Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats

European Journal of Pharmacology

Volumn 680, Issue 1-3, 2012, Pages 41-48

  He, Xiao Li ^a   Wang, Yue Hua ^b   Bi, Ming Gang ^a   Du, Guan Hua ^b  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Chronic cerebral hypoperfusion; Chrysin; Inflammation; Oxidative stress; Spatial learning; White matter lesion

Indexed keywords

CATALASE; CHRYSIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE PEROXIDASE; LIPID PEROXIDE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN DAMAGE; BRAIN PERFUSION; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DRUG DOSE COMPARISON; ENZYME ACTIVITY; ESCAPE BEHAVIOR; HIPPOCAMPUS; IMMUNOREACTIVITY; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; MORRIS WATER MAZE TEST; NERVE DEGENERATION; NERVE INJURY; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREATMENT DURATION; WHITE MATTER;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASTROCYTES; BRAIN; BRAIN DAMAGE, CHRONIC; BRAIN ISCHEMIA; CAROTID ARTERY, COMMON; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; DEMENTIA; FLAVONOIDS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE PEROXIDASE; LEARNING DISORDERS; LIPID PEROXIDES; MALE; MAZE LEARNING; MEMORY DISORDERS; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 84862832586     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.01.025     Document Type: Article

References (33)

1. G. Aliev, M.A. Smith, M.E. Obrenovich, J.C. de la Torre, and G. Perry Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease Neurotox. Res. 5 2003 491 504
2. B. Borroni, D. Anchisi, B. Paghera, B. Vicini, N. Kerrouche, V. Garibotto, A. Terzi, L.A. Vignolo, M. Di Luca, R. Giubbini, A. Padovani, and D. Perani Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD Neurobiol. Aging 27 2006 24 31 (Pubitemid 41627946)
3. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
4. H. Cho, C.W. Yun, W.K. Park, J.Y. Kong, K.S. Kim, Y. Park, S. Lee, and B.K. Kim Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives Pharmacol. Res. 49 2004 37 43 (Pubitemid 37324901)
5. Z.Z. Chong, F. Li, and K. Maiese Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease Prog. Neurobiol. 75 2005 207 246 (Pubitemid 40693131)
6. J.C. de la Torre Vascular basis of Alzheimer's pathogenesis Ann. N. Y. Acad. Sci. 977 2002 196 215
7. J. Duarte, R. Jimenez, I.C. Villar, F. Perez-Vizcaino, J. Jimenez, and J. Tamargo Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta Planta Med. 67 2001 567 569 (Pubitemid 32800430)
8. M. Encinas, R. De Juan, A. Marcos, P. Gil, A. Barabash, C. Fernandez, C. De Ugarte, and J.A. Cabranes Regional cerebral blood flow assessed with 99mTc-ECD SPET as a marker of progression of mild cognitive impairment to Alzheimer's disease Eur. J. Nucl. Med. Mol. Imaging 30 2003 1473 1480 (Pubitemid 37356114)
9. E. Farkas, and P.G. Luiten Cerebral microvascular pathology in aging and Alzheimer's disease Prog. Neurobiol. 64 2001 575 611 (Pubitemid 32304447)
10. E. Farkas, P.G. Luiten, and F. Bari Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases Brain Res. Rev. 54 2007 162 180 (Pubitemid 46498166)
11. I. Fridovich Superoxide radical and superoxide dismutases Annu. Rev. Biochem. 64 1995 97 112
12. X.L. He, Y.H. Wang, M. Gao, X.X. Li, T.T. Zhang, and G.H. Du Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage Brain Res. 1249 2009 212 221
