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Volumn 20, Issue 19, 2014, Pages 5808-5817

Intervention on toll-like receptors in pancreatic cancer

Author keywords

Adjuvant therapy; Intervention; Pancreatic cancer; Pathophysiological mechanism; Toll like receptor

Indexed keywords

CETUXIMAB; FOLINIC ACID; GELATINASE A; GELATINASE B; GEMCITABINE; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRINOTECAN; KRESTIN; LIPOPOLYSACCHARIDE; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MATRIX METALLOPROTEINASE; MYELOID DIFFERENTIATION FACTOR 88; OXALIPLATIN; POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; TUMOR MARKER;

EID: 84901236766     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i19.5808     Document Type: Review
Times cited : (48)

References (85)
  • 1
    • 0027118569 scopus 로고
    • Pancreatic carcinoma
    • [PMID: 1732772 DOI: 10.1056/nejm199202133260706]
    • Warshaw AL, Fernández-del Castillo C. Pancreatic carcinoma. N Engl J Med 1992; 326: 455-465 [PMID: 1732772 DOI: 10.1056/nejm199202133260706]
    • (1992) N Engl J Med , vol.326 , pp. 455-465
    • Warshaw, A.L.1    Fernández-del Castillo, C.2
  • 2
    • 1642588228 scopus 로고    scopus 로고
    • Pancreatic cancer
    • [PMID: 15051286 DOI: 10.1016/ S0140-6736(04)15841-8]
    • Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet 2004; 363: 1049-1057 [PMID: 15051286 DOI: 10.1016/ S0140-6736(04)15841-8]
    • (2004) Lancet , vol.363 , pp. 1049-1057
    • Li, D.1    Xie, K.2    Wolff, R.3    Abbruzzese, J.L.4
  • 3
    • 84872967522 scopus 로고    scopus 로고
    • Cancer statistics, 2013
    • [PMID: 23335087 DOI: 10.3322/caac.21166]
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30 [PMID: 23335087 DOI: 10.3322/caac.21166]
    • (2013) CA Cancer J Clin , vol.63 , pp. 11-30
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 4
    • 62249117097 scopus 로고    scopus 로고
    • Familial pancreatic cancer
    • [PMID: 19260742 DOI: 10.1043/1543-2165-133.3.365]
    • Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med 2009; 133: 365-374 [PMID: 19260742 DOI: 10.1043/1543-2165-133.3.365]
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 365-374
    • Shi, C.1    Hruban, R.H.2    Klein, A.P.3
  • 5
    • 84866514182 scopus 로고    scopus 로고
    • The burning question: Why is smoking a risk factor for pancreatic cancer?
    • [PMID: 22898636 DOI: 10.1016/j.pan.2012.06.002]
    • Pandol SJ, Apte MV, Wilson JS, Gukovskaya AS, Edderkaoui M. The burning question: why is smoking a risk factor for pancreatic cancer? Pancreatology 2012; 12: 344-349 [PMID: 22898636 DOI: 10.1016/j.pan.2012.06.002]
    • (2012) Pancreatology , vol.12 , pp. 344-349
    • Pandol, S.J.1    Apte, M.V.2    Wilson, J.S.3    Gukovskaya, A.S.4    Edderkaoui, M.5
  • 6
    • 84872274536 scopus 로고    scopus 로고
    • Diabetes mellitus and cancer risk: Review of the epidemiological evidence
    • [PMID: 23066889 DOI: 10.1111/cas.12043]
    • Shikata K, Ninomiya T, Kiyohara Y. Diabetes mellitus and cancer risk: review of the epidemiological evidence. Cancer Sci 2013; 104: 9-14 [PMID: 23066889 DOI: 10.1111/cas.12043]
    • (2013) Cancer Sci , vol.104 , pp. 9-14
    • Shikata, K.1    Ninomiya, T.2    Kiyohara, Y.3
  • 7
    • 84876796439 scopus 로고    scopus 로고
    • Inflammation, autophagy, and obesity: Common features in the pathogenesis of pancreatitis and pancreatic cancer
    • [PMID: 23622129 DOI: 10.1053/j.gastro.2013.02.007]
    • Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology 2013; 144: 1199-1209. e4 [PMID: 23622129 DOI: 10.1053/j.gastro.2013.02.007]
    • (2013) Gastroenterology , vol.144
    • Gukovsky, I.1    Li, N.2    Todoric, J.3    Gukovskaya, A.4    Karin, M.5
  • 8
    • 69949185673 scopus 로고    scopus 로고
    • Update on pancreatic intraepithelial neoplasia
    • [PMID: 18787611]
    • Hruban RH, Maitra A, Goggins M. Update on pancreatic intraepithelial neoplasia. Int J Clin Exp Pathol 2008; 1: 306-316 [PMID: 18787611]
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 306-316
    • Hruban, R.H.1    Maitra, A.2    Goggins, M.3
  • 9
    • 34249898611 scopus 로고    scopus 로고
    • Molecular genetics of pancreatic intraepithelial neoplasia
    • [PMID: 17520196 DOI: 10.1007/s00534-006-1166-5]
