Cocaine-associated retiform purpura: A C5b-9-mediated microangiopathy syndrome associated with enhanced apoptosis and high levels of intercellular adhesion molecule-1 expression

American Journal of Dermatopathology

Volumn 35, Issue 7, 2013, Pages 722-730

  Magro, Cynthia M ^a   Wang, Xuan ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; C5b 9; Cocaine; ICAM 1; Purpura

Indexed keywords

CASPASE 3; CELL ADHESION MOLECULE; COCAINE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHOSPHOLIPID ANTIBODY;

ADULT; ANEMIA; APOPTOSIS; ARTICLE; CASE REPORT; COCAINE ASSOCIATED RETIFORM PURPURA; DEPRESSION; DRUG INDUCED DISEASE; FEMALE; HEMATURIA; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LEUKOPENIA; MACROPHAGE; MICROANGIOPATHY; MICROENVIRONMENT; NECROTIZING ARTERITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; PURPURA; SEROLOGY; SKIN DISEASE; THROMBOCYTOPENIA; VASCULITIS;

ADULT; APOPTOSIS; COCAINE; COCAINE-RELATED DISORDERS; COMPLEMENT MEMBRANE ATTACK COMPLEX; DRUG CONTAMINATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; LEVAMISOLE; MIDDLE AGED; PURPURA; SYNDROME; THROMBOTIC MICROANGIOPATHIES;

EID: 84885019473     PISSN: 01931091     EISSN: 15330311     Source Type: Journal    
DOI: 10.1097/DAD.0b013e31827eaf0b     Document Type: Article

References (52)

