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Volumn 14, Issue 1, 2013, Pages

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

Author keywords

CD8+ T cells; Chronic obstructive pulmonary disease; Lung; Toll like receptors

Indexed keywords

CD3 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; CXCL9 CHEMOKINE; EOTAXIN; FAS LIGAND; GAMMA INTERFERON; GRANZYME A; GRANZYME B; IMIQUIMOD; INTERLEUKIN 13; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PERFORIN; RANTES; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

EID: 84873026033     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-13     Document Type: Article
Times cited : (58)

References (51)
  • 2
    • 66749141807 scopus 로고    scopus 로고
    • Systemic manifestations and comorbidities of COPD
    • 10.1183/09031936.00128008, 19407051
    • Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009, 33:1165-1185. 10.1183/09031936.00128008, 19407051.
    • (2009) Eur Respir J , vol.33 , pp. 1165-1185
    • Barnes, P.J.1    Celli, B.R.2
  • 5
    • 0030900606 scopus 로고    scopus 로고
    • Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1
    • O'Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK. Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med 1997, 155:852-857.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 852-857
    • O'Shaughnessy, T.C.1    Ansari, T.W.2    Barnes, N.C.3    Jeffery, P.K.4
  • 6
    • 34548830799 scopus 로고    scopus 로고
    • CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity
    • 10.2353/ajpath.2007.061177, 1959492, 17640964
    • Freeman CM, Curtis JL, Chensue SW. CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. Am J Pathol 2007, 171:767-776. 10.2353/ajpath.2007.061177, 1959492, 17640964.
    • (2007) Am J Pathol , vol.171 , pp. 767-776
    • Freeman, C.M.1    Curtis, J.L.2    Chensue, S.W.3
  • 7
    • 77953402276 scopus 로고    scopus 로고
    • Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15
    • 10.4049/jimmunol.1000006, 20427767
    • Freeman CM, Han MK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak TJ, Sonstein J, Todt JC, Ames TM, et al. Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol 2010, 184:6504-6513. 10.4049/jimmunol.1000006, 20427767.
    • (2010) J Immunol , vol.184 , pp. 6504-6513
    • Freeman, C.M.1    Han, M.K.2    Martinez, F.J.3    Murray, S.4    Liu, L.X.5    Chensue, S.W.6    Polak, T.J.7    Sonstein, J.8    Todt, J.C.9    Ames, T.M.10
  • 8
    • 34250197133 scopus 로고    scopus 로고
    • CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice
    • Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol 2007, 178:8090-8096.
    • (2007) J Immunol , vol.178 , pp. 8090-8096
    • Maeno, T.1    Houghton, A.M.2    Quintero, P.A.3    Grumelli, S.4    Owen, C.A.5    Shapiro, S.D.6
  • 9
    • 36048966608 scopus 로고    scopus 로고
    • CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
    • 10.1016/j.yexmp.2007.08.020, 2140237, 17950725
    • Borchers MT, Wesselkamper SC, Harris NL, Deshmukh H, Beckman E, Vitucci M, Tichelaar JW, Leikauf GD. CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp Mol Pathol 2007, 83:301-310. 10.1016/j.yexmp.2007.08.020, 2140237, 17950725.
    • (2007) Exp Mol Pathol , vol.83 , pp. 301-310
    • Borchers, M.T.1    Wesselkamper, S.C.2    Harris, N.L.3    Deshmukh, H.4    Beckman, E.5    Vitucci, M.6    Tichelaar, J.W.7    Leikauf, G.D.8
  • 10
    • 33646554531 scopus 로고    scopus 로고
    • Inflammatory cells in the airways in COPD
    • 10.1136/thx.2004.024463, 2111192, 16648353
    • O'Donnell R, Breen D, Wilson S, Djukanovic R. Inflammatory cells in the airways in COPD. Thorax 2006, 61:448-454. 10.1136/thx.2004.024463, 2111192, 16648353.
    • (2006) Thorax , vol.61 , pp. 448-454
    • O'Donnell, R.1    Breen, D.2    Wilson, S.3    Djukanovic, R.4
  • 13
    • 84859033550 scopus 로고    scopus 로고
    • Invariant natural killer T cells in chronic obstructive pulmonary disease
    • 10.1111/j.1440-1843.2011.02104.x, 22098381