    • Feldmann G, Beaty R, Hruban RH, Maitra A. Molecular genetics of pancreatic intraepithelial neoplasia. J Hepatobiliary Pancreat Surg 2007; 14: 224-232 [PMID: 17520196 DOI: 10.1007/s00534-006-1166-5]
    • (2007) J Hepatobiliary Pancreat Surg , vol.14 , pp. 224-232
    • Feldmann, G.1    Beaty, R.2    Hruban, R.H.3    Maitra, A.4
  • 10
    • 84876786403 scopus 로고    scopus 로고
    • A starring role for stellate cells in the pancreatic cancer microenvironment
    • [PMID: 23622130 DOI: 10.1053/j.gastro.2012.11.037]
    • Apte MV, Wilson JS, Lugea A, Pandol SJ. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology 2013; 144: 1210-1219 [PMID: 23622130 DOI: 10.1053/j.gastro.2012.11.037]
    • (2013) Gastroenterology , vol.144 , pp. 1210-1219
    • Apte, M.V.1    Wilson, J.S.2    Lugea, A.3    Pandol, S.J.4
  • 11
    • 70449719361 scopus 로고    scopus 로고
    • Identification of human pancreatic cancer stem cells
    • [PMID: 19582426 DOI: 10.1007/978-1-59745-280-9_10]
    • Li C, Lee CJ, Simeone DM. Identification of human pancreatic cancer stem cells. Methods Mol Biol 2009; 568: 161-173 [PMID: 19582426 DOI: 10.1007/978-1-59745-280-9_10]
    • (2009) Methods Mol Biol , vol.568 , pp. 161-173
    • Li, C.1    Lee, C.J.2    Simeone, D.M.3
  • 12
    • 84868212819 scopus 로고    scopus 로고
    • Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head
    • [PMID: 22931216 DOI: 10.1111/j.1349-7006.2012.02411.x]
    • Yoshikawa K, Mitsunaga S, Kinoshita T, Konishi M, Takahashi S, Gotohda N, Kato Y, Aizawa M, Ochiai A. Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head. Cancer Sci 2012; 103: 2012-2020 [PMID: 22931216 DOI: 10.1111/j.1349-7006.2012.02411.x]
    • (2012) Cancer Sci , vol.103 , pp. 2012-2020
    • Yoshikawa, K.1    Mitsunaga, S.2    Kinoshita, T.3    Konishi, M.4    Takahashi, S.5    Gotohda, N.6    Kato, Y.7    Aizawa, M.8    Ochiai, A.9
  • 13
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • [PMID: 20427809 DOI: 10.1056/NEJMra0901557]
    • Hidalgo M. Pancreatic cancer. N Engl J Med 2010; 362: 1605-1617 [PMID: 20427809 DOI: 10.1056/NEJMra0901557]
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 14
    • 84866755869 scopus 로고    scopus 로고
    • New insights into pancreatic cancer biology
    • [PMID: 22987949 DOI: 10.1093/annonc/mds313]
    • Hidalgo M. New insights into pancreatic cancer biology. Ann Oncol 2012; 23 Suppl 10: x135-x138 [PMID: 22987949 DOI: 10.1093/annonc/mds313]
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 10
    • Hidalgo, M.1
  • 16
    • 70350635407 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance in pancreatic cancer: Molecular mechanisms and potential solutions
    • [PMID: 19214867 DOI: 10.1080/00365520902745039]
    • Andersson R, Aho U, Nilsson BI, Peters GJ, Pastor-Anglada M, Rasch W, Sandvold ML. Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions. Scand J Gastroenterol 2009; 44: 782-786 [PMID: 19214867 DOI: 10.1080/00365520902745039]
    • (2009) Scand J Gastroenterol , vol.44 , pp. 782-786
    • Andersson, R.1    Aho, U.2    Nilsson, B.I.3    Peters, G.J.4    Pastor-Anglada, M.5    Rasch, W.6    Sandvold, M.L.7
  • 17
    • 84880315622 scopus 로고    scopus 로고
    • Pancreatic cancer-cost for overtreatment with gemcitabine
    • [PMID: 23244671 DOI: 10.3109/0284186X.2012.744 140]
    • Ansari D, Tingstedt B, Andersson R. Pancreatic cancer-cost for overtreatment with gemcitabine. Acta Oncol 2013; 52: 1146-1151 [PMID: 23244671 DOI: 10.3109/0284186X.2012.744 140]
    • (2013) Acta Oncol , vol.52 , pp. 1146-1151
    • Ansari, D.1    Tingstedt, B.2    Andersson, R.3
  • 18
    • 84880057880 scopus 로고    scopus 로고
    • First line therapy for metastatic pancreatic cancer
    • [PMID: 23846923 DOI: 10.6092/1590-8577/1667]
    • Jarboe J, Saif MW. First line therapy for metastatic pancreatic cancer. JOP 2013; 14: 340-343 [PMID: 23846923 DOI: 10.6092/1590-8577/1667]
    • (2013) JOP , vol.14 , pp. 340-343
    • Jarboe, J.1    Saif, M.W.2
  • 19
    • 84885762423 scopus 로고    scopus 로고
    • Links between Toll-like receptor 4 and breast cancer
    • [PMID: 23526132 DOI: 10.4161/onci.22945]
    • Ahmed A, Redmond HP, Wang JH. Links between Toll-like receptor 4 and breast cancer. Oncoimmunology 2013; 2: e22945 [PMID: 23526132 DOI: 10.4161/onci.22945]
    • (2013) Oncoimmunology , vol.2
