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Volumn 303, Issue , 2013, Pages 139-146

Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis

Author keywords

Epithelial to mesenchymal transition (EMT); Invasion and metastasis; Lung cancer; Resveratrol; TGF 1

Indexed keywords

BIOLOGICAL MARKER; FIBRONECTIN; RESVERATROL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAI1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 84870899757     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.09.017     Document Type: Article
Times cited : (152)

References (52)
  • 2
    • 79959863770 scopus 로고    scopus 로고
    • TGFβ/TNFα-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype
    • Asiedu M.K., Ingle J.N., Behrens M.D., Radisky D.C., Knutson K.L. TGFβ/TNFα-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res. 2011, 71:4707-4719.
    • (2011) Cancer Res. , vol.71 , pp. 4707-4719
    • Asiedu, M.K.1    Ingle, J.N.2    Behrens, M.D.3    Radisky, D.C.4    Knutson, K.L.5
  • 3
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5:493-506.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 4
    • 77954848597 scopus 로고    scopus 로고
    • Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds
    • Bisht K., Wagner K.H., Bulmer A.C. Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds. Toxicology 2010, 278:88-100.
    • (2010) Toxicology , vol.278 , pp. 88-100
    • Bisht, K.1    Wagner, K.H.2    Bulmer, A.C.3
  • 6
    • 77954760921 scopus 로고    scopus 로고
    • Epidermal growth factor-induced epithelial-mesenchymal transition in human esophageal carcinoma cells-a model for the study of metastasis
    • Cai Z., Wang Q., Zhou Y., Zheng L., Chiu J.F., He Q.Y. Epidermal growth factor-induced epithelial-mesenchymal transition in human esophageal carcinoma cells-a model for the study of metastasis. Cancer Lett. 2010, 296:88-95.
    • (2010) Cancer Lett. , vol.296 , pp. 88-95
    • Cai, Z.1    Wang, Q.2    Zhou, Y.3    Zheng, L.4    Chiu, J.F.5    He, Q.Y.6
  • 10
    • 77954372059 scopus 로고    scopus 로고
    • Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms
    • Copple B.L. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010, 30:669-682.
    • (2010) Liver Int. , vol.30 , pp. 669-682
    • Copple, B.L.1
  • 12
    • 67349234999 scopus 로고    scopus 로고
    • Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    • Danz E.D., Skramsted J., Henry N., Bennett J.A., Keller R.S. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic. Biol. Med. 2009, 46:1589-1597.
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 1589-1597
    • Danz, E.D.1    Skramsted, J.2    Henry, N.3    Bennett, J.A.4    Keller, R.S.5
  • 13
    • 84857147817 scopus 로고    scopus 로고
    • Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
    • Du R., Sun W., Xia L., Zhao A., Yu Y., Zhao L., Wang H., Huang C., Sun S. Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS ONE 2012, 7:e30771.
    • (2012) PLoS ONE , vol.7
    • Du, R.1    Sun, W.2    Xia, L.3    Zhao, A.4    Yu, Y.5    Zhao, L.6    Wang, H.7    Huang, C.8    Sun, S.9
  • 14
    • 79960952144 scopus 로고    scopus 로고
    • IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    • Fernando R.I., Castillo M.D., Litzinger M., Hamilton D.H., Palena C. IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res. 2011, 71:5296-5306.
    • (2011) Cancer Res. , vol.71 , pp. 5296-5306
    • Fernando, R.I.1    Castillo, M.D.2    Litzinger, M.3    Hamilton, D.H.4    Palena, C.5
  • 15
    • 44949129961 scopus 로고    scopus 로고
    • Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol
    • Floyd Z.E., Wang Z.Q., Kilroy G., Cefalu W.T. Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. Metabolism 2008, 57:S32-S38.
    • (2008) Metabolism , vol.57
    • Floyd, Z.E.1    Wang, Z.Q.2    Kilroy, G.3    Cefalu, W.T.4
  • 17
    • 77449108417 scopus 로고    scopus 로고
    • VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop
    • Gonzalez-Moreno O., Lecanda J., Green J.E., Segura V., Catena R., Serrano D., Calvo A. VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop. Exp. Cell Res. 2010, 316:554-567.
    • (2010) Exp. Cell Res. , vol.316 , pp. 554-567
    • Gonzalez-Moreno, O.1    Lecanda, J.2    Green, J.E.3    Segura, V.4    Catena, R.5    Serrano, D.6    Calvo, A.7
  • 18
    • 77952896646 scopus 로고    scopus 로고
