Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 14, 2010, Pages 6246-6251

  Korman, Tyler Paz ^a   Crawford, Jason M ^b   Labonte, Jason W ^b   Newman, Adam G ^b   Wong, Justin ^a   Townsend, Craig A ^b   Tsai, Shiou Chuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Biosynthesis; Fungal metabolism; Mutagenesis

Indexed keywords

AFLATOXIN B1; POLYKETIDE SYNTHASE; THIOL ESTER HYDROLASE;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CLAISEN REARRANGEMENT; CRYSTAL STRUCTURE; CYCLIZATION; HYDROLYSIS; HYDROPHOBICITY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; TOXIN SYNTHESIS;

AFLATOXINS; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; FUNGAL PROTEINS; HYDROPHOBICITY; MUTATION; POLYKETIDE SYNTHASES; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; THIOLESTER HYDROLASES;

EID: 77950901720     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0913531107     Document Type: Article

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