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Volumn 437, Issue 4, 2013, Pages 550-556

Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression

Author keywords

Celastrol; E cadherin; EMT; Invasion; Snail

Indexed keywords

CELASTROL; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

EID: 84881544682     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.113     Document Type: Article
Times cited : (55)

References (28)
  • 1
    • 0035906987 scopus 로고    scopus 로고
    • Epithelial-mesenchymal interactions in cancer and development
    • Arias A.M. Epithelial-mesenchymal interactions in cancer and development. Cell 2001, 105:425-431.
    • (2001) Cell , vol.105 , pp. 425-431
    • Arias, A.M.1
  • 2
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    • Vleminckx K., Vakaet L., Mareel M., Fiers W., van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991, 66:107-119.
    • (1991) Cell , vol.66 , pp. 107-119
    • Vleminckx, K.1    Vakaet, L.2    Mareel, M.3    Fiers, W.4    van Roy, F.5
  • 3
    • 0028245813 scopus 로고
    • Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness
    • Birchmeier W., Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta 1994, 1198:11-26.
    • (1994) Biochim. Biophys. Acta , vol.1198 , pp. 11-26
    • Birchmeier, W.1    Behrens, J.2
  • 6
    • 58149316623 scopus 로고    scopus 로고
    • Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3
    • Medici D., Hay E.D., Olsen B.R. Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol. Biol. Cell 2008, 19:4875-4887.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4875-4887
    • Medici, D.1    Hay, E.D.2    Olsen, B.R.3
  • 8
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai H., Allen J.T., Mason R.M., Kamimura T., Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir. Res. 2005, 6:56.
    • (2005) Respir. Res. , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 9
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J., Bottinger E.P. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005, 24:5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 10
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: a complex web in cancer progression
    • Ikushima H., Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat. Rev. Cancer 2010, 10:415-424.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 11
    • 1542344495 scopus 로고    scopus 로고
    • Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules
    • Calixto J.B., Campos M.M., Otuki M.F., Santos A.R. Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med. 2004, 70:93-103.
    • (2004) Planta Med. , vol.70 , pp. 93-103
    • Calixto, J.B.1    Campos, M.M.2    Otuki, M.F.3    Santos, A.R.4
  • 12
    • 33646406554 scopus 로고    scopus 로고
    • Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine", is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    • Yang H., Chen D., Cui Q.C., Yuan X., Dou Q.P. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine", is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006, 66:4758-4765.
    • (2006) Cancer Res. , vol.66 , pp. 4758-4765
    • Yang, H.1    Chen, D.2    Cui, Q.C.3    Yuan, X.4    Dou, Q.P.5
  • 14
    • 72149125851 scopus 로고    scopus 로고
    • Characterization of celastrol to inhibit hsp90 and cdc37 interaction
    • Zhang T., Li Y., Yu Y., Zou P., Jiang Y., Sun D. Characterization of celastrol to inhibit hsp90 and cdc37 interaction. J. Biol. Chem. 2009, 284:35381-35389.
    • (2009) J. Biol. Chem. , vol.284 , pp. 35381-35389
    • Zhang, T.1    Li, Y.2    Yu, Y.3    Zou, P.4    Jiang, Y.5    Sun, D.6
  • 16
    • 33750008443 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid
    • Lee J.H., Koo T.H., Yoon H., Jung H.S., Jin H.Z., Lee K., Hong Y.S., Lee J.J. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem. Pharmacol. 2006, 72:1311-1321.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1311-1321
    • Lee, J.H.1    Koo, T.H.2    Yoon, H.3    Jung, H.S.4    Jin, H.Z.5    Lee, K.6    Hong, Y.S.7    Lee, J.J.8
  • 18
    • 78149471440 scopus 로고    scopus 로고
    • Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way
    • Zhang D., Xu L., Cao F., Wei T., Yang C., Uzan G., Peng B. Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way. Cell Stress Chaperones 2010, 15:939-946.
    • (2010) Cell Stress Chaperones , vol.15 , pp. 939-946
    • Zhang, D.1    Xu, L.2    Cao, F.3    Wei, T.4    Yang, C.5    Uzan, G.6    Peng, B.7
  • 19
    • 79953161516 scopus 로고    scopus 로고
    • Fyn mediates transforming growth factor-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells
    • Kim A.N., Jeon W.K., Lim K.H., Lee H.Y., Kim W.J., Kim B.C. Fyn mediates transforming growth factor-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells. Biochem. Biophys. Res. Commun. 2011, 407:181-184.
    • (2011) Biochem. Biophys. Res. Commun. , vol.407 , pp. 181-184
    • Kim, A.N.1    Jeon, W.K.2    Lim, K.H.3    Lee, H.Y.4    Kim, W.J.5    Kim, B.C.6
  • 21
    • 77952469124 scopus 로고    scopus 로고
    • Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells
    • Tan X., Dagher H., Hutton C.A., Bourke J.E. Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells. Respir. Res. 2010, 11:21.
    • (2010) Respir. Res. , vol.11 , pp. 21
    • Tan, X.1    Dagher, H.2    Hutton, C.A.3    Bourke, J.E.4
  • 22
    • 78651319942 scopus 로고    scopus 로고
    • Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
    • Yadav V.R., Sung B., Prasad S., Kannappan R., Cho S.G., Liu M., Chaturvedi M.M., Aggarwal B.B. Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J. Mol. Med. (Berl) 2010, 88:1243-1253.
    • (2010) J. Mol. Med. (Berl) , vol.88 , pp. 1243-1253
    • Yadav, V.R.1    Sung, B.2    Prasad, S.3    Kannappan, R.4    Cho, S.G.5    Liu, M.6    Chaturvedi, M.M.7    Aggarwal, B.B.8
  • 23
    • 77950234271 scopus 로고    scopus 로고
    • Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
    • Pang X., Yi Z., Zhang J., Lu B., Sung B., Qu W., Aggarwal B.B., Liu M. Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res. 2010, 70:1951-1959.
    • (2010) Cancer Res. , vol.70 , pp. 1951-1959
    • Pang, X.1    Yi, Z.2    Zhang, J.3    Lu, B.4    Sung, B.5    Qu, W.6    Aggarwal, B.B.7    Liu, M.8
  • 24
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2002, 2:442-454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 25
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention
    • Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J. Am. Soc. Nephrol. 2004, 15:1-12.
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 1-12
    • Liu, Y.1
  • 26
    • 0028603343 scopus 로고
    • TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors
    • Miettinen P.J., Ebner R., Lopez A.R., Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol. 1994, 127:2021-2036.
    • (1994) J. Cell Biol. , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 27
  • 28
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.