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Volumn 12, Issue 6, 2012, Pages 467-474

Polysaccharide-K (PSK) increases p21WAF/Cip1 and promotes apoptosis in pancreatic cancer cells

Author keywords

Apoptosis; Pancreatic cancer; PSK; TLR

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; GEMCITABINE; KRESTIN; NEUTRALIZING ANTIBODY; PROTEIN BAX; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 84873085234     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2012.09.004     Document Type: Article
Times cited : (23)

References (40)
  • 1
    • 68449100485 scopus 로고    scopus 로고
    • Recent advances and developments in treatment strategies against pancreatic cancer
    • Fryer RA, Galustian C, Dalgleish AG. Recent advances and developments in treatment strategies against pancreatic cancer. Curr Clin Pharmacol 2009;4: 102-12.
    • (2009) Curr Clin Pharmacol , vol.4 , pp. 102-112
    • Fryer, R.A.1    Galustian, C.2    Dalgleish, A.G.3
  • 2
    • 68749086083 scopus 로고    scopus 로고
    • Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by ap-2alpha overexpression
    • Jonckheere N, Fauquette V, Stechly L, Saint-Laurent N, Aubert S, Susini C, et al. Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by ap-2alpha overexpression. Br J Cancer 2009;101:637-44.
    • (2009) Br J Cancer , vol.101 , pp. 637-644
    • Jonckheere, N.1    Fauquette, V.2    Stechly, L.3    Saint-Laurent, N.4    Aubert, S.5    Susini, C.6
  • 3
    • 34547445606 scopus 로고    scopus 로고
    • Cytotoxic therapy for advanced pancreatic adenocarcinoma
    • O'Reilly EM, Abou-Alfa GK. Cytotoxic therapy for advanced pancreatic adenocarcinoma. Semin Oncol 2007;34:347-53.
    • (2007) Semin Oncol , vol.34 , pp. 347-353
    • O'Reilly, E.M.1    Abou-Alfa, G.K.2
  • 5
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N Engl J Med 2010;362:1605-17.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 6
    • 0032508952 scopus 로고    scopus 로고
    • Trends in alternative medicine use in the united states, 1990-1997: Results of a follow-up national survey
    • Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, et al. Trends in alternative medicine use in the united states, 1990-1997: results of a follow-up national survey. J Am Med Assoc 1998;280:1569-75.
    • (1998) J Am Med Assoc , vol.280 , pp. 1569-1575
    • Eisenberg, D.M.1    Davis, R.B.2    Ettner, S.L.3    Appel, S.4    Wilkey, S.5    Van Rompay, M.6
  • 7
    • 0033918159 scopus 로고    scopus 로고
    • Complementary/ alternative medicine use in a comprehensive cancer center and the implications for oncology
    • Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE. Complementary/ alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol 2000;18:2505-14.
    • (2000) J Clin Oncol , vol.18 , pp. 2505-2514
    • Richardson, M.A.1    Sanders, T.2    Palmer, J.L.3    Greisinger, A.4    Singletary, S.E.5
  • 9
    • 0036327261 scopus 로고    scopus 로고
    • Anticancer effects andmechanisms of polysaccharide-k (psk): Implications of cancer immunotherapy
    • Fisher M, Yang LX. Anticancer effects andmechanisms of polysaccharide-k (psk): implications of cancer immunotherapy. Anticancer Res 2002;22:1737-54.
    • (2002) Anticancer Res , vol.22 , pp. 1737-1754
    • Fisher, M.1    Yang, L.X.2
  • 10
    • 11144356502 scopus 로고    scopus 로고
    • Adjuvant immunochemotherapy with oral tegafur/uracil plus psk in patients with stage ii or iii colorectal cancer: A randomised controlled study
    • Ohwada S, Ikeya T, Yokomori T, Kusaba T, Roppongi T, Takahashi T, et al. Adjuvant immunochemotherapy with oral tegafur/uracil plus psk in patients with stage ii or iii colorectal cancer: a randomised controlled study. Br J Cancer 2004;90:1003-10.
    • (2004) Br J Cancer , vol.90 , pp. 1003-1010
    • Ohwada, S.1    Ikeya, T.2    Yokomori, T.3    Kusaba, T.4    Roppongi, T.5    Takahashi, T.6
  • 11
    • 34248402493 scopus 로고    scopus 로고
    • Efficacy of adjuvant immunochemotherapy with polysaccharide k for patients with curative resections of gastric cancer
    • Oba K, Teramukai S, Kobayashi M, Matsui T, Kodera Y, Sakamoto J. Efficacy of adjuvant immunochemotherapy with polysaccharide k for patients with curative resections of gastric cancer. Cancer Immunol Immunother 2007;56: 905-11.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 905-911
    • Oba, K.1    Teramukai, S.2    Kobayashi, M.3    Matsui, T.4    Kodera, Y.5    Sakamoto, J.6
  • 12
    • 0030796940 scopus 로고    scopus 로고
    • Effect of krestin as adjuvant treatment following radical radiotherapy in nonsmall cell lung cancer patients
    • Hayakawa K, Mitsuhashi N, Saito Y, Nakayama Y, Furuta M, Nakamoto S, et al. Effect of krestin as adjuvant treatment following radical radiotherapy in nonsmall cell lung cancer patients. Cancer Detect Prev 1997;21:71-7.
