Sublytic C5b-9 triggers glomerular mesangial cell apoptosis via XAF1 gene activation mediated by p300-dependent IRF-1 acetylation

Cell Death and Disease

Volumn 5, Issue 4, 2014, Pages

  Qiu, W ^a   Zhou, J ^a   Zhu, G ^a   Zhao, D ^a   He, F ^a   Zhang, J ^a   Lu, Y ^a   Yu, T ^a   Liu, L ^a   Wang, Y ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Glomerular mesangial cell (GMC) apoptosis; Interferon regulatory factor 1 (IRF 1); P300; Sublytic C5b 9 complexes; Thy 1 nephritis (Thy 1N)

Indexed keywords

COMPLEMENT MEMBRANE ATTACK COMPLEX; E1A ASSOCIATED P300 PROTEIN; INTERFERON REGULATORY FACTOR 1; PROTEIN; THY 1 ANTIGEN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS ASSOCIATED FACTOR 1; EP300 PROTEIN, RAT; PROTEIN BINDING; SIGNAL PEPTIDE;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; GLOMERULUS; IN VITRO STUDY; IN VIVO STUDY; KIDNEY PARENCHYMA; MALE; MESANGIUM CELL; MOLECULAR BIOLOGY; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; URINE; XAF1 GENE; ANIMAL; CELL NUCLEUS; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TRANSCRIPTION INITIATION; ULTRASTRUCTURE;

ACETYLATION; ANIMALS; APOPTOSIS; CELL NUCLEUS; COMPLEMENT MEMBRANE ATTACK COMPLEX; E1A-ASSOCIATED P300 PROTEIN; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERFERON REGULATORY FACTOR-1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MESANGIAL CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; TRANSCRIPTIONAL ACTIVATION;

EID: 84901008781     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.153     Document Type: Article

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