    • Ahmed, A.1    Redmond, H.P.2    Wang, J.H.3
  • 20
    • 81855176234 scopus 로고    scopus 로고
    • Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer
    • [PMID: 21920464 DOI: 10.1053/j.gastro.2011.08.043]
    • Eyking A, Ey B, Rünzi M, Roig AI, Reis H, Schmid KW, Gerken G, Podolsky DK, Cario E. Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer. Gastroenterology 2011; 141: 2154-2165 [PMID: 21920464 DOI: 10.1053/j.gastro.2011.08.043]
    • (2011) Gastroenterology , vol.141 , pp. 2154-2165
    • Eyking, A.1    Ey, B.2    Rünzi, M.3    Roig, A.I.4    Reis, H.5    Schmid, K.W.6    Gerken, G.7    Podolsky, D.K.8    Cario, E.9
  • 21
    • 84863113633 scopus 로고    scopus 로고
    • Immunotherapies for non-small-cell lung cancer and mesothelioma
    • [PMID: 22748269 DOI: 10.1016/S1470-2045(12)70126-2]
    • Thomas A, Hassan R. Immunotherapies for non-small-cell lung cancer and mesothelioma. Lancet Oncol 2012; 13: e301-e310 [PMID: 22748269 DOI: 10.1016/S1470-2045(12)70126-2]
    • (2012) Lancet Oncol , vol.13
    • Thomas, A.1    Hassan, R.2
  • 23
    • 84901210724 scopus 로고    scopus 로고
    • Pancreatic cancer screening by TLR phenotyping
    • Abstract nr 894. [DOI: 10.1158/1538-7445.AM2011-894]
    • Rosenberg JS, Singh S, Raul S, Tong Z, Guha S. Pancreatic cancer screening by TLR phenotyping. Cancer Research 2011; 71: Abstract nr 894 [DOI: 10.1158/1538-7445.AM2011-894]
    • (2011) Cancer Research , vol.71
    • Rosenberg, J.S.1    Singh, S.2    Raul, S.3    Tong, Z.4    Guha, S.5
  • 24
    • 77955383770 scopus 로고    scopus 로고
    • DAMPening inflammation by modulating TLR signalling
    • 2010: [PMID: 20706656 DOI: 10.1155/2010/672395]
    • Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010; 2010: [PMID: 20706656 DOI: 10.1155/2010/672395]
    • (2010) Mediators Inflamm
    • Piccinini, A.M.1    Midwood, K.S.2
  • 25
    • 80051814602 scopus 로고    scopus 로고
    • Targeting of Toll-like receptors: A decade of progress in combating infectious diseases
    • [PMID: 21719349 DOI: 10.1016/S1473-3099(11)70099-8]
    • Hedayat M, Netea MG, Rezaei N. Targeting of Toll-like receptors: a decade of progress in combating infectious diseases. Lancet Infect Dis 2011; 11: 702-712 [PMID: 21719349 DOI: 10.1016/S1473-3099(11)70099-8]
    • (2011) Lancet Infect Dis , vol.11 , pp. 702-712
    • Hedayat, M.1    Netea, M.G.2    Rezaei, N.3
  • 26
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domaincontaining adaptors in Toll-like receptor signalling
    • [PMID: 17457343 DOI: 10.1038/ nri2079]
    • O'Neill LA, Bowie AG. The family of five: TIR-domaincontaining adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007; 7: 353-364 [PMID: 17457343 DOI: 10.1038/ nri2079]
    • (2007) Nat Rev Immunol , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 27
    • 67649422321 scopus 로고    scopus 로고
    • Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    • [PMID: 19474110 DOI: 10.1124/pr.109.001073]
    • O'Neill LA, Bryant CE, Doyle SL. Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 2009; 61: 177-197 [PMID: 19474110 DOI: 10.1124/pr.109.001073]
    • (2009) Pharmacol Rev , vol.61 , pp. 177-197
    • O'Neill, L.A.1    Bryant, C.E.2    Doyle, S.L.3
  • 28
    • 1642275654 scopus 로고    scopus 로고
    • Signaling danger: Tolllike receptors and their potential roles in kidney disease
    • [PMID: 15034087 DOI: 10.1097/01.ASN.0000121781.89599.16]
    • Anders HJ, Banas B, Schlöndorff D. Signaling danger: tolllike receptors and their potential roles in kidney disease. J Am Soc Nephrol 2004; 15: 854-867 [PMID: 15034087 DOI: 10.1097/01.ASN.0000121781.89599.16]
    • (2004) J Am Soc Nephrol , vol.15 , pp. 854-867
    • Anders, H.J.1    Banas, B.2    Schlöndorff, D.3
  • 30
    • 52049124515 scopus 로고    scopus 로고
    • Role of Toll like receptor signaling pathway in ischemic coronary artery disease
    • [PMID: 18508689 DOI: 10.2741/3397]
    • Satoh M, Ishikawa Y, Minami Y, Takahashi Y, Nakamura M. Role of Toll like receptor signaling pathway in ischemic coronary artery disease. Front Biosci 2008; 13: 6708-6715 [PMID: 18508689 DOI: 10.2741/3397]
    • (2008) Front Biosci , vol.13 , pp. 6708-6715
    • Satoh, M.1    Ishikawa, Y.2    Minami, Y.3    Takahashi, Y.4    Nakamura, M.5
  • 31
    • 0036918723 scopus 로고    scopus 로고