    • (1997) Cancer Detect Prev , vol.21 , pp. 71-77
    • Hayakawa, K.1    Mitsuhashi, N.2    Saito, Y.3    Nakayama, Y.4    Furuta, M.5    Nakamoto, S.6
  • 13
    • 37249013214 scopus 로고    scopus 로고
    • Bethesda (MD): U.S. National Institutes of Health, 19 Oct 2011
    • ClinicalTrials.gov. Bethesda (MD): U.S. National Institutes of Health. Available from: http://www.clinicaltrials.gov/ct2/results?Term~psk+and+cancer; 19 Oct 2011.
    • ClinicalTrials.gov
  • 14
    • 13544264408 scopus 로고    scopus 로고
    • Psk and trx80 inhibit b-cell growth in ebv-infected cord blood mononuclear cells through t cells activated by the monocyte products il-15 and il-12
    • Liu A, Arbiser JL, Holmgren A, Klein G, Klein E. Psk and trx80 inhibit b-cell growth in ebv-infected cord blood mononuclear cells through t cells activated by the monocyte products il-15 and il-12. Blood 2005;105:1606-13.
    • (2005) Blood , vol.105 , pp. 1606-1613
    • Liu, A.1    Arbiser, J.L.2    Holmgren, A.3    Klein, G.4    Klein, E.5
  • 15
    • 0036617275 scopus 로고    scopus 로고
    • Psk, a protein-bound polysaccharide, overcomes defective maturation of dendritic cells exposed to tumor-derived factors in vitro
    • Okuzawa M, Shinohara H, Kobayashi T, Iwamoto M, Toyoda M, Tanigawa N. Psk, a protein-bound polysaccharide, overcomes defective maturation of dendritic cells exposed to tumor-derived factors in vitro. Int J Oncol 2002;20: 1189-95.
    • (2002) Int J Oncol , vol.20 , pp. 1189-1195
    • Okuzawa, M.1    Shinohara, H.2    Kobayashi, T.3    Iwamoto, M.4    Toyoda, M.5    Tanigawa, N.6
  • 16
    • 78751474671 scopus 로고    scopus 로고
    • Polysaccharide krestin is a novel tlr2 agonist that mediates inhibition of tumor growth via stimulation of cd8 t cells and nk cells
    • Lu H, Yang Y, Gad E, Wenner CA, Chang A, Larson ER, et al. Polysaccharide krestin is a novel tlr2 agonist that mediates inhibition of tumor growth via stimulation of cd8 t cells and nk cells. Clin Cancer Res 2011;17:67-76.
    • (2011) Clin Cancer Res , vol.17 , pp. 67-76
    • Lu, H.1    Yang, Y.2    Gad, E.3    Wenner, C.A.4    Chang, A.5    Larson, E.R.6
  • 17
    • 80455144500 scopus 로고    scopus 로고
    • Tlr2 agonist psk activates human nk cells and enhances the anti-tumor effect of her2-targeted monoclonal antibody therapy
    • Lu H, Yang Y, Gad E, Inatsuka C, Wenner CA, Disis ML, et al. Tlr2 agonist psk activates human nk cells and enhances the anti-tumor effect of her2-targeted monoclonal antibody therapy. Clin Cancer Res 2011;17:6742-53.
    • (2011) Clin Cancer Res , vol.17 , pp. 6742-6753
    • Lu, H.1    Yang, Y.2    Gad, E.3    Inatsuka, C.4    Wenner, C.A.5    Disis, M.L.6
  • 18
    • 50649117322 scopus 로고    scopus 로고
    • Protein-bound polysaccharide k augments il-2 production from murine mesenteric lymph node cd4+ t cells by modulating t cell receptor signaling
    • Asai H, Iijima H, Matsunaga K, Oguchi Y, Katsuno H, Maeda K. Protein-bound polysaccharide k augments il-2 production from murine mesenteric lymph node cd4+ t cells by modulating t cell receptor signaling. Cancer Immunol Immunother 2008;57:1647-55.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1647-1655
    • Asai, H.1    Iijima, H.2    Matsunaga, K.3    Oguchi, Y.4    Katsuno, H.5    Maeda, K.6
  • 19
    • 77956707353 scopus 로고    scopus 로고
    • Role for toll-like receptor 4 in tnf-alpha secretion by murine macrophages in response to polysaccharide krestin, a trametes versicolor mushroom extract
    • Price LA, Wenner CA, Sloper DT, Slaton JW, Novack JP. Role for toll-like receptor 4 in tnf-alpha secretion by murine macrophages in response to polysaccharide krestin, a trametes versicolor mushroom extract. Fitoterapia 2010;81:914-9.
