W.2
  • 39
    • 0018413664 scopus 로고
    • Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. II. A method for the description of architecture and synaptology of the cell body and proximal dendritic segments
    • Conradi S, Kellerth JO, Berthold CH. Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. II. A method for the description of architecture and synaptology of the cell body and proximal dendritic segments. J Comp Neurol 1979;184:741-54
    • (1979) J Comp Neurol , vol.184 , pp. 741-754
    • Conradi, S.1    Kellerth, J.O.2    Berthold, C.H.3
  • 40
    • 4644362726 scopus 로고    scopus 로고
    • P38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis
    • Ackerley S, Grierson AJ, Banner S, et al. p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis. Mol Cell Neurosci 2004;26:354-64
    • (2004) Mol Cell Neurosci , vol.26 , pp. 354-364
    • Ackerley, S.1    Grierson, A.J.2    Banner, S.3
  • 41
  • 42
    • 0036941003 scopus 로고    scopus 로고
    • Motoneuron death in normal and spinal muscular atrophyYaffected human fetuses
    • Fidzianska A, Rafalowska J. Motoneuron death in normal and spinal muscular atrophyYaffected human fetuses. Acta Neuropathol 2002;104: 363-68
    • (2002) Acta Neuropathol , vol.104 , pp. 363-368
    • Fidzianska, A.1    Rafalowska, J.2
  • 43
    • 33847270640 scopus 로고    scopus 로고
    • Survival and death of mature avian motoneurons in organotypic slice culture: Trophic requirements for survival and different types of degeneration
    • Brunet N, Tarabal O, Portero-Otin M, et al. Survival and death of mature avian motoneurons in organotypic slice culture: Trophic requirements for survival and different types of degeneration. J Comp Neurol 2007;501: 669-90
    • (2007) J Comp Neurol , vol.501 , pp. 669-690
    • Brunet, N.1    Tarabal, O.2    Portero-Otin, M.3
  • 44
    • 73949128974 scopus 로고    scopus 로고
    • Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    • Chiu IM, Phatnani H, Kuligowski M, et al. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci USA 2009;106:20960-65
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20960-20965
    • Chiu, I.M.1    Phatnani, H.2    Kuligowski, M.3
  • 45
    • 10744232807 scopus 로고    scopus 로고
    • Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia
    • Oliveira AL, Hydling F, Olsson E, et al. Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia. Synapse 2003;50:117-29
    • (2003) Synapse , vol.50 , pp. 117-129
    • Oliveira, A.L.1    Hydling, F.2    Olsson, E.3
  • 46
    • 0030963408 scopus 로고    scopus 로고
    • Evidence that spinal interneurons undergo programmed cell death postnatally in the rat
    • Lawson SJ, Davies HJ, Bennett JP, et al. Evidence that spinal interneurons undergo programmed cell death postnatally in the rat. Eur J Neurosci 1997;9:794-99
    • (1997) Eur J Neurosci , vol.9 , pp. 794-799
    • Lawson, S.J.1    Davies, H.J.2    Bennett, J.P.3
  • 47
    • 84886816838 scopus 로고    scopus 로고
    • Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation
    • Peviani M, Salvaneschi E, Bontempi L, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis 2014;62C: 218-32
    • (2014) Neurobiol Dis , vol.62 C , pp. 218-232
    • Peviani, M.1    Salvaneschi, E.2    Bontempi, L.3
  • 48
    • 0014005616 scopus 로고
    • Electron microscopy: Two major synaptic types on spinal motoneurons
    • Bodian D. Electron microscopy: Two major synaptic types on spinal motoneurons. Science 1966;151:1093-94
    • (1966) Science , vol.151 , pp. 1093-1094
    • Bodian, D.1
  • 49
    • 71149108487 scopus 로고    scopus 로고
    • A cluster of cholinergic premotor interneurons modulates mouse locomotor activity
    • Zagoraiou L, Akay T, Martin JF, et al. A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron 2009;64: 645-62
    • (2009) Neuron , vol.64 , pp. 645-662
    • Zagoraiou, L.1    Akay, T.2    Martin, J.F.3
  • 50
    • 59149096854 scopus 로고    scopus 로고
    • Increase in presynaptic territory of C-terminals on lumbar motoneurons of G93A SOD1 mice during disease progression