1. Waller JM, Feramisco JD, Alberta-Wszolek L, et al. Cocaine-associated retiform purpura and neutropenia: is levamisole the culprit? J Am Acad Dermatol. 2010;63:530-535.
2. Walsh NM, Green PJ, Burlingame RW, et al. Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole. J Cutan Pathol. 2010;37:1212-1219.
3. Poon SH, Baliog CR Jr, Sams RN, et al. Syndrome of cocaine- levamisoleinduced cutaneous vasculitis and immune-mediated leukopenia. Semin Arthritis Rheum. 2011;41:434-444.
4. Graf J, Lynch K, Yeh CL, et al. Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine. Arthritis Rheum. 2011;63:3998-4001.
5. Mouzakis J, Somboonwit C, Lakshmi S, et al. Levamisole induced necrosis of the skin and neutropenia following intranasal cocaine use: a newly recognized syndrome. J Drugs Dermatol. 2011;10:1204-1207.
6. John S, Manda S, Hamrock D. Cocaine-induced thrombotic vasculopathy. Am J Med Sci. 2011;342:524-526.
7. Specks U. The growing complexity of the pathology associated with cocaine use. J Clin Rheumatol. 2011;17:167-168.
8. Ullrich K, Koval R, Koval E, et al. Five consecutive cases of a cutaneous vasculopathy in users of levamisole-adulterated cocaine. J Clin Rheumatol. 2011;17:193-196.
9. Zwang NA, Van Wagner LB, Rose S. A case of levamisole-induced systemic vasculitis and cocaine-induced midline destructive lesion: a case report. J Clin Rheumatol. 2011;17:197-200.
10. Milman N, Smith CD. Cutaneous vasculopathy associated with cocaine use. Arthritis Care Res (Hoboken). 2011;63:1195-1202.
11. Crowson AN, Magro CM. The role of microvascular injury in the pathogenesis of cutaneous lesions of dermatomyositis. Hum Pathol. 1996;27: 15-19. (Pubitemid 26015576)
12. Hubbard AK, Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radic Biol Med. 2000;28: 1379-1386. (Pubitemid 30623498)
13. Chen Y, Ke Q, Xiao YF, et al. Cocaine and catecholamines enhance inflammatory cell retention in the coronary circulation of mice by upregulation of adhesion molecules. Am J Physiol Heart Circ Physiol. 2005; 288:H2323-H2331. (Pubitemid 40604121)
14. Gan X, Zhang L, Berger O, et al. Cocaine enhances brain endothelial adhesion molecules and leukocyte migration. Clin Immunol. 1999;91:68-76.
15. Salvesen GS. Caspases: opening the boxes and interpreting the arrows. Cell Death Differ. 2002;9:3-5. (Pubitemid 34071988)
16. Rongioletti F, Ghio L, Ginevri F, et al. Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long-term treatment with levamisole in children. Br J Dermatol. 1999;140:948-951. (Pubitemid 29238474)
17. Tanhehco EJ, Yasojima K, McGeer PL, et al. Acute cocaine exposure up-regulates complement expression in rabbit heart. J Pharmacol Exp Ther. 2000;292:201-208. (Pubitemid 30026372)
18. Locke JE, Magro CM, Singer AL, et al. The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection. Am J Transplant. 2009;9:231-235.
19. Magro CM, Poe JC, Kim C, et al. Degos disease: a C5b-9/interferonalpha- mediated endotheliopathy syndrome. Am J Clin Pathol. 2011;135: 599-610.
20. Chapin J, Weksler B, Magro C, et al. Eculizumab in the treatment of refractory idiopathic thrombotic thrombocytopenic purpura. Br J Haematol. 2012;157:772-774.
21. Kerr H, Richards A. Complement-mediated injury and protection of endothelium: lessons from atypical haemolytic uraemic syndrome. Immunobiology. 2012;217:195-203.
22. Scheiring J, Rosales A, Zimmerhackl LB. Clinical practice. Today's understanding of the haemolytic uraemic syndrome. Eur J Pediatr. 2010;169:7-13.
23. Weitz M, Amon O, Bassler D, et al. Prophylactic eculizumab prior to kidney transplantation for atypical hemolytic uremic syndrome. Pediatr Nephrol. 2011;26:1325-1329.
24. Woodruff TM, Nandakumar KS, Tedesco F. Inhibiting the C5-C5a receptor axis. Mol Immunol. 2011;48:1631-1642.
25. Qiu W, Che N, Feng X, et al. Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation. Eur J Immunol. 2009;39: 3251-3266.
26. Tegla CA, Cudrici C, Patel S, et al. Membrane attack by complement: the assembly and biology of terminal complement complexes. Immunol Res. 2011;51:45-60.
27. Rus HG, Niculescu FI, Shin ML. Role of the C5b-9 complement complex in cell cycle and apoptosis. Immunol Rev. 2001;180:49-55. (Pubitemid 32472851)
28. Hughes J, Nangaku M, Alpers CE, et al. C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. Am J Physiol Renal Physiol. 2000;278:F747-F757. (Pubitemid 30351076)
29. Soane L, Cho HJ, Niculescu F, et al. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol. 2001; 167:2305-2311. (Pubitemid 32747544)
30. Niculescu F, Niculescu T, Rus H. C5b-9 terminal complement complex assembly on apoptotic cells in human arterial wall with atherosclerosis. Exp Mol Pathol. 2004;76:17-23. (Pubitemid 38096314)
31. Paletzki RF, Myakishev MV, Polesskaya O, et al. Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience. 2008;152:1040-1053.
32. Radwanska K, Valjent E, Trzaskos J, et al. Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway. Neuroscience. 2006;137:253-264. (Pubitemid 43031492)
33. Hope BT. Cocaine and the AP-1 transcription factor complex. Ann N Y Acad Sci. 1998;844:1-6. (Pubitemid 28367790)
34. Hope BT, Nye HE, Kelz MB, et al. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron. 1994;13:1235-1244. (Pubitemid 24372141)
35. Lee YW, Hennig B, Fiala M, et al. Cocaine activates redox-regulated transcription factors and induces TNF-alpha expression in human brain endothelial cells. Brain Res. 2001;920:125-133. (Pubitemid 33086786)
36. Muriach M, Lopez-Pedrajas R, Barcia JM, et al. Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramate. J Neurochem. 2010; 114:675-684.
37. Russo SJ, Wilkinson MB, Mazei-Robison MS, et al. Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci. 2009;29:3529-3537.
38. Lepsch LB, Munhoz CD, Kawamoto EM, et al. Cocaine induces cell death and activates the transcription nuclear factor kappa-B in PC12 cells. Mol Brain. 2009;2:3.
39. Dey S, Snow DM. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through TNF-alpha-mediated induction of Bax and phosphorylated c-Jun NH(2)-terminal kinase. J Neurochem. 2007; 103:542-556. (Pubitemid 47498012)
40. Rauch J, Subang R, D'Agnillo P, et al. Apoptosis and the antiphospholipid syndrome. J Autoimmun. 2000;15:231-235.
41. Valesini G, Alessandri C. New facet of antiphospholipid antibodies. Ann N Y Acad Sci. 2005;1051:487-497. (Pubitemid 41362777)
42. Rauch J, D'Agnillo P, Subang R, et al. Anti-phospholipid antibodies (aPL) and apoptosis: prothrombin-dependent aPL as a paradigm for phospholipid- dependent interactions with apoptotic cells. Thromb Res. 2004; 114:371-382. (Pubitemid 39422569)
43. Williams EL, Endean AL, Edwards CJ. Myocardial infarction in a young man with antiphospholipid syndrome and cocaine use. Lupus. 2007;16:444-446. (Pubitemid 47122219)
44. McGrath MM, Isakova T, Rennke HG, et al. Contaminated cocaine and antineutrophil cytoplasmic antibody-associated disease. Clin J Am Soc Nephrol. 2011;6:2799-2805.
45. Peikert T, Finkielman JD, Hummel AM, et al. Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive lesions. Arthritis Rheum. 2008;58:1546-1551. (Pubitemid 351705946)
46. Kettritz R, Choi M, Salanova B, et al. Fever-like temperatures affect neutrophil NF-kappaB signaling, apoptosis, and ANCA-antigen expression. J Am Soc Nephrol. 2006;17:1345-1353. (Pubitemid 43673414)
47. Kettritz R, Scheumann J, Xu Y, et al. TNF-alpha-accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspasedependent mechanism. Kidney Int. 2002;61:502-515. (Pubitemid 34102590)
48. Moosig F, Csernok E, Kumanovics G, et al. Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha). Clin Exp Immunol. 2000;122:499-503. (Pubitemid 32002213)
49. Symoens J, Veys E, Mielants M, et al. Adverse reactions to levamisole. Cancer Treat Rep. 1978;62:1721-1730. (Pubitemid 9132928)
50. Menni S, Pistritto G, Gianotti R, et al. Ear lobe bilateral necrosis by levamisole-induced occlusive vasculitis in a pediatric patient. Pediatr Dermatol. 1997;14:477-479. (Pubitemid 28012032)
51. Thompson RA, Lee SS. Antineutrophil cytoplasmic antibodies. Lancet. 1989;1:670-671. (Pubitemid 19078809)
52. Nassberger L, Sjoholm AG, Sturfelt G. Absence of circulating antineutrophil cytoplasm antibodies (ANCA) in severe vasculitis associated with rheumatoid arthritis. Scand J Rheumatol. 1990;19:189-192. (Pubitemid 20186802)