Post-injury atomoxetine treatment improves cognition following experimental traumatic brain injury

Journal of Neurotrauma

Volumn 25, Issue 3, 2008, Pages 248-256

  Reid, Wendy M ^a   Hamm, Robert J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Animal study; Atomoxetine; Dopamine; Fluid percussion injury; Morris water maze; Norepinephrine; Traumatic brain injury

Indexed keywords

ATOMOXETINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE MODEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; EXPERIMENTAL STUDY; INJURY SEVERITY; MALE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; TRAUMATIC BRAIN INJURY; TREATMENT RESPONSE;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BRAIN; BRAIN INJURIES; CATECHOLAMINES; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; MALE; MAZE LEARNING; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROPYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; TIME FACTORS; TREATMENT OUTCOME;

EID: 40949126576     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2007.0389     Document Type: Article

References (57)

1. Baranova, A.I., Whiting, M.D., and Hamm, R.J. (2006). Delayed, post-injury treatment with aniracetam improves cognitive performance after traumatic brain injury in rats. J. Neurotrauma 23, 1233-1240.
2. Brandeis, R., Brandys, Y., and Yehuda, S. (1989). The use of the Morris water maze in the study of memory and learning. Int. J. Neurosci. 48, 29-69.
3. Bymaster, F.P., Katner, J.S., Nelson, D.L., et al. (2002). Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27, 699-711.
4. Chen, M.J., Nguyen, T.V., Pike, C.J., and Russo-Neustadt, A.A. (2007). Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons. Cell Signal. 19, 114-128.
5. Christman, A.K., Fermo, J.D., and Markowitz, J.S. (2004). Atomoxetine, a novel treatment for attention-deficit-hyperactivity disorder. Pharmacotherapy 24, 1020-1036.
6. D'Sa, C., and Duman, R.S. (2002). Antidepressants and neuroplasticity. Bipolar Disord. 4, 183-194.
7. Dello, R.C., Boullerne, A.I., Gavrilyuk, V., and Feinstein, D.L. (2004). Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production. J. Neuroinflammation 1, 9.
8. Dixon, C.E., Lyeth, B.G., Povlishock, J.T., et al. (1987). A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119.
9. Dixon, C.E., Kraus, M.F., Kline, A.E., et al. (1999). Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats. Restor. Neurol. Neurosci. 14, 285-294.
10. Dunn-Meynell, A., Pan, S., and Levin, B.E. (1994). Focal traumatic brain injury causes widespread reductions in rat brain norepinephrine turnover from 6 to 24 h. Brain Res. 660, 88-95.
11. Emery, D.L., Raghupathi, R., Saatman, K.E., Fischer, I., Grady, M.S., and McIntosh, T.K. (2000). Bilateral growth-related protein expression suggests a transient increase in regenerative potential following brain trauma. J. Comp. Neurol. 424, 521-531.
12. Feeney, D.M., and Westerberg, V.S. (1990). Norepinephrine and brain damage: alpha noradrenergic pharmacology alters functional recovery after cortical trauma. Can. J. Psychol. 44, 233-252.
13. Feeney, D.M., Gonzales, A., and Law, W.A. (1981). Amphetamine restores locomotor function after motor cortex injury in the rat. Proc. West Pharmacol. Soc. 24, 15-17.
14. Forsyth, R.J., Jayamoni, B., and Paine, T.C. (2006). Monoaminergic agonists for acute traumatic brain injury. Cochrane Database Syst. Rev. CD003984.
15. Foster, D.J., Good, D.C., Fowlkes, A., and Sawaki, L. (2006). Atomoxetine enhances a short-term model of plasticity in humans. Arch. Phys. Med. Rehabil. 87, 216-221.
16. Fujinaka, T., Kohmura, E., Yuguchi, T., and Yoshimine, T. (2003). The morphological and neurochemical effects of diffuse brain injury on rat central noradrenergic system. Neurol. Res. 25, 35-41.
