Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells

Antioxidants and Redox Signaling

Volumn 7, Issue 1-2, 2005, Pages 287-300

  Varadharaj, Saradhadevi ^a   Watkins, Tonya ^b   Cardounel, Arturo J ^a   Garcia, Joe G N ^b   Zweier, Jay L ^a   Kuppusamy, Periannan ^a   Natarajan, Viswanathan ^b   Parinandi, Narasimham L ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CATALASE; CHELATING AGENT; FREE RADICAL; GLUTATHIONE; HYDROGEN PEROXIDE; IRON; REACTIVE OXYGEN METABOLITE; THIOL GROUP;

ANIMAL CELL; ARTICLE; BLOOD VESSEL TONE; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; LUNG CIRCULATION; MONOLAYER CULTURE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CATALASE; CATTLE; CELL SURVIVAL; CELLS, CULTURED; CHELATING AGENTS; CLINICAL TRIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENDOTHELIUM, VASCULAR; FREE RADICALS; GLUTATHIONE; HYDROGEN PEROXIDE; IRON; LUNG; MAGNETICS; MICROCIRCULATION; MODELS, BIOLOGICAL; MODELS, CHEMICAL; OXAZINES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROPYL GALLATE; REACTIVE OXYGEN SPECIES; TIME FACTORS; XANTHENES;

ANIMALIA; BOVINAE;

EID: 13244253640     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2005.7.287     Document Type: Article

References (78)

