IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

Cell Death and Differentiation

Volumn 17, Issue 4, 2010, Pages 699-709

  Gao, J ^a,b   Senthil, M ^b   Ren, B ^c   Yan, J ^b   Xing, Q ^b   Yu, J ^c   Zhang, L ^c   Yim, J H ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Gastric cancer; Interferon; IRF 1; PUMA

Indexed keywords

CASPASE 3; CASPASE 8; CYTOCHROME C; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; PROTEIN P53; PUMA PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; STOMACH CANCER; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; INTERFERON REGULATORY FACTOR-1; MITOCHONDRIAL PROTEINS; PHOSPHATIDYLSERINES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; STOMACH NEOPLASMS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

ADENOVIRIDAE;

EID: 77949539947     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.156     Document Type: Article

References (33)

1. Tamura T, Yanai H, Savitsky D, Taniguchi T. The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 2008; 26: 535-584.
2. Tamura T, Ishihara M, Lamphier MS, Tanaka N, Oishi I, Aizawa S et al. DNA damage-induced apoptosis and Ice gene induction in mitogenically activated T lymphocytes require IRF-1. Leukemia 1997; 11 (Suppl 3): 439-440.
3. Bouker KB, Skaar TC, Fernandez DR, O'Brien KA, Riggins RB, Cao D et al. Interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (Faslodex, Fulvestrant). Cancer Res 2004; 64: 4030-4039.
4. Bowie ML, Dietze EC, Delrow J, Bean GR, Troch MM, Marjoram RJ et al. Interferon-regulatory factor-1 is critical for tamoxifen-mediated apoptosis in human mammary epithelial cells. Oncogene 2004; 23: 8743-8755.
5. Stang MT, Armstrong MJ, Watson GA, Sung KY, Liu Y, Ren B et al. Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells. Oncogene 2007; 26: 6420-6430.
6. Clarke N, Jimenez-Lara AM, Voltz E, Gronemeyer H. Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL. EMBO J 2004; 23: 3051-3060.
7. Park SY, Seol JW, Lee YJ, Cho JH, Kang HS, Kim IS et al. IFN-gamma enhances TRAIL-induced apoptosis through IRF-1. Eur J Biochem 2004; 271: 4222-4228.
8. El Bougrini J, Pampin M, Chelbi-Alix MK. Arsenic enhances the apoptosis induced by interferon gamma: key role of IRF-1. Cell Mol Biol (Noisy-le-grand) 2006; 52: 9-15.
9. Beppu K, Morisaki T, Matsunaga H, Uchiyama A, Ihara E, Hirano K et al. Inhibition of interferon-gamma-activated nuclear factor-kappa B by cyclosporin A: a possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells. Biochem Biophys Res Commun 2003; 305: 797-805.
10. Suk K, Chang I, Kim YH, Kim S, Kim JY, Kim H et al. Interferon gamma (IFNgamma) and tumor necrosis factor alpha synergism in ME-180 cervical cancer cell apoptosis and necrosis. IFNgamma inhibits cytoprotective NF-kappa B through STAT1/IRF-1 pathways. J Biol Chem 2001; 276: 13153-13159.
11. Ruiz-Ruiz C, Ruiz de Almodovar C, Rodriguez A, Ortiz-Ferron G, Redondo JM, Lopez-Rivas A. The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1. J Biol Chem 2004; 279: 19712-19720.
12. Chow WA, Fang JJ, Yee JK. The IFN regulatory factor family participates in regulation of Fas ligand gene expression in T cells. J Immunol 2000; 164: 3512-3518.
13. Pizzoferrato E, Liu Y, Gambotto A, Armstrong MJ, Stang MT, Gooding WE et al. Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. Cancer Res 2004; 64: 8381-8388.
14. Tamura G, Ogasawara S, Nishizuka S, Sakata K, Maesawa C, Suzuki Y et al. Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach. Cancer Res 1996; 56: 612-615.
15. Nozawa H, Oda E, Ueda S, Tamura G, Maesawa C, Muto T et al. Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. Int J Cancer 1998; 77: 522-527.
16. Kim PK, Armstrong M, Liu Y, Yan P, Bucher B, Zuckerbraun BS et al. IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo. Oncogene 2004; 23: 1125-1135.
17. Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther 2005; 4: 139-163.
18. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997; 326 (Part 1): 1-16.
19. Yin XM. Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res 2000; 10: 161-167.
20. Ming L, Sakaida T, Yue W, Jha A, Zhang L, Yu J. Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis 2008; 29: 1878-1884.
21. Takaoka A, Tamura T, Taniguchi T. Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci 2008; 99: 467-478.
22. Harada H, Taniguchi T, Tanaka N. The role of interferon regulatory factors in the interferon system and cell growth control. Biochimie 1998; 80: 641-650.
23. Yim JH, Ro SH, Lowney JK, Wu SJ, Connett J, Doherty GM. The role of interferon regulatory factor-1 and interferon regulatory factor-2 in IFN-gamma growth inhibition of human breast carcinoma cell lines. J Interferon Cytokine Res 2003; 23: 501-511.
24. Abril E, Real LM, Serrano A, Jimenez P, Garcia A, Canton J et al. Unresponsiveness to interferon associated with STAT1 protein deficiency in a gastric adenocarcinoma cell line. Cancer Immunol Immunother 1998; 47: 113-120.
25. Takaoka A, Hayakawa S, Yanai H, Stoiber D, Negishi H, Kikuchi H et al. Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 2003; 424: 516-523.
26. Gomez-Benito M, Balsas P, Carvajal-Vergara X, Pandiella A, Anel A, Marzo I et al. Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin. Cell Signal 2007; 19: 844-854.
27. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ et al. p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003; 302: 1036-1038.
28. Kirchhoff S, Schaper F, Oumard A, Hauser H. In vivo formation of IRF-1 homodimers. Biochimie 1998; 80: 659-664.
29. Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev 2006; 6: 836-848.
30. Percario ZA, Giandomenico V, Fiorucci G, Chiantore MV, Vannucchi S, Hiscott J et al. Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway. Cell Growth Differ 1999; 10: 263-270.
31. Van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002; 415:530-536.
32. Sinicrope FA, Rego RL, Okumura K, Foster NR, O'Connell MJ, Sargent DJ et al. Prognostic impact of bim, puma, and noxa expression in human colon carcinomas. Clin Cancer Res 2008; 14: 5810-5818.
33. Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003; 100: 1931-1936.