Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition

FASEB Journal

Volumn 28, Issue 5, 2014, Pages 2073-2087

  Xiao, Weidong ^a,b,c   Feng, Yongjia ^a,b   Holst, Jens J ^d   Hartmann, Bolette ^d   Yang, Hua ^c   Teitelbaum, Daniel H ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Epithelial barrier function; Metabotropic glutamate receptor; Proliferation; Taste receptor

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 2; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GLUCAGON LIKE PEPTIDE 2; GLUTAMATE TRANSPORTER; KAINIC ACID DERIVATIVE; MESSENGER RNA; METABOTROPIC RECEPTOR 5 ANTAGONIST; METABOTROPIC RECEPTOR ANTAGONIST; SODIUM GLUCOSE COTRANSPORTER 1; TIGHT JUNCTION PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATROPHY; CELL FUNCTION; CELL GROWTH; CELL LOSS; CELL PROLIFERATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; EPITHELIAL BARRIER FUNCTION; FOOD DEPRIVATION; GASTROINTESTINAL TRACT FUNCTION; GENE EXPRESSION; GENE MUTATION; IMMUNOFLUORESCENCE MICROSCOPY; INTESTINAL ATROPHY; INTESTINE EPITHELIUM CELL; LUMINAL NUTRIENT SENSING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ISOLATION; TASTE BUD; THERAPY EFFECT; TOTAL PARENTERAL NUTRITION; UPREGULATION; WESTERN BLOTTING;

EPITHELIAL BARRIER FUNCTION; METABOTROPIC GLUTAMATE RECEPTOR; PROLIFERATION; TASTE RECEPTOR;

ANIMAL NUTRITION SCIENCES; ANIMALS; ATROPHY; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; EPITHELIAL CELLS; EPITHELIUM; FOOD; GLUCAGON-LIKE PEPTIDE 2; GLUTAMIC ACID; INTESTINAL MUCOSA; INTESTINES; JEJUNUM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PARENTERAL NUTRITION, TOTAL; PERMEABILITY; PIPERIDINES; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THIAZOLES;

EID: 84901020488     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-238311     Document Type: Article

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