Modulation of transient receptor potential vanilloid subtype 1 (trpv1) and norepinephrine transporters (net) protect against oxidative stress, cellular injury, and vascular dementia

Current Neurovascular Research

Volumn 11, Issue 2, 2014, Pages 94-106

  Gupta, Surbhi ^a   Sharma, Bhupesh ^b,c   Singh, Prabhat ^a   Sharma, Brij Mohan ^b  

^a Neuropharmacology Lab Department of Pharmacology School of Pharmacy   (India)

^b BHARAT INSTITUTE OF TECHNOLOGY   (India)

^c Dilshad Garden   (India)

Author keywords

2 3 5 Triphenylterazolium chloride staining; Acetylcholinesterase; Atomoxetine; Morris water maze; Oxidative stress; Two vessel occlusion; Vanillin

Indexed keywords

ACETYLCHOLINESTERASE; ATOMOXETINE; CATALASE; GLUTATHIONE; MALONALDEHYDE; NORADRENALIN TRANSPORTER; SUPEROXIDE DISMUTASE; VANILLIN; VANILLOID RECEPTOR 1; ADRENERGIC RECEPTOR AFFECTING AGENT; ANTIOXIDANT; BENZALDEHYDE DERIVATIVE; PROPYLAMINE; SLC6A2 PROTEIN, MOUSE; TRPV1 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CAROTID ARTERY LIGATION; CELL DAMAGE; COMMON CAROTID ARTERY; CONTROLLED STUDY; ENZYME ACTIVITY; LEARNING; LOCOMOTION; MEMORY; MORRIS WATER MAZE TEST; MOTOR COORDINATION; MOUSE; MULTIINFARCT DEMENTIA; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PERFUSION; PRIORITY JOURNAL; ANIMAL; BRAIN; COMPLICATION; DEMENTIA, VASCULAR; DISEASE MODEL; DRUG EFFECTS; FEMALE; MALE; MAZE TEST; METABOLISM; PATHOLOGY; VASCULARIZATION;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIOXIDANTS; BENZALDEHYDES; BRAIN; BRAIN ISCHEMIA; DEMENTIA, VASCULAR; DISEASE MODELS, ANIMAL; FEMALE; MALE; MAZE LEARNING; MICE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; PROPYLAMINES; TRPV CATION CHANNELS;

EID: 84900528245     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/1567202611666140305221854     Document Type: Article

References (75)