    • Differential recognition of structural details of bacterial lipopeptides by toll-like receptors
    • [PMID: 12432564]
    • Morr M, Takeuchi O, Akira S, Simon MM, Mühlradt PF. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. Eur J Immunol 2002; 32: 3337-3347 [PMID: 12432564]
    • (2002) Eur J Immunol , vol.32 , pp. 3337-3347
    • Morr, M.1    Takeuchi, O.2    Akira, S.3    Simon, M.M.4    Mühlradt, P.F.5
  • 32
    • 0034650420 scopus 로고    scopus 로고
    • Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2-and MyD88-dependent signaling pathway
    • [PMID: 10623793]
    • Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Mühlradt PF, Akira S. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2-and MyD88-dependent signaling pathway. J Immunol 2000; 164: 554-557 [PMID: 10623793]
    • (2000) J Immunol , vol.164 , pp. 554-557
    • Takeuchi, O.1    Kaufmann, A.2    Grote, K.3    Kawai, T.4    Hoshino, K.5    Morr, M.6    Mühlradt, P.F.7    Akira, S.8
  • 34
    • 0038189845 scopus 로고    scopus 로고
    • Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells
    • [PMID: 12777064 DOI: 10.1078/0171-2985-00234]
    • Weigt H, Mühlradt PF, Emmendörffer A, Krug N, Braun A. Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells. Immunobiology 2003; 207: 223-233 [PMID: 12777064 DOI: 10.1078/0171-2985-00234]
    • (2003) Immunobiology , vol.207 , pp. 223-233
    • Weigt, H.1    Mühlradt, P.F.2    Emmendörffer, A.3    Krug, N.4    Braun, A.5
  • 35
    • 34548316162 scopus 로고    scopus 로고
    • Intratumoural injection of the toll-like receptor-2/6 agonist 'macrophage-activating lipopeptide-2' in patients with pancreatic carcinoma: A phase I/II trial
    • [PMID: 17667928 DOI: 10.1038/ sj.bjc.6603903]
    • Schmidt J, Welsch T, Jäger D, Mühlradt PF, Büchler MW, Märten A. Intratumoural injection of the toll-like receptor-2/6 agonist 'macrophage-activating lipopeptide-2' in patients with pancreatic carcinoma: a phase I/II trial. Br J Cancer 2007; 97: 598-604 [PMID: 17667928 DOI: 10.1038/ sj.bjc.6603903]
    • (2007) Br J Cancer , vol.97 , pp. 598-604
    • Schmidt, J.1    Welsch, T.2    Jäger, D.3    Mühlradt, P.F.4    Büchler, M.W.5    Märten, A.6
  • 36
    • 84863284114 scopus 로고    scopus 로고
    • Polysaccharide-K (PSK) in cancer--old story, new possibilities?
    • [PMID: 22204346 DOI: 10.2174/092986712798992020]
    • Sun C, Rosendahl AH, Wang XD, Wu DQ, Andersson R. Polysaccharide-K (PSK) in cancer--old story, new possibilities? Curr Med Chem 2012; 19: 757-762 [PMID: 22204346 DOI: 10.2174/092986712798992020]
    • (2012) Curr Med Chem , vol.19 , pp. 757-762
    • Sun, C.1    Rosendahl, A.H.2    Wang, X.D.3    Wu, D.Q.4    Andersson, R.5
  • 38
    • 78751474671 scopus 로고    scopus 로고
    • Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells
    • [PMID: 21068144 DOI: 10.1158/1078-0432.CCR-10-1763]
    • Lu H, Yang Y, Gad E, Wenner CA, Chang A, Larson ER, Dang Y, Martzen M, Standish LJ, Disis ML. Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clin Cancer Res 2011; 17: 67-76 [PMID: 21068144 DOI: 10.1158/1078-0432.CCR-10-1763]
    • (2011) Clin Cancer Res , vol.17 , pp. 67-76
    • Lu, H.1    Yang, Y.2    Gad, E.3    Wenner, C.A.4    Chang, A.5    Larson, E.R.6    Dang, Y.7    Martzen, M.8    Standish, L.J.9    Disis, M.L.10
  • 40
    • 84873085234 scopus 로고    scopus 로고
    • Polysaccharide-K (PSK) increases p21(WAF/Cip1) and promotes apoptosis in pancreatic cancer cells
    • [PMID: 23217280 DOI: 10.1016/j.pan.2012.09.004]
    • Rosendahl AH, Sun C, Wu D, Andersson R. Polysaccharide-K (PSK) increases p21(WAF/Cip1) and promotes apoptosis in pancreatic cancer cells. Pancreatology 2012; 12: 467-474 [PMID: 23217280 DOI: 10.1016/j.pan.2012.09.004]
    • (2012) Pancreatology , vol.12 , pp. 467-474
    • Rosendahl, A.H.1    Sun, C.2    Wu, D.3    Andersson, R.4
  • 41
    • 84869989377 scopus 로고    scopus 로고
    • Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy
    • [PMID: 23098072 DOI: 10.1021/ jm301002f]
    • Huynh AS, Chung WJ, Cho HI, Moberg VE, Celis E, Morse DL, Vagner J. Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy. J Med Chem 2012; 55: 9751-9762 [PMID: 23098072 DOI: 10.1021/ jm301002f]
    • (2012) J Med Chem , vol.55 , pp. 9751-9762