    • Chi SY, Ban HJ, Kwon YS, Oh IJ, Kim KS, Kim YI, Kim YC, Lim SC. Invariant natural killer T cells in chronic obstructive pulmonary disease. Respirology 2012, 17:486-492. 10.1111/j.1440-1843.2011.02104.x, 22098381.
    • (2012) Respirology , vol.17 , pp. 486-492
    • Chi, S.Y.1    Ban, H.J.2    Kwon, Y.S.3    Oh, I.J.4    Kim, K.S.5    Kim, Y.I.6    Kim, Y.C.7    Lim, S.C.8
  • 14
    • 77956711464 scopus 로고    scopus 로고
    • Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients
    • Urbanowicz RA, Lamb JR, Todd I, Corne JM, Fairclough LC. Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients. Resp Res 2010, 11:76.
    • (2010) Resp Res , vol.11 , pp. 76
    • Urbanowicz, R.A.1    Lamb, J.R.2    Todd, I.3    Corne, J.M.4    Fairclough, L.C.5
  • 15
    • 84872914507 scopus 로고    scopus 로고
    • Enhanced cytotoxic function of NK and NKT-like cells associated with decreased CD94 (Kp43) in the COPD airway
    • Hodge G, Mukaro V, Holmes M, Reynolds PN, Hodge S. Enhanced cytotoxic function of NK and NKT-like cells associated with decreased CD94 (Kp43) in the COPD airway. Respirology 2012, 18:369-376.
    • (2012) Respirology , vol.18 , pp. 369-376
    • Hodge, G.1    Mukaro, V.2    Holmes, M.3    Reynolds, P.N.4    Hodge, S.5
  • 16
    • 22544450733 scopus 로고    scopus 로고
    • Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells
    • Caron G, Duluc D, Fremaux I, Jeannin P, David C, Gascan H, Delneste Y. Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells. J Immunol 2005, 175:1551-1557.
    • (2005) J Immunol , vol.175 , pp. 1551-1557
    • Caron, G.1    Duluc, D.2    Fremaux, I.3    Jeannin, P.4    David, C.5    Gascan, H.6    Delneste, Y.7
  • 18
    • 2442592788 scopus 로고    scopus 로고
    • Toll-like receptor ligands directly promote activated CD4+ T cell survival
    • 2833313, 15128790
    • Gelman AE, Zhang J, Choi Y, Turka LA. Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol 2004, 172:6065-6073. 2833313, 15128790.
    • (2004) J Immunol , vol.172 , pp. 6065-6073
    • Gelman, A.E.1    Zhang, J.2    Choi, Y.3    Turka, L.A.4
  • 20
    • 67649559511 scopus 로고    scopus 로고
    • Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex
    • 10.1002/eji.200838866, 19405031
    • Komai-Koma M, Gilchrist DS, Xu D. Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex. Eur J Immunol 2009, 39:1564-1572. 10.1002/eji.200838866, 19405031.
    • (2009) Eur J Immunol , vol.39 , pp. 1564-1572
    • Komai-Koma, M.1    Gilchrist, D.S.2    Xu, D.3
  • 21
    • 34249981238 scopus 로고    scopus 로고
    • TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help
    • 10.1182/blood-2006-10-053256, 17339421
    • Hervas-Stubbs S, Olivier A, Boisgerault F, Thieblemont N, Leclerc C. TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Blood 2007, 109:5318-5326. 10.1182/blood-2006-10-053256, 17339421.
    • (2007) Blood , vol.109 , pp. 5318-5326
    • Hervas-Stubbs, S.1    Olivier, A.2    Boisgerault, F.3    Thieblemont, N.4    Leclerc, C.5
  • 22
    • 79961012464 scopus 로고    scopus 로고
    • Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors
    • 10.1177/1753425910372000, 20682587
    • Qiu F, Maniar A, Diaz MQ, Chapoval AI, Medvedev AE. Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors. Innate Immun 2011, 17:375-387. 10.1177/1753425910372000, 20682587.
    • (2011) Innate Immun , vol.17 , pp. 375-387
    • Qiu, F.1    Maniar, A.2    Diaz, M.Q.3    Chapoval, A.I.4    Medvedev, A.E.5
  • 23
    • 77952784713 scopus 로고    scopus 로고
    • Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease
    • 10.4049/jimmunol.0903654, 20228194
    • Motz GT, Eppert BL, Wortham BW, Amos-Kroohs RM, Flury JL, Wesselkamper SC, Borchers MT. Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease. J Immunol 2010, 184:4460-4469. 10.4049/jimmunol.0903654, 20228194.
    • (2010) J Immunol , vol.184 , pp. 4460-4469
    • Motz, G.T.1    Eppert, B.L.2    Wortham, B.W.3    Amos-Kroohs, R.M.4    Flury, J.L.5    Wesselkamper, S.C.6    Borchers, M.T.7
  • 24
    • 80655132160 scopus 로고    scopus 로고
    • Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease
    • Nadigel J, Prefontaine D, Baglole CJ, Maltais F, Bourbeau J, Eidelman DH, Hamid Q. Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease. Resp Res 2011, 12:149.
    • (2011) Resp Res , vol.12 , pp. 149
    • Nadigel, J.1    Prefontaine, D.2    Baglole, C.J.3    Maltais, F.4    Bourbeau, J.5    Eidelman, D.H.6    Hamid, Q.7
  • 26
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002, 168:4531-4537.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 27
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember KA, Godowski PJ. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 2002, 168:554-561.
    • (2002) J Immunol , vol.168 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2
  • 31
    • 38349190718 scopus 로고    scopus 로고
    • Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke
    • MacRedmond RE, Greene CM, Dorscheid DR, McElvaney NG, O'Neill SJ. Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Resp Res 2007, 8:84.
    • (2007) Resp Res , vol.8 , pp. 84
    • MacRedmond, R.E.1    Greene, C.M.2    Dorscheid, D.R.3    McElvaney, N.G.4    O'Neill, S.J.5
  • 34
  • 35
    • 42949090409 scopus 로고    scopus 로고
    • Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4 + CD25+ regulatory T-lymphocyte response to tobacco smoking
    • 10.1183/09031936.00010407, 18057064
    • Barcelo B, Pons J, Ferrer JM, Sauleda J, Fuster A, Agusti AG. Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4 + CD25+ regulatory T-lymphocyte response to tobacco smoking. Eur Respir J 2008, 31:555-562. 10.1183/09031936.00010407, 18057064.
    • (2008) Eur Respir J , vol.31 , pp. 555-562
    • Barcelo, B.1    Pons, J.2    Ferrer, J.M.3    Sauleda, J.4    Fuster, A.5    Agusti, A.G.6
  • 36
    • 66649127821 scopus 로고    scopus 로고
    • Immunologic aspects of chronic obstructive pulmonary disease
    • Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. Eur J Immunol 2009, 360:2445-2454.
    • (2009) Eur J Immunol , vol.360 , pp. 2445-2454
    • Cosio, M.G.1    Saetta, M.2    Agusti, A.3
  • 38
    • 54049096321 scopus 로고    scopus 로고
    • Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity
    • 10.1096/fj.08-108274, 2537425, 18587008
    • Asprodites N, Zheng L, Geng D, Velasco-Gonzalez C, Sanchez-Perez L, Davila E. Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J 2008, 22:3628-3637. 10.1096/fj.08-108274, 2537425, 18587008.
    • (2008) FASEB J , vol.22 , pp. 3628-3637
    • Asprodites, N.1    Zheng, L.2    Geng, D.3    Velasco-Gonzalez, C.4    Sanchez-Perez, L.5    Davila, E.6
  • 39
    • 33745305540 scopus 로고    scopus 로고
    • Conserved nontypeable Haemophilus influenzae-derived TLR2-binding lipopeptides synergize with IFN-beta to increase cytokine production by resident murine and human alveolar macrophages
    • 2373263, 16785566
    • Punturieri A, Copper P, Polak T, Christensen PJ, Curtis JL. Conserved nontypeable Haemophilus influenzae-derived TLR2-binding lipopeptides synergize with IFN-beta to increase cytokine production by resident murine and human alveolar macrophages. J Immunol 2006, 177:673-680. 2373263, 16785566.
    • (2006) J Immunol , vol.177 , pp. 673-680
    • Punturieri, A.1    Copper, P.2    Polak, T.3    Christensen, P.J.4    Curtis, J.L.5
  • 40
    • 0034110061 scopus 로고    scopus 로고
    • Infectious etiology of acute exacerbations of chronic bronchitis
    • 10.1378/chest.117.5_suppl_2.380S, 10843981
    • Sethi S. Infectious etiology of acute exacerbations of chronic bronchitis. Chest 2000, 117:380S-385S. 10.1378/chest.117.5_suppl_2.380S, 10843981.
    • (2000) Chest , vol.117
    • Sethi, S.1
  • 41
    • 3242751816 scopus 로고    scopus 로고
    • Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease
    • 10.1164/rccm.200403-354OC, 15117742
    • Murphy TF, Brauer AL, Schiffmacher AT, Sethi S. Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004, 170:266-272. 10.1164/rccm.200403-354OC, 15117742.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 266-272
