Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

Molecular and Cellular Biology

Volumn 24, Issue 22, 2004, Pages 10083-10098

  Dornan, David ^a,b   Eckert, Mirjam ^a   Wallace, Maura ^a   Shimizu, Harumi ^a,b   Ramsay, Eleanor ^a   Hupp, Ted R ^a   Ball, Kathryn L ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; INTERFERON REGULATORY FACTOR 1; PROTEIN P21; PROTEIN P300; PROTEIN P53;

ACETYLATION; ALLOSTERISM; ARTICLE; BINDING SITE; CARCINOGENESIS; DELETION MUTANT; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; DNA-BINDING PROTEINS; E1A-ASSOCIATED P300 PROTEIN; HUMANS; INTERFERON REGULATORY FACTOR-1; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECOMBINANT PROTEINS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 7644223905     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.22.10083-10098.2004     Document Type: Article

References (40)

1. Appella, E., and C. W. Anderson. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268:2764-2772.
2. Barlev, N. A., L. Liu, N. H. Chehab, K. Mansfield, K. G. Harris, T. D. Halazonetis, and S. L. Berger. 2001. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell 8:1243-1254.
3. Boultwood, J., C. Fidler, S. Lewis, A. MacCarthy, H. Sheridan, S. Kelly, D. Oscier, V. J. Buckle, and J. S. Wainscoat. 1993. Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q-chromosome in some patients with the 5q- syndrome. Blood 82:2611-2616.
4. Burysek, L., W. S. Yeow, B. Lubyova, M. Kellum, S. L. Schafer, Y. Q. Huang, and P. M. Pitha. 1999. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. J. Virol. 73:7334-7342.
5. Caspari, T. 2000. How to activate p53. Curr. Biol. 10:R315-R317.
6. Craig, A., M. Scott, L. Burch, G. Smith, K. Ball, and T. Hupp. 2003. Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. EMBO Rep. 4:787-792.
7. Craig, A. L., L. Burch, B. Vojtesek, J. Mikutowska, A. Thompson, and T. R. Hupp. 1999. Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers. Biochem. J. 342:133-141.
8. Dornan, D., and T. R. Hupp. 2001. Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300. EMBO Rep. 2:139-144.
9. Dornan, D., H. Shimizu, N. D. Perkins, and T. R. Hupp. 2003. DNA-dependent acetylation of p53 by the transcription coactivator p300. J. Biol. Chem. 278:13431-13441.
10. Dornan, D., H. Shimizu, L. Burch, A. J. Smith, and T. R. Hupp. 2003. The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53. Mol. Cell Biol. 23:8846-8861.
11. Espinosa, J. M., and B. M. Emerson. 2001. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell 8:57-69.
12. Gu, W., and R. G. Roeder. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
13. Hupp, T. R., and D. P. Lane. 1994. Allosteric activation of latent p53 tetramers. Curr. Biol. 4:865-875.
14. Hupp, T. R., D. P. Lane, and K. L. Ball. 2000. Strategies for manipulating the p53 pathway in the treatment of human cancer. Biochem J. 352:1-17.
15. Iyer, N. G., S. F. Chin, H. Ozdag, Y. Daigo, D. E. Hu, M. Cariati, K. Brindle, S. Aparicio, C. Caldas, et al. 2004. p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Proc. Natl. Acad. Sci. USA 101:7386-7391.
16. Kirchhoff, S., and H. Hauser. 1999. Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis. Oncogene 18:3725-3736.
17. Kroger, A., M. Koster, K. Schroeder, H. Hauser, and P. P. Mueller. 2002. Activities of IRF-1. J. Interferon Cytokine Res. 22:5-14.
18. Lane, D. P., and T. R. Hupp. 2003. Drug discovery and p53. Drug Discov. Today 8:347-355.
19. Matsuyama, T., T. Kimura, M. Kitagawa, K. Pfeffer, T. Kawakami, N. Watanabe, T. M. Kundig, K. Amakawa, K. Kishihara, A. Wakeham, et al. 1993. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75:83-97.
