Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: A potential mechanism for the preservation of epithelial barrier function

Journal of Interferon and Cytokine Research

Volumn 30, Issue 2, 2010, Pages 67-79

  Nose, Keisuke ^a   Yang, Hua ^a,b   Sun, Xiaoyi ^a   Nose, Satoko ^a   Koga, Hiroyuki ^a   Feng, Yongjia ^a   Miyasaka, Eiichi ^a   Teitelbaum, Daniel H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLGLUTAMINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 7;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENTERIC FEEDING; EPITHELIUM CELL; LYMPHOCYTE; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOTAL PARENTERAL NUTRITION;

ANIMALS; EPITHELIAL CELLS; EPITHELIUM; GLUTAMINE; INTERFERON-GAMMA; INTERLEUKIN-10; INTESTINE, SMALL; MALE; MICE; MICE, INBRED C57BL; PARENTERAL NUTRITION, TOTAL; PERMEABILITY; PHENOTYPE; TIGHT JUNCTIONS;

MUS;

EID: 77649302757     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2009.0046     Document Type: Article

References (63)

1. Alverdy JC. 1990. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr 14(4 Suppl):109S-113S.
2. Avissar NE, Sax HC, Toia L. 2008. In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent. Dig Dis Sci 53(8):2113-2125.
3. Benmerah A, Badrichani A, Ngohou K, Mégarbané B, Bègue B, Cerf-Bensussan N. 1994. Homotypic aggregation of CD103 (alpha E beta 7)+ lymphocytes by an anti-CD103 antibody, HML-4. Eur J Immunol 24(9):2243-2249.
4. Bérard M P, Zazzo JF, Condat P, Vasson M P, Cynober L. 2000. Total par-enteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical patients hospitalized in intensive care units. Crit Care Med 28(11):3637-3644.
5. Buchman AL, Mestecky J, Moukarzel A, Ament ME. 1995. Intestinal immune function is unaffected by parenteral nutrition in man. J Am Coll Nutr 14(6):656-661.
6. Croitoru K, Ernst P. 1993. Intraepithelial lymphocyte lineage and function. The interactions between the intestinal epithelium and the intraepithelial lymphocyte. In: Kiyono H, McGhee J, eds. Mucosal immunology: intraepithelial lymphocytes. New York: Raven Press, Ltd. pp. 79-88.
7. DeWitt RC, Wu Y, Renegar KB, Kudsk KA. 1999. Glutamine-enriched total parenteral nutrition preserves respiratory immunity and improves survival to a Pseudomonas Pneumonia. J Surg Res 84(1):13-18.
8. Di Leo V, Yang PC, Berin MC, Perdue MH. 2002. Factors regulating the effect of IL-4 on intestinal epithelial barrier function. Int Arch Allergy Immunol 129(3):219-227.
9. Ding L, Li J. 2003. Effects of glutamine on intestinal permeability and bacterial translocation in TPN-rats with endotoxemia. World J Gastroenterol 9:1327-1332.
10. Ding LA, Li JS. 2003. Effects of glutamine on intestinal permeability and bacterial translocation in TPN-rats with endotoxemia. World J Gastroenterol 9(6):1327-1332.
11. Ernst PB, Petit A, Befus AD, Clark DA, Rosenthal KL, Ishizaka T, Bienenstock J. 1985. Murine intestinal intraepithelial lymphocytes II. Comparison of freshly isolated and cultured intraepi-thelial lymphocytes. Eur J Immunol 15(3):216-221.
12. Evans ME, Jones D P, Ziegler TR. 2005. Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway. Am J Physiol Gastrointest Liver Physiol 289(3):G388-G396.
13. Farr A, Nelson A, Truex J, Hosier S. 1991. Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium. J Histochem Cytochem 39(5):645-653.
14. Fujihashi K, Kawabata S, Hiroi T, Yamamoto M, McGhee JR, Nishikawa S, Kiyono H. 1996. Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes. Proc Natl Acad Sci USA 93(8):3613-3618.
15. Fujihashi K, Yamamoto M, McGhee JR, Beagley KW, Kiyono H. 1993. Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8-and CD4+CD8+ T cells for helper activity. Int Immunol 5(11):1473-1481.
16. Fukatsu K, Kudsk KA, Zarzaur BL, Wu Y, Hanna MK, DeWitt RC. 2001. TPN decreases IL-4 and IL-10 mRNA expression in lipo-polysaccharide stimulated intestinal lamina propria cells but glutamine supplementation preserves the expression. Shock 15(4):318-322.
17. Fukatsu K, Moriya T, Maeshima Y, Omata J, Yaguchi Y, Ikezawa F, Mochizuki H, Hiraide H. 2005. Exogenous interleukin 7 affects gut-associated lymphoid tissue in mice receiving total paren-teral nutrition. Shock 24(6):541-546.
