Chemometrics applications in biotechnology processes: Predicting column integrity and impurity clearance during reuse of chromatography resin

Biotechnology Progress

Volumn 28, Issue 5, 2012, Pages 1308-1314

  Rathore, Anurag S ^a   Mittal, Shachi ^a   Lute, Scott ^b   Brorson, Kurt ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Bioprocessing; Chemometrics; Column integrity; Column reuse; Impurity clearance; Multivariate data analysis; MVDA

Indexed keywords

BACK PRESSURES; BIOPROCESSING; CHEMOMETRICS; CHROMATOGRAPHY COLUMNS; CHROMATOGRAPHY MEDIA; CHROMATOGRAPHY RESIN; CLEANABILITY; COLUMN PACKINGS; COLUMN PERFORMANCE; COST-OF-GOODS; DATA SETS; FEED MATERIALS; HOUSING UNITS; IMPURITIES IN; INDUSTRY PRACTICES; LABORATORY SCALE; MULTIVARIATE DATA ANALYSIS; MVDA; NUMBER OF CYCLES; PRODUCT-LIFE-CYCLE; SEPARATION MEDIA; UNDERPERFORMANCE;

BIOTECHNOLOGY; FORECASTING; IMPURITIES; MANUFACTURE; MULTIVARIANT ANALYSIS; ORGANIC ACIDS;

COLUMN CHROMATOGRAPHY;

MONOCLONAL ANTIBODY; RESIN; STAPHYLOCOCCUS PROTEIN A;

AFFINITY CHROMATOGRAPHY; ARTICLE; BIOTECHNOLOGY; CHEMISTRY; INSTRUMENTATION; ISOLATION AND PURIFICATION; METHODOLOGY;

ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CHROMATOGRAPHY, AFFINITY; RESINS, SYNTHETIC; STAPHYLOCOCCAL PROTEIN A;

EID: 84867350799     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1610     Document Type: Article

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