Structure-activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 8, 2005, Pages 2809-2823

  Maccari, Rosanna ^a   Ottanà, Rosaria ^a   Curinga, Carmela ^a   Vigorita, Maria Gabriella ^a   Rakowitz, Dietmar ^b   Steindl, Theodora ^b   Langer, Thierry ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

2,4 Thiazolidinediones; Aldose reductase; Diabetes mellitus; Molecular modelling

Indexed keywords

(5 BIPHENYL 4 METHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETIC ACID METHYL ESTER; (5 BIPHENYL 4 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETIC ACID; (5 NAPHTHALEN 1 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETIC ACID; (5 NAPHTHALEN 1 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)ACETIC ACID METHYL ESTER; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (3 AMINOBENZYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 (3 HYDROXYBENZYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 (3 NITROBENZYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 (4 AMINOBENZYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 (4 BENZYLOXYBENZYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 (4 HYDROXYBENZYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 (4 NITROBENZYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 BIPHENYL 4 YLMETHYLENE 2,4 THIAZOLIDINEDIONE; 5 NAPHTHALEN 1 YLMETHYLENE 2,4 THIAZOLIDINEDIONE; ALDOSE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; [2,4 DIOXO 5 (4 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]ACETIC ACID; [2,4 DIOXO 5 (4 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER; [5 (3 AMINOBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER; [5 (3 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 (3 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER; [5 (3 NITROBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 (3 NITROBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER; [5 (4 AMINOBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER; [5 (4 BENZYLOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 (4 BENZYLOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER; [5 (4 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 (4 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER; [5 (4 NITROBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 (4 NITROBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID METHYL ESTER;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR MODEL; PHARMACOPHORE; SIMULATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 15244355411     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.02.026     Document Type: Article

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