Identification of new non-carboxylic acid containing inhibitors of aldose reductase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 4049-4055

  Maccari, Rosanna ^a   Ciurleo, Rosella ^a   Giglio, Marco ^a   Cappiello, Mario ^b   Moschini, Roberta ^b   Corso, Antonella Del ^b   Mura, Umberto ^b   Ottanà, Rosaria ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

2,4 Thiazolidinediones; Aldose reductase inhibitors; Diabetes complications; In vitro inhibition

Indexed keywords

5 (NAPHTHALEN 1 YLMETHYLIDENE) 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 (NAPHTHALEN 2 YLMETHYLIDENE) 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(3 HYDROXYPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(3 METHOXYPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(3 PHENOXYPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(4 BENZYLOXYPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(4 HYDROXYPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(4 METHOXYPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(4 PHENOXYPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 [(4 PHENYLPHENYL)METHYLIDENE] 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; 5 ARYLIDENE 3 (3,3,3 TRIFLUORO 2 OXOPROPYL) 2,4 THIAZOLIDINEDIONE; ALDOSE REDUCTASE INHIBITOR; SORBINIL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; COW; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; X RAY DIFFRACTION;

ALDEHYDE REDUCTASE; ANIMALS; CHLOROFLUOROCARBONS, METHANE; ENZYME INHIBITORS; HUMANS; KETONES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 77953137883     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.016     Document Type: Article

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