17. 3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites. Neurosci. Lett. 157, 203-206.
18. Gladstone, D.J., and Black, S.E. (2000). Enhancing recovery after stroke with noradrenergic pharmacotherapy: a new frontier? Can. J. Neurol. Sci. 27, 97-105.
19. Goldstein, L.B. (2006). Neurotransmitters and motor activity: effects on functional recovery after brain injury. NeuroRx 3, 451-457.
20. Goldstein, L.B., and Davis, J.N. (1990). Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat. Brain Res. 508, 305-309.
21. Gu, Q. (2002). Neuromodulatory transmitter systems in the cortex and their role in cortical plasticity. Neuroscience 111, 815-835.
22. Hamm, R.J. (2001). Neurobehavioral assessment of outcome following traumatic brain injury in rats: an evaluation of selected measures. J. Neurotrauma 18, 1207-1216.
23. Kline, A.E., Yan, H.Q., Bao, J., Marion, D.W., and Dixon, C.E. (2000). Chronic methylphenidate treatment enhances water maze performance following traumatic brain injury in rats. Neurosci. Lett. 280, 163-166.
24. Kline, A.E., Massucci, J.L., Marion, D.W., and Dixon, C.E. (2002). Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact. J. Neurotrauma 19, 415-425.
25. Kobori, N., and Dash, P.K. (2006). Reversal of brain injury-induced prefrontal glutamic acid decarboxylase expression and working memory deficits by D1 receptor antagonism. J. Neurosci. 26, 4236-4246.
26. Kobori, N., Clifton, G.L., and Dash, P.K. (2006). Enhanced catecholamine synthesis in the prefrontal cortex after traumatic brain injury: implications for prefrontal dysfunction. J. Neurotrauma 23, 1094-1102.
27. Kolb, B., and Sutherland, R.J. (1992). Noradrenaline depletion blocks behavioral sparing and alters cortical morphogenesis after neonatal frontal cortex damage in rats. J. Neurosci. 12, 2321-2330.
28. Laifenfeld, D., Klein, E., and Ben-Shachar, D. (2002). Norepinephrine alters the expression of genes involved in neuronal sprouting and differentiation: relevance for major depression and antidepressant mechanisms. J. Neurochem. 83, 1054-1064.
29. Lee, J., Duan, W., and Mattson, M.P. (2002). Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J. Neurochem. 82, 1367-1375.
30. Leone, H., and Polsonetti, B.W. (2005). Amantadine for traumatic brain injury: does it improve cognition and reduce agitation? J. Clin. Pharm. Ther. 30, 101-104.
31. Madrigal, J.L., Feinstein, D.L., and Dello, R.C. (2005). Norepinephrine protects cortical neurons against microglial-induced cell death. J. Neurosci. Res. 81, 390-396.
32. Marien, M.R., Colpaert, F.C., and Rosenquist, A.C. (2004). Noradrenergic mechanisms in neurodegenerative diseases: a theory. Brain Res. Brain Res. Rev. 45, 38-78.
33. Massucci, J.L., Kline, A.E., Ma, X., Zafonte, R.D., and Dixon, C.E. (2004). Time dependent alterations in dopamine tissue levels and metabolism after experimental traumatic brain injury in rats. Neurosci. Lett. 372, 127-131.
34. Mattiuz, E.L., Ponsler, G.D., Barbuch, R.J., et al. (2003). Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog. Drug Metab. Dispos. 31, 88-97.
35. McAllister, T.W., Flashman, L.A., McDonald, B.C., and Saykin, A.J. (2006). Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. J. Neurotrauma 23, 1450-1467.
36. McDowell, S., Whyte, J., and D'Esposito, M. (1998). Differential effect of a dopaminergic agonist on prefrontal function in traumatic brain injury patients. Brain 121, 1155-1164.
37. McIntosh, T.K., Yu, T., and Gennarelli, T.A. (1994). Alterations in regional brain catecholamine concentrations after experimental brain injury in the rat. J. Neurochem. 63, 1426-1433.