    • (2010) Fitoterapia , vol.81 , pp. 914-919
    • Price, L.A.1    Wenner, C.A.2    Sloper, D.T.3    Slaton, J.W.4    Novack, J.P.5
  • 20
    • 51349116472 scopus 로고    scopus 로고
    • Immunochemotherapy with psk and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer
    • Sakai T, Yamashita Y, Maekawa T, Mikami K, Hoshino S, Shirakusa T. Immunochemotherapy with psk and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer. Cancer Biother Radiopharm 2008;23:461-7.
    • (2008) Cancer Biother Radiopharm , vol.23 , pp. 461-467
    • Sakai, T.1    Yamashita, Y.2    Maekawa, T.3    Mikami, K.4    Hoshino, S.5    Shirakusa, T.6
  • 21
    • 33750122077 scopus 로고    scopus 로고
    • A randomized phase iii trial of postoperative adjuvant therapy with s-1 alone versus s-1 plus psk for stage ii/iiia gastric cancer: Hokuriku-kinki immunochemo- therapy study group-gastric cancer (hkit-gc)
    • Ueda Y, Fujimura T, Kinami S, Hirono Y, Yamaguchi A, Naitoh H, et al. A randomized phase iii trial of postoperative adjuvant therapy with s-1 alone versus s-1 plus psk for stage ii/iiia gastric cancer: Hokuriku-kinki immunochemo- therapy study group-gastric cancer (hkit-gc). Jpn J Clin Oncol 2006; 36:519-22.
    • (2006) Jpn J Clin Oncol , vol.36 , pp. 519-522
    • Ueda, Y.1    Fujimura, T.2    Kinami, S.3    Hirono, Y.4    Yamaguchi, A.5    Naitoh, H.6
  • 22
    • 44049107491 scopus 로고    scopus 로고
    • The immunomodulator psk induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis
    • Jimenez-Medina E, Berruguilla E, Romero I, Algarra I, Collado A, Garrido F, et al. The immunomodulator psk induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer 2008; 8:78.
    • (2008) BMC Cancer , vol.8 , pp. 78
    • Jimenez-Medina, E.1    Berruguilla, E.2    Romero, I.3    Algarra, I.4    Collado, A.5    Garrido, F.6
  • 23
    • 0034955586 scopus 로고    scopus 로고
    • Protein-bound polysaccharide psk inhibits tumor invasiveness by downregulation of tgf-beta1 and mmps
    • Zhang H, Morisaki T, Matsunaga H, Sato N, Uchiyama A, Hashizume K, et al. Protein-bound polysaccharide psk inhibits tumor invasiveness by downregulation of tgf-beta1 and mmps. Clin Exp Metastasis 2000;18:343-52.
    • (2000) Clin Exp Metastasis , vol.18 , pp. 343-352
    • Zhang, H.1    Morisaki, T.2    Matsunaga, H.3    Sato, N.4    Uchiyama, A.5    Hashizume, K.6
  • 24
    • 79955795151 scopus 로고    scopus 로고
    • Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
    • Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM, et al. Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 2011;145:571-83.
    • (2011) Cell , vol.145 , pp. 571-583
    • Brady, C.A.1    Jiang, D.2    Mello, S.S.3    Johnson, T.M.4    Jarvis, L.A.5    Kozak, M.M.6
  • 25
    • 0032544268 scopus 로고    scopus 로고
    • Apoptotic pathways: The roads to ruin
    • Green DR. Apoptotic pathways: the roads to ruin. Cell 1998;94:695-8.
    • (1998) Cell , vol.94 , pp. 695-698
    • Green, D.R.1
  • 26
    • 33745077384 scopus 로고    scopus 로고
    • Immunobiology of toll-like receptors: Emerging trends
    • Pandey S, Agrawal DK. Immunobiology of toll-like receptors: emerging trends. Immunol Cell Biol 2006;84:333-41.
    • (2006) Immunol Cell Biol , vol.84 , pp. 333-341
    • Pandey, S.1    Agrawal, D.K.2
  • 27
    • 77954259621 scopus 로고    scopus 로고
    • Expression and significance of tlr4 and hif-1alpha in pancreatic ductal adenocarcinoma
    • Zhang JJ, Wu HS, Wang L, Tian Y, Zhang JH, Wu HL. Expression and significance of tlr4 and hif-1alpha in pancreatic ductal adenocarcinoma. World J Gastroenterol 2010;16:2881-8.