    • Huynh, A.S.1    Chung, W.J.2    Cho, H.I.3    Moberg, V.E.4    Celis, E.5    Morse, D.L.6    Vagner, J.7
  • 44
    • 73849145679 scopus 로고    scopus 로고
    • PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression
    • [PMID: 19784070 DOI: 10.1038/onc.2009.298]
    • Lee Y, Kim SJ, Park HD, Park EH, Huang SM, Jeon SB, Kim JM, Lim DS, Koh SS. PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression. Oncogene 2010; 29: 56-67 [PMID: 19784070 DOI: 10.1038/onc.2009.298]
    • (2010) Oncogene , vol.29 , pp. 56-67
    • Lee, Y.1    Kim, S.J.2    Park, H.D.3    Park, E.H.4    Huang, S.M.5    Jeon, S.B.6    Kim, J.M.7    Lim, D.S.8    Koh, S.S.9
  • 45
    • 78651407343 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation
    • [PMID: 20802527 DOI: 10.1038/onc.2010.401]
    • Park HD, Lee Y, Oh YK, Jung JG, Park YW, Myung K, Kim KH, Koh SS, Lim DS. Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation. Oncogene 2011; 30: 201-211 [PMID: 20802527 DOI: 10.1038/onc.2010.401]
    • (2011) Oncogene , vol.30 , pp. 201-211
    • Park, H.D.1    Lee, Y.2    Oh, Y.K.3    Jung, J.G.4    Park, Y.W.5    Myung, K.6    Kim, K.H.7    Koh, S.S.8    Lim, D.S.9
  • 48
    • 72249091840 scopus 로고    scopus 로고
    • Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells
    • [PMID: 19887600 DOI: 10.1158/0008-5472.CAN-09-1602]
    • Shojaei H, Oberg HH, Juricke M, Marischen L, Kunz M, Mundhenke C, Gieseler F, Kabelitz D, Wesch D. Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells. Cancer Res 2009; 69: 8710-8717 [PMID: 19887600 DOI: 10.1158/0008-5472.CAN-09-1602]
    • (2009) Cancer Res , vol.69 , pp. 8710-8717
    • Shojaei, H.1    Oberg, H.H.2    Juricke, M.3    Marischen, L.4    Kunz, M.5    Mundhenke, C.6    Gieseler, F.7    Kabelitz, D.8    Wesch, D.9
  • 51
    • 67649515610 scopus 로고    scopus 로고
    • Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades
    • [PMID: 19424602 DOI: 10.3892/ijmm_00000190]
    • Katoh M, Katoh M. Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. Int J Mol Med 2009; 23: 763-769 [PMID: 19424602 DOI: 10.3892/ijmm_00000190]
    • (2009) Int J Mol Med , vol.23 , pp. 763-769
    • Katoh, M.1    Katoh, M.2
  • 52
    • 17844410902 scopus 로고    scopus 로고
    • Thyrocytes express a functional toll-like receptor 3: Overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis
    • [PMID: 15661832 DOI: 10.1210/me.2004-0100]
    • Harii N, Lewis CJ, Vasko V, McCall K, Benavides-Peralta U, Sun X, Ringel MD, Saji M, Giuliani C, Napolitano G, Goetz DJ, Kohn LD. Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. Mol Endocrinol 2005; 19: 1231-1250 [PMID: 15661832 DOI: 10.1210/me.2004-0100]
    • (2005) Mol Endocrinol , vol.19 , pp. 1231-1250
    • Harii, N.1    Lewis, C.J.2    Vasko, V.3    McCall, K.4    Benavides-Peralta, U.5    Sun, X.6    Ringel, M.D.7    Saji, M.8    Giuliani, C.9    Napolitano, G.10    Goetz, D.J.11    Kohn, L.D.12
  • 53
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • [PMID: 19808018 DOI: 10.1016/ j.cmet.2009.08.013]
    • Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, Brüning JC. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 2009; 10: 249-259 [PMID: 19808018 DOI: 10.1016/ j.cmet.2009.08.013]
    • (2009) Cell Metab , vol.10 , pp. 249-259
    • Kleinridders, A.1    Schenten, D.2    Könner, A.C.3    Belgardt, B.F.4    Mauer, J.5    Okamura, T.6    Wunderlich, F.T.7    Medzhitov, R.8    Brüning, J.C.9
  • 54
    • 84873684086 scopus 로고    scopus 로고
    • Controversial role of toll-like receptors in acute pancreatitis
    • [PMID: 23431068 DOI: 10.3748/wjg.v19. i5.616]
    • Vaz J, Akbarshahi H, Andersson R. Controversial role of toll-like receptors in acute pancreatitis. World J Gastroenterol 2013; 19: 616-630 [PMID: 23431068 DOI: 10.3748/wjg.v19. i5.616]
    • (2013) World J Gastroenterol , vol.19 , pp. 616-630
    • Vaz, J.1    Akbarshahi, H.2    Andersson, R.3
  • 55
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • [PMID: 17615359 DOI: 10.1126/science.1140488]
    • Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 2007; 317: 124-127 [PMID: 17615359 DOI: 10.1126/science.1140488]
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 56
    • 79952724783 scopus 로고    scopus 로고
    • Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