1. Anderson M and Grankvist K. Ascorbate-induced free radical toxicity to isolated islet cells. Int J Biochem 27: 493-498, 1995.
2. Arrigoni O and De Tullio MC. Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta 1569: 1-9, 2002.
3. Badder SL, Bruchelt G, Carmine TG, Lode HN, Rieth AG, and Niethammer, D. Ascorbic acid-mediated iron release from cellular ferritin and its relation to the formation of DNA strand breaks in neuroblastoma cells. J Cancer Res Clin Oncol 120: 415-421, 1994.
4. Balla J, Vercellotti GM, Nath K, Yachie A, Nagy E, Eaton JW, and Balla G. Haem, haem oxygenase and ferritin in vascular endothelial cell injury. Nephrol Dial Transplant 18: v8-v12, 2003.
5. Barbera JA, Peinado VI, and Santos S. Pulmonary hypertension in chronic obstructive pulmonary disease. Eur Respir J 21: 892-905, 2003.
6. Beckman JA, Goldfine AB, Gordon MB, and Creager MA. Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation 103: 1618-1623, 2001.
7. Bellomo G and Mirabelli F. Oxidative stress and cytoskeletal alterations. Ann N Y Acad Sci 663: 97-109, 1992.
8. Bergsten P, Amitai G, Kehr J, Dhariwal KR, Kelin HG, and Levine M. Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation. J Biol Chem 265: 2584-2587, 1990.
9. Block ER. Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells. J Cell Physiol 146: 362-369, 1991.
10. Bors W and Buettner GR. The vitamin C radical and its reactions. In: Vitamin C in Health and Disease, edited by Packer L and Fuchs J. New York, NY: Marcel Dekker, 1997, pp. 75-94.
11. Bradley JR, Thiru S, and Pober JS. Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules. Am J Pathol 147: 627-641, 1995.
12. Bray TM. Antioxidants and oxidative stress in health and disease: Introduction. Proc Soc Exp Biol Med 222: 195, 1999.
13. Buettner GR and Jurkiewicz BA. Ascorbate free radical as a marker of oxidative stress: an EPR study. Free Radic Biol Med 14: 49-55, 1993.
14. Buettner GR and Jurkiewicz BA. Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiat Res 145: 532-541, 1996.
15. Cai L, Koropatnick J, and Cherian MG. Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper. Chem Biol Interact 137: 75-88, 2001.
16. Carr AC and Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 69: 1086-1107, 1999.
17. Carr A and Frei B. The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Radic Biol Med 28: 1806-1814, 2000.
18. Casciari JJ, Riordan NH, Schmidt TL, Meng XL, Jackson JA, and Riordan HD. Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours. Br J Cancer 84: 1544-1550, 2001.
19. Chen SH, Wu HL, Lin MT, Jen CJ, Wing LY, Tsao CJ, and Chang WC. Cytoprotective effect of reduced glutathione in hydrogen peroxide-induced endothelial injury. Prostaglandins Leukot Essent Fatty Acids 45: 299-305, 1992.
20. Chepada T, Cadau M, Girin P, Frey J, and Chamson A. Monitoring of ascorbate at a constant rate in cell culture: effect on cell growth. In Vitro Cell Dev Biol Anim 37: 26-30, 2001.
21. Clement MV, Ramalingam J, Long LH, and Halliwell B. The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide. Antioxid Redox Signal 3: 157-163, 2001.
22. Deutsch JC. Ascorbic acid oxidation by hydrogen peroxide. Anal Biochem 255: 1-7, 1998.
23. Dröge W. Oxidative stress and aging. Adv Exp Med Biol 543: 191-200, 2003.
24. Ek A, Strom K, and Cotgreve IA. The uptake of ascorbic acid into human umbilical vein endothelial cells and its effect on oxidant insult. Biochem Pharmacol 50: 1339-1346, 1995.
25. Forman HJ, Dickinson DA, and Iles KE. HNE-signaling pathways leading to its elimination. Mol Aspects Med 24: 189-194, 2003.
26. Grossmann M, Dobrev D, Himmel HM, Ravens U, and Kirch W. Ascorbic acid-induced modulation of venous tone in humans. Hypertension 37: 949-954, 2001.
27. Halliwell B. Vitamin C: antioxidant or pro-oxidant in vivo? Free Radic Res 25: 439-454, 1996.
28. Halliwell B. Vitamin C: poison, prophylactic or panacea? Trends Biochem Sci 24: 255-259, 1999.
29. Hamabe A, Takase B, Uehata A, Kurita A, Ohsuzu F, and Tamai S. Impaired endothelium-dependent vasodilation in brachial artery in variant angina pectoris and the effect of intravenous administration of vitamin C. Am J Cardiol 87: 1154-1159, 2001.
30. Hanashima C and Namiki H. Reduced viability of vascular endothelial cells by high concentration of ascorbic acid in vitreous humor. Cell Biol Int 23: 287-298, 1999.
31. Hinshaw DB, Burger JM, Armstrong BC, and Hyslop, PA. Mechanisms of endothelial shape change in oxidant injury. J Surg Res 46: 339-349, 1989.
32. Hirai N, Kawano H, Hirashima O, Motoyama T, Moriyama Y, Sakamoto T, Kugiyama K, Ogawa H, Nakao K, and Yasue H. Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C. Am J Physiol Heart Circ Physiol 279: H1172-H1178, 2000.
33. Hiraishi H, Terano A, Razandi M, Pedram A, Sugimoto T, Harada T, and Ivey KJ. Reactive oxygen metabolite-induced toxicity to cultured bovine endothelial cells: status of cellular iron in mediating injury. J Cell Physiol 160: 132-134, 1994.
34. Hirashima O, Kawano H, Motoyama T, Nobutaka H, Ohagushi M, Kugiyama K, Ogawa H, and Yasue H. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina. Am J Cardiol 35: 1860-1866, 2000.
35. Hoey J. Editorial: a cure for miracles. Can Med Assoc J 164: 317, 2001.
36. Jamison M, Gilloteaux J, Venugopal M, Koch JA, Sowick C, Shah R, and Summers JL. Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C and vitamin K3 combinations against human prostatic carcinoma cells. Tissue Cell 28: 687-701, 1996.
37. Kahl R and Hildebrandt AG. Methodology for studying antioxidant activity and mechanisms of action of antioxidants. Food Chem Toxicol 24: 1007-1014, 1986.
38. Kruszewski M. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res 531: 81-92, 2003.
39. Langlois M, Duprez D, Delanghe J, De Buyzere M, and Clement DL. Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis. Circulation 103: 1863-1868, 2001.
40. Li L and Lau BH. A simplified in vitro model of oxidant injury using vascular endothelial cells. In Vitro Cell Dev Biol Anim 29: 531-536, 1993.
41. May JM. Ascorbate function and metabolism in the human erythrocyte. Front Biosci 3: 1-10, 1998.