18. Fukui T, Katamura K, Abe N, Kiyomasu T, Iio J, Ueno H, Mayumi M, Furusho K. 1997. IL-7 induces proliferation, variable cytokine-producing ability and IL-2 responsiveness in naive CD4+ T-cells from human cord blood. Immunol Lett 59(1):21-28.
19. Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S. 1994. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol 127(6 Pt 1):1617-1626.
20. Gianotti L, Alexander JW, Gennari R, Pyles T, Babcock GF. 1995. Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. JPEN J Parenter Enteral Nutr 19(1):69-74.
21. Grass GM, Sweetana SA. 1988. In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell. Pharm Res 5(6):372-376.
22. Hayday A, Theodorid is E, Ramsburg E, Sh ires J. 2001. Intraepithelial lymphocytes: exploring the Third Way in immunology. Nat Immunol 2(11):997-1003.
23. Helton WS. 1994. The pathophysiologic signif cance of alterations in intestinal permeability induced by total parenteral nutrition and glutamine. JPEN J Parenter Enteral Nutr 18(4):289-290.
24. Horio Y, Osawa S, Takagaki K, Hishida A, Furuta T, Ikuma M. 2008. Glutamine supplementation increases Th1-cytokine responses in murine intestinal intraepithelial lymphocytes. Cytokine 44(1):92-95.
25. Inagaki-Ohara K, Sawaguchi A, Suganuma T, Matsuzaki G, Nawa Y. 2005. Intraepithelial lymphocytes express junctional molecules in murine small intestine. Biochem Biophys Res Commun 331(4):977-983.
26. Kiristioglu I, Antony P, Fan Y, Forbush B, Mosley RL, Yang H, Teitelbaum DH. 2002. Total parenteral nutrition-associated changes in mouse intestinal intraepithelial lymphocytes. Dig Dis Sci 47(5):1147-1157.
27. Kiristioglu I, Forbush B, Teitelbaum D, Heidelberg K. 1999. Loss of enteral nutrition results in alterations in the intestinal intraepi-thelial lymphocytes. Gastroenterology 114:G4135.
28. Kiristioglu I, Teitelbaum DH. 1998. Alteration of the intestinal intra-epithelial lymphocytes during total parenteral nutrition. J Surg Res 79(2):91-96.
29. Kudsk KA, Li J, Renegar KB. 1996. Loss of upper respiratory tract immunity with parenteral feeding. Ann Surg 223(6):629-635; discussion 635.
30. Kunisawa J, Takahashi I, Okudaira A, Hiroi T, Katayama K, Ariyama T, Tsutsumi Y, Nakagawa S, Kiyono H, Mayumi T. 2002. Lack of antigen-specif c immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur J Immunol 32(8):2347-2355.
31. Li J, Gocinski B, Henken B, Kudsk K. 1995. Effects of parenteral nutrition on gut-associated lymphoid tissue. J Traum 39:44-52.
32. Li J, Langkamp-Henken B, Suzuki K, Stahlgren LH. 1994. Glutamine prevents parenteral nutrition-induced increases in intestinal permeability [see comments]. JPEN J Parenter Enteral Nutr 18:303-307.
33. Liu Y, Nusrat A, Schnell FJ, Reaves TA, Walsh S, Pochet M, Parkos CA. 2000. Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci 113 (Pt 13):2363-2374.
34. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402-408.
35. Madara JL, Trier JS. 1982. Structure and permeability of goblet cell tight junctions in rat small intestine. J Membr Biol 66(2):145-157.
36. Moore FA, Moore EE, Jones TN, McCroskey BL, Peterson VM. 1989. TEN versus TPN following major abdominal trauma - reduced septic morbidity. J Trauma 29:916-922; discussion 922-913.
37. Nagafuchi S, Totsuka M, Hachimura S, Goto M, Takahashi T, Yajima T, Kuwata T, Kaminogawa S. 2000. Dietary nucleotides increase the proportion of a TCR gammadelta+ subset of intraepithelial lymphocytes (IEL) and IL-7 production by intestinal epithelial cells (IEC); implications for modif cation of cellular and molecular cross-talk between IEL and IEC by dietary nucleotides. Biosci Biotechnol Biochem 64(7):1459-1465.
38. O'Brien DP, Nelson LA, Kemp CJ, Williams JL, Wang Q, Erwin CR, Hasselgren PO, Warner BW. 2002. Intestinal permeability and bacterial translocation are uncoupled after small bowel resection. J Pediatr Surg 37(3):390-394.
39. Planchon S, Fiocchi C, Takafuji V, Roche JK. 1999. Transforming growth factor-beta1 preserves epithelial barrier function: iden-tif cation of receptors, biochemical intermediates, and cytokine antagonists. J Cell Physiol 181(1):55-66.
40. Planchon SM, Martins CA, Guerrant RL, Roche JK. 1994. Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine. J Immunol 153(12):5730-5739.