    • Pullen AH, Athanasiou D. Increase in presynaptic territory of C-terminals on lumbar motoneurons of G93A SOD1 mice during disease progression. Eur J Neurosci 2009;29:551-61
    • (2009) Eur J Neurosci , vol.29 , pp. 551-561
    • Pullen, A.H.1    Athanasiou, D.2
  • 51
    • 84884765656 scopus 로고    scopus 로고
    • Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival
    • Saxena S, Roselli F, Singh K, et al. Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. Neuron 2013;80:80-96
    • (2013) Neuron , vol.80 , pp. 80-96
    • Saxena, S.1    Roselli, F.2    Singh, K.3
  • 52
    • 84893464166 scopus 로고    scopus 로고
    • Characterization of early pathogenesis in the SOD1 G93A mouse model of ALS. Part i Background and methods
    • Vinsant S, Mansfield C, Jimenez-Moreno R, et al. Characterization of early pathogenesis in the SOD1 G93A mouse model of ALS. Part I. Background and methods. Brain Behav 2013;3:335-50
    • (2013) Brain Behav , vol.3 , pp. 335-350
    • Vinsant, S.1    Mansfield, C.2    Jimenez-Moreno, R.3
  • 53
    • 84893493940 scopus 로고    scopus 로고
    • Characterization of early pathogenesis in the SOD1 G93A mouse model of ALS. Part II Results and discussion
    • Vinsant S, Mansfield C, Jimenez-Moreno R, et al. Characterization of early pathogenesis in the SOD1 G93A mouse model of ALS. Part II. Results and discussion. Brain Behav 2013;3:431-57
    • (2013) Brain Behav , vol.3 , pp. 431-457
    • Vinsant, S.1    Mansfield, C.2    Jimenez-Moreno, R.3
  • 54
    • 79951552531 scopus 로고    scopus 로고
    • NO orchestrates the loss of synaptic boutons from adult "sick" motoneurons: Modeling a molecular mechanism
    • Moreno-Lopez B, Sunico CR, Gonzalez-Forero D. NO orchestrates the loss of synaptic boutons from adult "sick" motoneurons: Modeling a molecular mechanism. Mol Neurobiol 2011;43:41-66
    • (2011) Mol Neurobiol , vol.43 , pp. 41-66
    • Moreno-Lopez, B.1    Sunico, C.R.2    Gonzalez-Forero, D.3
  • 55
    • 0034574572 scopus 로고    scopus 로고
    • Rho GTPases in neuronal morphogenesis
    • Luo L. Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 2000;1:173-80
    • (2000) Nat Rev Neurosci , vol.1 , pp. 173-180
    • Luo, L.1
  • 56
    • 0036441201 scopus 로고    scopus 로고
    • Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity
    • Luo L. Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu Rev Cell Dev Biol 2002;18:601-35
    • (2002) Annu Rev Cell Dev Biol , vol.18 , pp. 601-635
    • Luo, L.1
  • 57
    • 0029786313 scopus 로고    scopus 로고
    • Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase
    • Amano M, Ito M, Kimura K, et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem 1996;271: 20246-49
    • (1996) J Biol Chem , vol.271 , pp. 20246-20249
    • Amano, M.1    Ito, M.2    Kimura, K.3
  • 58
    • 84867511739 scopus 로고    scopus 로고
    • SMN is required for sensory-motor circuit function in Drosophila
    • Imlach WL, Beck ES, Choi BJ, et al. SMN is required for sensory-motor circuit function in Drosophila. Cell 2012;151:427-39
    • (2012) Cell , vol.151 , pp. 427-439
    • Imlach, W.L.1    Beck, E.S.2    Choi, B.J.3
  • 59
    • 67651004474 scopus 로고    scopus 로고
    • SMN, profilin IIa and plastin 3: A link between the deregulation of actin dynamics and SMA pathogenesis
    • Bowerman M, Anderson CL, Beauvais A, et al. SMN, profilin IIa and plastin 3: A link between the deregulation of actin dynamics and SMA pathogenesis. Mol Cell Neurosci 2009;42:66-74
    • (2009) Mol Cell Neurosci , vol.42 , pp. 66-74
    • Bowerman, M.1    Anderson, C.L.2    Beauvais, A.3
  • 60
    • 23844454498 scopus 로고    scopus 로고
    • Regular exercise prolongs survival in a type 2 spinal muscular atrophy model mouse
    • Grondard C, Biondi O, Armand AS, et al. Regular exercise prolongs survival in a type 2 spinal muscular atrophy model mouse. J Neurosci 2005;25:7615-22
    • (2005) J Neurosci , vol.25 , pp. 7615-7622
    • Grondard, C.1    Biondi, O.2    Armand, A.S.3
  • 61
    • 0034639745 scopus 로고    scopus 로고
    • Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: An animal model for spinal muscular atrophy type III
