PCAF Acetylates β-catenin and improves its stability

Molecular Biology of the Cell

Volumn 20, Issue 1, 2009, Pages 419-427

  Ge, Xinjian ^a   Jin, Qihuang ^a   Zhang, Fang ^a   Yan, Tingting ^a   Zhai, Qiwei ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; HISTONE ACETYLTRANSFERASE PCAF; LYSINE; P300-CBP-ASSOCIATED FACTOR; WNT PROTEIN;

ACETYLATION; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; UBIQUITINATION; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL MOTION; COLON TUMOR; GENETICS; MALE; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

MUS MUSCULUS;

ACETYLATION; ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; COLONIC NEOPLASMS; HUMANS; LYSINE; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; P300-CBP TRANSCRIPTION FACTORS; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; WNT PROTEINS;

EID: 63049111216     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-08-0792     Document Type: Article

References (59)

1. Abbas-Terki, T., Blanco-Bose, W., Deglon, N., Pralong, W., and Aebischer, P. (2002). Lentiviral-mediated RNA interference. Hum. Gene Ther. 13, 2197-2201.
2. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. (1997). beta-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16, 3797-3804.
3. Aleman, M. J., DeYoung, M. P., Tress, M., Keating, P., Perry, G. W., and Narayanan, R. (2005). Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. Proc. Natl. Acad. Sci. USA 102, 12765-12770.
4. Blanco, J. C., Minucci, S., Lu, J., Yang, X. J., Walker, K. K., Chen, H., Evans, R. M., Nakatani, Y., and Ozato, K. (1998). The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev. 12, 1638-1651.
5. Brunet, A. et al. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015.
6. Chao, C., Wu, Z., Mazur, S. J., Borges, H., Rossi, M., Lin, T., Wang, J. Y., Anderson, C. W., Appella, E., and Xu, Y. (2006). Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol. Cell. Biol. 26, 6859-6869.
7. Clapper, M. L., Coudry, J., and Chang, W. C. (2004). beta-Catenin- mediated signaling: a molecular target for early chemopreventive intervention. Mutat. Res. 555, 97-105.
8. Clevers, H. (2004). Wnt breakers in colon cancer. Cancer Cell 5, 5-6.
9. Clevers, H. (2006). Wnt/ β-catenin signaling in development and disease. Cell 127, 469-480.
10. Cohen, H. Y., Lavu, S., Bitterman, K. J., Hekking, B., Imahiyerobo, T. A., Miller, C., Frye, R., Ploegh, H., Kessler, B. M., and Sinclair, D. A. (2004a). Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol. Cell 13, 627-638.
11. Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., and Sinclair, D. A. (2004b). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390-392.
12. Dihlmann, S., and von Knebel Doeber, M. (2005). Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics. Int. J. Cancer 113, 515-524.
13. Doucas, H., Garcea, G., Neal, C. P., Manson, M. M., and Berry, D. P. (2005). Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance. Eur. J. Cancer 41, 365-379.
14. Dvory-Sobol, H., Sagiv, E., Kazanov, D., Ben-Ze'ev, A., and Arber, N. (2006). Targeting the active beta-catenin pathway to treat cancer cells. Mol. Cancer Ther. 5, 2861-2871.
15. Feyt, C., Kienlen-Campard, P., Leroy, K., N'Kuli, F., Courtoy, P. J., Brion, J.-P., and Octave, J.-N. (2005). Lithium chloride increases the production of amyloid-{beta} peptide independently from its inhibition of glycogen synthase kinase 3. J. Biol. Chem. 280, 33220-33227.
16. Firestein, R. et al. (2008). The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 3, e2020.
17. Fulco, M., Schiltz, R. L., Iezzi, S., King, M. T., Zhao, P., Kashiwaya, Y., Hoffman, E., Veech, R. L., and Sartorelli, V. (2003). Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12, 51-62.
18. Gay, F., Calvo, D., Lo, M.-C., Ceron, J., Maduro, M., Lin, R., and Shi, Y. (2003). Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Genes Dev. 17, 717-722.
19. Giles, R. H., van Es, J. H., and Clevers, H. (2003). Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 1653, 1-24.
20. Hecht, A., Vleminckx, K., Stemmler, M. P., van Roy, F., and Kemler, R. (2000). The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates. EMBO J. 19, 1839-1850.
21. Ionov, Y., Matsui, S., and Cowell, J. K. (2004). A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability. Proc. Natl. Acad. Sci. USA 101, 1273-1278.
22. Jia, H., Yan, T., Feng, Y., Zeng, C., Shi, X., and Zhai, Q. (2007). Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axonprotective function. Neurosci. Lett. 413, 46-51.
23. Jiang, H., Lu, H., Schiltz, R. L., Pise-Masison, C. A., Ogryzko, V. V., Nakatani, Y., and Brady, J. N. (1999). PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner. Mol. Cell. Biol. 19, 8136-8145.
24. Levy, L., Wei, Y., Labalette, C., Wu, Y., Renard, C. A., Buendia, M. A., and Neuveut, C. (2004). Acetylation of beta-catenin by p300 regulates beta-cate-nin-Tcf4 interaction. Mol. Cell. Biol. 24, 3404-3414.
25. Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G. H., Tan, Y., Zhang, Z., Lin, X., and He, X. (2002). Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847.
