Basal gene expression by lung CD4+ T cells in chronic obstructive pulmonary disease identifies independent molecular correlates of airflow obstruction and emphysema extent

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Freeman, Christine M ^a,b   McCubbrey, Alexandra L ^c   Crudgington, Sean ^b   Nelson, Joshua ^b   Martinez, Fernando J ^b   Han, MeiLan K ^b   Washko Jr , George R ^d   Chensue, Stephen W ^a,b,c   Arenberg, Douglas A ^b   Meldrum, Catherine A ^b   McCloskey, Lisa ^b   Curtis, Jeffrey L ^a,b,c  

^a VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIBODY; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TELOMERASE; TRANSCRIPTION FACTOR FOXP3;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; CD4+ T LYMPHOCYTE; CELL ISOLATION; CELL STIMULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; EFFECTOR CELL; EMPHYSEMA; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FOXP3+ REGULATORY T LYMPHOCYTE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; PHENOTYPE; POLARIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; RNA SYNTHESIS; RNA TRANSCRIPTION; SPIROMETRY; T LYMPHOCYTE SUBPOPULATION; TELOMERE HOMEOSTASIS; TH1 CELL; TH17 CELL; TH2 CELL; AGED; GENETICS; IMMUNOLOGY; LUNG; LUNG EMPHYSEMA; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; PATHOLOGY; SEVERITY OF ILLNESS INDEX;

AGED; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; GENE EXPRESSION; HUMANS; LUNG; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; SEVERITY OF ILLNESS INDEX;

EID: 84900551412     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096421     Document Type: Article

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