    • TGFβ signalling: a complex web in cancer progression
    • Ikushima H., Miyazono K. TGFβ signalling: a complex web in cancer progression. Nat. Rev. Cancer 2010, 10:415-424.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 20
    • 79960262017 scopus 로고    scopus 로고
    • Resveratrol impairs the release of steroid-resistant cytokines from bacterial endotoxin-exposed alveolar macrophages in chronic obstructive pulmonary disease
    • Knobloch J., Hag H., Jungck D., Urban K., Koch A. Resveratrol impairs the release of steroid-resistant cytokines from bacterial endotoxin-exposed alveolar macrophages in chronic obstructive pulmonary disease. Basic Clin. Pharmacol. Toxicol. 2011, 109:138-143.
    • (2011) Basic Clin. Pharmacol. Toxicol. , vol.109 , pp. 138-143
    • Knobloch, J.1    Hag, H.2    Jungck, D.3    Urban, K.4    Koch, A.5
  • 21
    • 48649098427 scopus 로고    scopus 로고
    • Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells
    • Kong D., Wang Z., Sarkar S.H., Li Y., Banerjee S., Saliganan A., Kim H.R., Cher M.L., Sarkar F.H. Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells. Stem Cells 2008, 26:1425-1435.
    • (2008) Stem Cells , vol.26 , pp. 1425-1435
    • Kong, D.1    Wang, Z.2    Sarkar, S.H.3    Li, Y.4    Banerjee, S.5    Saliganan, A.6    Kim, H.R.7    Cher, M.L.8    Sarkar, F.H.9
  • 22
    • 51349132313 scopus 로고    scopus 로고
    • Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives
    • Kundu J.K., Surh Y.J. Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett. 2008, 269:243-261.
    • (2008) Cancer Lett. , vol.269 , pp. 243-261
    • Kundu, J.K.1    Surh, Y.J.2
  • 24
    • 77956531086 scopus 로고    scopus 로고
    • Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3
    • Li J., Qu X., Ricardo S.D., Bertram J.F., Nikolic-Paterson D.J. Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3. Am. J. Pathol. 2010, 177:1065-1071.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1065-1071
    • Li, J.1    Qu, X.2    Ricardo, S.D.3    Bertram, J.F.4    Nikolic-Paterson, D.J.5
  • 25
    • 34447273318 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo
    • Li T., Fan G.X., Wang W., Li T., Yuan Y.K. Resveratrol induces apoptosis influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo. Int. Immunopharmacol. 2007, 7:1221-1231.
    • (2007) Int. Immunopharmacol. , vol.7 , pp. 1221-1231
    • Li, T.1    Fan, G.X.2    Wang, W.3    Li, T.4    Yuan, Y.K.5
  • 26
    • 77957590701 scopus 로고    scopus 로고
    • Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinases
    • Liu P.L., Tsai J.R., Charles A.L., Hwang J.J., Chou S.H., Ping Y.H., Lin F.Y., Chen Y.L., Hung C.Y., Chen W.C., Chen Y.H., Chong I.W. Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinases. Mol. Nutr. Food Res. 2010, 54(Suppl. 2):S196-S204.
    • (2010) Mol. Nutr. Food Res. , vol.54 , Issue.SUPPL. 2
    • Liu, P.L.1    Tsai, J.R.2    Charles, A.L.3    Hwang, J.J.4    Chou, S.H.5    Ping, Y.H.6    Lin, F.Y.7    Chen, Y.L.8    Hung, C.Y.9    Chen, W.C.10    Chen, Y.H.11    Chong, I.W.12
  • 28
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L., Teruya-Feldstein J., Weinberg R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449:682-688.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 30
    • 33745273633 scopus 로고    scopus 로고
    • Resveratrol suppresses tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells
    • Moon S.O., Kim W., Sung M.J., Lee S., Kang K.P., Kim D.H., Lee S.Y., So J.N., Park S.K. Resveratrol suppresses tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells. Mol. Pharmacol. 2006, 70:112-119.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 112-119
    • Moon, S.O.1    Kim, W.2    Sung, M.J.3    Lee, S.4    Kang, K.P.5    Kim, D.H.6    Lee, S.Y.7    So, J.N.8    Park, S.K.9
  • 32
    • 38649122031 scopus 로고    scopus 로고
    • Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro
    • Olas B., Wachowicz B., Tomczak A., Erler J., Stochmal A., Oleszek W. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets 2008, 19:70-77.
    • (2008) Platelets , vol.19 , pp. 70-77
    • Olas, B.1    Wachowicz, B.2    Tomczak, A.3    Erler, J.4    Stochmal, A.5    Oleszek, W.6
  • 33
    • 34347330516 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells
    • Onoue T., Uchida D., Begum N.M., Tomizuka Y., Yoshida H., Sato M. Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells. Int. J. Oncol. 2006, 29:1133-1138.
