Process analytical technology applied for end-point detection of pharmaceutical blending by combining two calibration-free methods: Simultaneously monitoring specific near-infrared peak intensity and moving block standard deviation

Powder Technology

Volumn 210, Issue 2, 2011, Pages 122-131

  Momose, Wataru ^a,b,c   Imai, Keiji ^a   Yokota, Shoji ^a   Yonemochi, Etsuo ^b,c   Terada, Katsuhide ^b,c  

^a ASTELLAS PHARMA INC   (Japan)

^b TOHO UNIVERSITY   (Japan)

^c PAT Committee   (Japan)

Author keywords

Acousto optical tunable filter; Blend uniformity; Near infrared spectroscopy; Partial least squares regression; Process analytical technology; Two calibration free methods

Indexed keywords

ACOUSTO-OPTICAL TUNABLE FILTER; BLEND UNIFORMITY; PARTIAL LEAST SQUARES REGRESSION; PROCESS ANALYTICAL TECHNOLOGY; TWO CALIBRATION-FREE METHODS;

AUTOMATIC TRAIN CONTROL; BLENDING; CALIBRATION; DRUG PRODUCTS; INFRARED SPECTROSCOPY; LEAST SQUARES APPROXIMATIONS; MONITORING; NEAR INFRARED SPECTROSCOPY; POINT CONTACTS; PRINCIPAL COMPONENT ANALYSIS; STATISTICS; TEXTILES; ULTRAVIOLET SPECTROSCOPY;

INFRARED DEVICES;

ACTIVE PHARMACEUTICAL INGREDIENT; CHEMICAL COMPOUND; NICALDIPINE HYDROCHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; BLENDING; CALCULATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; MONITORING; NEAR INFRARED REFLECTANCE SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PROCESS TECHNOLOGY; ULTRAVIOLET SPECTROSCOPY;

EID: 79955482269     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2011.03.005     Document Type: Article

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