Unravelling the mechanisms of help for CD8+ T cell responses

Immunologic Research

Volumn 45, Issue 2-3, 2009, Pages 209-217

  Livingstone, Alexandra M ^a   Wilson, Elizabeth B ^a   Ontiveros, Fernando ^a   Wang, Jyh Chiang E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

CD4+ T cell help; CD8+ T cell; Dendritic cells; T cell memory

Indexed keywords

INTERFERON; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; VACCINE;

ADOPTIVE TRANSFER; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURVIVAL; CYTOKINE RELEASE; DENDRITIC CELL; GENE TARGETING; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; IMMUNIZATION; IMMUNOLOGIC MEMORY; MICE; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 72449142802     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-009-8102-0     Document Type: Review

References (46)

1. MJ Bevan 2004 Helping the CD8(+) T-cell response Nat Rev Immunol 4 595 602 10.1038/nri1413 1:CAS:528:DC%2BD2cXmtFWktro%3D 15286726
2. DJ Shedlock H Shen 2003 Requirement for CD4 T cell help in generating functional CD8 T cell memory Science 300 337 339 10.1126/science.1082305 1:CAS:528:DC%2BD3sXislyqtLc%3D 12690201 (Pubitemid 36433726)
3. JC Sun MJ Bevan 2003 Defective CD8 T cell memory following acute infection without CD4 T cell help Science 300 339 342 10.1126/science.1083317 1:CAS:528:DC%2BD3sXislyqtb4%3D 12690202 (Pubitemid 36433727)
4. F Castellino RN Germain 2007 Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells J Immunol 178 778 787 1:CAS:528:DC%2BD2sXhvVajsg%3D%3D 17202339
5. F Castellino AY Huang G Altan-Bonnet S Stoll C Scheinecker RN Germain 2006 Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction Nature 440 890 895 10.1038/nature04651 1:CAS:528:DC%2BD28XjsVWktbY%3D 16612374
6. A Le Bon N Etchart C Rossmann M Ashton S Hou D Gewert P Borrow DF Tough 2003 Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon Nat Immunol 4 1009 1015 10.1038/ni978 14502286 (Pubitemid 37265922)
7. JC Sun MJ Bevan 2004 Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells J Immunol 172 3385 3389 1:CAS:528:DC%2BD2cXhvVKjsbo%3D 15004136
8. JC Wang AM Livingstone 2003 Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo J Immunol 171 6339 6343 1:CAS:528:DC%2BD3sXpsV2rs7k%3D 14662830
9. C Bourgeois B Rocha C Tanchot 2002 A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory Science 297 2060 2063 10.1126/science.1072615 1:CAS:528:DC%2BD38Xnt1ansLg%3D 12242444 (Pubitemid 35052536)
10. EM Janssen EE Lemmens T Wolfe U Christen MG von Herrath SP Schoenberger 2003 CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes Nature 421 852 856 10.1038/nature01441 1:CAS:528: DC%2BD3sXht1KqtLo%3D 12594515 (Pubitemid 36254145)
11. JC Sun MA Williams MJ Bevan 2004 CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection Nat Immunol 5 927 933 10.1038/ni1105 1:CAS:528:DC%2BD2cXntVKruro%3D 15300249 (Pubitemid 39276237)
12. GJ Fernando V Khammanivong GR Leggatt WJ Liu IH Frazer 2002 The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation Eur J Immunol 32 1541 1549 10.1002/1521-4141(200206)32:6<1541::AID-IMMU1541>3.0.CO;2-S 1:CAS:528:DC%2BD38Xksl2it7w%3D 12115636 (Pubitemid 34679142)
13. AM Livingstone M Kuhn 1999 Dendritic cells need T cell help to prime cytotoxic T cell responses to strong antigens Eur J Immunol 29 2826 2834 10.1002/(SICI)1521-4141(199909)29:09<2826::AID-IMMU2826>3.0.CO;2-M 1:CAS:528:DyaK1MXlvFOqtLg%3D 10508257