    • (2010) World J Gastroenterol , vol.16 , pp. 2881-2888
    • Zhang, J.J.1    Wu, H.S.2    Wang, L.3    Tian, Y.4    Zhang, J.H.5    Wu, H.L.6
  • 28
    • 77954214387 scopus 로고    scopus 로고
    • Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray
    • Morse DL, Balagurunathan Y, Hostetter G, Trissal M, Tafreshi NK, Burke N, et al. Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochem Pharmacol 2010;80: 748-54.
    • (2010) Biochem Pharmacol , vol.80 , pp. 748-754
    • Morse, D.L.1    Balagurunathan, Y.2    Hostetter, G.3    Trissal, M.4    Tafreshi, N.K.5    Burke, N.6
  • 31
    • 0030859290 scopus 로고    scopus 로고
    • Activation of the receptor for advanced glycation end products triggers a p21(ras)- dependent mitogen-activated protein kinase pathway regulated by oxidant stress
    • Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. Activation of the receptor for advanced glycation end products triggers a p21(ras)- dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem 1997;272:17810-4.
    • (1997) J Biol Chem , vol.272 , pp. 17810-17814
    • Lander, H.M.1    Tauras, J.M.2    Ogiste, J.S.3    Hori, O.4    Moss, R.A.5    Schmidt, A.M.6
  • 32
    • 79953154967 scopus 로고    scopus 로고
    • Cd40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, et al. Cd40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011;331:1612-6.
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3    Saboury, B.4    Teitelbaum, U.R.5    Sun, W.6
  • 33
    • 79958776238 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer: Old drugs, new paradigms
    • Conroy T, Gavoille C, Adenis A. Metastatic pancreatic cancer: old drugs, new paradigms. Curr Opin Oncol 2011;23:390-5.
    • (2011) Curr Opin Oncol , vol.23 , pp. 390-395
    • Conroy, T.1    Gavoille, C.2    Adenis, A.3
  • 34
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, Padhye S, et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res 2009;69:5575-83.
    • (2009) Cancer Res , vol.69 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3    Kong, D.4    Mohammad, M.5    Padhye, S.6
  • 35
    • 25444493107 scopus 로고    scopus 로고
    • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    • Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ, et al. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 2005; 65:9064-72.
    • (2005) Cancer Res , vol.65 , pp. 9064-9072
    • Banerjee, S.1    Zhang, Y.2    Ali, S.3    Bhuiyan, M.4    Wang, Z.5    Chiao, P.J.6
  • 36
    • 84866742346 scopus 로고    scopus 로고
    • A phase ii randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma
    • Ko AH, Youssoufian H, Gurtler J, Dicke K, Kayaleh O, Lenz HJ, et al. A phase ii randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma. Invest New Drugs 2012;30:1597-606.
    • (2012) Invest New Drugs , vol.30 , pp. 1597-1606
    • Ko, A.H.1    Youssoufian, H.2    Gurtler, J.3    Dicke, K.4    Kayaleh, O.5    Lenz, H.J.6
  • 37
    • 0037960266 scopus 로고    scopus 로고
    • Pskmediated nf-kappab inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells nor-p1
    • Zhang H, Morisaki T, Nakahara C, Matsunaga H, Sato N, Nagumo F, et al. Pskmediated nf-kappab inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells nor-p1. Oncogene 2003;22:2088-96.
    • (2003) Oncogene , vol.22 , pp. 2088-2096
    • Zhang, H.1    Morisaki, T.2    Nakahara, C.3    Matsunaga, H.4    Sato, N.5    Nagumo, F.6
  • 39
    • 59849115856 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
    • Farrell JJ, Elsaleh H, Garcia M, Lai R, Ammar A, Regine WF, et al. Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2009;136:187-95.
    • (2009) Gastroenterology , vol.136 , pp. 187-195
    • Farrell, J.J.1    Elsaleh, H.2    Garcia, M.3    Lai, R.4    Ammar, A.5    Regine, W.F.6
  • 40
    • 0026515888 scopus 로고
    • Activation of human natural killer cells by the protein-bound polysaccharide psk independently of interferon and interleukin 2
    • Kariya Y, Inoue N, Kihara T, Okamoto N, Sugie K, Mori T, et al. Activation of human natural killer cells by the protein-bound polysaccharide psk independently of interferon and interleukin 2. Immunol Lett 1992;31: 241-5.
    • (1992) Immunol Lett , vol.31 , pp. 241-245
    • Kariya, Y.1    Inoue, N.2    Kihara, T.3    Okamoto, N.4    Sugie, K.5    Mori, T.6


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