    • [PMID: 21339327 DOI: 10.1084/jem.20101876]
    • De Monte L, Reni M, Tassi E, Clavenna D, Papa I, Recalde H, Braga M, Di Carlo V, Doglioni C, Protti MP. Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J Exp Med 2011; 208: 469-478 [PMID: 21339327 DOI: 10.1084/jem.20101876]
    • (2011) J Exp Med , vol.208 , pp. 469-478
    • De Monte, L.1    Reni, M.2    Tassi, E.3    Clavenna, D.4    Papa, I.5    Recalde, H.6    Braga, M.7    Di Carlo, V.8    Doglioni, C.9    Protti, M.P.10
  • 57
    • 84873564101 scopus 로고    scopus 로고
    • Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines
    • [PMID: 23296709 DOI: 10.4049/jimmunol.1201725]
    • Wu Y, Lu J, Antony S, Juhasz A, Liu H, Jiang G, Meitzler JL, Hollingshead M, Haines DC, Butcher D, Roy K, Doroshow JH. Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines. J Immunol 2013; 190: 1859-1872 [PMID: 23296709 DOI: 10.4049/jimmunol.1201725]
    • (2013) J Immunol , vol.190 , pp. 1859-1872
    • Wu, Y.1    Lu, J.2    Antony, S.3    Juhasz, A.4    Liu, H.5    Jiang, G.6    Meitzler, J.L.7    Hollingshead, M.8    Haines, D.C.9    Butcher, D.10    Roy, K.11    Doroshow, J.H.12
  • 59
    • 0036334059 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
    • [PMID: 12167581 DOI: 10.1007/BF02574483]
    • Bloomston M, Zervos EE, Rosemurgy AS. Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol 2002; 9: 668-674 [PMID: 12167581 DOI: 10.1007/BF02574483]
    • (2002) Ann Surg Oncol , vol.9 , pp. 668-674
    • Bloomston, M.1    Zervos, E.E.2    Rosemurgy, A.S.3
  • 60
    • 77951973979 scopus 로고    scopus 로고
    • Primers on molecular pathways: Lipopolysaccharide signaling-potential role in pancreatitis and pancreatic cancer
    • [PMID: 20460943 DOI: 10.1159/000299987]
    • Del Pozo JL. Primers on molecular pathways: lipopolysaccharide signaling-potential role in pancreatitis and pancreatic cancer. Pancreatology 2010; 10: 114-118 [PMID: 20460943 DOI: 10.1159/000299987]
    • (2010) Pancreatology , vol.10 , pp. 114-118
    • Del Pozo, J.L.1
  • 61
    • 84879663836 scopus 로고    scopus 로고
    • M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway
    • [PMID: 23752129 DOI: 10.1038/labinvest. 2013.69]
    • Liu CY, Xu JY, Shi XY, Huang W, Ruan TY, Xie P, Ding JL. M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. Lab Invest 2013; 93: 844-854 [PMID: 23752129 DOI: 10.1038/labinvest. 2013.69]
    • (2013) Lab Invest , vol.93 , pp. 844-854
    • Liu, C.Y.1    Xu, J.Y.2    Shi, X.Y.3    Huang, W.4    Ruan, T.Y.5    Xie, P.6    Ding, J.L.7
  • 62
    • 77954259621 scopus 로고    scopus 로고
    • Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma
    • [PMID: 20556833 DOI: 10.3748/wjg.v16.i23.2881]
    • Zhang JJ, Wu HS, Wang L, Tian Y, Zhang JH, Wu HL. Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma. World J Gastroenterol 2010; 16: 2881-2888 [PMID: 20556833 DOI: 10.3748/wjg.v16.i23.2881]
    • (2010) World J Gastroenterol , vol.16 , pp. 2881-2888
    • Zhang, J.J.1    Wu, H.S.2    Wang, L.3    Tian, Y.4    Zhang, J.H.5    Wu, H.L.6
  • 63
    • 84862815577 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 upregulates the expression of Toll-like receptor 4 in pancreatic cancer cells under hypoxic conditions
    • [PMID: 22487528 DOI: 10.1016/j.pan.2012.02.015]
    • Fan P, Zhang JJ, Wang B, Wu HQ, Zhou SX, Wang CY, Zhang JH, Tian Y, Wu HS. Hypoxia-inducible factor-1 upregulates the expression of Toll-like receptor 4 in pancreatic cancer cells under hypoxic conditions. Pancreatology 2012; 12: 170-178 [PMID: 22487528 DOI: 10.1016/j.pan.2012.02.015]
    • (2012) Pancreatology , vol.12 , pp. 170-178
    • Fan, P.1    Zhang, J.J.2    Wang, B.3    Wu, H.Q.4    Zhou, S.X.5    Wang, C.Y.6    Zhang, J.H.7    Tian, Y.8    Wu, H.S.9
  • 64
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • [PMID: 17479101 DOI: 10.1038/nm1589]
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007; 13: 552-559 [PMID: 17479101 DOI: 10.1038/nm1589]
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 65
    • 84885831036 scopus 로고    scopus 로고
    • Signaling via MYD88 in the pancreatic tumor microenvironment: A double-edged sword
    • [PMID: 23483804 DOI: 10.4161/onci.22567]
    • Zambirinis CP, Miller G. Signaling via MYD88 in the pancreatic tumor microenvironment: A double-edged sword. Oncoimmunology 2013; 2: e22567 [PMID: 23483804 DOI: 10.4161/onci.22567]