26. Liu, J., Stevens, J., Rote, C. A., Yost, H. J., Hu, Y., Neufeld, K. L., White, R. L., and Matsunami, N. (2001). Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol. Cell 7, 927-936.
27. Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., and Berger, S. L. (1999). p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol. Cell. Biol. 19, 1202-1209.
28. Liu, W. et al. (2000). Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling. Nat. Genet. 26, 146-147.
29. Logan, C. Y., and Nusse, R. (2004). The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781-810.
30. Martinez-Balbas, M. A., Bauer, U. M., Nielsen, S. J., Brehm, A., and Kouzarides, T. (2000). Regulation of E2F1 activity by acetylation. EMBO J. 19, 662-671.
31. Matsuzawa, S.-I., and Reed, J. C. (2001). Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses. Mol. Cell 7, 915-926.
32. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. (1997). Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275, 1787-1790.
33. Muraoka, M., Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Shitara, N., Chong, J. M., Iwama, T., and Miyaki, M. (1996). p300 gene alterations in colorectal and gastric carcinomas. Oncogene 12, 1565-1569.
34. Nelson, W. J., and Nusse, R. (2004). Convergence of Wnt, {beta}-Catenin, and Cadherin Pathways. Science 303, 1483-1487.
35. Okumura, K., Mendoza, M., Bachoo, R. M., DePinho, R. A., Cavenee, W. K., and Furnari, F. B. (2006). PCAF Modulates PTEN Activity. J. Biol. Chem. 281, 26562-26568.
36. Pan, W., Jia, Y., Wang, J., Tao, D., Gan, X., Tsiokas, L., Jing, N., Wu, D., and Li, L. (2005). Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells. Proc. Natl. Acad. Sci. USA 102, 17378-17383.
37. Patel, J. H. et al. (2004). The c-MYC Oncoprotein Is a Substrate of the Acetyl-transferases hGCN5/PCAF and TIP60. Mol. Cell. Biol. 24, 10826-10834.
38. Qian, Y., Luo, J., Leonard, S. S., Harris, G. K., Millecchia, L., Flynn, D. C., and Shi, X. (2003). Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis. J. Biol. Chem. 278, 16189-16197.
39. Reya, T., and Clevers, H. (2005). Wnt signalling in stem cells and cancer. Nature 434, 843-850.
40. Sartorelli, V., Puri, P. L., Hamamori, Y., Ogryzko, V., Chung, G., Nakatani, Y., Wang, J. Y., and Kedes, L. (1999). Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol. Cell 4, 725-734.
41. Schiltz, R. L., and Nakatani, Y. (2000). The PCAF acetylase complex as a potential tumor suppressor. Biochim. Biophys. Acta 1470, M37-M53.
42. Shibamoto, S., Higano, K., Takada, R., Ito, F., Takeichi, M., and Takada, S. (1998). Cytoskeletal reorganization by soluble Wnt-3a protein signalling. Genes Cells 3, 659-670.
43. Spilianakis, C., Papamatheakis, J., and Kretsovali, A. (2000). Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol. Cell. Biol. 20, 8489-8498.
44. Stambolic, V., Ruel, L., and Woodgett, J. R. (1996). Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr. Biol. 6, 1664-1668.
45. Sterner, D. E., and Berger, S. L. (2000). Acetylation of Histones and Transcription-Related Factors. Microbiol. Mol. Biol. Rev. 64, 435-459.
46. Stimson, L. et al. (2005). Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol. Cancer Ther. 4, 1521-1532.
47. Sun, Y., Kolligs, F. T., Hottiger, M. O., Mosavin, R., Fearon, E. R., and Nabel, G. J. (2000). Regulation of beta-catenin transformation by the p300 transcriptional coactivator. Proc. Natl. Acad. Sci. USA 97, 12613-12618.
48. Takemaru, K. I., and Moon, R. T. (2000). The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J. Cell Biol. 149, 249-254.
49. van den Brink, G. R. et al. (2004). Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat. Genet. 36, 277-282.
50. Willert, K., and Jones, K. A. (2006). Wnt signaling: is the party in the nucleus? Genes Dev. 20, 1394-1404.
51. Winer, I. S., Bommer, G. T., Gonik, N., and Fearon, E. R. (2006). Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation. J. Biol. Chem. 281, 26181-26187.
52. Wolf, D., Rodova, M., Miska, E. A., Calvet, J. P., and Kouzarides, T. (2002). Acetylation of beta-catenin by CREB-binding protein (CBP). J. Biol. Chem. 277, 25562-25567.
53. Xu, W., Edmondson, D. G., Evrard, Y. A., Wakamiya, M., Behringer, R. R., and Roth, S. Y. (2000). Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat. Genet. 26, 229-232.
54. Yamauchi, T., Yamauchi, J., Kuwata, T., Tamura, T., Yamashita, T., Bae, N., Westphal, H., Ozato, K., and Nakatani, Y. (2000). Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc. Natl. Acad. Sci. USA 97, 11303-11306.
55. Yang, X.-J., Ogryzko, V. V., Nishikawa, J.-i., Howard, B. H., and Nakatani, Y. (1996). A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319-324.
56. Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., and Mayo, M. W. (2004). Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380.
57. Yuan, Z., Zhang, X., Sengupta, N., Lane, W. S., andSeto, E. (2007). SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27, 149-162.
58. Zhang, Q., Yao, H., Vo, N., and Goodman, R. H. (2000). Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP. Proc. Natl. Acad. Sci. USA 97, 14323-14328.
59. Zhao, L. Y., Liu, Y., Bertos, N. R., Yang, X. J., and Liao, D. (2003). PCAF is a coactivator for p73-mediated transactivation. Oncogene 22, 8316-8329.