    • Jablonka S, Schrank B, Kralewski M, et al. Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: An animal model for spinal muscular atrophy type III. Hum Mol Genet 2000; 9:341-46
    • (2000) Hum Mol Genet , vol.9 , pp. 341-346
    • Jablonka, S.1    Schrank, B.2    Kralewski, M.3
  • 62
    • 0021157469 scopus 로고
    • Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis
    • Hirano A, Nakano I, Kurland LT, et al. Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 1984;43:471-80
    • (1984) J Neuropathol Exp Neurol , vol.43 , pp. 471-480
    • Hirano, A.1    Nakano, I.2    Kurland, L.T.3
  • 63
    • 0034701295 scopus 로고    scopus 로고
    • Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy
    • Frugier T, Tiziano FD, Cifuentes-Diaz C, et al. Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy. Hum Mol Genet 2000;9:849-58
    • (2000) Hum Mol Genet , vol.9 , pp. 849-858
    • Frugier, T.1    Tiziano, F.D.2    Cifuentes-Diaz, C.3
  • 64
    • 33748261830 scopus 로고    scopus 로고
    • Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
    • Gould TW, Buss RR, Vinsant S, et al. Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci 2006;26:8774-86
    • (2006) J Neurosci , vol.26 , pp. 8774-8786
    • Gould, T.W.1    Buss, R.R.2    Vinsant, S.3
  • 65
    • 79951704433 scopus 로고    scopus 로고
    • Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease
    • Philips T, Robberecht W. Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease. Lancet Neurol 2011;10:253-63
    • (2011) Lancet Neurol , vol.10 , pp. 253-263
    • Philips, T.1    Robberecht, W.2
  • 66
    • 0019037273 scopus 로고
    • Glial bundles of nerve roots in Werdnig-Hoffmann disease
    • Chou SM. Glial bundles of nerve roots in Werdnig-Hoffmann disease. Ann Neurol 1980;8:79-82
    • (1980) Ann Neurol , vol.8 , pp. 79-82
    • Chou, S.M.1
  • 67
    • 0020620039 scopus 로고
    • Glial bundles in spinal nerve roots: A form of isomorphic gliosis at the junction of the central and peripheral nervous system
    • Ghatak NR. Glial bundles in spinal nerve roots: A form of isomorphic gliosis at the junction of the central and peripheral nervous system. Neuropathol Appl Neurobiol 1983;9:391-401
    • (1983) Neuropathol Appl Neurobiol , vol.9 , pp. 391-401
    • Ghatak, N.R.1
  • 68
    • 0020029981 scopus 로고
    • Morphological and morphometric studies on the spinal cord lesion in Werdnig-Hoffmann disease
    • Kumagai T, Hashizume Y. Morphological and morphometric studies on the spinal cord lesion in Werdnig-Hoffmann disease. Brain Dev 1982; 4:87-96
    • (1982) Brain Dev , vol.4 , pp. 87-96
    • Kumagai, T.1    Hashizume, Y.2
  • 69
    • 58449137250 scopus 로고    scopus 로고
    • An autopsy case of spinal muscular atrophy type III (Kugelberg-Welander disease
    • Kuru S, Sakai M, Konagaya M, et al. An autopsy case of spinal muscular atrophy type III (Kugelberg-Welander disease). Neuropathology 2009; 29:63-67
    • (2009) Neuropathology , vol.29 , pp. 63-67
    • Kuru, S.1    Sakai, M.2    Konagaya, M.3
  • 70
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 1996;19:312-18
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 72
    • 0024199439 scopus 로고
    • Functional plasticity of microglia: A review
    • Streit WJ, Graeber MB, Kreutzberg GW. Functional plasticity of microglia: A review. Glia 1988;1:301-7
    • (1988) Glia , vol.1 , pp. 301-307
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 73
    • 70349248433 scopus 로고    scopus 로고
    • Development of microglia in the chick embryo spinal cord: Implications in the regulation of motoneuronal survival and death
    • Calderó J, Brunet N, Ciutat D, et al. Development of microglia in the chick embryo spinal cord: Implications in the regulation of motoneuronal survival and death. J Neurosci Res 2009;87:2447-66
    • (2009) J Neurosci Res , vol.87 , pp. 2447-2466
    • Caldero, J.1    Brunet, N.2    Ciutat, D.3
  • 74
    • 84878428344 scopus 로고    scopus 로고
    • Notch signaling pathway is activated in motoneurons of spinal muscular atrophy
    • Caraballo-Miralles V, Cardona-Rossinyol A, Garcera A, et al. Notch signaling pathway is activated in motoneurons of spinal muscular atrophy. Int J Mol Sci 2013;14:11424-37