1. Sudduth TL, Powell DK, Smith CD, Greenstein A, Wilcock DM. Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J Cereb Blood Flow Metab 2013. doi: 10.1038/jcbfm.2013.1.
2. Chen Y, Mancuso J, Zhao Z, et al. Vasodilation by in vivo activation of astrocyte endfeet via two-photon calcium uncaging as a strategy to prevent brain ischemia. J Biomed Opt 2013; 18(12): 126012.
3. de la Torre JC, Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia, Cardiovasc. Psychiatry Neurol 2012; 2012: 367516.
4. Xi Y, Wang M, Zhang W, et al. Neuronal damage, central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion. Neurobiol Learn Mem 2013. pii: S1074-7427(13)00244-X. doi: 10.1016/j.nlm.2013.11.016. PMID: 24315928.
5. Guang HM, Du GH. Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats. Eur J Pharmacol 2006; 542(1-3): 77-83.
6. Vriens J, Appendino G, Nilius B. Review Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol 2009; 75(6): 1262-79.
7. Pecze L, Blum W, Schwaller B. Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin. Biochim Biophys Acta 2012. pii: S0167-4889(12)00252-2. doi: 10.1016/j.bbamcr.2012.08.018.
8. Goswami C, Rademacher N, Smalla KH, et al. TRPV1 acts as a synaptic protein and regulates vesicle recycling. J Cell Sci 2010; 123(12): 2045-57.
9. Gregorio-Teruel L, Valente P, González-Ros JM, Fernández-Ballester G, Ferrer-Montiel A. Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation. J Gen Physiol 2014; 143(3): 361-75.
10. Morales-Lázaro SL, Simon SA, Rosenbaum T. The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). J Physiol 2013; 591(13): 3109-21.
11. Winter Z, Buhala A, Ötvös F, et al. Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel-an overview of the current mutational data. Mol Pain 2013; 9: 30.
12. Ma W, Quirion R. Review Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain. Expert Opin Ther Targets 2007; 11(3): 307-20.
13. Palazzo E, Luongo L, de Novellis V, Berrino L, Rossi F, Maione S. Moving towards supraspinal TRPV1 receptors for chronic pain relief. Mol Pain 2010; 6: 66.
14. Grotenhermen F. Pharmacology of cannabinoids. Neuro Endocrinol Lett 2004; 25(1-2): 14-23.
15. Ray AM, Benham CD, Roberts JC, et al. Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h). J Neurosci 2003; 23(31): 10146-53.
16. Almeida V, Peres FF, Levin R, et al. Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: The SHR strain. Schizophr Res 2014. pii: S0920-9964(14)00062-0. doi: 10.1016/j.schres. 2014.01.039.
17. Tai A, Sawano T, Yazama F, Ito H. Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays. Biochim Biophys Acta 2011; 1810 (2): 170-7.
18. Wu SL, Chen JC, Li CC, Lo HY, Ho TY, Hsiang CY. Vanillin improves and prevents trinitrobenzene sulfonic acid-induced colitis in mice. J Pharmacol Exp Ther 2009; 330(2): 370-6.
19. Muzzi M, Felici R, Cavone L, et al. Ischemic neuroprotection by TRPV1 receptor-induced hypothermia. J Cereb Blood Flow Metab 2012; 32(6): 978-82.
20. Bennion D, Jensen T, Walther C, et al. Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system. Neuropharmacology 2011; 61(4): 730-8.
21. Zhou J. Norepinephrine transporter inhibitors and their therapeutic potential. Drugs Future 2004; 29(12): 1235-1244.
22. Simonini MV, Polak PE, Sharp A, McGuire S, Galea E, Feinstein DL. Increasing CNS noradrenaline reduces EAE severity. J Neuroimmune Pharmacol 2010; 5(2): 252-9.
23. Bari A, Aston-Jones G (2013). Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons. Neuropharmacology 64: 53-64.
24. Reid WM, Hamm RJ. Post-injury atomoxetine treatment improves cognition following experimental traumatic brain injury. J Neurotrauma 2008; 25(3): 248-56.
25. Makni M, Chtourou Y, Garoui EM, Boudawara T, Fetoui H. Carbon tetrachloride-induced nephrotoxicity and DNA damage in rats: protective role of vanillin. Hum Exp Toxicol 2012; 31(8): 844-52.
26. Tamburella A, Micale V, Mazzola C, Salomone S, Drago F. The selective norepinephrine reuptake inhibitor atomoxetine counteracts behavioral impairments in trimethyltin-intoxicated rats. Eur J Pharmacol 2012; 683(1-3): 148-54.
