Multivariate PAT solutions for biopharmaceutical cultivation: Current progress and limitations

Trends in Biotechnology

Volumn 32, Issue 6, 2014, Pages 329-336

  Mercier, Sarah M ^a   Diepenbroek, Bas ^a   Wijffels, Rene H ^b   Streefland, Mathieu ^b  

^a CRUCELL HOLLAND BV   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Biopharmaceutical industry; Cell cultivation; Process analytical technology; Quality by design

Indexed keywords

INDUSTRY;

BIOPHARMACEUTICAL INDUSTRY; CELL CULTIVATION; CULTIVATION PROCESS; MULTIVARIATE DATA ANALYSIS; PHARMACEUTICAL INDUSTRY; PROCESS ANALYTICAL TECHNOLOGY; PROCESS INFORMATION; QUALITY BY DESIGNS;

MULTIVARIANT ANALYSIS;

BIOPROCESS; CELL CULTURE; DATA ANALYSIS; DOCUMENTATION; DRUG INDUSTRY; EXPERIMENTATION; GOOD MANUFACTURING PRACTICE; HUMAN; MEASUREMENT ERROR; MULTIVARIATE ANALYSIS; ONLINE MONITORING; PRIORITY JOURNAL; PROCESS ANALYTICAL TECHNOLOGY; PROCESS CONTROL; PROCESS DEVELOPMENT; PROCESS TECHNOLOGY; REVIEW; SYSTEMS BIOLOGY; BIOTECHNOLOGY; CULTURE TECHNIQUE; FACTUAL DATABASE; PHARMACEUTICS; PROCEDURES; STATISTICAL MODEL;

BIOPHARMACEUTICS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; DATABASES, FACTUAL; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84901001859     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2014.03.008     Document Type: Review

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