    • (2013) Int J Mol Sci , vol.14 , pp. 11424-11437
    • Caraballo-Miralles, V.1    Cardona-Rossinyol, A.2    Garcera, A.3
  • 75
    • 71249105739 scopus 로고    scopus 로고
    • Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways
    • Morga E, Mouad-Amazzal L, Felten P, et al. Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways. Glia 2009;57:1741-53
    • (2009) Glia , vol.57 , pp. 1741-1753
    • Morga, E.1    Mouad-Amazzal, L.2    Felten, P.3
  • 76
    • 13344286293 scopus 로고    scopus 로고
    • Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
    • Rothstein JD, Dykes-Hoberg M, Pardo CA, et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1996;16:675-86
    • (1996) Neuron , vol.16 , pp. 675-686
    • Rothstein, J.D.1    Dykes-Hoberg, M.2    Pardo, C.A.3
  • 77
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cellYbased ALS model
    • Di Giorgio FP, Carrasco MA, Siao MC, et al. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cellYbased ALS model. Nat Neurosci 2007;10:608-14
    • (2007) Nat Neurosci , vol.10 , pp. 608-614
    • Di Giorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3
  • 78
    • 80052783545 scopus 로고    scopus 로고
    • Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
    • Haidet-Phillips AM, Hester ME, Miranda CJ, et al. Astrocytes from familial and sporadic ALS patients are toxic to motor neurons. Nat Biotechnol 2011;29:824-28
    • (2011) Nat Biotechnol , vol.29 , pp. 824-828
    • Haidet-Phillips, A.M.1    Hester, M.E.2    Miranda, C.J.3
  • 79
    • 34247475338 scopus 로고    scopus 로고
    • Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    • Nagai M, Re DB, Nagata T, et al. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 2007;10:615-22
    • (2007) Nat Neurosci , vol.10 , pp. 615-622
    • Nagai, M.1    Re, D.B.2    Nagata, T.3
  • 80
    • 80052294692 scopus 로고    scopus 로고
    • Astrocytes are endogenous regulators of basal transmission at central synapses
    • Panatier A, Vallee J, Haber M, et al. Astrocytes are endogenous regulators of basal transmission at central synapses. Cell 2011;146:785-98
    • (2011) Cell , vol.146 , pp. 785-798
    • Panatier, A.1    Vallee, J.2    Haber, M.3
  • 81
    • 33744973545 scopus 로고    scopus 로고
    • Astrocyte reactivity influences the number of presynaptic terminals apposed to spinal motoneurons after axotomy
    • Emirandetti A, Graciele Zanon R, Sabha M Jr, et al. Astrocyte reactivity influences the number of presynaptic terminals apposed to spinal motoneurons after axotomy. Brain Res 2006;1095:35-42
    • (2006) Brain Res , vol.1095 , pp. 35-42
    • Emirandetti, A.1    Graciele Zanon, R.2    Sabha Jr., M.3
  • 83
    • 0019321644 scopus 로고
    • Elimination of synapses in the developing nervous system
    • Purves D, Lichtman JW. Elimination of synapses in the developing nervous system. Science 1980;210:153-57
    • (1980) Science , vol.210 , pp. 153-157
    • Purves, D.1    Lichtman, J.W.2
  • 84
    • 34648847089 scopus 로고    scopus 로고
    • Smn depletion alters profilin II expression and leads to upregulation of the RhoA/ROCK pathway and defects in neuronal integrity
    • Bowerman M, Shafey D, Kothary R. Smn depletion alters profilin II expression and leads to upregulation of the RhoA/ROCK pathway and defects in neuronal integrity. J Mol Neurosci 2007;32:120-31
    • (2007) J Mol Neurosci , vol.32 , pp. 120-131
    • Bowerman, M.1    Shafey, D.2    Kothary, R.3
  • 85
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer?s disease is a synaptic failure
    • Selkoe DJ. Alzheimer?s disease is a synaptic failure. Science 2002;298: 789-91
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 86
    • 0029068713 scopus 로고
    • Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease
    • Ince PG, Slade J, Chinnery RM, et al. Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease. J Neuropathol Exp Neurol 1995;54:673-79
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 673-679
    • Ince, P.G.1    Slade, J.2    Chinnery, R.M.3
  • 87
