Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 11, 2008, Pages 5840-5852

  Maccari, Rosanna ^a   Ottanà, Rosaria ^a   Ciurleo, Rosella ^a   Rakowitz, Dietmar ^b   Matuszczak, Barbara ^b   Laggner, Christian ^b   Langer, Thierry ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

2,4 Thiazolidinediones; Aldose reductase; Diabetes mellitus; Induced fit docking

Indexed keywords

2 (5 BIPHENYL 4 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL) N HYDROXYACETAMIDE; 2 (5 BIPHENYL 4 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETAMIDE; 2 (5 NAPHTHALEN 1 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETAMIDE; 2 (5 NAPHTHALEN 2 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETAMIDE; 2 [2,4 DIOXO 5 (3 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]ACETAMIDE; 2 [2,4 DIOXO 5 (4 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]ACETAMIDE; 2 [5 (3 HYDROXY 4 METHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; 2 [5 (3 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; 2 [5 (3 METHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; 2 [5 (4 BENZYLOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL] N HYDROXYACETAMIDE; 2 [5 (4 HYDROXY 3 METHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; 2 [5 (4 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; 2 [5 (4 METHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ALDEHYDE REDUCTASE; AMIDE; CARBOXYLIC ACID; EPALRESTAT; FIDARESTAT; LIDORESTAT; N HYDROXY 2 (5 NAPHTHALEN 1 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETAMIDE; N HYDROXY 2 (5 NAPHTHALEN 2 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETAMIDE; N HYDROXY 2 [2,4 DIOXO 5 (3 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]ACETAMIDE; N HYDROXY 2 [2,4 DIOXO 5 (4 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]ACETAMIDE; N HYDROXY 2 [5 (4 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; PHENOL; SORBINIL; TOLRESTAT; UNINDEXED DRUG; ZOPOLRESTAT;

ARTICLE; BINDING SITE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; HYDROGEN BOND;

ALDEHYDE REDUCTASE; ANIMALS; BINDING SITES; CARBOXYLIC ACIDS; CATTLE; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; GLYCERALDEHYDE; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURAL HOMOLOGY, PROTEIN; THIAZOLIDINEDIONES;

EID: 44449137462     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.072     Document Type: Article

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