    • (2013) Oncoimmunology , vol.2
    • Zambirinis, C.P.1    Miller, G.2
  • 66
    • 84876236738 scopus 로고    scopus 로고
    • Induction of TRIF-or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer
    • [PMID: 23549168 DOI: 10.4161/cc.24488]
    • Zambirinis CP, Ochi A, Barilla R, Greco S, Deutsch M, Miller G. Induction of TRIF-or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer. Cell Cycle 2013; 12: 1153-1154 [PMID: 23549168 DOI: 10.4161/cc.24488]
    • (2013) Cell Cycle , vol.12 , pp. 1153-1154
    • Zambirinis, C.P.1    Ochi, A.2    Barilla, R.3    Greco, S.4    Deutsch, M.5    Miller, G.6
  • 69
    • 84863475067 scopus 로고    scopus 로고
    • TLR9 agonists induced cell death in Burkitt's lymphoma cells is variable and influenced by TLR9 polymorphism
    • [PMID: 22717578 DOI: 10.1038/cddis.2012.60]
    • Noack J, Jordi M, Zauner L, Alessi D, Burch A, Tinguely M, Hersberger M, Bernasconi M, Nadal D. TLR9 agonists induced cell death in Burkitt's lymphoma cells is variable and influenced by TLR9 polymorphism. Cell Death Dis 2012; 3: e323 [PMID: 22717578 DOI: 10.1038/cddis.2012.60]
    • (2012) Cell Death Dis , vol.3
    • Noack, J.1    Jordi, M.2    Zauner, L.3    Alessi, D.4    Burch, A.5    Tinguely, M.6    Hersberger, M.7    Bernasconi, M.8    Nadal, D.9
  • 70
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • [PMID: 16763660 DOI: 10.1038/nrd2059]
    • Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006; 5: 471-484 [PMID: 16763660 DOI: 10.1038/nrd2059]
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 72
    • 22244438547 scopus 로고    scopus 로고
    • Therapeutic synergism of gemcitabine and CpG-oligodeoxynucleotides in an orthotopic human pancreatic carcinoma xenograft
    • [PMID: 16024642 DOI: 10.1158/0008-5472.CAN-05-0602]
    • Pratesi G, Petrangolini G, Tortoreto M, Addis A, Belluco S, Rossini A, Selleri S, Rumio C, Menard S, Balsari A. Therapeutic synergism of gemcitabine and CpG-oligodeoxynucleotides in an orthotopic human pancreatic carcinoma xenograft. Cancer Res 2005; 65: 6388-6393 [PMID: 16024642 DOI: 10.1158/0008-5472.CAN-05-0602]
    • (2005) Cancer Res , vol.65 , pp. 6388-6393
    • Pratesi, G.1    Petrangolini, G.2    Tortoreto, M.3    Addis, A.4    Belluco, S.5    Rossini, A.6    Selleri, S.7    Rumio, C.8    Menard, S.9    Balsari, A.10
  • 73
    • 0033497861 scopus 로고    scopus 로고
    • Growth factor receptors are differentially expressed in cancers of the papilla of vater and pancreas
    • [PMID: 10615931 DOI: 10.1097/00000658-199912000-00005]. discussion 774-775
    • Friess H, Wang L, Zhu Z, Gerber R, Schröder M, Fukuda A, Zimmermann A, Korc M, Büchler MW. Growth factor receptors are differentially expressed in cancers of the papilla of vater and pancreas. Ann Surg 1999; 230: 767-774; discussion 774-775 [PMID: 10615931 DOI: 10.1097/00000658-199912000-00005]
    • (1999) Ann Surg , vol.230 , pp. 767-774
    • Friess, H.1    Wang, L.2    Zhu, Z.3    Gerber, R.4    Schröder, M.5    Fukuda, A.6    Zimmermann, A.7    Korc, M.8    Büchler, M.W.9
  • 74
    • 84860267502 scopus 로고    scopus 로고
    • Systemic treatment of advanced pancreatic cancer
    • [PMID: 22226241 DOI: 10.1016/j.ctrv.2011.12.004]
    • Heinemann V, Haas M, Boeck S. Systemic treatment of advanced pancreatic cancer. Cancer Treat Rev 2012; 38: 843-853 [PMID: 22226241 DOI: 10.1016/j.ctrv.2011.12.004]
    • (2012) Cancer Treat Rev , vol.38 , pp. 843-853
    • Heinemann, V.1    Haas, M.2    Boeck, S.3
  • 75
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclo-nal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II Trial
    • [PMID: 15226328 DOI: 10.1200/JCO.2004.12.040]
    • Xiong HQ, Rosenberg A, LoBuglio A, Schmidt W, Wolff RA, Deutsch J, Needle M, Abbruzzese JL. Cetuximab, a monoclo-nal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J Clin Oncol 2004; 22: 2610-2616 [PMID: 15226328 DOI: 10.1200/JCO.2004.12.040]
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    LoBuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6    Needle, M.7    Abbruzzese, J.L.8
  • 76
    • 31544452826 scopus 로고    scopus 로고
    • Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors
    • [PMID: 16428503 DOI: 10.1158/1078-0432. CCR-05-1943]
    • Damiano V, Caputo R, Bianco R, D'Armiento FP, Leonardi A, De Placido S, Bianco AR, Agrawal S, Ciardiello F, Tortora G. Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors. Clin Cancer Res 2006; 12: 577-583 [PMID: 16428503 DOI: 10.1158/1078-0432. CCR-05-1943]
    • (2006) Clin Cancer Res , vol.12 , pp. 577-583
    • Damiano, V.1    Caputo, R.2    Bianco, R.3    D'Armiento, F.P.4    Leonardi, A.5    De Placido, S.6    Bianco, A.R.7    Agrawal, S.8    Ciardiello, F.9    Tortora, G.10
  • 78
    • 51249084219 scopus 로고    scopus 로고
    • DNA vector augments inflammation in epithelial cells via EGFR-dependent regulation of TLR4 and TLR2
    • [PMID: 18403779 DOI: 10.1165/rcmb.2007-0458OC]
    • Liu K, Anderson GP, Bozinovski S. DNA vector augments inflammation in epithelial cells via EGFR-dependent regulation of TLR4 and TLR2. Am J Respir Cell Mol Biol 2008; 39: 305-311 [PMID: 18403779 DOI: 10.1165/rcmb.2007-0458OC]
    • (2008) Am J Respir Cell Mol Biol , vol.39 , pp. 305-311
    • Liu, K.1    Anderson, G.P.2    Bozinovski, S.3
  • 79
    • 79955940011 scopus 로고    scopus 로고
    • Effects of CPG ODN on biological behavior of PANC-1 and expression of TLR9 in pancreatic cancer
    • [PMID: 21448350 DOI: 10.3748/wjg.v17.i8.996]
    • Wu HQ, Wang B, Zhu SK, Tian Y, Zhang JH, Wu HS. Effects of CPG ODN on biological behavior of PANC-1 and expression of TLR9 in pancreatic cancer. World J Gastroenterol 2011; 17: 996-1003 [PMID: 21448350 DOI: 10.3748/wjg.v17.i8.996]
    • (2011) World J Gastroenterol , vol.17 , pp. 996-1003
    • Wu, H.Q.1    Wang, B.2    Zhu, S.K.3    Tian, Y.4    Zhang, J.H.5    Wu, H.S.6
  • 81
    • 84876807399 scopus 로고    scopus 로고
    • Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma
    • [PMID: 23622132 DOI: 10.1053/j.gastro.2012.12.042]
    • Zheng L, Xue J, Jaffee EM, Habtezion A. Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma. Gastroenterology 2013; 144: 1230-1240 [PMID: 23622132 DOI: 10.1053/j.gastro.2012.12.042]
    • (2013) Gastroenterology , vol.144 , pp. 1230-1240
    • Zheng, L.1    Xue, J.2    Jaffee, E.M.3    Habtezion, A.4
  • 82
    • 0023967438 scopus 로고
    • Regional chemotherapy for colorectal cancer metastatic to the liver
    • [PMID: 3079322 DOI: 10.1158/1078-0432. CCR-10-3074]
    • Venook AP, Stagg RJ, Lewis BJ. Regional chemotherapy for colorectal cancer metastatic to the liver. Oncology (Williston Park) 1988; 2: 19-26 [PMID: 3079322 DOI: 10.1158/1078-0432. CCR-10-3074]
    • (1988) Oncology (Williston Park) , vol.2 , pp. 19-26
    • Venook, A.P.1    Stagg, R.J.2    Lewis, B.J.3
  • 83
    • 84884555918 scopus 로고    scopus 로고
    • Comparison of MUC4 expression in primary pancreatic cancer and paired lymph node metastases
    • [PMID: 24047396 DOI: 10.3109/00365521. 2013.832368]
    • Ansari D, Urey C, Gundewar C, Bauden MP, Andersson R. Comparison of MUC4 expression in primary pancreatic cancer and paired lymph node metastases. Scand J Gastroenterol 2013; 48: 1183-1187 [PMID: 24047396 DOI: 10.3109/00365521. 2013.832368]
    • (2013) Scand J Gastroenterol , vol.48 , pp. 1183-1187
    • Ansari, D.1    Urey, C.2    Gundewar, C.3    Bauden, M.P.4    Andersson, R.5
  • 84
    • 70249142891 scopus 로고    scopus 로고
    • Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model
    • [PMID: 19561111 DOI: 10.4049/jimmunol.0900736]
    • Hamzah J, Altin JG, Herringson T, Parish CR, Hämmerling GJ, O'Donoghue H, Ganss R. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J Immunol 2009; 183: 1091-1098 [PMID: 19561111 DOI: 10.4049/jimmunol.0900736]
    • (2009) J Immunol , vol.183 , pp. 1091-1098
    • Hamzah, J.1    Altin, J.G.2    Herringson, T.3    Parish, C.R.4    Hämmerling, G.J.5    O'Donoghue, H.6    Ganss, R.7
  • 85
    • 79959267977 scopus 로고    scopus 로고
    • Toll-like receptors, inflammation, metabolism and obesity
    • [PMID: 21599616 DOI: 10.3109/13813455.2011.5 62514]
    • Fresno M, Alvarez R, Cuesta N. Toll-like receptors, inflammation, metabolism and obesity. Arch Physiol Biochem 2011; 117: 151-164 [PMID: 21599616 DOI: 10.3109/13813455.2011.5 62514]
    • (2011) Arch Physiol Biochem , vol.117 , pp. 151-164
    • Fresno, M.1    Alvarez, R.2    Cuesta, N.3


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