    • 0027968404 scopus 로고
    • Synapse loss in anterior horn neurons in amyotrophic lateral sclerosis
    • Sasaki S, Maruyama S. Synapse loss in anterior horn neurons in amyotrophic lateral sclerosis. Acta Neuropathol 1994;88:222-27
    • (1994) Acta Neuropathol , vol.88 , pp. 222-227
    • Sasaki, S.1    Maruyama, S.2
  • 89
    • 0029985237 scopus 로고    scopus 로고
    • Synaptophysin expression in the anterior horn of Werdnig-Hoffmann disease
    • Ikemoto A, Hirano A, Matsumoto S, et al. Synaptophysin expression in the anterior horn of Werdnig-Hoffmann disease. J Neurol Sci 1996; 136:94-100
    • (1996) J Neurol Sci , vol.136 , pp. 94-100
    • Ikemoto, A.1    Hirano, A.2    Matsumoto, S.3
  • 90
    • 0030197991 scopus 로고    scopus 로고
    • Synaptic alterations of anterior horn cells in Werdnig-Hoffmann disease
    • Yamanouchi Y, Yamanouchi H, Becker LE. Synaptic alterations of anterior horn cells in Werdnig-Hoffmann disease. Pediatr Neurol 1996;15:32-35
    • (1996) Pediatr Neurol , vol.15 , pp. 32-35
    • Yamanouchi, Y.1    Yamanouchi, H.2    Becker, L.E.3
  • 91
    • 31544437449 scopus 로고    scopus 로고
    • Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy
    • Jablonka S, Karle K, Sandner B, et al. Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy. Hum Mol Genet 2006;15:511-18
    • (2006) Hum Mol Genet , vol.15 , pp. 511-518
    • Jablonka, S.1    Karle, K.2    Sandner, B.3
  • 92
    • 84858054407 scopus 로고    scopus 로고
    • Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction
    • Gogliotti RG, Quinlan KA, Barlow CB, et al. Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. J Neurosci 2012;32:3818-29
    • (2012) J Neurosci , vol.32 , pp. 3818-3829
    • Gogliotti, R.G.1    Quinlan, K.A.2    Barlow, C.B.3
  • 93
    • 84862883258 scopus 로고    scopus 로고
    • Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy
    • Martinez TL, Kong L, Wang X, et al. Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy. J Neurosci 2012;32:8703-15
    • (2012) J Neurosci , vol.32 , pp. 8703-8715
    • Martinez, T.L.1    Kong, L.2    Wang, X.3
  • 94
    • 84873363396 scopus 로고    scopus 로고
    • Preservation of VGLUT1 synapses on ventral calbindin-immunoreactive interneurons and normal locomotor function in a mouse model of spinal muscular atrophy
    • Thirumalai V, Behrend RM, Birineni S, et al. Preservation of VGLUT1 synapses on ventral calbindin-immunoreactive interneurons and normal locomotor function in a mouse model of spinal muscular atrophy. J Neurophysiol 2013;109:702-10
    • (2013) J Neurophysiol , vol.109 , pp. 702-710
    • Thirumalai, V.1    Behrend, R.M.2    Birineni, S.3
  • 95
    • 84863778245 scopus 로고    scopus 로고
    • Remodeling of synapses in the CA1 area of the hippocampus after transient global ischemia
    • Ruan YW, Han XJ, Shi ZS, et al. Remodeling of synapses in the CA1 area of the hippocampus after transient global ischemia. Neuroscience 2012;218:268-77
    • (2012) Neuroscience , vol.218 , pp. 268-277
    • Ruan, Y.W.1    Han, X.J.2    Shi, Z.S.3
  • 96
    • 34249984721 scopus 로고    scopus 로고
    • The phagocytic capacity of neurones
    • Bowen S, Ateh DD, Deinhardt K, et al. The phagocytic capacity of neurones. Eur J Neurosci 2007;25:2947-55
    • (2007) Eur J Neurosci , vol.25 , pp. 2947-2955
    • Bowen, S.1    Ateh, D.D.2    Deinhardt, K.3
  • 97
    • 0016768865 scopus 로고
    • A quantitative analysis of boutons with different types of synapse in normal and injured hypoglossal nuclei
    • Sumner BE. A quantitative analysis of boutons with different types of synapse in normal and injured hypoglossal nuclei. Exp Neurol 1975;49: 406-17
    • (1975) Exp Neurol , vol.49 , pp. 406-417
    • Sumner, B.E.1
  • 98
    • 77952318830 scopus 로고    scopus 로고
    • Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model
    • Bowerman M, Beauvais A, Anderson CL, et al. Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model. Hum Mol Genet 2010;19:1468-78
    • (2010) Hum Mol Genet , vol.19 , pp. 1468-1478
    • Bowerman, M.1    Beauvais, A.2    Anderson, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.