27. Gupta S, Sharma B. Pharmacological modulation of I1-imidazoline and-2-adrenoceptors in sub acute brain ischemia induced vascular dementia. Eur J Pharmacol 2014a; 723: 80-90.
28. Gupta S, Sharma B. Pharmacological benefit of I1-imidazoline receptors activation and nuclear factor kappa-B (NF-kB) modulation in experimental Huntington's disease. Brain Res Bull 2014. doi: 10.1016/j.brainresbull.2014.02. 007.
29. Sharma B, Singh N. Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats. Psychopharmacology (Berl.) 2011a; 215(4): 677-687.
30. Sharma B, Singh N. Salutary effect of NF-B inhibitor and folacin in hyperhomocysteinemia-hyperlipidemia induced vascular dementia. Prog Neuropsychopharmacol Biol Psychiatry 2012a; 38(2): 207-215.
31. Sharma B, Singh N. Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats. Pharmacol Biochem Behav 2013; 103(4): 821-30.
32. Sharma B, Singh N. Behavioral and biochemical investigations to explore pharmacological potential of PPAR-gamma agonists in vascular dementia of diabetic rats. Pharmacol Biochem Behav 2011b; 100(2): 320-329.
33. Sharma B, Singh N. Experimental hypertension induced vascular dementia: pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor. Pharmacol Biochem Behav 2012b; 102(1): 101-108.
34. Sharma B, Singh N. Pitavastatin and 4-hydroxy-3-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes. Curr Neurovasc Res 2010; 7(3): 180-191.
35. Sharma B, Singh N. Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats. Psychopharmacology (Berl.) 2012c; 223(3): 307-317.
36. Sharma B, Sharma PM. Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors. Toxicol Appl Pharmacol 2013; 273(1): 180-8.
37. Shibata M, Yamasaki N, Miyakawa T, Kalaria RN, Fujita Y, Ohtani R, Ihara M, Takahashi R, Tomimoto H. Selective impairment of working memory in a mouse model of chronic cerebralhypoperfusion. Stroke 2007; 38(10): 2826-2832.
38. Yao ZH, Zhang JJ, Xie XF. Enriched environment prevents cognitive impairment and tau hyperphosphorylation after chronic cerebral hypoperfusion. Curr Neurovasc Res 2012; 9(3): 176-184.
39. Du J, Ma M, Zhao Q, et al. Mitochondrial bioenergetic deficits in the hippocampi of rats with chronic ischemia-induced vascular dementia. Neuroscience 2013; 231: 345-352.
40. Kitamura A, Fujita Y, Oishi N, et al. Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiol Aging 2012; 33(5): 1012.
41. Liu H, Zhang J. Cerebral hypoperfusion and cognitive impairment: the pathogenic role of vascular oxidative stress. Int J Neurosci 2012; 122(9): 494-499.
42. Shu Y, Zhang H, Kang T, et al. PI3K/Akt Signal Pathway Involved in the Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion in Rats. PLoS One 2013; 8(12): e81901.
43. Xi Y, Wang M, Zhang W, et al. Neuronal damage, central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion. Neurobiol Learn Mem 2013; 109C: 7-19.
44. Cai QY, Chen XS, Zhan XL, Yao ZX. Protective effects of catalpol on oligodendrocyte death and myelin breakdown in a rat model of chronic cerebral hypoperfusion. Neurosci Lett 2011; 497(1): 22-6.
45. Xu B, Li XX, He GR, et al. Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats. Eur J Pharmacol 2010; 627(1-3): 99-105.
46. Kuang X, Du JR, Liu YX, Zhang GY, Peng HY. Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. Pharmacol Biochem Behav 2008; 88(3): 213-21.
47. Genro BP, de Oliveira Alvares L, Quillfeldt JA. Role of TRPV1 in consolidation of fear memories depends on the averseness of the conditioning procedure. Neurobiol Learn Mem 2012; 97(4): 355-60.
48. Pegorini S, Zani A, Braida D, Guerini-Rocco C, Sala M. Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection. Br J Pharmacol 2006; 147(5): 552-9.
49. Li HB, Mao RR, Zhang JC, Yang Y, Cao J, Xu L. Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory. Biol Psychiatry 2008; 64(4): 286-92.
50. You IJ, Jung YH, Kim MJ, et al. Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT-A, GABA(A), and NMDA receptors. Neuropharmacology 2012; 62(2): 1034-43.
51. Spicarova D, Nerandzic V, Palecek J. Update on the role of spinal cord TRPV1 receptors in pain modulation. Physiol Res. 2014; 63(1): S225-36.
