Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 402-414

  Narasimhan, Madhusudhanan ^a   Hong, Jennifer ^b   Atieno, Nancy ^b   Muthusamy, Vasanthi R ^b   Davidson, Christopher J ^b   Abu Rmaileh, Naser ^b   Richardson, Russell S ^b,c,d   Gomes, Aldrin V ^e   Hoidal, John R ^b   Rajasekaran, Namakkal S ^b,c  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Free radicals; Nrf2; PAX7 MyoD; Skeletal muscle; Stem cells

Indexed keywords

MYOD PROTEIN; PROTEIN KINASE B; PROTEIN P53; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR PAX7; UBIQUITIN; MYOD1 MYOGENIC DIFFERENTIATION PROTEIN; NFE2L2 PROTEIN, MOUSE; PAX7 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL POPULATION; CONTROLLED STUDY; DEFENSE MECHANISM; DOWN REGULATION; ENDURANCE EXERCISE STRESS; ENDURANCE TRAINING; GENETIC REGULATION; GENETIC TRANSCRIPTION; MOUSE; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE REGENERATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; REPRESSOR GENE; SKELETAL MUSCLE; STEM CELL; UBIQUITINATION; WILD TYPE; AGING; ANIMAL; ANTIOXIDANT RESPONSIVE ELEMENT; DEFICIENCY; EXERCISE TOLERANCE; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AGING; ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; APOPTOSIS; EXERCISE TOLERANCE; GENE EXPRESSION REGULATION; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; MYOD PROTEIN; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PAX7 TRANSCRIPTION FACTOR; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

EID: 84900426703     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.02.023     Document Type: Article

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