42. May JM. How does ascorbic acid prevent endothelial dysfunction? Free Radic Biok Med 28: 1421-1429, 2000.
43. May JM, Qu Z, and Li X. Requirement for GSH in recycling of ascorbic acid in endothelial cells. Biochem Pharmacol 62: 873-881, 2001.
44. Middleton E Jr, Kandaswami C, and Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751, 2000.
45. Natarajan V and Garcia JGN. Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium. J Lab Clin Med 121: 337-347, 1993.
46. Padayatty JS and Levine M. Reevaluation of ascorbate in cancer treatment: emerging evidence, open minds and serendipity. J Am Coll Nutr 19: 423-425, 2000.
47. Padayatty JS and Levine M. New insights into physiology and pharmacology of vitamin C. Can Med Assoc J 164: 353-355, 2001.
48. Padayatty JS, Katz A, Wang Y, Eck P, Kwon O, Lee J-H, Chen S, Corpe C, Dutta A, Dutta SK, and Levine M. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr 22: 18-35, 2003.
49. Padayatty JS, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, and Levine M. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 140: 533-537, 2004.
50. Paolini M, Pozzetti L, Pedulli GF, Marchesi E, and Cantelli-Forti G. The nature of prooxidant activity of vitamin C. Life Sci 64: 273-278, 1999.
51. Parinandi NL, Scribner WM, Vepa S, Shi S, and Natarajan V. Phospholipase D activation in endothelial cells is redox sensitive. Antioxid Redox Signal 1: 193-210, 1999.
52. Parinandi NL, Kleinberg MA, Usatyuk PV, Cummings RJ, Pennathur A, Cardounel AJ, Zweier, JL, Garcia JGN, and Natarajan V. Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am J Physiol Lung Cell Mol Physiol 284: L26-L38, 2003.
53. Peterkofsky B and Prather W. Cytotoxicity of ascorbate and other reducing agents towards cultured fibroblasts as a result of hydrogen peroxide formation. J Cell Physiol 90: 61-70, 1997.
54. Pietri S, Culcasi M, Stella L, and Cozzone PJ. Ascorbyl free radical as a reliable indicator of free-radical-mediated myocardial ischemic and post-ischemic injury. A real-time continuous flow ESR study. Eur J Biochem 193: 845-854, 1990.
55. Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, and Lunec J. Vitamin C exhibits pro-oxidant properties. Nature 392: 559, 1998.
56. Prat AG and Turrens JF. Ascorbate- and hemoglobin-dependent brain chemiluminescence. Free Radic Biol Med 8: 319-325, 1990.
57. Roomi MW, House D, Eckert-Maksic M, Maksic ZB, and Tsao CS. Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives. Cancer Lett 122: 93-99, 1998.
58. Roy S, Parinandi N, Zeigelstein R, Hu Q, Pei Y, Travers JB, and Natarajan V. Hyperoxia alters phorbol ester-induced phospholipase D activation in bovine lung microvascular endothelial cells. Antioxid Redox Signal 5: 217-228, 2003.
59. Sakagami H and Satoh K. Effect of ascorbate oxidase on radical intensity and cytotoxic activity of ascorbate. Anticancer Res 17: 1163-1166, 1997.
60. Sakagami H and Satoh K. Modulating factors of radical intensity and cytotoxic activity of ascorbate (review). Anticancer Res 17: 3513-3520, 1997.
61. Sakagami H and Satoh K. Detection of drug-drug interaction by ESR spectroscopy. Nippon Yakurigaku Zasshi 113: 349-356, 1999.
62. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, Kuribayashi N, Sakagami T, Momose K, and Takeda M. Relationship between ascorbyl radical intensity and apoptosis-inducing activity. Anticancer Res 16: 2635-2644, 1996.
63. Sakagami H, Satoh K, Ida Y, Hosaka M, Arakawa H, and Maeda M. Interaction between sodium ascorbate and dopamine. Free Radic Biol Med 25: 1013-1020, 1998.
64. Salacinski HJ, Punshon G, Krijgsman B, Hamilton G, and Seifalian AM. A hybrid compliant vascular graft seeded with microvascular endothelial cells extracted from human omentum. J Artif Organs 25: 974-982, 2001.
65. Satoh K and Sakagami H. Effect of metal ions on radical intensity and cytotoxic activity of ascorbate. Anticancer Res 17: 1125-1129, 1997.
66. Schmidt RJ, Chung LY, Andrews AM, and Turner TD. Toxicity of L-ascorbic acid to L929 fibroblast cultures: relevance to biocompatibility testing of materials for use in wound management. J Biomed Mater Res 27: 521-530, 1993.
67. Schor AM, Schor SL, and Alien TD. Effects of culture conditions on the proliferation, morphology and migration of bovine aortic endothelial cells. J Cell Sci 62: 267-285, 1983.
68. Schrammel A, Koesling D, Schmidt K, and Mayer B. Inhibition of purified soluble guanylyl cyclase by L-ascorbic acid. Cardiovascular Res 47: 602-608, 2000.
69. Sestili P, Brandi G, Brambilla L, Cattabeni F, and Cantoni O. Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts. J Pharmacol Exp Ther 277: 1719-1725, 1996.
70. Sherman DL, Keaney JF, Biegelsen ES, Duffy SJ, Coffman JD, and Vita JA. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension 35: 936-941, 2000.
71. Song JH, Shin SH, and Ross GM. Prooxidant effects of ascorbate in rat brain slices. J Neurosci Res 58: 328-336, 1999.
72. Tiwari A, Salacinski HJ, Punshon G, Hamilton G, and Seifalian AM. Development of a hybrid cardiovascular graft using a tissue engineering approach. FASEB J 16: 791-796, 2002.
73. Toborek M, Blanc EM, Kaiser S, Mattson MP, and Hennig B. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. J Lipid Res 38: 2155-2167, 1997.
74. 2+ in diperoxovanadate-induced cytoskeletal remodeling and endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol 285: L1006-L1007, 2003.
75. Usatyuk PV, Vepa S, Watkins T, He D, Parinandi NL, and Natarajan V. Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells. Antioxid Redox Signal 5: 723-730, 2003.
76. Vepa S, Scribner WM, Parinandi NL, English D, Garcia JG, and Natarajan V. Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells. Am J Physiol 277: L150-L158, 1999.
77. Yue BY, Niedra R, and Baum JL. Effects of ascorbic acid on cultured corneal endothelial cells. Invest Ophthalmol Vis Sci 19: 1471-1476, 1980.
78. Zweier JL, Broderick R, Kuppusamy R, Thompson-Gorman S, and Lutty GA. Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. J Biol Chem 269: 24156-24162, 1994.