    • (2006) Int. J. Oncol. , vol.29 , pp. 1133-1138
    • Onoue, T.1    Uchida, D.2    Begum, N.M.3    Tomizuka, Y.4    Yoshida, H.5    Sato, M.6
  • 35
    • 67349150481 scopus 로고    scopus 로고
    • Inhibition of suicidal erythrocyte death by resveratrol
    • Qadri S.M., Föller M., Lang F. Inhibition of suicidal erythrocyte death by resveratrol. Life Sci. 2009, 85:33-38.
    • (2009) Life Sci. , vol.85 , pp. 33-38
    • Qadri, S.M.1    Föller, M.2    Lang, F.3
  • 38
    • 32844461956 scopus 로고    scopus 로고
    • Resveratrol downregulates the constitutional activation of nuclear factor-κB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle and induction of apoptosis
    • Sun C., Hu Y., Liu X., Wu T., Wang Y., He W., Wei W. Resveratrol downregulates the constitutional activation of nuclear factor-κB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle and induction of apoptosis. Cancer Genet. Cytogenet. 2006, 165:9-19.
    • (2006) Cancer Genet. Cytogenet. , vol.165 , pp. 9-19
    • Sun, C.1    Hu, Y.2    Liu, X.3    Wu, T.4    Wang, Y.5    He, W.6    Wei, W.7
  • 39
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 40
  • 43
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: mechanisms markers and strategies to overcome drug resistance in the clinic
    • Voulgari A., Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms markers and strategies to overcome drug resistance in the clinic. Biochim. Biophys. Acta 2009, 1796:75-90.
    • (2009) Biochim. Biophys. Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 45
    • 84055207487 scopus 로고    scopus 로고
    • IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway
    • Yadav A., Kumar B., Datta J., Teknos T.N., Kumar P. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway. Mol. Cancer Res. 2011, 9:1658-1667.
    • (2011) Mol. Cancer Res. , vol.9 , pp. 1658-1667
    • Yadav, A.1    Kumar, B.2    Datta, J.3    Teknos, T.N.4    Kumar, P.5
  • 46
    • 62749173154 scopus 로고    scopus 로고
    • Resveratrol analog-3,5,4'-trimethoxy-trans-stilbene inhibits invasion of human lung adenocarcinoma cells by suppressing the MAPK pathway and decreasing matrix metalloproteinase-2 expression
    • Yang Y.T., Weng C.J., Ho C.T., Yen G.C. Resveratrol analog-3,5,4'-trimethoxy-trans-stilbene inhibits invasion of human lung adenocarcinoma cells by suppressing the MAPK pathway and decreasing matrix metalloproteinase-2 expression. Mol. Nutr. Food Res. 2009, 53:407-416.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 407-416
    • Yang, Y.T.1    Weng, C.J.2    Ho, C.T.3    Yen, G.C.4
  • 48
    • 84862781190 scopus 로고    scopus 로고
    • Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation
    • Zhang H., Liu H., Borok Z., Davies K.J., Ursini F., Forman H.J. Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic. Biol. Med. 2012, 52:1437-1442.
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 1437-1442
    • Zhang, H.1    Liu, H.2    Borok, Z.3    Davies, K.J.4    Ursini, F.5    Forman, H.J.6
  • 50
    • 27644508837 scopus 로고    scopus 로고
    • Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
    • Zhang Q., Tang X., Lu Q.Y., Zhang Z.F., Brown J., Le A.D. Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Mol. Cancer Ther. 2005, 4:1465-1474.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1465-1474
    • Zhang, Q.1    Tang, X.2    Lu, Q.Y.3    Zhang, Z.F.4    Brown, J.5    Le, A.D.6
  • 51
    • 84857395835 scopus 로고    scopus 로고
    • Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells
    • Zhong L.M., Zong Y., Sun L., Guo J.Z., Zhang W., He Y., Song R., Wang W.M., Xiao C.J., Lu D. Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PLoS ONE 2012, 7:e32195.
    • (2012) PLoS ONE , vol.7
    • Zhong, L.M.1    Zong, Y.2    Sun, L.3    Guo, J.Z.4    Zhang, W.5    He, Y.6    Song, R.7    Wang, W.M.8    Xiao, C.J.9    Lu, D.10
  • 52
    • 80052094283 scopus 로고    scopus 로고
    • Homeostatic chemokine receptors and organ-specific metastasis
    • Zlotnik A., Burkhardt A.M., Homey B. Homeostatic chemokine receptors and organ-specific metastasis. Nat. Rev. Immunol. 2011, 11:597-606.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 597-606
    • Zlotnik, A.1    Burkhardt, A.M.2    Homey, B.3


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