Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 1-14

  Maccari, Rosanna ^a   Vitale, Rosa Maria ^b   Ottanà, Rosaria ^a   Rocchiccioli, Marco ^c   Marrazzo, Agostino ^d   Cardile, Venera ^d   Graziano, Adriana Carol Eleonora ^d   Amodeo, Pietro ^b   Mura, Umberto ^c   Del Corso, Antonella ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

5 (carbamoylmethoxy) benzylidene 2 oxo thioxo 4 thiazolidinone derivatives; 5 Arylidene 4 thiazolidinone derivatives; Aldose reductase; Anti inflammatory agents; Enzyme inhibitors; Molecular modelling

Indexed keywords

2 [2 METHOXY 4 (4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENEMETHYL)PHENOXY]ACETAMIDE; 2 [2 METHOXY 5 (4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENEMETHYL)PHENOXY]ACETAMIDE; 2 [3 (2,4 DIOXOTHIAZOLIDIN 5 YLIDENEMETHYL)PHENOXY]ACETAMIDE; 2 [3 (4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENEMETHYL)PHENOXY]ACETAMIDE; 2 [4 (2,4 DIOXOTHIAZOLIDIN 5 YLIDENEMETHYL) 2 METHOXYPHENOXY]ACETAMIDE; 2 [4 (2,4 DIOXOTHIAZOLIDIN 5 YLIDENEMETHYL)PHENOXY]ACETAMIDE; 2 [4 (4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENEMETHYL)PHENOXY]ACETAMIDE; 2 [5 (2,4 DIOXOTHIAZOLIDIN 5 YLIDENEMETHYL) 2 METHOXYPHENOXY]ACETAMIDE; 4 THIAZOLIDINONE DERIVATIVE; ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG; [5 [(3 CARBAMOYLMETHOXY 4 METHOXYPHENYL)METHYLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [(3 CARBAMOYLMETHOXY 4 METHOXYPHENYL)METHYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [(3 CARBAMOYLMETHOXYPHENYL)METHYLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACI; [5 [(3 CARBAMOYLMETHOXYPHENYL)METHYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [(4 CARBAMOYLMETHOXY 3 METHOXYPHENYL)METHYLIDENE] 2,4 OXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [(4 CARBAMOYLMETHOXY 3 METHOXYPHENYL)METHYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [(4 CARBAMOYLMETHOXYPHENYL)METHYLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACI; [5 [(4 CARBAMOYLMETHOXYPHENYL)METHYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; ENZYME INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; THIAZOLIDINE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BINDING; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KERATINOCYTE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BOVINAE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; LENS; METABOLISM; SYNTHESIS;

ALDEHYDE REDUCTASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATTLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; LENS, CRYSTALLINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 84900451019     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.003     Document Type: Article

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