52. Fenwick AJ, Wu SW, Peters JH. Isolation of TRPV1 independent mechanisms of spontaneous and asynchronous glutamate release at primary afferent to NTS synapses. Front Neurosci 2014; 8: 6.
53. Kundu A, Mitra A. Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities. Plant Foods Hum Nutr 2013; 68: 247-53.
54. Wilson CA, Terry AV Jr. Variable maternal stress in rats alters locomotor activity, social behavior, and recognition memory in the adult offspring. Pharmacol Biochem Behav 2013; 104: 47-61.
55. Wee S, Woolverton WL. Evaluation of the reinforcing effects of atomoxetine in monkeys: comparison to methylphenidate and desipramine. Drug Alcohol Depend 2004; 75(3): 271-6.
56. Clinton SM, Sucharski IL, Finlay JM. Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex. Psychopharmacology (Berl) 2006; 183(4): 404-12.
57. Zhang L, Ouyang M, Ganellin CR, Thomas SA. The slow afterhyperpolarization: a target of-1-adrenergic signaling in hippocampus-dependent memory retrieval. J Neurosci 2013; 33(11): 5006-16.
58. De Bundel D, Femenía T, DuPont CM, et al. Hippocampal and prefrontal dopamine D1/5 receptor involvement in the memoryenhancing effect of reboxetine. Int J Neuropsychopharmacol 2013; 16(9): 2041-51.
59. Tzavara ET, Bymaster FP, Overshiner CD, et al. Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine. Mol Psychiatry 2006; 11(2): 187-95.
60. Aliev G, Smith MA, Obrenovich ME, de la Torre JC, Perry G. Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotox Res 2003; 5(7): 491-504.
61. Schilling T, Eder C. Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation. J Neuroimmunol 2009; 216(1-2): 118-21.
62. Nazirolu M, Ci B, Ozgül C. Neuroprotection induced by Nacetylcysteine against cytosolic glutathione depletion-induced Ca2+ influx in dorsal root ganglion neurons of mice: role of TRPV1 channels. Neuroscience 2013; 242: 151-60.
63. Park ES, Kim SR, Jin BK. Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress. Brain Res Bull 2012; 89(3-4): 92-6.
64. Dai Z, Xiao J, Liu SY, Cui L, Hu GY, Jiang DJ. Rutaecarpine inhibits hypoxia/reoxygenation-induced apoptosis in rat hippocampal neurons. Neuropharmacology 2008; 55(8): 1307-12.
65. Berdyshev EV, Schmid PC, Krebsbach RJ, et al. Cannabinoid receptor cell signalling by N-acylethanolamines. Biochem J 2001; 360: 67-75.
66. Kamat JP, Ghosh A, Devasagayam TP. Vanillin as an antioxidant in rat liver mitochondria: inhibition of protein oxidation and lipid peroxidation induced by photosensitization. Mol Cell Biochem 2000; 209(1-2): 47-53.
67. Schmidt AJ, Clement HW, Gebhardt S, et al. Impact of psychostimulants and atomoxetine on the expression of 8-hydroxyguanine glycosylase 1 in human cells. J Neural Transm 2010; 117(6): 793-7.
68. Mao W, Iwai C, Qin F, Liang CS. Norepinephrine induces endoplasmic reticulum stress and downregulation of norepinephrine transporter density in PC12 cells via oxidative stress. Am J Physiol Heart Circ Physiol 2005; 288(5): H2381-9.
69. He XL, Wang YH, Bi MG, Du GH. Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats. Eur J Pharmacol 2012; 680(1-3): 41-8.
70. Ganzella M, de Oliveira ED, Comassetto DD, et al. Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion. Neurol Sci 2012; 33(5): 985-97.
71. Yoon S, Zuccarello M, Rapoport RM. Sensory nerves and transient receptor potential vanilloid 1 channels in CO2 regulation of cerebrovascular tone. Respir Physiol Neurobiol 2014. pii: S1569-9048(14)00043-3. doi: 10.1016/j.resp.2014. 02.002.
72. Khatibi NH, Jadhav V, Charles S, et al. Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxicischemic brain injury in rats. Acta Neurochir Suppl. 2011; 111: 225-30.
73. Cao Z, Balasubramanian A, Marrelli SP. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. Am J Physiol Regul Integr Comp Physiol 2014; 306(2): R149-56.
74. Lee JG, Yon JM, Lin C, Jung AY, Jung KY, Nam SY. Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons. Food Chem Toxicol 2012; 50(11): 3877-85.
75. Wu X, Jiang H, Yu L, Hu X, Liu W. Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia. J Biomed Biotechnol. 2012; 2012: 732909.