Sublytic C5b-9 complexes induce proliferative changes of glomerular mesangial cells in rat Thy-1 nephritis through TRAF6-mediated PI3K-dependent Akt1 activation

Journal of Pathology

Volumn 226, Issue 4, 2012, Pages 619-632

  Qiu, Wen ^a   Zhang, Yan ^a   Liu, Xiaomei ^a   Zhou, Jianbo ^a   Li, Yan ^a   Zhou, Ying ^a   Shan, Kai ^a   Xia, Mei ^a   Che, Nan ^a   Feng, Xuefeng ^a   Zhao, Dan ^a   Wang, Yingwei ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

glomerular mesangial cells (GMC); PI3K Akt1; sublytic C5b 9 complexes; Thy 1 nephritis (Thy 1N); TNF receptor associated factor 6 (TRAF6); ubiquitination

Indexed keywords

BETA ACTIN; COLLAGEN TYPE 4; COMPLEMENT COMPONENT C5B; COMPLEMENT COMPONENT C9; CYCLIN D2; CYCLINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN AKT1; PROTEIN KINASE B; THY 1 ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

AKT1 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; KIDNEY PARENCHYMA; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MESANGIUM CELL; NEPHRITIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PI3K GENE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; TRAF6 GENE; UBIQUITINATION;

ANIMALS; ANTIGENS, THY-1; CELL PROLIFERATION; COMPLEMENT MEMBRANE ATTACK COMPLEX; GENE SILENCING; GLOMERULAR MESANGIUM; ISOANTIBODIES; MALE; MESANGIAL CELLS; NEPHRITIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEINURIA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITINATION;

EID: 84856709088     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.3011     Document Type: Article

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