13. C. Humpel, and J. Marksteiner Cerebrovascular damage as a cause for Alzheimer's disease Curr. Neurovasc. Res. 2 2005 341 347 (Pubitemid 41297371)
14. H. Izuta, M. Shimazama, S. Tazawa, Y. Araki, S. Mishima, and H. Hara Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells J. Agric. Food Chem. 56 2008 8944 8953
15. S. Kasparova, V. Brezova, M. Valko, J. Horecky, V. Mlynarik, T. Liptaj, O. Vancova, O. Ulicna, and D. Dobrota Study of the oxidative stress in a rat model of chronic brain hypoperfusion Neurochem. Int. 46 2005 601 611 (Pubitemid 40614863)
16. D.J. Krupa, J.K. Thompson, and R.F. Thompson Localization of a memory trace in the mammalian brain Science 260 1993 989 991 (Pubitemid 23209974)
17. T. Lapidot, M.D. Walker, and J. Kanner Antioxidant and prooxidant effects of phenolics on pancreatic beta-cells in vitro J. Agric. Food Chem. 50 2002 7220 7225 (Pubitemid 35424880)
18. W.R. Markesbery Oxidative stress hypothesis in Alzheimer's disease Free Radic. Biol. Med. 23 1997 134 147 (Pubitemid 27217017)
19. L.D. Mercer, B.L. Kelly, M.K. Horne, and P.M. Beart Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures Biochem. Pharmacol. 69 2005 339 345 (Pubitemid 41556580)
20. L. Minghetti Role of inflammation in neurodegenerative diseases Curr. Opin. Neurol. 18 2005 315 321 (Pubitemid 40813762)
21. R. Morris Developments of a water-maze procedure for studying spatial learning in the rat J. Neurosci. Methods 11 1984 47 60 (Pubitemid 14088970)
22. J. Ni, H. Ohta, K. Matsumoto, and H. Watanabe Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats Brain Res. 653 1994 231 236 (Pubitemid 24252843)
23. F. Nobili, F. Copello, F. Buffoni, P. Vitali, N. Girtler, C. Bordoni, E. Safaie-Semnani, G. Mariani, and G. Rodriguez Regional cerebral blood flow and prognostic evaluation in Alzheimer's disease Dement. Geriatr. Cogn. Disord. 12 2001 89 97 (Pubitemid 32149713)
24. Y. Peng, S. Xu, G. Chen, L. Wang, Y. Feng, and X. Wang l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats J. Pharmacol. Exp. Ther. 321 2007 902 910 (Pubitemid 46762705)
25. P. Rapta, V. Misik, A. Stasko, and I. Vrabel Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study Free Radic. Biol. Med. 18 1995 901 908
26. G.C. Roman Brain hypoperfusion: a critical factor in vascular dementia Neurol. Res. 26 2004 454 458 (Pubitemid 38879227)
27. C. Sarti, L. Pantoni, L. Bartolini, and D. Inzitari Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models J. Neurol. Sci. 203-204 2002 263 266 (Pubitemid 35287408)
28. M. Sopala, and W. Danysz Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory J. Neural Transm. 108 2001 1445 1456 (Pubitemid 34020448)
29. E. Tarkowski, A.M. Liljeroth, L. Minthon, A. Tarkowski, A. Wallin, and K. Blennow Cerebral pattern of pro- and anti-inflammatory cytokines in dementias Brain Res. Bull. 61 2003 255 260 (Pubitemid 36952471)
30. H. Wakita, H. Tomimoto, I. Akiguchi, and J. Kimura Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study Acta Neuropathol. 87 1994 484 492 (Pubitemid 24128976)
31. T. Watanabe, N. Zhang, M. Liu, R. Tanaka, Y. Mizuno, and T. Urabe Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion Stroke 37 2006 1539 1545 (Pubitemid 44305739)
32. C.A. Williams, J.B. Harborne, M. Newman, J. Greenham, and J. Eagles Chrysin and other leaf exudate flavonoids in the genus Pelargonium Phytochemistry 46 1997 1349 1353 (Pubitemid 28000402)
33. X.L. Zhao, X.B. Fang, and D.P. Li Establishing vascular dementia model in rats J. Chin. Med. Univ. 31 2002 166 167