14. AM Livingstone M Kuhn 2002 Peptide-pulsed splenic dendritic cells prime long-lasting CD8(+) T cell memory in the absence of cross-priming by host APC Eur J Immunol 32 281 290 10.1002/1521-4141(200201)32:1<281::AID-IMMU281>3. 0.CO;2-P 1:CAS:528:DC%2BD38XhtV2jt78%3D 11782019 (Pubitemid 34092845)
15. VP Badovinac KA Messingham A Jabbari JS Haring JT Harty 2005 Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination Nat Med 11 748 756 10.1038/nm1257 1:CAS:528:DC%2BD2MXmt1ajur4%3D 15951824 (Pubitemid 41021207)
16. JT Harty VP Badovinac 2008 Shaping and reshaping CD8+ T-cell memory Nat Rev Immunol 8 107 119 10.1038/nri2251 1:CAS:528:DC%2BD1cXhtVGis74%3D 18219309 (Pubitemid 351161304)
17. RM Steinman 1991 The dendritic cell system and its role in immunogenicity Annu Rev Immunol 9 271 296 10.1146/annurev.iy.09.040191.001415 1:CAS:528:DyaK3MXmt12kurc%3D 1910679
18. J Banchereau RM Steinman 1998 Dendritic cells and the control of immunity Nature 392 245 252 10.1038/32588 1:CAS:528:DyaK1cXitFWrsr8%3D 9521319 (Pubitemid 28155090)
19. Ontiveros F. The influence of innate immune mechanisms on CD4+ and CD8+ T cell responses. University of Rochester, Rochester, USA; 2008.
20. EB Wilson AM Livingstone 2008 Cutting Edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses J Immunol 181 7445 7448 1:CAS:528:DC%2BD1cXhtl2gs7jL 19017930
21. MJ Barnden J Allison WR Heath FR Carbone 1998 Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements Immunol Cell Biol 76 34 40 10.1046/j.1440-1711.1998.00709.x 1:CAS:528:DyaK1cXisFegtLo%3D 9553774 (Pubitemid 28194695)
22. SR Bennett FR Carbone F Karamalis RA Flavell JF Miller WR Heath 1998 Help for cytotoxic-T-cell responses is mediated by CD40 signalling Nature 393 478 480 10.1038/30996 1:CAS:528:DyaK1cXjs1Kmtro%3D 9624004 (Pubitemid 28292195)
23. JP Ridge F Di Rosa P Matzinger 1998 A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell Nature 393 474 478 10.1038/30989 1:CAS:528:DyaK1cXjs1Kms7s%3D 9624003 (Pubitemid 28292194)
24. SP Schoenberger RE Toes EI van Der Voort R Offringa CJ Melief 1998 T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions Nature 393 480 483 10.1038/31002 1:CAS:528:DyaK1cXjs1Kmtbw%3D 9624005 (Pubitemid 28292196)
25. A Lanzavecchia 1998 Immunology. Licence to kill Nature 393 413 414 10.1038/30845 1:CAS:528:DyaK1cXjs1Kisrk%3D 9623994 (Pubitemid 28292171)
26. DH Schuurhuis S Laban RE Toes P Ricciardi-Castagnoli MJ Kleijmeer EI van der Voort D Rea R Offringa HJ Geuze CJ Melief F Ossendorp 2000 Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli J Exp Med 192 145 150 10.1084/jem.192.1.145 1:CAS:528:DC%2BD3cXkslaitbk%3D 10880536 (Pubitemid 30470816)
27. P Matzinger 1994 Tolerance, danger, and the extended family Annu Rev Immunol 12 991 1045 1:STN:280:DyaK2c3otVOqsA%3D%3D 8011301
28. C Tanchot B Rocha 2003 CD8 and B cell memory: same strategy, same signals Nat Immunol 4 431 432 10.1038/ni0503-431 1:CAS:528:DC%2BD3sXjtlaktrg%3D 12719734 (Pubitemid 36592434)
29. BO Lee L Hartson TD Randall 2003 CD40-deficient, influenza-specific CD8 memory T cells develop and function normally in a CD40-sufficient environment J Exp Med 198 1759 1764 10.1084/jem.20031440 1:CAS:528:DC%2BD3sXps1egu74%3D 14657225 (Pubitemid 37494168)
30. Wang J-C. The role of CD4+ T help for primary and memory CD8+ T cell responses against non-infectious antigens. University of Rochester, Rochester, USA; 2006.
31. GM Behrens M Li GM Davey J Allison RA Flavell FR Carbone WR Heath 2004 Helper requirements for generation of effector CTL to islet beta cell antigens J Immunol 172 5420 5426 1:CAS:528:DC%2BD2cXjt1CktrY%3D 15100283