38. McIntosh, T.K., Smith, D.H., and Garde, E. (1996). Therapeutic approaches for the prevention of secondary brain injury. Eur. J. Anaesthesiol. 13, 291-309.
39. Meythaler, J.M., Brunner, R.C., Johnson, A., and Novack, T.A. (2002). Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial. J. Head Trauma Rehabil. 17, 300-313.
40. Moron, J.A., Brockington, A., Wise, R.A., Rocha, B.A., and Hope, B.T. (2002). Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J. Neurosci. 22, 389-395.
41. Nakagawa, S., Kim, J.E., Lee, R., et al. (2002). Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J. Neurosci. 22, 3673-3682.
42. Napolitano, E., Elovic, E.P., and Qureshi, A.I. (2005). Pharmacological stimulant treatment of neurocognitive and functional deficits after traumatic and non-traumatic brain injury. Med. Sci. Monit. 11, RA212-RA220.
43. O'Dell, D.M., and Hamm, R.J. (1995). Chronic postinjury administration of MDL 26,479 (Suritozole), a negative modulator at the GABAA receptor, and cognitive impairment in rats following traumatic brain injury. J. Neurosurg. 83, 878-883.
44. Pike, B.R., and Hamm, R.J. (1995). Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 686, 37-43.
45. Prasad, M.R., Dose, J.M., Dhillion, H.S., Carbary, T., and Kraemer, P.J. (1995). Amphetamine affects the behavioral outcome of lateral fluid percussion brain injury in the rat. Restor. Neurol. Neurosci. 9, 65-75.
46. Ripley, D.L. (2006). Atomoxetine for individuals with traumatic brain injury. J. Head Trauma Rehabil. 21, 85-88.
47. Salmond, C.H., and Sahakian, B.J. (2005). Cognitive outcome in traumatic brain injury survivors. Curr. Opin. Crit. Care 11, 111-116.
48. Smith, D.C., Modglin, A.A., Roosevelt, R.W., et al. (2005). Electrical stimulation of the vagus nerve enhances cognitive and motor recovery following moderate fluid percussion injury in the rat. J. Neurotrauma 22, 1485-1502.
49. Sutherland, R.J., Kolb, B., Whishaw, I.Q., and Becker, J.B. (1982). Cortical noradrenaline depletion eliminates sparing of spatial learning after neonatal frontal cortex damage in the rat. Neurosci. Lett. 32, 125-130.
50. Sutton, R.L., and Feeney, D.M. (1992). -Noradrenergic agonists and antagonists affect recovery and maintenance of beam-walking ability after sensorimotor cortex ablation in the rat. Restor. Neurol. Neurosci. 9, 1-11.
51. Swanson, C.J., Perry, K.W., Koch-Krueger, S., Katner, J., Svensson, K.A., and Bymaster, F.P. (2006). Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat. Neuropharmacology 50, 755-760.
52. Tzavara, E.T., Bymaster, F.P., Overshiner, C.D., et al. (2006). Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine. Mol. Psychiatry 11, 187-195.
53. Warden, D.L., Gordon, B., McAllister, T.W., et al. (2006). Guidelines for the pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury. J. Neurotrauma 23, 1468-1501.
54. Whiting, M.D., and Hamm, R.J. (2004). Treating chronic cognitive impairment after traumatic brain injury: a review of post-traumatic neurotransmitter-based interventions. Phys. Rehabil. Med. 16, 273-290.
55. Whyte, J., Hart, T., Vaccaro, M., et al. (2004). Effects of methylphenidate on attention deficits after traumatic brain injury: a multidimensional, randomized, controlled trial. Am. J. Phys. Med. Rehabil. 83, 401-420.
56. Yan, H.Q., Kline, A.E., Ma, X., Hooghe-Peters, E.L., Marion, D.W., and Dixon, C.E. (2001). Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury. Neuroreport 12, 2323-2327.
57. Zhu, J., Hamm, R.J., Reeves, T.M., Povlishock, J.T., and Phillips, L.L. (2000). Postinjury administration of L-deprenyl improves cognitive function and enhances neuroplasticity after traumatic brain injury. Exp. Neurol. 166, 136-152.