41. Schön MP, Arya A, Murphy EA, Adams CM, Strauch UG, Agace WW, Marsal J, Donohue JP, Her H, Beier DR, Olson S, Lefrancois L, Brenner MB, Grusby MJ, Parker CM. 1999. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-def cient mice. J Immunol 162(11):6641-6649.
42. Seth A, Basuroy S, Sheth P, Rao RK. 2004. L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer. Am J Physiol Gastrointest Liver Physiol 287(3):G510-G517.
43. Singleton KD, Wischmeyer PE. 2008. Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. JPEN J Parenter Enteral Nutr 32(4):371-376.
44. Souba WW, Herskowitz K, Salloum RM, Chen MK, Austgen TR. 1990. Gut glutamine metabolism. JPEN J Parenter Enteral Nutr 14(4 Suppl):45S - 50S.
45. Sun X, Spencer AU, Yang H, Haxhija EQ, Teitelbaum DH. 2006. Impact of caloric intake on parenteral nutrition-associated intestinal morphology and mucosal barrier function. JPEN J Parenter Enteral Nutr 30(6):474-479.
46. Sun X, Yang H, Nose K, Nose S, Haxhija EQ, Koga H, Feng Y, Teitelbaum DH. 2008. Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 294(1):G139-G147.
47. van der Hulst RR, van Kreel BK, von Meyenfeldt MF, Brummer RJ, Arends JW, Deutz NE, Soeters PB. 1993. Glutamine and the preservation of gut integrity. Lancet 341(8857):1363-1365.
48. Wang F, Schwarz BT, Graham W V, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. 2006. IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 131(4):1153-1163.
49. Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, Aiso S, Hibi T, Ishii H. 1995. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest 95(6): 2945-2953.
50. Yang H, Antony PA, Wildhaber BE, Teitelbaum DH. 2004. Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratino-cyte growth factor modulates epithelial growth in the mouse. J Immunol 172(7):4151-4158.
51. Yang H, Fan Y, Teitelbaum DH. 2003a. Intraepithelial lymphocyte-derived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in mice. Am J Physiol Gastrointest Liver Physiol 284:G629-G637.
52. Yang H, Finaly R, Teitelbaum DH. 2003b. Alteration in epithelial permeability and ion transport in a mouse model of total paren-teral nutrition. Critical Care Medicine 31:1118-1125.
53. Yang H, Gumucio D, Teitelbaum D. 2008a. Intestinal specif c over-expression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after TPN administration. Ann Surg 248:849-856.
54. Yang H, Kiristioglu I, Fan Y, Forbush B, Bishop DK, Antony PA, Zhou H, Teitelbaum DH. 2002a. Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutrition. Ann Surg 236:226-234.
55. Yang H, Kiritioglu I, Forbush B, Bishiop D, Antony P, Teitelbaum D. 2002b. Total parenteral nutrition results in altered expression of cytokines in intestinal intraepithelial lymphocytes and a loss of epithelial barrier function in the mouse. Ann Surg 236: 226-234.
56. Yang H, Madison B, Gumucio D, Teitelbaum D. 2008b. Specif c overexpression of IL-7 in the intestinal mucosa: the role in intestinal intraepithelial lymphocyte development. Am J Physiol Gastrointest Liver Physiol 294:G1421-G1430.
57. Yang H, Spencer AU, Teitelbaum DH. 2005. Interleukin-7 administration alters intestinal intraepithelial lymphocyte phenotype and function in vivo. Cytokine 31(6):419-428.
58. Yang H, Sun X, Haxhija EQ, Teitelbaum DH. 2007. Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 292(1):G84-G91.
59. Yang H, Tazuke Y, Ko K, Teitelbaum D. 2003c. TPN administration alters intestinal epithelial cell derived IL-7: Potential mechanism for alteration in intraepithelial lymphocyte changes. JPEN 27:S6.
60. Yang H, Fan Y, Teitelbaum DH. 2003. Intraepithelial lymphocyte-derived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in mice. Am J Physiol Gastrointest Liver Physiol 284(4):G629-G637.
61. Zarzaur BL, Ikeda S, Johnson CD, Le T, Sacks G, Kudsk KA. 2002. Mucosal immunity preservation with bombesin or glutamine is not dependent on mucosal addressin cell adhesion molecule-1 expression. JPEN J Parenter Enteral Nutr 26(5):265-70; discussion 270.
62. Zhang SC, Wang W, Ren WY, He BM, Zhou K, Zhu WN. 2003. Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis. World J Gastroenterol 9(3):534-538.
63. Ziegler TR, Bazargan N, Leader LM, Martindale RG. 2000. Glutamine and the gastrointestinal tract. Curr Opin Clin Nutr Metab Care 3(5):355-362.