32. J Hernandez S Aung K Marquardt LA Sherman 2002 Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens J Exp Med 196 323 333 10.1084/jem.20011612 1:CAS:528:DC%2BD38XmtVOhtLw%3D 12163561 (Pubitemid 34875662)
33. CL Ahonen CL Doxsee SM McGurran TR Riter WF Wade RJ Barth JP Vasilakos RJ Noelle RM Kedl 2004 Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN J Exp Med 199 775 784 10.1084/jem.20031591 1:CAS:528:DC%2BD2cXisVaguro%3D 15007094 (Pubitemid 38375197)
34. DK Sojka D Bruniquel RH Schwartz NJ Singh 2004 IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition J Immunol 172 6136 6143 1:CAS:528:DC%2BD2cXjs1Ojurs%3D 15128800
35. L Yang T Mosmann 2004 Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions Eur J Immunol 34 1617 1626 10.1002/eji.200424939 1:CAS:528:DC%2BD2cXltFKru78%3D 15162431 (Pubitemid 39256043)
36. SM Eaton EM Burns K Kusser TD Randall L Haynes 2004 Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses J Exp Med 200 1613 1622 10.1084/jem.20041395 1:CAS:528:DC%2BD2cXhtFGmurbP 15611289 (Pubitemid 40094185)
37. JF McDyer Z Li S John X Yu CY Wu JA Ragheb 2002 IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: disruption of both IL-12-dependent and -independent pathways of IFN-gamma production J Immunol 169 2736 2746 1:CAS:528:DC%2BD38XmsF2ns7s%3D 12193748
38. MF Bachmann P Wolint S Walton K Schwarz A Oxenius 2007 Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections Eur J Immunol 37 1502 1512 10.1002/eji.200637023 1:CAS:528: DC%2BD2sXntVSgs74%3D 17492805 (Pubitemid 46947854)
39. MA Williams AJ Tyznik MJ Bevan 2006 Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells Nature 441 890 893 10.1038/nature04790 1:CAS:528:DC%2BD28XlvVGltro%3D 16778891 (Pubitemid 43910424)
40. J Banchereau V Pascual AK Palucka 2004 Autoimmunity through cytokine-induced dendritic cell activation Immunity 20 539 550 10.1016/S1074-7613(04)00108-6 1:CAS:528:DC%2BD2cXksFartrc%3D 15142523 (Pubitemid 38638124)
41. JM Curtsinger JO Valenzuela P Agarwal D Lins MF Mescher 2005 Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation J Immunol 174 4465 4469 1:CAS:528:DC%2BD2MXivFKisbg%3D 15814665
42. GA Kolumam S Thomas LJ Thompson J Sprent K Murali-Krishna 2005 Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection J Exp Med 202 637 650 10.1084/jem.20050821 1:CAS:528:DC%2BD2MXhtVSjs7zJ 16129706 (Pubitemid 41248415)
43. E Janssen K Tabeta MJ Barnes S Rutschmann S McBride KS Bahjat SP Schoenberger AN Theofilopoulos B Beutler K Hoebe 2006 Efficient T cell activation via a toll-interleukin 1 receptor-independent pathway Immunity 24 787 799 10.1016/j.immuni.2006.03.024 1:CAS:528:DC%2BD28Xms1CrtLo%3D 16782034 (Pubitemid 43867366)
44. A MartIn-Fontecha S Sebastiani UE Hopken M Uguccioni M Lipp A Lanzavecchia F Sallusto 2003 Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming J Exp Med 198 615 621 10.1084/jem.20030448 1:CAS:528:DC%2BD3sXms1WisLo%3D 12925677 (Pubitemid 37040395)
45. NS Joshi SM Kaech 2008 Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation J Immunol 180 1309 1315 1:CAS:528:DC%2BD1cXotlGjtQ%3D%3D 18209024
46. EM Janssen NM Droin EE Lemmens MJ Pinkoski SJ Bensinger BD Ehst TS Griffith DR Green SP Schoenberger 2005 CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death Nature 434 88 93 10.1038/nature03337 1:CAS:528:DC%2BD2MXhslClsLc%3D 15744305 (Pubitemid 40349390)