    • Murphy, T.F.1    Brauer, A.L.2    Schiffmacher, A.T.3    Sethi, S.4
  • 42
    • 0033135754 scopus 로고    scopus 로고
    • Haemophilus influenzae localized in epithelial cell layers is shielded from antibiotics and antibody-mediated bactericidal activity
    • 10.1006/mpat.1998.0269, 10222210
    • van Schilfgaarde M, Eijk P, Regelink A, van Ulsen P, Everts V, Dankert J, van Alphen L. Haemophilus influenzae localized in epithelial cell layers is shielded from antibiotics and antibody-mediated bactericidal activity. Microb Pathog 1999, 26:249-262. 10.1006/mpat.1998.0269, 10222210.
    • (1999) Microb Pathog , vol.26 , pp. 249-262
    • van Schilfgaarde, M.1    Eijk, P.2    Regelink, A.3    van Ulsen, P.4    Everts, V.5    Dankert, J.6    van Alphen, L.7
  • 43
    • 0035845592 scopus 로고    scopus 로고
    • Survival of nontypeable Haemophilus influenzae in macrophages
    • 10.1111/j.1574-6968.2001.tb10820.x, 11557140
    • Craig JE, Cliffe A, Garnett K, High NJ. Survival of nontypeable Haemophilus influenzae in macrophages. FEMS Microbiol Lett 2001, 203:55-61. 10.1111/j.1574-6968.2001.tb10820.x, 11557140.
    • (2001) FEMS Microbiol Lett , vol.203 , pp. 55-61
    • Craig, J.E.1    Cliffe, A.2    Garnett, K.3    High, N.J.4
  • 45
    • 0034606218 scopus 로고    scopus 로고
    • Interferon gamma induction of pulmonary emphysema in the adult murine lung
    • 10.1084/jem.192.11.1587, 2193095, 11104801
    • Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000, 192:1587-1600. 10.1084/jem.192.11.1587, 2193095, 11104801.
    • (2000) J Exp Med , vol.192 , pp. 1587-1600
    • Wang, Z.1    Zheng, T.2    Zhu, Z.3    Homer, R.J.4    Riese, R.J.5    Chapman, H.A.6    Shapiro, S.D.7    Elias, J.A.8
  • 46
    • 0037106511 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown
    • 10.1164/rccm.200202-097OC, 12231496
    • Churg A, Dai J, Tai H, Xie C, Wright JL. Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am J Respir Crit Care Med 2002, 166:849-854. 10.1164/rccm.200202-097OC, 12231496.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 849-854
    • Churg, A.1    Dai, J.2    Tai, H.3    Xie, C.4    Wright, J.L.5
  • 47
    • 0037447184 scopus 로고    scopus 로고
    • Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release
    • 10.1164/rccm.200212-1396OC, 12522030
    • Churg A, Wang RD, Tai H, Wang X, Xie C, Dai J, Shapiro SD, Wright JL. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med 2003, 167:1083-1089. 10.1164/rccm.200212-1396OC, 12522030.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1083-1089
    • Churg, A.1    Wang, R.D.2    Tai, H.3    Wang, X.4    Xie, C.5    Dai, J.6    Shapiro, S.D.7    Wright, J.L.8
  • 48
    • 4444322565 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse
    • 10.1164/rccm.200404-511OC, 15184206
    • Churg A, Wang RD, Tai H, Wang X, Xie C, Wright JL. Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2004, 170:492-498. 10.1164/rccm.200404-511OC, 15184206.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 492-498
    • Churg, A.1    Wang, R.D.2    Tai, H.3    Wang, X.4    Xie, C.5    Wright, J.L.6
  • 50
    • 56149110848 scopus 로고    scopus 로고
    • MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection
    • 2835404, 18768833
    • Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol 2008, 181:3804-3810. 2835404, 18768833.
    • (2008) J Immunol , vol.181 , pp. 3804-3810
    • Rahman, A.H.1    Cui, W.2    Larosa, D.F.3    Taylor, D.K.4    Zhang, J.5    Goldstein, D.R.6    Wherry, E.J.7    Kaech, S.M.8    Turka, L.A.9
  • 51
    • 70349583503 scopus 로고    scopus 로고
    • The contribution of direct TLR signaling to T cell responses
    • 10.1007/s12026-009-8113-x, 19597998
    • Rahman AH, Taylor DK, Turka LA. The contribution of direct TLR signaling to T cell responses. Immunol Res 2009, 45:25-36. 10.1007/s12026-009-8113-x, 19597998.
    • (2009) Immunol Res , vol.45 , pp. 25-36
    • Rahman, A.H.1    Taylor, D.K.2    Turka, L.A.3


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