20. Merika, M., A. J. Williams, G. Chen, T. Collins, and D. Thanos. 1998. Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol. Cell 1:277-287.
21. Nozawa, H., E. Oda, K. Nakao, M. Ishihara, S. Ueda, T. Yokochi, K. Ogasawara, Y. Nakatsuru, S. Shimizu, Y. Ohira, K. Hioki, S. Aizawa, T. Ishikawa, M. Katsuki, T. Muto, T. Taniguchi, and N. Tanaka. 1999. Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. Genes Dev. 13:1240-1245.
22. Ogasawara, S., G. Tamura, C. Maesawa, Y. Suzuki, K. Ishida, N. Satoh, N. Uesugi, K. Saito, and R. Satodate. 1996. Common deleted region on the long arm of chromosome 5 in esophageal carcinoma. Gastroenterology 110:52-57.
23. Oren, M. 2003. Decision making by p53: life, death and cancer. Cell Death Differ. 10:431-442.
24. Orlando, V., H. Strutt, and R. Paro. 1997. Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11:205-214.
25. Pamment, J., E. Ramsay, M. Kelleher, D. Dornan, and K. L. Ball. 2002. Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. Oncogene 21:7776-7785.
26. Prost, S., C. O. Bellamy, D. S. Cunningham, and D. J. Harrison. 1998. Altered DNA repair and dysregulation of p53 in IRF-1 null hepatocytes. FASEB J. 12:181-188.
27. Sakaguchi, K., J. E. Herrera, S. Saito, T. Miki, M. Bustin, A. Vassilev, C. W. Anderson, and E. Appella. 1998. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12:2831-2841.
28. Schon, O., A. Friedler, M. Bycroft, S. M. Freund, and A. R. Fersht. 2002. Molecular mechanism of the interaction between MDM2 and p53. J. Mol. Biol. 323:491-501.
29. Seo, T., J. Park, D. Lee, S. G. Hwang, and J. Choe. 2001. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus binds to p53 and represses p53-dependent transcription and apoptosis. J. Virol. 75:6193-6198.
30. Shieh, S. Y., J. Ahn, K. Tamai, Y. Taya, and C. Prives. 2000. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14:289-300.
31. Shikama, N., C. W. Lee, S. France, L. Delavaine, J. Lyon, M. Krstic-Demonacos, and N. B. La Thangue. 1999. A novel cofactor for p300 that regulates the p53 response. Mol. Cell 4:365-376.
32. 1 and S phase expression of the interferon regulatory factor-1 gene. Mol. Endocrinol. 8:345-355.
33. Tamura, G., S. Ogasawara, S. Nishizuka, K. Sakata, C. Maesawa, Y. Suzuki, M. Terashima, K. Saito, and R. Satodate. 1996. Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach. Cancer Res. 56:612-615.
34. Tamura, T., M. Ishihara, M. S. Lamphier, N. Tanaka, I. Oishi, S. Aizawa, T. Matsuyama, T. W. Mak, S. Taki, and T. Taniguchi. 1995. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376:596-599.
35. Tanaka, N., M. Ishihara, M. Kitagawa, H. Harada, T. Kimura, T. Matsuyama, M. S. Lamphier, S. Aizawa, T. W. Mak, and T. Taniguchi. 1994. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77:829-839.
36. Tanaka, N., M. Ishihara, M. S. Lamphier, H. Nozawa, T. Matsuyama, T. W. Mak, S. Aizawa, T. Tokino, M. Oren, and T. Taniguchi. 1996. Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature 382:816-818.
37. Taniguchi, T., and A. Takaoka. 2002. The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr. Opin. Immunol. 14:111-116.
38. Wahl, G. M., and A. M. Carr. 2001. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat. Cell Biol. 3:E277-E286.
39. Willman, C. L., C. E. Sever, M. G. Pallavicini, H. Harada, N. Tanaka, M. L. Slovak, H. Yamamoto, K. Harada, T. C. Meeker, A. F. List, et al. 1993. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science 259:968-971.
40. Yuan, Z. M., Y. Huang, T. Ishiko, S. Nakada, T. Utsugisawa, H. Shioya, Y. Utsugisawa, K. Yokoyama, R. Weichselbaum, Y. Shi, and D. Kufe. 1999. Role for p300 in stabilization of p53 in the response to DNA damage. J. Biol. Chem. 274:1883-1886.