Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion

Cancer Research

Volumn 71, Issue 8, 2011, Pages 3121-3131

  Alsarraj, Jude ^a   Walker, Renard C ^a   Webster, Joshua D ^a   Geiger, Thomas R ^a   Crawford, Nigel P S ^a,c   Simpson, R Mark ^a   Ozato, Keiko ^b   Hunter, Kent W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRD4 GENE; BREAST CANCER; CANCER GROWTH; CANCER STEM CELL; CARBOXY TERMINAL SEQUENCE; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG METASTASIS; METASTASIS INHIBITION; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; BREAST NEOPLASMS; CELL GROWTH PROCESSES; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; PROLINE-RICH PROTEIN DOMAINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 79954603178     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-4417     Document Type: Article

References (38)

1. Chung CT, Carlson RW. Goals and objectives in the management of metastatic breast cancer. Oncologist 2003;8:514-20. (Pubitemid 37467366)
2. Lifsted T, Le VT, Williams M, Muller W, Klein-Szanto A, Buetow KH, et al. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer 1998;77:640-4. (Pubitemid 28340915)
3. Crawford NP, Ziogas A, Peel DJ, Hess J, nton-Culver H, Hunter KW. Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res 2006;8:R16.
4. Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, et al. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. PLoS Genet 2007;3:e214.
5. Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, et al. Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci U S A 2008;105:6380-5. (Pubitemid 351758354)
6. Crawford NP, Walker RC, Lukes L, Officewala JS, Williams RW, Hunter KW. The Diasporin Pathway: A tumor progression-related transcriptional network that predicts breast cancer survival. Clin Exp Metastasis 2008;25:357-69.
7. Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K. The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci U S A 2003;100:8758-63. (Pubitemid 36899172)
8. Farina A, Hattori M, Qin J, Nakatani Y, Minato N, Ozato K. Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. Mol Cell Biol 2004;24:9059-69. (Pubitemid 39313910)
9. Bisgrove DA, Mahmoudi T, Henklein P, Verdin E. Conserved P-TEFbinteracting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A 2007;104:13690-5. (Pubitemid 350003382)
10. Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K. The bromodomain protein Brd4 is a positive regulatory component of PTEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell 2005;19:523-34. (Pubitemid 41140009)
11. Pei XF, Noble MS, Davoli MA, Rosfjord E, Tilli MT, Furth PA, et al. Explant-cell culture of primary mammary tumors from MMTV-c-Myc transgenic mice. In Vitro Cell Dev Biol Anim 2004;40:14-21. (Pubitemid 38756888)
12. French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: A novel mechanism in aggressive carcinoma. Cancer Res 2003;63:304-7. (Pubitemid 36152484)
13. Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Gonzalez A, Gazdar AF, et al. Cloned fusion product from a rare t(15;19)(q13.2; p13.1) inhibit S phase in vitro. J Med Genet 2005;42:558-64. (Pubitemid 40993831)
14. Ivshina AV, George J, Senko O, Mow B, Putti TC, Smeds J, et al. Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res 2006;66:10292-301. (Pubitemid 44799747)
15. Yang J, Weinberg RA. Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 2008;14: 818-29. (Pubitemid 351757205)
16. Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, et al. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A 2001;98:10356-61. (Pubitemid 32803024)
17. Fidler IJ, Poste G. The "seed and soil" hypothesis revisited. Lancet Oncol 2008;9:808.
18. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54.
19. Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65: 5506-11. (Pubitemid 40911148)
20. Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003;17: 1253-70. (Pubitemid 36583168)
21. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008;133:704-15. (Pubitemid 351636299)
22. Gregory PA, Bracken CP, Bert AG, Goodall GJ. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 2008;7: 3112-8.
23. Worley LA, Long MD, Onken MD, Harbour JW. Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling. Melanoma Res 2008;18:184-90. (Pubitemid 351684663)
24. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131:1109-23. (Pubitemid 350235025)
25. Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 2008;14:2348-60.
26. French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal CP, et al. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol 2001;159:1987-92. (Pubitemid 33104253)
27. Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Gonzalez A, Gazdar AF, et al. Cloned fusion product from a rare t(15;19)(q13.2; p13.1) inhibit S phase in vitro. J Med Genet 2005;42:558-64. (Pubitemid 40993831)
28. French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, et al. BRD-NUT oncoproteins: A family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 2008;27:2237-42. (Pubitemid 351483375)
29. den Bakker MA, Beverloo BH, Van Den Heuvel-Eibrink MM, Meeuwis CA, Tan LM, Johnson LA, et al. NUT midline carcinoma of the parotid gland with mesenchymal differentiation. Am J Surg Pathol 2009;33:1253-8.
30. Park YG, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat Genet 2005;37:1055-62. (Pubitemid 41486657)
31. Thiery JP, Tucker GC, Boyer B, Valles AM, Gavrilovic J, Moens G, et al. [Mechanisms of induced epithelium-fibroblast conversion in a line of vesical cancer in the rat]. Pathol Biol (Paris)1989;37:1034. (Pubitemid 19280768)
32. Boyer B, Tucker GC, Valles AM, Gavrilovic J, Thiery JP. Reversible transition towards a fibroblastic phenotype in a rat carcinoma cell line. Int J Cancer Suppl 1989;4:69-75. (Pubitemid 19283182)
33. Jechlinger M, Grunert S, Tamir IH, Janda E, Ludemann S, Waerner T, et al. Expression profiling of epithelial plasticity in tumor progression. Oncogene 2003;22:7155-69. (Pubitemid 37378548)
34. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117:927-39. (Pubitemid 38798858)
35. Cardiff RD. The pathology of EMT in mouse mammary tumorigenesis. J Mammary Gland Biol Neoplasia 2010;15:225-33.
36. Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED, et al. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 2007;213:374-83. (Pubitemid 47509716)
37. Monteiro J, Fodde R. Cancer stemness and metastasis: Therapeutic consequences and perspectives. Eur J Cancer 2010;46: 1198-203.
38. Crawford NP, Yang H, Mattaini KR, Hunter KW. The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. J Biol Chem 2009;284:28660-73.